• 1656 Citations
  • 20 h-Index
19982019

Research output per year

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Research Output

  • 1656 Citations
  • 20 h-Index
  • 42 Article
  • 6 Review article
  • 1 Chapter
  • 1 Comment/debate
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Article
2019

Nanodiscs for Structural Biology in a Membranous Environment

Yokogawa, M., Fukuda, M. & Osawa, M., 2019 Jan 1, In : Chemical & pharmaceutical bulletin. 67, 4, p. 321-326 6 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

Kano, H., Toyama, Y., Imai, S., Iwahashi, Y., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2019 Dec 1, In : Nature communications. 10, 1, 2008.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail

Sawazaki, R., Imai, S., Yokogawa, M., Hosoda, N., Hoshino, S. I., Mio, M., Mio, K., Shimada, I. & Osawa, M., 2018 Dec 1, In : Scientific Reports. 8, 1, 19659.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR

Maruyama, T., Imai, S., Kusakizako, T., Hattori, M., Ishitani, R., Nureki, O., Ito, K., Maturana, A. D., Shimada, I. & Osawa, M., 2018 Apr 3, In : eLife. 7, e31596.

Research output: Contribution to journalArticle

3 Citations (Scopus)
5 Citations (Scopus)
2017

ATP-dependent modulation of MgtE in Mg2+ homeostasis

Tomita, A., Zhang, M., Jin, F., Zhuang, W., Takeda, H., Maruyama, T., Osawa, M., Hashimoto, K. I., Kawasaki, H., Ito, K., Dohmae, N., Ishitani, R., Shimada, I., Yan, Z., Hattori, M. & Nureki, O., 2017 Dec 1, In : Nature communications. 8, 1, 148.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses

Toyama, Y., Kano, H., Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2017 Feb 22, In : Nature Communications. 8, 14523.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2016

Disulfide mapping the voltage-sensing mechanism of a voltage-dependent potassium channel

Nozaki, T., Ozawa, S. I., Harada, H., Kimura, T., Osawa, M. & Shimada, I., 2016 Nov 17, In : Scientific Reports. 6, 37303.

Research output: Contribution to journalArticle

1 Citation (Scopus)
20 Citations (Scopus)
2015

Structural basis for the inhibition of voltage-dependent K+ channel by gating modifier toxin

Ozawa, S. I., Kimura, T., Nozaki, T., Harada, H., Shimada, I. & Osawa, M., 2015 Sep 18, In : Scientific Reports. 5, 14226.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2014

Backbone resonance assignments for G protein α(i3) subunit in the GDP-bound state

Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2014 Oct 1, In : Biomolecular NMR Assignments. 8, 2, p. 237-241 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Cross-saturation and transferred cross-saturation experiments

Ueda, T., Takeuchi, K., Nishida, N., Stampoulis, P., Kofuku, Y., Osawa, M. & Shimada, I., 2014 May, In : Quarterly Reviews of Biophysics. 47, 2, p. 143-187 45 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Functional dynamics of cell surface membrane proteins

Nishida, N., Osawa, M., Takeuchi, K., Imai, S., Stampoulis, P., Kofuku, Y., Ueda, T. & Shimada, I., 2014 Apr, In : Journal of Magnetic Resonance. 241, 1, p. 86-96 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT

Esaki, K., Yoshinaga, S., Tsuji, T., Toda, E., Terashima, Y., Saitoh, T., Kohda, D., Kohno, T., Osawa, M., Ueda, T., Shimada, I., Matsushima, K. & Terasawa, H., 2014 Dec, In : FEBS Journal. 281, 24, p. 5552-5566 15 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2013

Backbone resonance assignments for the cytoplasmic region of the Mg 2+ transporter MgtE in the Mg2+-unbound state

Maruyama, T., Imai, S., Osawa, M., Hattori, M., Ishitani, R., Nureki, O. & Shimada, I., 2013 Apr 1, In : Biomolecular NMR Assignments. 7, 1, p. 93-96 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2012

Backbone resonance assignments for G protein αi3 subunit in the GTP-bound state

Mase, Y., Yokogawa, M., Osawa, M. & Shimada, I., 2012 Jan 1, In : Biomolecular NMR Assignments. 6, 2, p. 217-220 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Biological role of the two overlapping poly(A)-binding protein interacting motifs 2 (PAM2) of eukaryotic releasing factor eRF3 in mRNA decay

Osawa, M., Hosoda, N., Nakanishi, T., Uchida, N., Kimura, T., Imai, S., Machiyama, A., Katada, T., Hoshino, S. I. & Shimada, I., 2012 Nov 1, In : RNA. 18, 11, p. 1957-1967 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Functional equilibrium of the KcsA structure revealed by NMR

Imai, S., Osawa, M., Mita, K., Toyonaga, S., Machiyama, A., Ueda, T., Takeuchi, K., Oiki, S. & Shimada, I., 2012 Nov 16, In : Journal of Biological Chemistry. 287, 47, p. 39634-39641 8 p.

Research output: Contribution to journalArticle

Open Access
37 Citations (Scopus)

Spatial distribution of cytoplasmic domains of the Mg 2+- transporter MgtE, in a solution lacking Mg 2+, revealed by paramagnetic relaxation enhancement

Imai, S., Maruyama, T., Osawa, M., Hattori, M., Ishitani, R., Nureki, O. & Shimada, I., 2012 Oct 1, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1824, 10, p. 1129-1135 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
28 Citations (Scopus)
2011
36 Citations (Scopus)

Structure determination of a protein assembly by amino acid selective cross-saturation

Kanamori, E., Igarashi, S., Osawa, M., Fukunishi, Y., Shimada, I. & Nakamura, H., 2011 Jan 1, In : Proteins: Structure, Function and Bioinformatics. 79, 1, p. 179-190 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2010
1 Citation (Scopus)

NMR analyses of the interaction between CCR5 and its ligand using functional reconstitution of CCR5 in lipid bilayers

Yoshiura, C., Kofuku, Y., Ueda, T., Mase, Y., Yokogawa, M., Osawa, M., Terashima, Y., Matsushima, K. & Shimada, I., 2010 May 19, In : Journal of the American Chemical Society. 132, 19, p. 6768-6777 10 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Quantitative characterization of tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation

Ruan, L., Osawa, M., Hosoda, N., Imai, S., Machiyama, A., Katada, T., Hoshino, S. I. & Shimada, I., 2010 Sep 3, In : Journal of Biological Chemistry. 285, 36, p. 27624-27631 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Structural basis underlying the dual gate properties of KcsA

Imai, S., Osawa, M., Takeuchi, K. & Shimada, I., 2010 Apr 6, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6216-6221 6 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)
2009

Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1)

Yokogawa, M., Muramatsu, T., Takeuchi, K., Osawa, M. & Shimada, I., 2009 Jun 1, In : Biomolecular NMR Assignments. 3, 1, p. 125-128 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Evidence for the direct interaction of spermine with the inwardly retifying potassium channel

Osawa, M., Yokogawa, M., Muramatsu, T., Mase, Y. & Shimada, I., 2009 Sep 18, In : Journal of Biological Chemistry. 284, 38, p. 26117-26126 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2008

Amino acid selective cross-saturation method for identification of proximal residue pairs in a protein-protein complex

Igarashi, S., Osawa, M., Takeuchi, K., Ozawa, S. I. & Shimada, I., 2008 Sep 10, In : Journal of the American Chemical Society. 130, 36, p. 12168-12176 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2007

Mechanism of mRNA deadenylation: Evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases

Funakoshi, Y., Doi, Y., Hosoda, N., Uchida, N., Osawa, M., Shimada, I., Tsujimoto, M., Suzuki, T., Katada, T. & Hoshino, S. I., 2007 Dec 1, In : Genes and Development. 21, 23, p. 3135-3148 14 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)

Nickel binding to NikA: An additional binding site reconciles spectroscopy, calorimetry and crystallography

Addy, C., Ohara, M., Kawai, F., Kidera, A., Ikeguchi, M., Fuchigami, S., Osawa, M., Shimada, I., Park, S. Y., Tame, J. R. H. & Heddle, J. G., 2007 Feb 1, In : Acta Crystallographica Section D: Biological Crystallography. 63, 2, p. 221-229 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Structural basis of the collagen-binding mode of discoidin domain receptor 2

Ichikawa, O., Osawa, M., Nishida, N., Goshima, N., Nomura, N. & Shimada, I., 2007 Sep 19, In : EMBO Journal. 26, 18, p. 4168-4176 9 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Structural insights into activation of phosphatidylinositol 4-kinase (Pik1) by yeast frequenin (Frq1)

Strahl, T., Huttner, I. G., Lusin, J. D., Osawa, M., King, D., Thorner, J. & Ames, J. B., 2007 Oct 19, In : Journal of Biological Chemistry. 282, 42, p. 30949-30959 11 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)
2005

Mg2+ and Ca2+ differentially regulate DNA binding and dimerization of DREAM

Osawa, M., Dace, A., Tong, K. I., Valiveti, A., Ikura, M. & Ames, J. B., 2005 May 6, In : Journal of Biological Chemistry. 280, 18, p. 18008-18014 7 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)
2003

Molecular interactions of yeast frequenin (Frq1) with the phosphatidylinositol 4-kinase isoform, Pik1

Huttner, I. G., Strahl, T., Osawa, M., King, D. S., Ames, J. B. & Thorner, J., 2003 Feb 14, In : Journal of Biological Chemistry. 278, 7, p. 4862-4874 13 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2001

Calcium-regulated DNA Binding and Oligomerization of the Neuronal Calcium-sensing Protein, Calsenilin/DREAM/KChIP3

Osawa, M., Tong, K. I., Lilliehook, C., Wasco, W., Buxbaum, J. D., Cheng, H. Y. M., Penninger, J. M., Ikura, M. & Ames, J. B., 2001 Nov 2, In : Journal of Biological Chemistry. 276, 44, p. 41005-41013 9 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Target-induced conformational adaptation of calmodulin revealed by the crystal structure of a complex with nematode Ca2+/calmodulin-dependent kinase kinase peptide

Kurokawa, H., Osawa, M., Kurihara, H., Katayama, N., Tokumitsu, H., Swindells, M. B., Kainosho, M. & Ikura, M., 2001 Sep 7, In : Journal of Molecular Biology. 312, 1, p. 59-68 10 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)
2000

Mechanism of superoxide dismutase-like activity of Fe(II) and Fe(III) complexes of tetrakis-N,N,N',N'(2-pyridylmethyl)ethylenediamine

Hirano, T., Hirobe, M., Kobayashi, K., Odani, A., Yamauchi, O., Ohsawa, M., Satow, Y. & Nagano, T., 2000 Feb, In : Chemical and Pharmaceutical Bulletin. 48, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)
1999

A novel target recognition revealed by calmodulin in complex with Ca2+-calmodulin-dependent kinase kinase

Osawa, M., Tokumitsu, H., Swindells, M. B., Kurihara, H., Orita, M., Shibanuma, T., Furuya, T. & Ikura, M., 1999 Sep 11, In : Nature structural biology. 6, 9, p. 819-824 6 p.

Research output: Contribution to journalArticle

215 Citations (Scopus)

Evidence for calmodulin inter-domain compaction in solution induced by W-7 binding

Osawa, M., Kuwamoto, S., Izumi, Y., Yap, K. L., Ikura, M., Shibanuma, T., Yokokura, H., Hidaka, H. & Matsushima, N., 1999 Jan 15, In : FEBS Letters. 442, 2-3, p. 173-177 5 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Symmetric covalent linkage of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) results in novel derivatives with increased inhibitory activities against calcium/calmodulin complex

Yokokura, H., Osawa, M., Inoue, T., Umezawa, I., Naito, Y., Ikura, M. & Hidaka, H., 1999 Dec 15, In : Drug Design and Discovery. 16, 3, p. 203-216 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1998

Solution structure of calmodulin-W-7 complex: The basis of diversity in molecular recognition

Osawa, M., Swindells, M. B., Tanikawa, J., Tanaka, T., Mase, T., Furuya, T. & Ikura, M., 1998 Feb 13, In : Journal of Molecular Biology. 276, 1, p. 165-176 12 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)