Fingerprint Fingerprint is based on mining the text of the persons scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 1 Similar Profiles
Proteins Medicine & Life Sciences
Cyclic Nucleotides Medicine & Life Sciences
Cyclic AMP-Dependent Protein Kinases Medicine & Life Sciences
Phosphotransferases Medicine & Life Sciences
Cyclic AMP Receptors Medicine & Life Sciences
Guanine Medicine & Life Sciences
Frustration Medicine & Life Sciences
Binding Sites Medicine & Life Sciences

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Research Output 2012 2015

  • 130 Citations
  • 7 h-Index
  • 9 Article
  • 1 Review article
5 Citations

Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα

Akimoto, M., McNicholl, E. T., Ramkissoon, A., Moleschi, K., Taylor, S. S. & Melacini, G. 2015 Nov 30 In : PLoS Biology. 13, 11, e1002305

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Magnetic Resonance Spectroscopy
Catalytic Domain
6 Citations

Measurement of State-Specific Association Constants in Allosteric Sensors through Molecular Stapling and NMR

Moleschi, K. J., Akimoto, M. & Melacini, G. 2015 Aug 6 In : Journal of the American Chemical Society. 137, 33, p. 10777-10785 9 p.

Research output: Contribution to journalArticle

Association reactions
Chemical shift
Nuclear magnetic resonance
7 Citations

Roe of dynamics in the autoinhibition and activation of the hyperpolarization-activated cyclic nucleotide-modulated (HCN) ion channels

Vanschouwen, B., Akimoto, M., Sayadi, M., Fogolari, F. & Melacini, G. 2015 Jul 17 In : Journal of Biological Chemistry. 290, 29, p. 17642-17654 13 p.

Research output: Contribution to journalArticle

Cyclic Nucleotides
Ion Channels
Molecular Dynamics Simulation
9 Citations

Allosteric linkers in cAMP signalling

Akimoto, M., Moleschi, K., Boulton, S., VanSchouwen, B., Selvaratnam, R., Taylor, S. S. & Melacini, G. 2014 Feb In : Biochemical Society Transactions. 42, 1, p. 139-144 6 p.

Research output: Contribution to journalArticle

Allosteric Regulation
Cyclic AMP-Dependent Protein Kinases
25 Citations

A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP

Akimoto, M., Zhang, Z., Boulton, S., Selvaratnam, R., Van Schouwen, B., Gloyd, M., Accili, E. A., Lange, O. F. & Melacini, G. 2014 Aug 8 In : Journal of Biological Chemistry. 289, 32, p. 22205-22220 16 p.

Research output: Contribution to journalArticle

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Cyclic Nucleotides