If you made any changes in Pure these will be visible here soon.

Research Output 2004 2020

  • 861 Citations
  • 13 h-Index
  • 48 Article
  • 1 Conference contribution
Filter
Article
2020

Distribution of tight junctions in the primate cochlear lateral wall

Saeki, T., Hosoya, M., Shibata, S., Okano, H., Fujioka, M. & Ogawa, K., 2020 Jan 19, In : Neuroscience Letters. 717, 134686.

Research output: Contribution to journalArticle

Tight Junctions
Cochlea
Inner Ear
Primates
Endolymph
2019
1 Citation (Scopus)

Anatomical and surgical evaluation of the common marmoset as an animal model in hearing research

Kurihara, S., Fujioka, M., Hata, J., Yoshida, T., Hirabayashi, M., Yamamoto, Y., Ogawa, K., Kojima, H. & Okano, H. J., 2019 Jun 3, In : Frontiers in Neuroanatomy. 13, 60.

Research output: Contribution to journalArticle

Open Access
Callithrix
Inner Ear
Hearing
Animal Models
Diffusion Tensor Imaging
1 Citation (Scopus)

A VEGF receptor vaccine demonstrates preliminary efficacy in neurofibromatosis type 2

Tamura, R., Fujioka, M., Morimoto, Y., Ohara, K., Kosugi, K., Oishi, Y., Sato, M., Ueda, R., Fujiwara, H., Noji, S., Oishi, N., Ogawa, K., Kawakami, Y., Ohira, T., Yoshida, K. & Toda, M., 2019 Dec 1, In : Nature communications. 10, 1, 5758.

Research output: Contribution to journalArticle

Open Access
Neurofibromatosis 2
vaccines
Vascular Endothelial Growth Factor Receptor
Vaccines
Tumors

Comprehensive analysis of syndromic hearing loss patients in Japan

Ideura, M., Nishio, S. Y., Moteki, H., Takumi, Y., Miyagawa, M., Sato, T., Kobayashi, Y., Ohyama, K., Oda, K., Matsui, T., Ito, T., Suzumura, H., Nagai, K., Izumi, S., Nishiyama, N., Komori, M., Kumakawa, K., Takeda, H., Kishimoto, Y., Iwasaki, S. & 21 others, Furutate, S., Ishikawa, K., Fujioka, M., Nakanishi, H., Nakayama, J., Horie, R., Ohta, Y., Naito, Y., Kakudo, M., Sakaguchi, H., Kataoka, Y., Sugahara, K., Hato, N., Nakagawa, T., Tsuchihashi, N., Kanda, Y., Kihara, C., Tono, T., Miyanohara, I., Ganaha, A. & Usami, S. I., 2019 Dec 1, In : Scientific reports. 9, 1, 11976.

Research output: Contribution to journalArticle

Open Access
Hearing Loss
Japan
Jervell-Lange Nielsen Syndrome
Branchio-Oto-Renal Syndrome
CHARGE Syndrome
1 Citation (Scopus)

Estimating the concentration of therapeutic range using disease-specific iPS cells: Low-dose rapamycin therapy for Pendred syndrome

Hosoya, M., Saeki, T., Saegusa, C., Matsunaga, T., Okano, H., Fujioka, M. & Ogawa, K., 2019 Jun 1, In : Regenerative Therapy. 10, p. 54-63 10 p.

Research output: Contribution to journalArticle

Audition
Sirolimus
Cell death
Cells
Stem cells

Generation of a human iPS cell line (CGMH.SLC26A4919-2) from a Pendred syndrome patient carrying SLC26A4 c.919-2A>G splice-site mutation

Cheng, Y. F., Chan, Y. H., Hu, C. J., Lu, Y. C., Saeki, T., Hosoya, M., Saegusa, C., Fujioka, M., Okano, H., Weng, S. M., Hsu, C. J., Chang, K. H. & Wu, C. C., 2019 Oct 1, In : Stem Cell Research. 40, 101524.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Cell Line
Mutation
Genes
Germ Layers
2018

A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset (Callithrix jacchus)

Kurihara, S., Fujioka, M., Yoshida, T., Koizumi, M., Ogawa, K., Kojima, H. & Okano, H. J., 2018 Feb 27, In : Journal of visualized experiments : JoVE. 132

Research output: Contribution to journalArticle

Callithrix
Audition
Inner Ear
Primates
Hearing Loss

Endoscopic surgical approach to internal auditory canal and cerebellopontine angle

Oishi, N., Nishiyama, T. & Fujioka, M., 2018 May 1, In : Otolaryngology - Head and Neck Surgery (Japan). 90, 6, p. 406-410 5 p.

Research output: Contribution to journalArticle

Cerebellopontine Angle
4 Citations (Scopus)

Engraftment of Human Pluripotent Stem Cell-derived Progenitors in the Inner Ear of Prenatal Mice

Takeda, H., Hosoya, M., Fujioka, M., Saegusa, C., Saeki, T., Miwa, T., Okano, H. & Minoda, R., 2018 Dec 1, In : Scientific Reports. 8, 1, 1941.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Inner Ear
Cell Transplantation
Hearing Loss
Stem Cells
1 Citation (Scopus)

Expression pattern of EYA4 in the common marmoset (Callithrix jacchus) cochlea

Matsuzaki, S., Hosoya, M., Okano, H., Fujioka, M. & Ogawa, K., 2018 Jan 1, In : Neuroscience Letters. 662, p. 185-188 4 p.

Research output: Contribution to journalArticle

Callithrix
Cochlea
Primates
Eustachian Tube
Otitis Media with Effusion
1 Citation (Scopus)

Visualization of nerve fibers around the carotid bifurcation with use of a 9.4 Tesla microscopic magnetic resonance diffusion tensor imaging with tractography

Saito, S., Ozawa, H., Fujioka, M., Hikishima, K., Hata, J., Kurihara, S., Okano, H. J. & Ogawa, K., 2018 Oct 1, In : Head and Neck. 40, 10, p. 2228-2234 7 p.

Research output: Contribution to journalArticle

Diffusion Tensor Imaging
Nerve Fibers
Neck
Magnetic Resonance Spectroscopy
Magnetic Fields
2017
11 Citations (Scopus)

Autophagy is essential for hearing in mice

Fujimoto, C., Iwasaki, S., Urata, S., Morishita, H., Sakamaki, Y., Fujioka, M., Kondo, K., Mizushima, N. & Yamasoba, T., 2017 May 11, In : Cell Death and Disease. 8, 5, e2780.

Research output: Contribution to journalArticle

Autophagy
Hearing
Hair
Hearing Loss
Auditory Hair Cells
5 Citations (Scopus)

Characterization of slow-cycling cells in the mouse cochlear lateral wall

Li, Y., Watanabe, K., Fujioka, M. & Ogawa, K., 2017 Jun 1, In : PLoS One. 12, 6, e0179293.

Research output: Contribution to journalArticle

Spiral Ligament of Cochlea
Ligaments
Cochlea
ligaments
Deoxyuridine
14 Citations (Scopus)

Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss

Hosoya, M., Fujioka, M., Sone, T., Okamoto, S., Akamatsu, W., Ukai, H., Ueda, H. R., Ogawa, K., Matsunaga, T. & Okano, H., 2017 Jan 3, In : Cell Reports. 18, 1, p. 68-81 14 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cochlea
Audition
Stem cells
Hearing Loss
2 Citations (Scopus)

Prevalence of TECTA mutation in patients with mid-frequency sensorineural hearing loss

Yamamoto, N., Mutai, H., Namba, K., Morita, N., Masuda, S., Nishi, Y., Nakano, A., Masuda, S., Fujioka, M., Kaga, K., Ogawa, K. & Matsunaga, T., 2017 Sep 25, In : Orphanet Journal of Rare Diseases. 12, 1, 157.

Research output: Contribution to journalArticle

Sensorineural Hearing Loss
Mutation
Hearing Loss
Genetic Association Studies
Inner Ear
2016
4 Citations (Scopus)
Cochlea
Deafness
Primates
Genes
Callithrix
18 Citations (Scopus)
Cochlea
Hearing Loss
Primates
Deafness
Callithrix
2 Citations (Scopus)
Wolfram Syndrome
Callithrix
Cochlea
Primates
Genes
7 Citations (Scopus)
Cochlea
Primates
Anions
Callithrix
Homeostasis
1 Citation (Scopus)

Sustained effect of hyaluronic acid in subcutaneous administration to the cochlear spiral ganglion

Inagaki, Y., Fujioka, M., Kanzaki, S., Watanabe, K., Oishi, N., Itakura, G., Yasuda, A., Shibata, S., Nakamura, M., James Okano, H., Okano, H. & Ogawa, K., 2016 Apr 1, In : PLoS One. 11, 4, e0153957.

Research output: Contribution to journalArticle

Spiral Ganglion
hyaluronic acid
luciferin
Cochlea
subcutaneous injection
2015
14 Citations (Scopus)

Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells

Tsuchihashi, N. A., Hayashi, K., Dan, K., Goto, F., Nomura, Y., Fujioka, M., Kanzaki, S., Komune, S. & Ogawa, K., 2015, In : Oncotarget. 6, 6, p. 3644-3655 12 p.

Research output: Contribution to journalArticle

AMP-Activated Protein Kinases
Autophagy
Oxidative Stress
Galactosidases
Phosphorylation
13 Citations (Scopus)

ERK2 mediates inner hair cell survival and decreases susceptibility to noise-induced hearing loss

Kurioka, T., Matsunobu, T., Satoh, Y., Niwa, K., Endo, S., Fujioka, M. & Shiotani, A., 2015 Nov 18, In : Scientific Reports. 5, 16839.

Research output: Contribution to journalArticle

Inner Auditory Hair Cells
Noise-Induced Hearing Loss
Extracellular Signal-Regulated MAP Kinases
Cell Survival
Knockout Mice
1 Citation (Scopus)

Erratum to Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma [Neuron 77, (2013), 58-69]

Mizutari, K., Fujioka, M., Hosoya, M., Bramhall, N., Okano, H. J., Okano, H. & Edge, A. S. B., 2015 Apr 8, In : Neuron. 86, 1, p. 341 1 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Manipulating cell fate in the cochlea: A feasible therapy for hearing loss

Fujioka, M., Okano, H. & Edge, A. S. B., 2015 Mar 1, In : Trends in Neurosciences. 38, 3, p. 139-144 6 p.

Research output: Contribution to journalArticle

Cochlea
Hearing Loss
Auditory Hair Cells
Regeneration
Mammals
4 Citations (Scopus)
Inner Ear
Drug Delivery Systems
Injections
Pharmaceutical Preparations
Luciferases
24 Citations (Scopus)

The autophagy pathway maintained signaling crosstalk with the Keap1-Nrf2 system through p62 in auditory cells under oxidative stress

Hayashi, K., Dan, K., Goto, F., Tshuchihashi, N., Nomura, Y., Fujioka, M., Kanzaki, S. & Ogawa, K., 2015 Feb 1, In : Cellular Signalling. 27, 2, p. 382-393 12 p.

Research output: Contribution to journalArticle

Autophagy
Oxidative Stress
Cell Death
Necrosis
Sirolimus
2014

A case of igg4-related pharyngolaryngitis

Suzuki, N., Fujioka, M., Araki, Y., Ozawa, H. & Kawaura, M., 2014, In : Practica Oto-Rhino-Laryngologica. 107, 3, p. 227-233 7 p.

Research output: Contribution to journalArticle

Immunoglobulin G
Steroids
Pancreatitis
Adrenal Cortex Hormones
Epiglottis
40 Citations (Scopus)
Sensorineural Hearing Loss
Cochlea
Inner Ear
Spiral Ligament of Cochlea
Macrophages

Long-term effects of tinnitus retraining therapy involving monaural noise generators

Inagaki, Y., Oishi, N., Kanzaki, S., Wakabayashi, S., Fujioka, M., Watabe, T., Watanabe, R., Wasano, K., Yamada, H., Kojima, T., Shinden, S. & Ogawa, K., 2014, In : Journal of Otolaryngology of Japan. 117, 2, p. 116-121 6 p.

Research output: Contribution to journalArticle

Tinnitus
Noise
Therapeutics
Directive Counseling
Equipment and Supplies
59 Citations (Scopus)

Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin

Nakamura-Ishizu, A., Takubo, K., Fujioka, M. & Suda, T., 2014 Nov 14, In : Biochemical and Biophysical Research Communications. 454, 2, p. 353-357 5 p.

Research output: Contribution to journalArticle

Thrombopoietin
Megakaryocytes
Hematopoietic Stem Cells
Stem cells
Ablation
10 Citations (Scopus)
3-nitropropionic acid
Sensorineural Hearing Loss
Cochlea
electron transport chain
Audition
2013
1 Citation (Scopus)

[Current status and perspectives of the research in Pendred syndrome].

Matsunaga, T., Fujioka, M. & Hosoya, M., 2013, In : Unknown Journal. 71, 12, p. 2215-2222 8 p.

Research output: Contribution to journalArticle

deafness
Hearing Loss
Goiter
Research
Mutation
4 Citations (Scopus)

A psychometric validation of the Japanese versions of new questionnaires on tinnitus (THI-12, TRS, TRSw, TSS, and TSSw)

Wasano, K., Kanzaki, S., Sakashita, T., Takahashi, M., Inoue, Y., Saito, H., Fujioka, M., Watabe, T., Watanabe, R., Sunami, K., Kato, S., Kabaya, K., Shinden, S. & Ogawa, K., 2013 May, In : Acta Oto-Laryngologica. 133, 5, p. 491-498 8 p.

Research output: Contribution to journalArticle

Tinnitus
Psychometrics
Equipment and Supplies
Reproducibility of Results
Surveys and Questionnaires
188 Citations (Scopus)

Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma

Mizutari, K., Fujioka, M., Hosoya, M., Bramhall, N., Okano, H. J., Okano, H. & Edge, A. S. B., 2013 Jan 9, In : Neuron. 77, 1, p. 58-69 12 p.

Research output: Contribution to journalArticle

Auditory Hair Cells
Noise-Induced Hearing Loss
Hearing
Regeneration
Cell Transdifferentiation
2 Citations (Scopus)

Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma

Mizutari, K., Fujioka, M., Hosoya, M., Bramhall, N., Okano, H., Okano, H. & Edge, A. B., 2013 Apr 24, In : Neuron. 78, 2, p. 403 1 p.

Research output: Contribution to journalArticle

2012
4 Citations (Scopus)

Noninvasive biological evaluation of response to pranlukast treatment in pediatric patients with Japanese cedar pollinosis

Gotoh, M., Okubo, K., Hashiguchi, K., Wakabayashi, K. I., Kanzaki, S., Tanaka, N., Fujioka, M., Kawashima, K., Suematsu, K., Sasaki, K., Iwasaki, M. & Yamamotoya, H., 2012 Nov, In : Allergy and Asthma Proceedings. 33, 6, p. 459-466 8 p.

Research output: Contribution to journalArticle

Cryptomeria
Seasonal Allergic Rhinitis
Nasal Obstruction
Eosinophil Cationic Protein
Pediatrics
15 Citations (Scopus)
drug delivery systems
Inner Ear
Drug Delivery Systems
ears
Photons
5 Citations (Scopus)

Pranlukast dry syrup inhibits symptoms of Japanese cedar pollinosis in children using OHIO Chamber

Wakabayashi, K. I., Hashiguchi, K., Kanzaki, S., Fujioka, M., Tanaka, N., Kawashima, K., Suematsu, K., Yamamotoya, H., Iwasaki, M., Gotoh, M., Horibe, S., Naito, K. & Okubo, K., 2012 Jan, In : Allergy and Asthma Proceedings. 33, 1, p. 102-109 8 p.

Research output: Contribution to journalArticle

Cryptomeria
Seasonal Allergic Rhinitis
Nose
Placebos
Nasal Obstruction
2011
7 Citations (Scopus)

Expression and function of Sox21 during mouse cochlea development

Hosoya, M., Fujioka, M., Matsuda, S., Ohba, H., Shibata, S., Nakagawa, F., Watabe, T., Wakabayashi, K. I., Saga, Y., Ogawa, K., Okano, H. J. & Okano, H., 2011 Jul, In : Neurochemical Research. 36, 7, p. 1261-1269 9 p.

Research output: Contribution to journalArticle

Cochlea
Cells
Audition
Labeling
Genes
13 Citations (Scopus)

Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation

Fujioka, M., Tokano, H., Fujioka, K. S., Okano, H. & Edge, A. S. B., 2011 Jun 1, In : Journal of Clinical Investigation. 121, 6, p. 2462-2469 8 p.

Research output: Contribution to journalArticle

Auditory Hair Cells
Glucose Intolerance
Alopecia
Deafness
Inner Ear
64 Citations (Scopus)

Notch signaling alters sensory or neuronal cell fate specification of inner ear stem cells

Jeon, S. J., Fujioka, M., Kim, S. C. & Edge, A. S. B., 2011 Jun 8, In : Journal of Neuroscience. 31, 23, p. 8351-8358 8 p.

Research output: Contribution to journalArticle

Inner Ear
Stem Cells
Basic Helix-Loop-Helix Transcription Factors
Up-Regulation
Neurons
2010
6 Citations (Scopus)

Balance dysfunction resulting from acute inner ear energy failure is caused primarily by vestibular hair cell damage

Mizutari, K., Fujioka, M., Nakagawa, S., Fujii, M., Ogawa, K. & Matsunaga, T., 2010 May 1, In : Journal of Neuroscience Research. 88, 6, p. 1262-1272 11 p.

Research output: Contribution to journalArticle

Vestibular Hair Cells
Inner Ear
Stereocilia
3-nitropropionic acid
Animal Models
71 Citations (Scopus)

Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea

Wakabayashi, K., Fujioka, M., Kanzaki, S., Okano, H. J., Shibata, S., Yamashita, D., Masuda, M., Mihara, M., Ohsugi, Y., Ogawa, K. & Okano, H., 2010 Apr, In : Neuroscience Research. 66, 4, p. 345-352 8 p.

Research output: Contribution to journalArticle

Cochlea
Hearing Loss
Noise
Interleukin-6
Spiral Ganglion

Otosclerosis update (2) - Treatment and prevention

Ogawa, K., Inoue, Y., Saito, H., Kanzaki, S., Okamoto, Y., Mizutari, K., Suzuki, T., Oishi, N., Watada, Y., Watabe, T. & Fujioka, M., 2010 Feb, In : Practica Oto-Rhino-Laryngologica. 103, 2, p. 103-112 10 p.

Research output: Contribution to journalArticle

Ear Diseases
Otosclerosis
Apatites
Ceramics
Hearing
2007
8 Citations (Scopus)

Impaired motor functions in mice lacking the RNA-binding protein Hzf

Iijima, T., Ogura, H., Takatsuki, K., Kawahara, S., Wakabayashi, K., Nakayama, D., Fujioka, M., Kimura, Y., Bernstein, A., Okano, H. J., Kirino, Y. & Okano, H., 2007 Jun, In : Neuroscience Research. 58, 2, p. 183-189 7 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
Zinc Fingers
Neuronal Plasticity
Protein Biosynthesis
Cerebellum
2006
54 Citations (Scopus)

Nuclear factor-kappa B nuclear translocation in the cochlea of mice following acoustic overstimulation

Masuda, M., Nagashima, R., Kanzaki, S., Fujioka, M., Ogita, K. & Ogawa, K., 2006 Jan 12, In : Brain Research. 1068, 1, p. 237-247 11 p.

Research output: Contribution to journalArticle

NF-kappa B
Cochlea
Acoustics
Noise
DNA
169 Citations (Scopus)

Proinflammatory cytokines expression in noise-induced damaged cochlea

Fujioka, M., Kanzaki, S., Okano, H. J., Masuda, M., Ogawa, K. & Okano, H., 2006 Mar, In : Journal of Neuroscience Research. 83, 4, p. 575-583 9 p.

Research output: Contribution to journalArticle

Cochlea
Noise
Interleukin-6
Cytokines
Spiral Ligament of Cochlea
2004
Brain Abscess
Cysts
Optic Neuritis
Skull Base
Visual Acuity