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2020

5-Aminosalicylic acid intolerance is associated with a risk of adverse clinical outcomes and dysbiosis in patients with ulcerative colitis

Mizuno, S., Ono, K., Mikami, Y., Naganuma, M., Fukuda, T., Minami, K., Masaoka, T., Terada, S., Yoshida, T., Saigusa, K., Hirahara, N., Miyata, H., Suda, W., Hattori, M. & Kanai, T., 2020 Jan 1, In : Intestinal Research. 18, 1, p. 69-78 10 p.

Research output: Contribution to journalArticle

Open Access

Efficacy of apheresis as maintenance therapy for patients with ulcerative colitis in an open-label prospective multicenter randomised controlled trial

for the CAPTAIN study Group, 2020 Apr 1, In : Journal of gastroenterology. 55, 4, p. 390-400 11 p.

Research output: Contribution to journalArticle

High-resolution melt analysis enables simple genotyping of complicated polymorphisms of codon 18 rendering the NUDT15 diplotype

for the MENDEL study group, 2020 Jan 1, In : Journal of gastroenterology. 55, 1, p. 67-77 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Indigo naturalis is effective even in treatment-refractory patients with ulcerative colitis: a post hoc analysis from the INDIGO study

For the INDIGO Study Group, 2020 Feb 1, In : Journal of gastroenterology. 55, 2, p. 169-180 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Mucosal concentrations of N-acetyl-5-aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine

Fukuda, T., Naganuma, M., Takabayashi, K., Hagihara, Y., Tanemoto, S., Nomura, E., Yoshimatsu, Y., Sugimoto, S., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Mutaguchi, M., Inoue, N., Ogata, H., Iwao, Y., Abe, T. & Kanai, T., 2020 Jan 1, (Accepted/In press) In : Journal of Gastroenterology and Hepatology (Australia).

Research output: Contribution to journalArticle

Open Access

Non-adherence to Medications in Pregnant Ulcerative Colitis Patients Contributes to Disease Flares and Adverse Pregnancy Outcomes

Watanabe, C., Nagahori, M., Fujii, T., Yokoyama, K., Yoshimura, N., Kobayashi, T., Yamagami, H., Kitamura, K., Takashi, K., Nakamura, S., Naganuma, M., Ishihara, S., Esaki, M., Yonezawa, M., Kunisaki, R., Sakuraba, A., Kuji, N., Miura, S., Hibi, T., Suzuki, Y. & 1 others, Hokari, R., 2020 Jan 1, (Accepted/In press) In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Predictive factors for achievement of mucosal healing by budesonide 2-mg foam in ulcerative colitis: A pooled analysis of data from two clinical trials

Hibi, T., Naganuma, M., Oda, E., Yamada, Y., Chujoh, Y., Yoshihara, R. & Watanabe, M., 2020 Jan 1, In : Intestinal Research. 18, 1, p. 56-68 13 p.

Research output: Contribution to journalArticle

Open Access
2019

Adverse events in patients with ulcerative colitis treated with indigo naturalis: a Japanese nationwide survey

INDIGO survey Group, 2019 Oct 1, In : Journal of gastroenterology. 54, 10, p. 891-896 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Clinical utility of novel ultrathin single-balloon enteroscopy: A feasibility study

Takabayashi, K., Hosoe, N., Miyanaga, R., Fukuhara, S., Hukuhara, K., Mizuno, S., Naganuma, M., Yahagi, N., Ogata, H. & Kanai, T., 2019 Jan 1, In : Endoscopy. 51, 5, p. 468-471 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis

Yoshimatsu, Y., Naganuma, M., Sugimoto, S., Tanemoto, S., Umeda, S., Fukuda, T., Nomura, E., Yoshida, K., Ono, K., Mutaguchi, M., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Takabayashi, K., Ogata, H., Iwao, Y. & Kanai, T., 2019 Jan 1, In : Digestion.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Efficacy and safety of JAK inhibitors; Including therapeutic positioning

Naganuma, M., 2019 Jan 1, In : Journal of Japanese Society of Gastroenterology. 116, 3, p. 200-207 8 p.

Research output: Contribution to journalArticle

Efficacy of therapeutic intervention for patients with an ulcerative colitis mayo endoscopic score of 1

Fukuda, T., Naganuma, M., Sugimoto, S., Ono, K., Nanki, K., Mizuno, S., Hukuhara, K., Mutaguchi, M., Nakazato, Y., Takabayashi, K., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2019 Mar 14, In : Inflammatory bowel diseases. 25, 4, p. 782-788 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Middle-term prognosis in patients with ulcerative colitis who achieved clinical and endoscopic remission by budesonide rectal foam

ESCORT study Group, 2019 Jan 1, In : PloS one. 14, 8, e0220413.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Toll-Like Receptor 7 Agonist–Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells

Kiyohara, H., Sujino, T., Teratani, T., Miyamoto, K., Arai, M. M., Nomura, E., Harada, Y., Aoki, R., Koda, Y., Mikami, Y., Mizuno, S., Naganuma, M., Hisamatsu, T. & Kanai, T., 2019, In : CMGH. 7, 1, p. 135-156 22 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Withdrawal of thiopurines in Crohn’s disease treated with scheduled adalimumab maintenance: a prospective randomised clinical trial (DIAMOND2)

DIAMOND2 Study Group, 2019 Oct 1, In : Journal of gastroenterology. 54, 10, p. 860-870 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

5-Aminosalicylic acid aggravates colitis mimicking exacerbation of ulcerative colitis

Miyoshi, J., Matsuoka, K., Yoshida, A., Naganuma, M., Hisamatsu, T., Yajima, T., Inoue, N., Okamoto, S., Iwao, Y., Ogata, H., Ueno, F., Hibi, T. & Kanai, T., 2018 Oct 1, In : Intestinal Research. 16, 4, p. 635-640 6 p.

Research output: Contribution to journalArticle

A male Korean who was diagnosed with chronic enteropathy associated with SLCO2A1 (CEAS): Case report with literature review

Sun, X., Hosoe, N., Miyanaga, R., Hukuhara, K., Mizuno, S., Takabayashi, K., Naganuma, M., Niizeki, H., Seki, A., Ogata, H. & Kanai, T., 2018 Jan 1, In : BMJ Open Gastroenterology. 5, 1, e000223.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Author’s reply: can budesonide form be alterative treatment for ulcerative proctosigmoiditis?

Naganuma, M., 2018 Apr 3, (Accepted/In press) In : Journal of Gastroenterology. p. 1-2 2 p.

Research output: Contribution to journalArticle

Effect of elemental diet combined with infliximab dose escalation in patients with Crohn's disease with loss of response to infliximab: CERISIER trial

Hisamatsu, T., Kunisaki, R., Nakamura, S., Tsujikawa, T., Hirai, F., Nakase, H., Watanabe, K., Yokoyama, K., Nagahori, M., Kanai, T., Naganuma, M., Michimae, H., Andoh, A., Yamada, A., Yokoyama, T., Kamata, N., Tanaka, S., Suzuki, Y., Hibi, T. & Watanabe, M., 2018 Jan 1, In : Intestinal Research. 16, 3, p. 494-498 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis

INDIGO Study Group, 2018 Mar 1, In : Gastroenterology. 154, 4, p. 935-947 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Establishment of a Novel Scoring System for Colon Capsule Endoscopy to Assess the Severity of Ulcerative Colitis-Capsule Scoring of Ulcerative Colitis

Hosoe, N., Nakano, M., Takeuchi, K., Endo, Y., Matsuoka, K., Abe, T., Omori, T., Hayashida, M., Kobayashi, T., Yoshida, A., Mizuno, S., Nakazato, Y., Naganuma, M., Kanai, T., Watanabe, M., Ueno, F., Suzuki, Y., Hibi, T. & Ogata, H., 2018 Nov 29, In : Inflammatory Bowel Diseases. 24, 12, p. 2641-2647 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2018 Oct 1, In : PLoS One. 13, 10, e0204632.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Nanki, K., Mizuno, S., Matsuoka, K., Ono, K., Sugimoto, S., Kiyohara, H., Arai, M., Nakashima, M., Takeshita, K., Saigusa, K., Senoh, M., Fukuda, T., Naganuma, M., Kato, H., Suda, W., Hattori, M. & Kanai, T., 2018 Jan 1, In : Intestinal Research. 16, 1, p. 142-146 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
19 Citations (Scopus)

ß-(1,3)-Glucan derived from Candida albicans induces inflammatory cytokines from macrophages and lamina propria mononuclear cells derived from patients with Crohn's disease

Mori, K., Naganuma, M., Mizuno, S., Suzuki, H., Kitazume, M. T., Shimamura, K., Chiba, S., Sugita, A., Matsuoka, K., Hisamatsu, T. & Kanai, T., 2018 Jan 1, In : Intestinal Research. 16, 3, p. 384-392 9 p.

Research output: Contribution to journalArticle

Open Access

Surveillance for dysplasia in patients with ulcerative colitis: Discrepancy between guidelines and practice

Shinozaki, M., Kobayashi, K., Kunisaki, R., Hisamatsu, T., Naganuma, M., Takahashi, K. I., Iwao, Y., Suzuki, Y., Watanabe, M., Itabashi, M., Torii, A., Takazoe, M. & Sugita, A., 2018 Apr, In : GASTROENTEROLOGICAL ENDOSCOPY. 60, 4, p. 1033-1043 11 p.

Research output: Contribution to journalArticle

The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study

Kurokawa, S., Kishimoto, T., Mizuno, S., Masaoka, T., Naganuma, M., Liang, K. C., Kitazawa, M., Nakashima, M., Shindo, C., Suda, W., Hattori, M., Kanai, T. & Mimura, M., 2018 Aug 1, In : Journal of Affective Disorders. 235, p. 506-512 7 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

The role of colorectal endoscopic submucosal dissection in patients with ulcerative colitis

Kinoshita, S., Uraoka, T., Nishizawa, T., Naganuma, M., Iwao, Y., Ochiai, Y., Fujimoto, A., Goto, O., Shimoda, M., Ogata, H., Kanai, T. & Yahagi, N., 2018 Apr 1, In : Gastrointestinal Endoscopy. 87, 4, p. 1079-1084 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2017

Bifidobacterium-Rich Fecal Donor May Be a Positive Predictor for Successful Fecal Microbiota Transplantation in Patients with Irritable Bowel Syndrome

Mizuno, S., Masaoka, T., Naganuma, M., Kishimoto, T., Kitazawa, M., Kurokawa, S., Nakashima, M., Takeshita, K., Suda, W., Mimura, M., Hattori, M. & Kanai, T., 2017 Jun 21, (Accepted/In press) In : Digestion. p. 29-38 10 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
12 Citations (Scopus)

Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study

Naganuma, M., Aoyama, N., Tada, T., Kobayashi, K., Hirai, F., Watanabe, K., Watanabe, M. & Hibi, T., 2017 Aug 4, (Accepted/In press) In : Journal of Gastroenterology. p. 1-13 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Correction to: Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study

Naganuma, M., Aoyama, N., Tada, T., Kobayashi, K., Hirai, F., Watanabe, K., Watanabe, M. & Hibi, T., 2017 Oct 13, (Accepted/In press) In : Journal of Gastroenterology. p. 1-3 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Difficulties in Performing Mesalazine Enemas and Factors Related to Discontinuation among Patients with Ulcerative Colitis

Kawakami, A., Tanaka, M., Ochiai, R., Naganuma, M., Kunisaki, R. & Kazuma, K., 2017 Jan 1, In : Gastroenterology Nursing. 40, 2, p. 101-108 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Endocytoscopy can be used to assess histological healing in ulcerative colitis

Nakazato, Y., Naganuma, M., Sugimoto, S., Bessho, R., Arai, M., Kiyohara, H., Ono, K., Nanki, K., Mutaguchi, M., Mizuno, S., Kobayashi, T., Hosoe, N., Shimoda, M., Abe, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2017 Mar 13, (Accepted/In press) In : Endoscopy.

Research output: Contribution to journalArticle

12 Citations (Scopus)
13 Citations (Scopus)

Glycolysis regulates LPS-induced cytokine production in M2 polarized human macrophages

Chiba, S., Hisamatsu, T., Suzuki, H., Mori, K., Kitazume, M. T., Shimamura, K., Mizuno, S., Nakamoto, N., Matsuoka, K., Naganuma, M. & Kanai, T., 2017 Mar 1, In : Immunology Letters. 183, p. 17-23 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients

Mizuno, S., Wakui, M., Machida, Y., Hosoe, N., Hisamatsu, T., Ishida, T., Kameyama, K., Naganuma, M. & Kanai, T., 2017 Dec 1, In : Medicine (United States). 96, 51, e9237.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice

Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., Suda, W., Hattori, M., Amagai, M., Ohyama, M. & Kanai, T., 2017 Aug 15, In : Cell Reports. 20, 7, p. 1513-1524 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Limited identification of dual-time-point positron emission tomography/computed tomography in advanced colorectal neoplasms

Kashiwagi, K., Nakazato, Y., Arai, M., Iwasaki, E., Naganuma, M., Inoue, N., Iwao, Y., Ogata, H., Murakami, K. & Kanai, T., 2017, In : Internal Medicine. 56, 11, p. 1287-1292 6 p.

Research output: Contribution to journalArticle

Long-term safety and efficacy of adalimumab for intestinal Behçet's disease in the open label study following a phase 3 clinical trial

Inoue, N., Kobayashi, K., Naganuma, M., Hirai, F., Ozawa, M., Arikan, D., Huang, B., Robinson, A. M., Thakkar, R. B. & Hibi, T., 2017, In : Intestinal Research. 15, 3, p. 395-401 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Single fecal microbiota transplantation failed to change intestinal microbiota and had limited effectiveness against ulcerative colitis in Japanese patients

Mizuno, S., Nanki, K., Matsuoka, K., Saigusa, K., Ono, K., Arai, M., Sugimoto, S., Kiyohara, H., Nakashima, M., Takeshita, K., Naganuma, M., Suda, W., Hattori, M. & Kanai, T., 2017, In : Intestinal Research. 15, 1, p. 68-74 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Surveillance for dysplasia in patients with ulcerative colitis: Discrepancy between guidelines and practice

Shinozaki, M., Kobayashi, K., Kunisaki, R., Hisamatsu, T., Naganuma, M., Takahashi, K. I., Iwao, Y., Suzuki, Y., Watanabe, M., Itabashi, M., Torii, A., Takazoe, M. & Sugita, A., 2017 Jul, In : Digestive Endoscopy. 29, 5, p. 584-593 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
7 Citations (Scopus)

What strategies do ulcerative colitis patients employ to facilitate adherence?

Kawakami, A., Tanaka, M., Naganuma, M., Maeda, S., Kunisaki, R. & Yamamoto-Mitani, N., 2017 Jan 27, In : Patient Preference and Adherence. 11, p. 157-163 7 p.

Research output: Contribution to journalArticle

2016

A single species of clostridium Subcluster XIVa decreased in ulcerative colitis patients

Takeshita, K., Mizuno, S., Mikami, Y., Sujino, T., Saigusa, K., Matsuoka, K., Naganuma, M., Sato, T., Takada, T., Tsuji, H., Kushiro, A., Nomoto, K. & Kanai, T., 2016 Dec 1, In : Inflammatory Bowel Diseases. 22, 12, p. 2802-2810 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study

Sugimoto, S., Naganuma, M., Kiyohara, H., Arai, M., Ono, K., Mori, K., Saigusa, K., Nanki, K., Takeshita, K., Takeshita, T., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hisamatsu, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2016 Mar 10, (Accepted/In press) In : Digestion. p. 193-201 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Endoscopic Severity Predicts Long-Term Prognosis in Crohn's Disease Patients with Clinical Remission

Naganuma, M., Hisamatsu, T., Matsuoka, K., Kiyohara, H., Arai, M., Sugimoto, S., Mori, K., Nanki, K., Ohno, K., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hosoe, N., Inoue, N., Iwao, Y., Ogata, H. & Kanai, T., 2016 Jan 1, In : Digestion. 93, 1, p. 66-71 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Findings of ulceration and severe stricture on MRE can predict prognosis of Crohn’s disease in patients treated with anti-TNF treatment

Naganuma, M., Okuda, S., Hisamatsu, T., Matsuoka, K., Mori, K., Hosoe, N., Nakazato, Y., Ogata, H. & Kanai, T., 2016 Aug 23, (Accepted/In press) In : Abdominal Radiology. p. 1-11 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)