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Research Output 1995 2019

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Article
2019
Indigo Carmine
Ulcerative Colitis
Pulmonary Hypertension
Intussusception
Liver Diseases

Clinical utility of novel ultrathin single-balloon enteroscopy: A feasibility study

Takabayashi, K., Hosoe, N., Miyanaga, R., Fukuhara, S., Hukuhara, K., Mizuno, S., Naganuma, M., Yahagi, N., Ogata, H. & Kanai, T., 2019 Jan 1, In : Endoscopy. 51, 5, p. 468-471 4 p.

Research output: Contribution to journalArticle

Feasibility Studies
Conscious Sedation
Ileum
Outpatients
Safety

Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis

Yoshimatsu, Y., Naganuma, M., Sugimoto, S., Tanemoto, S., Umeda, S., Fukuda, T., Nomura, E., Yoshida, K., Ono, K., Mutaguchi, M., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Takabayashi, K., Ogata, H., Iwao, Y. & Kanai, T., 2019 Jan 1, In : Digestion.

Research output: Contribution to journalArticle

Indigo Carmine
Suppositories
Ulcerative Colitis
Therapeutics
Rectum
Colitis
Ulcerative Colitis
Neoplasms
Mucous Membrane
Colectomy

Efficacy and safety of JAK inhibitors; Including therapeutic positioning

Naganuma, M., 2019 Jan 1, In : Journal of Japanese Society of Gastroenterology. 116, 3, p. 200-207 8 p.

Research output: Contribution to journalArticle

Safety
Therapeutics

Efficacy of therapeutic intervention for patients with an ulcerative colitis mayo endoscopic score of 1

Fukuda, T., Naganuma, M., Sugimoto, S., Ono, K., Nanki, K., Mizuno, S., Hukuhara, K., Mutaguchi, M., Nakazato, Y., Takabayashi, K., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2019 Mar 14, In : Inflammatory bowel diseases. 25, 4, p. 782-788 7 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Recurrence
Colonoscopy
Therapeutics
Blood Vessels

How Can We Assess "Complete Healing" Beyond Endoscopic Remission?

Fukuda, T., Naganuma, M. & Kanai, T., 2019 May 4, In : Inflammatory bowel diseases. 25, 6, p. e68

Research output: Contribution to journalArticle

Idiopathic Thrombocytopenic Purpura Responsive to Surgery for Crohn's Disease

Mizuno, S., Naganuma, M. & Kanai, T., 2019 Feb 21, In : Inflammatory bowel diseases. 25, 3, p. e26

Research output: Contribution to journalArticle

Idiopathic Thrombocytopenic Purpura
Crohn Disease
Cellular Structures
Cadherins
Ulcerative Colitis
Colitis
Signet Ring Cell Carcinoma
1 Citation (Scopus)

Toll-Like Receptor 7 Agonist–Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells

Kiyohara, H., Sujino, T., Teratani, T., Miyamoto, K., Arai, M. M., Nomura, E., Harada, Y., Aoki, R., Koda, Y., Mikami, Y., Mizuno, S., Naganuma, M., Hisamatsu, T. & Kanai, T., 2019 Jan 1, In : CMGH. 7, 1, p. 135-156 22 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 7
imiquimod
Dextran Sulfate
Dermatitis
Colitis
1 Citation (Scopus)
Crohn Disease
Randomized Controlled Trials
Maintenance
Adrenal Cortex Hormones
Adalimumab
2018

5-Aminosalicylic acid aggravates colitis mimicking exacerbation of ulcerative colitis

Miyoshi, J., Matsuoka, K., Yoshida, A., Naganuma, M., Hisamatsu, T., Yajima, T., Inoue, N., Okamoto, S., Iwao, Y., Ogata, H., Ueno, F., Hibi, T. & Kanai, T., 2018 Oct 1, In : Intestinal Research. 16, 4, p. 635-640 6 p.

Research output: Contribution to journalArticle

Mesalamine
Colitis
Ulcerative Colitis
Colonoscopy
Inflammatory Bowel Diseases
2 Citations (Scopus)

A male Korean who was diagnosed with chronic enteropathy associated with SLCO2A1 (CEAS): Case report with literature review

Sun, X., Hosoe, N., Miyanaga, R., Hukuhara, K., Mizuno, S., Takabayashi, K., Naganuma, M., Niizeki, H., Seki, A., Ogata, H. & Kanai, T., 2018 Jan 1, In : BMJ Open Gastroenterology. 5, 1, e000223.

Research output: Contribution to journalArticle

Melena
Mutation
Genes
Exons
Capsule Endoscopes

Author’s reply: can budesonide form be alterative treatment for ulcerative proctosigmoiditis?

Naganuma, M., 2018 Apr 3, (Accepted/In press) In : Journal of Gastroenterology. p. 1-2 2 p.

Research output: Contribution to journalArticle

Proctocolitis
Budesonide
1 Citation (Scopus)

Effect of elemental diet combined with infliximab dose escalation in patients with Crohn's disease with loss of response to infliximab: CERISIER trial

Hisamatsu, T., Kunisaki, R., Nakamura, S., Tsujikawa, T., Hirai, F., Nakase, H., Watanabe, K., Yokoyama, K., Nagahori, M., Kanai, T., Naganuma, M., Michimae, H., Andoh, A., Yamada, A., Yokoyama, T., Kamata, N., Tanaka, S., Suzuki, Y., Hibi, T. & Watanabe, M., 2018 Jan 1, In : Intestinal Research. 16, 3, p. 494-498 5 p.

Research output: Contribution to journalArticle

Formulated Food
Crohn Disease
Infliximab
23 Citations (Scopus)

Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis

INDIGO Study Group, 2018 Mar 1, In : Gastroenterology. 154, 4, p. 935-947 13 p.

Research output: Contribution to journalArticle

Indigo Carmine
Ulcerative Colitis
Randomized Controlled Trials
Placebos
Pulmonary Hypertension
1 Citation (Scopus)

Establishment of a Novel Scoring System for Colon Capsule Endoscopy to Assess the Severity of Ulcerative Colitis-Capsule Scoring of Ulcerative Colitis

Hosoe, N., Nakano, M., Takeuchi, K., Endo, Y., Matsuoka, K., Abe, T., Omori, T., Hayashida, M., Kobayashi, T., Yoshida, A., Mizuno, S., Nakazato, Y., Naganuma, M., Kanai, T., Watanabe, M., Ueno, F., Suzuki, Y., Hibi, T. & Ogata, H., 2018 Nov 29, In : Inflammatory Bowel Diseases. 24, 12, p. 2641-2647 7 p.

Research output: Contribution to journalArticle

Capsule Endoscopy
Ulcerative Colitis
Capsules
Colon
Colonoscopy
1 Citation (Scopus)

Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2018 Oct 1, In : PLoS One. 13, 10, e0204632.

Research output: Contribution to journalArticle

Crohn disease
Crohn Disease
tumor necrosis factors
therapeutics
Tumor Necrosis Factor-alpha
1 Citation (Scopus)

Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Nanki, K., Mizuno, S., Matsuoka, K., Ono, K., Sugimoto, S., Kiyohara, H., Arai, M., Nakashima, M., Takeshita, K., Saigusa, K., Senoh, M., Fukuda, T., Naganuma, M., Kato, H., Suda, W., Hattori, M. & Kanai, T., 2018 Jan 1, In : Intestinal Research. 16, 1, p. 142-146 5 p.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Ulcerative Colitis
Dysbiosis
Recurrence
12 Citations (Scopus)
Pharmacogenetics
Leukopenia
Inflammatory Bowel Diseases
Codon
Multicenter Studies

Surveillance for dysplasia in patients with ulcerative colitis: Discrepancy between guidelines and practice

Shinozaki, M., Kobayashi, K., Kunisaki, R., Hisamatsu, T., Naganuma, M., Takahashi, K. I., Iwao, Y., Suzuki, Y., Watanabe, M., Itabashi, M., Torii, A., Takazoe, M. & Sugita, A., 2018 Apr 1, In : Gastroenterological Endoscopy. 60, 4, p. 1033-1043 11 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Practice Guidelines
Colonoscopy
Biopsy
Physicians
14 Citations (Scopus)

The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study

Kurokawa, S., Kishimoto, T., Mizuno, S., Masaoka, T., Naganuma, M., Liang, K. C., Kitazawa, M., Nakashima, M., Shindo, C., Suda, W., Hattori, M., Kanai, T. & Mimura, M., 2018 Aug 1, In : Journal of Affective Disorders. 235, p. 506-512 7 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
Constipation
Observational Studies
Psychiatry
Diarrhea
11 Citations (Scopus)

The role of colorectal endoscopic submucosal dissection in patients with ulcerative colitis

Kinoshita, S., Uraoka, T., Nishizawa, T., Naganuma, M., Iwao, Y., Ochiai, Y., Fujimoto, A., Goto, O., Shimoda, M., Ogata, H., Kanai, T. & Yahagi, N., 2018 Apr 1, In : Gastrointestinal Endoscopy. 87, 4, p. 1079-1084 6 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Confidence Intervals
Biopsy
Carcinoma
Unnecessary Procedures
2017
25 Citations (Scopus)

Bifidobacterium-Rich Fecal Donor May Be a Positive Predictor for Successful Fecal Microbiota Transplantation in Patients with Irritable Bowel Syndrome

Mizuno, S., Masaoka, T., Naganuma, M., Kishimoto, T., Kitazawa, M., Kurokawa, S., Nakashima, M., Takeshita, K., Suda, W., Mimura, M., Hattori, M. & Kanai, T., 2017 Jun 21, (Accepted/In press) In : Digestion. p. 29-38 10 p.

Research output: Contribution to journalArticle

Bifidobacterium
Irritable Bowel Syndrome
Tissue Donors
Dysbiosis
Psychology
11 Citations (Scopus)
Crohn Disease
Differential Diagnosis
Ulcer
Enteritis
Genes
4 Citations (Scopus)

Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study

Naganuma, M., Aoyama, N., Tada, T., Kobayashi, K., Hirai, F., Watanabe, K., Watanabe, M. & Hibi, T., 2017 Aug 4, (Accepted/In press) In : Journal of Gastroenterology. p. 1-13 13 p.

Research output: Contribution to journalArticle

Budesonide
Ulcerative Colitis
Double-Blind Method
Inflammation
Placebos
1 Citation (Scopus)

Correction to: Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study

Naganuma, M., Aoyama, N., Tada, T., Kobayashi, K., Hirai, F., Watanabe, K., Watanabe, M. & Hibi, T., 2017 Oct 13, (Accepted/In press) In : Journal of Gastroenterology. p. 1-3 3 p.

Research output: Contribution to journalArticle

Budesonide
Ulcerative Colitis
Double-Blind Method
Inflammation
11 Citations (Scopus)

Endocytoscopy can be used to assess histological healing in ulcerative colitis

Nakazato, Y., Naganuma, M., Sugimoto, S., Bessho, R., Arai, M., Kiyohara, H., Ono, K., Nanki, K., Mutaguchi, M., Mizuno, S., Kobayashi, T., Hosoe, N., Shimoda, M., Abe, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2017 Mar 13, (Accepted/In press) In : Endoscopy.

Research output: Contribution to journalArticle

Ulcerative Colitis
Rectum
Biopsy
Light
10 Citations (Scopus)
Mucous Membrane
Sigmoid Colon
Colonoscopy
Ulcerative Colitis
Rectum
5 Citations (Scopus)

Glycolysis regulates LPS-induced cytokine production in M2 polarized human macrophages

Chiba, S., Hisamatsu, T., Suzuki, H., Mori, K., Kitazume, M. T., Shimamura, K., Mizuno, S., Nakamoto, N., Matsuoka, K., Naganuma, M. & Kanai, T., 2017 Mar 1, In : Immunology Letters. 183, p. 17-23 7 p.

Research output: Contribution to journalArticle

Glycolysis
Lipopolysaccharides
Macrophages
Cytokines
Macrophage Colony-Stimulating Factor
1 Citation (Scopus)

Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients

Mizuno, S., Wakui, M., Machida, Y., Hosoe, N., Hisamatsu, T., Ishida, T., Kameyama, K., Naganuma, M. & Kanai, T., 2017 Dec 1, In : Medicine (United States). 96, 51, e9237.

Research output: Contribution to journalArticle

Peritoneal Panniculitis
Prostaglandins E
Fat Necrosis
Interstitial Lung Diseases
Rare Diseases
9 Citations (Scopus)

Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice

Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., Suda, W., Hattori, M., Amagai, M., Ohyama, M. & Kanai, T., 2017 Aug 15, In : Cell Reports. 20, 7, p. 1513-1524 12 p.

Research output: Contribution to journalArticle

Dysbiosis
Alopecia
Lactobacillus
Biotin
Physiology

Limited identification of dual-time-point positron emission tomography/computed tomography in advanced colorectal neoplasms

Kashiwagi, K., Nakazato, Y., Arai, M., Iwasaki, E., Naganuma, M., Inoue, N., Iwao, Y., Ogata, H., Murakami, K. & Kanai, T., 2017, In : Internal Medicine. 56, 11, p. 1287-1292 6 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Neoplasms
Adenoma
Positron Emission Tomography Computed Tomography
Colonoscopy
7 Citations (Scopus)

Long-term safety and efficacy of adalimumab for intestinal Behçet's disease in the open label study following a phase 3 clinical trial

Inoue, N., Kobayashi, K., Naganuma, M., Hirai, F., Ozawa, M., Arikan, D., Huang, B., Robinson, A. M., Thakkar, R. B. & Hibi, T., 2017, In : Intestinal Research. 15, 3, p. 395-401 7 p.

Research output: Contribution to journalArticle

Intestinal Diseases
Phase III Clinical Trials
Safety
Therapeutics
Symptom Assessment
13 Citations (Scopus)

Single fecal microbiota transplantation failed to change intestinal microbiota and had limited effectiveness against ulcerative colitis in Japanese patients

Mizuno, S., Nanki, K., Matsuoka, K., Saigusa, K., Ono, K., Arai, M., Sugimoto, S., Kiyohara, H., Nakashima, M., Takeshita, K., Naganuma, M., Suda, W., Hattori, M. & Kanai, T., 2017, In : Intestinal Research. 15, 1, p. 68-74 7 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Information Services
Tissue Donors
Dysbiosis
Clinical Trials
3 Citations (Scopus)

Surveillance for dysplasia in patients with ulcerative colitis: Discrepancy between guidelines and practice

Shinozaki, M., Kobayashi, K., Kunisaki, R., Hisamatsu, T., Naganuma, M., Takahashi, K. I., Iwao, Y., Suzuki, Y., Watanabe, M., Itabashi, M., Torii, A., Takazoe, M. & Sugita, A., 2017, (Accepted/In press) In : Digestive Endoscopy.

Research output: Contribution to journalArticle

Ulcerative Colitis
Practice Guidelines
Colonoscopy
Biopsy
Physicians
6 Citations (Scopus)
Mesalamine
colitis
relapse
remission
Ulcerative Colitis

What strategies do ulcerative colitis patients employ to facilitate adherence?

Kawakami, A., Tanaka, M., Naganuma, M., Maeda, S., Kunisaki, R. & Yamamoto-Mitani, N., 2017 Jan 27, In : Patient Preference and Adherence. 11, p. 157-163 7 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
medication
medicine
outpatient clinic
questionnaire
2016
12 Citations (Scopus)

A single species of clostridium Subcluster XIVa decreased in ulcerative colitis patients

Takeshita, K., Mizuno, S., Mikami, Y., Sujino, T., Saigusa, K., Matsuoka, K., Naganuma, M., Sato, T., Takada, T., Tsuji, H., Kushiro, A., Nomoto, K. & Kanai, T., 2016 Dec 1, In : Inflammatory Bowel Diseases. 22, 12, p. 2802-2810 9 p.

Research output: Contribution to journalArticle

Clostridium
Ulcerative Colitis
Colitis
Inflammatory Bowel Diseases
Inflammation
30 Citations (Scopus)

Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study

Sugimoto, S., Naganuma, M., Kiyohara, H., Arai, M., Ono, K., Mori, K., Saigusa, K., Nanki, K., Takeshita, K., Takeshita, T., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hisamatsu, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2016 Mar 10, (Accepted/In press) In : Digestion. p. 193-201 9 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Prospective Studies
Safety
Indigo Carmine
Occult Blood

Difficulties in Performing Mesalazine Enemas and Factors Related to Discontinuation Among Patients With Ulcerative Colitis

Kawakami, A., Tanaka, M., Ochiai, R., Naganuma, M., Kunisaki, R. & Kazuma, K., 2016 Aug 3, (Accepted/In press) In : Gastroenterology Nursing.

Research output: Contribution to journalArticle

Mesalamine
Enema
Ulcerative Colitis
Outpatients
Cross-Sectional Studies
1 Citation (Scopus)

Endoscopic Severity Predicts Long-Term Prognosis in Crohn's Disease Patients with Clinical Remission

Naganuma, M., Hisamatsu, T., Matsuoka, K., Kiyohara, H., Arai, M., Sugimoto, S., Mori, K., Nanki, K., Ohno, K., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hosoe, N., Inoue, N., Iwao, Y., Ogata, H. & Kanai, T., 2016 Jan 1, In : Digestion. 93, 1, p. 66-71 6 p.

Research output: Contribution to journalArticle

Crohn Disease
Recurrence
Colonoscopy
C-Reactive Protein
Cohort Studies
7 Citations (Scopus)

Findings of ulceration and severe stricture on MRE can predict prognosis of Crohn’s disease in patients treated with anti-TNF treatment

Naganuma, M., Okuda, S., Hisamatsu, T., Matsuoka, K., Mori, K., Hosoe, N., Nakazato, Y., Ogata, H. & Kanai, T., 2016 Aug 23, (Accepted/In press) In : Abdominal Radiology. p. 1-11 11 p.

Research output: Contribution to journalArticle

Crohn Disease
Pathologic Constriction
Therapeutics
Recurrence
Magnetic Resonance Spectroscopy
17 Citations (Scopus)

Glycolytic pathway affects differentiation of human monocytes to regulatory macrophages

Suzuki, H., Hisamatsu, T., Chiba, S., Mori, K., Kitazume, M. T., Shimamura, K., Nakamoto, N., Matsuoka, K., Ebinuma, H., Naganuma, M. & Kanai, T., 2016 Aug 1, In : Immunology Letters. 176, p. 18-27 10 p.

Research output: Contribution to journalArticle

Glycolysis
Monocytes
Macrophages
Interleukin-10
Phenotype
39 Citations (Scopus)

Indole compounds may be promising medicines for ulcerative colitis

Sugimoto, S., Naganuma, M. & Kanai, T., 2016 May 9, (Accepted/In press) In : Journal of Gastroenterology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Indigo Carmine
Tryptophan
Aryl Hydrocarbon Receptors
indole

Novel Topics in Inflammatory Bowel Disease

Sakuraba, A., Armuzzi, A., Keyashian, K. & Naganuma, M., 2016, In : BioMed Research International. 2016, 8958751.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Pregnancy outcome in women with inflammatory bowel disease treated with anti-tumor necrosis factor and/or thiopurine therapy: A multicenter study from Japan

Japanese study group for pregnant women with IBD, 2016, In : Intestinal Research. 14, 2, p. 139-145 7 p.

Research output: Contribution to journalArticle

Pregnancy Outcome
Inflammatory Bowel Diseases
Multicenter Studies
Japan
Tumor Necrosis Factor-alpha
21 Citations (Scopus)

The ulcerative colitis endoscopic index of severity is useful to predict medium- to long-term prognosis in ulcerative colitis patients with clinical remission

Arai, M., Naganuma, M., Sugimoto, S., Kiyohara, H., Ono, K., Mori, K., Saigusa, K., Nanki, K., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hosoe, N., Matsuoka, K., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2016, In : Journal of Crohn's and Colitis. 10, 11, p. 1303-1309 7 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Colonoscopy
Recurrence
Hemorrhage
C-Reactive Protein
20 Citations (Scopus)

Twice-daily budesonide 2-mg foam induces complete mucosal healing in patients with distal ulcerative colitis

Naganuma, M., Aoyama, N., Suzuki, Y., Nishino, H., Kobayashi, K., Hirai, F., Watanabe, K. & Hibi, T., 2016, In : Journal of Crohn's and Colitis. 10, 7, p. 828-836 9 p.

Research output: Contribution to journalArticle

Budesonide
Ulcerative Colitis
Placebos
Mesalamine
Suppositories
11 Citations (Scopus)

Ulcerative colitis endoscopic index of severity is associated with long-term prognosis in ulcerative colitis patients treated with infliximab

Saigusa, K., Matsuoka, K., Sugimoto, S., Arai, M., Kiyohara, H., Takeshita, K., Mizuno, S., Mori, K., Nanki, K., Takeshita, T., Nakazato, Y., Yajima, T., Naganuma, M., Hisamatsu, T., Ogata, H., Iwao, Y. & Kanai, T., 2016 Sep 1, In : Digestive Endoscopy. 28, 6, p. 665-670 6 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Therapeutics
Observer Variation
Infliximab
Colonoscopy