• 1168 Citations
  • 21 h-Index
1993 …2019
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Research Output 1993 2019

  • 1168 Citations
  • 21 h-Index
  • 59 Article
  • 1 Chapter
2019
Fatty Liver
Ultrasonography
Pancreas
Odds Ratio
Magnetic Resonance Imaging
Intervertebral Disc Degeneration
Cross-Sectional Studies
Confidence Intervals
Hand Strength
Osteoporosis
3 Citations (Scopus)

Spinal epidural lipomatosis is a previously unrecognized manifestation of metabolic syndrome

Ishihara, S., Fujita, N., Azuma, K., Michikawa, T., Yagi, M., Tsuji, T., Takayama, M., Matsumoto, H., Nakamura, M., Matsumoto, M. & Watanabe, K., 2019 Mar 1, In : Spine Journal. 19, 3, p. 493-500 8 p.

Research output: Contribution to journalArticle

Lipomatosis
Fats
Intra-Abdominal Fat
Subcutaneous Fat
Odds Ratio
2018
4 Citations (Scopus)

Carotid plaque score and risk of cardiovascular mortality in the oldest old: Results from the TOOTH study

Hirata, T., Arai, Y., Takayama, M., Abe, Y., Ohkuma, K. & Takebayashi, T., 2018 Jan 1, In : Journal of Atherosclerosis and Thrombosis. 25, 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

Cardiovascular Diseases
Mortality
Hazards
Cohort Studies
Ultrasonics
2 Citations (Scopus)

Relative validity of brief-type self-administered diet history questionnaire among very old Japanese aged 80 years or older

Kobayashi, S., Yuan, X., Sasaki, S., Osawa, Y., Hirata, T., Abe, Y., Takayama, M., Arai, Y., Masui, Y. & Ishizaki, T., 2018 Jan 1, (Accepted/In press) In : Public Health Nutrition.

Research output: Contribution to journalArticle

Diet Records
Diet
Food
Population
Surveys and Questionnaires
2017
2 Citations (Scopus)
Cerebrovascular Disorders
Ultrasonography
Magnetic Resonance Imaging
Chronic Renal Insufficiency
Kidney
1 Citation (Scopus)

Identification of dietary patterns and their relationships with general and oral health in the very old

Osawa, Y., Arai, Y., Takayama, M., Hirata, T., Kawasaki, M., Abe, Y., Iinuma, T., Sasaki, S. & Hirose, N., 2017, In : Asia Pacific Journal of Clinical Nutrition. 26, 2, p. 262-270 9 p.

Research output: Contribution to journalArticle

Bite Force
Oral Health
Dentures
Health Status
Population
7 Citations (Scopus)
Glomerular Filtration Rate
Chronic Renal Insufficiency
Population
Kidney Diseases
Obesity
6 Citations (Scopus)

Longitudinal association of hypertension and diabetes mellitus with cognitive functioning in a general 70-year-old population: The SONIC study

Ryuno, H., Kamide, K., Gondo, Y., Kabayama, M., Oguro, R., Nakama, C., Yokoyama, S., Nagasawa, M., Maeda-Hirao, S., Imaizumi, Y., Takeya, M., Yamamoto, H., Takeda, M., Takami, Y., Itoh, N., Takeya, Y., Yamamoto, K., Sugimoto, K., Nakagawa, T., Yasumoto, S. & 8 others, Ikebe, K., Inagaki, H., Masui, Y., Takayama, M., Arai, Y., Ishizaki, T., Takahashi, R. & Rakugi, H., 2017 Jul 1, In : Hypertension Research. 40, 7, p. 665-670 6 p.

Research output: Contribution to journalArticle

Diabetes Mellitus
Hypertension
Population
Social Adjustment
Dyslipidemias
2 Citations (Scopus)

Maintenance of the paraspinal muscles may protect against radiographic knee osteoarthritis

Azuma, K., Sera, Y., Shinjo, T., Takayama, M., Shiomi, E., Momoshima, S., Iwao, Y., Ishida, H. & Matsumoto, H., 2017 Aug 10, In : Open Access Rheumatology: Research and Reviews. 9, p. 151-158 8 p.

Research output: Contribution to journalArticle

Paraspinal Muscles
Knee Osteoarthritis
Maintenance
Abdominal Muscles
Knee

Perceived swallowing problems and mortality risk in very elderly people ≥85 years old: Results of the Tokyo Oldest Old Survey on Total Health study

Iinuma, T., Hirata, T., Arai, Y., Takayama, M., Abe, Y., Fukumoto, M., Fukui, Y. & Gionhaku, N., 2017, (Accepted/In press) In : Gerodontology.

Research output: Contribution to journalArticle

Tokyo
Deglutition
Mortality
Health
Oral Health
4 Citations (Scopus)

Relationships of muscle echo intensity with walking ability and physical activity in the very old population

Osawa, Y., Arai, Y., Oguma, Y., Hirata, T., Abe, Y., Azuma, K., Takayama, M. & Hirose, N., 2017 Apr 1, In : Journal of Aging and Physical Activity. 25, 2, p. 189-195 7 p.

Research output: Contribution to journalArticle

Walking
Muscles
Population
Patella
Thigh
2 Citations (Scopus)

Satisfaction with dietary life affects oral health-related quality of life and subjective well-being in very elderly people

Iinuma, T., Arai, Y., Takayama, M., Takayama, M., Abe, Y., Osawa, Y., Fukumoto, M., Fukui, Y., Shioda, Y., Hirose, N., Komiyama, K. & Gionhaku, N., 2017, In : Journal of oral science. 59, 2, p. 207-213 7 p.

Research output: Contribution to journalArticle

Oral Health
Quality of Life
Geriatrics
Odds Ratio
Confidence Intervals
Tokyo
Cholinergic Antagonists
Health Surveys
Hypnotics and Sedatives
Pharmaceutical Preparations
2 Citations (Scopus)
Independent Living
Tokyo
Japan
Exercise
Surveys and Questionnaires
2016
4 Citations (Scopus)

Association between maximum occlusal force and 3-year all-cause mortality in community-dwelling elderly people

Iinuma, T., Arai, Y., Takayama, M., Abe, Y., Ito, T., Kondo, Y., Hirose, N. & Gionhaku, N., 2016 Sep 1, In : BMC Oral Health. 16, 1, 82.

Research output: Contribution to journalArticle

Bite Force
Independent Living
Mortality
Proportional Hazards Models
Oral Health
5 Citations (Scopus)
Carotid Artery Diseases
Cytomegalovirus Infections
Cytomegalovirus
Cognition
Carotid Stenosis
7 Citations (Scopus)

Differences in the association between high blood pressure and cognitive functioning among the general Japanese population aged 70 and 80 years: The SONIC study

Ryuno, H., Kamide, K., Gondo, Y., Nakama, C., Oguro, R., Kabayama, M., Kawai, T., Kusunoki, H., Yokoyama, S., Imaizumi, Y., Takeya, M., Yamamoto, H., Takeda, M., Takami, Y., Itoh, N., Yamamoto, K., Takeya, Y., Sugimoto, K., Nakagawa, T., Ikebe, K. & 7 others, Inagaki, H., Masui, Y., Ishizaki, T., Takayama, M., Arai, Y., Takahashi, R. & Rakugi, H., 2016 Jul 1, In : Hypertension Research. 39, 7, p. 557-563 7 p.

Research output: Contribution to journalArticle

Blood Pressure
Hypertension
Population
Nutritional Status
Serum Albumin
11 Citations (Scopus)
Intra-Abdominal Fat
Subcutaneous Fat
Insulin Resistance
Homeostasis
Aging of materials
8 Citations (Scopus)

Effects of the APOE ε4 allele and education on cognitive function in Japanese centenarians

Ishioka, Y. L., Gondo, Y., Fuku, N., Inagaki, H., Masui, Y., Takayama, M., Abe, Y., Arai, Y. & Hirose, N., 2016 Aug 24, (Accepted/In press) In : Age. p. 1-9 9 p.

Research output: Contribution to journalArticle

Apolipoprotein E4
Cognition
Alleles
Education
Young Adult
2015
27 Citations (Scopus)

Association of visceral fat area, smoking, and alcohol consumption with reflux esophagitis and Barrett's esophagus in Japan

Matsuzaki, J., Suzuki, H., Kobayakawa, M., Inadomi, J. M., Takayama, M., Makino, K., Iwao, Y., Sugino, Y. & Kanai, T., 2015 Jul 30, In : PLoS One. 10, 7, e0133865.

Research output: Contribution to journalArticle

esophageal diseases
Peptic Esophagitis
visceral fat
Barrett Esophagus
Intra-Abdominal Fat

Centenarian studies: An interdisciplinary research on healthy longevity

Arai, Y., Takayama, M., Inagaki, H., Gondo, Y., Masui, Y. & Hirose, N., 2015 Jan 1, Aging Mechanisms: Longevity, Metabolism, and Brain Aging. Springer Japan, p. 31-49 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Interdisciplinary Studies
Adiponectin
Medical problems
Research
Bone
50 Citations (Scopus)

Denture wearing during sleep doubles the risk of pneumonia in the very elderly

Iinuma, T., Arai, Y., Abe, Y., Takayama, M., Fukumoto, M., Fukui, Y., Iwase, T., Takebayashi, T., Hirose, N., Gionhaku, N. & Komiyama, K., 2015 Mar 25, In : Journal of Dental Research. 94, p. 28S-36S

Research output: Contribution to journalArticle

Dentures
Pneumonia
Sleep
Oral Health
Confidence Intervals
81 Citations (Scopus)

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians

Arai, Y., Martin-Ruiz, C. M., Takayama, M., Abe, Y., Takebayashi, T., Koyasu, S., Suematsu, M., Hirose, N. & von Zglinicki, T., 2015 Oct 1, In : EBioMedicine. 2, 10, p. 1549-1558 10 p.

Research output: Contribution to journalArticle

Telomere
Longitudinal Studies
Aging of materials
Inflammation
Hazards
2014
21 Citations (Scopus)

Physical independence and mortality at the extreme limit of life span: Supercentenarians study in Japan

Arai, Y., Inagaki, H., Takayama, M., Abe, Y., Saito, Y., Takebayashi, T., Gondo, Y. & Hirose, N., 2014, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 69, 4, p. 486-494 9 p.

Research output: Contribution to journalArticle

Japan
Mortality
Survival
Activities of Daily Living
Telephone
2013
18 Citations (Scopus)

Association of marine-origin N-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old

Takayama, M., Arai, Y., Sasaki, S., Hashimoto, M., Shimizu, K., Abe, Y. & Hirose, N., 2013 Jan, In : Journal of Nutrition, Health and Aging. 17, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

Independent Living
Eicosapentaenoic Acid
Docosahexaenoic Acids
Omega-3 Fatty Acids
Erythrocyte Membrane
2012
44 Citations (Scopus)

Maximum occlusal force and physical performance in the oldest old: The Tokyo oldest old survey on total health

Iinuma, T., Arai, Y., Fukumoto, M., Takayama, M., Abe, Y., Asakura, K., Nishiwaki, Y., Takebayashi, T., Iwase, T., Komiyama, K., Gionhaku, N. & Hirose, N., 2012 Jan, In : Journal of the American Geriatrics Society. 60, 1, p. 68-76 9 p.

Research output: Contribution to journalArticle

Bite Force
Tokyo
Health
Comorbidity
Interleukin-6
2011
55 Citations (Scopus)

Adipokines and aging

Arai, Y., Takayama, M., Abe, Y. & Hirose, N., 2011, In : Journal of Atherosclerosis and Thrombosis. 18, 7, p. 545-550 6 p.

Research output: Contribution to journalArticle

Adipokines
Adipose Tissue
Aging of materials
Tissue
Insulin Resistance
21 Citations (Scopus)

Proteomic analysis of plasma proteins in Japanese semisuper centenarians

Miura, Y., Sato, Y., Arai, Y., Abe, Y., Takayama, M., Toda, T., Hirose, N. & Endo, T., 2011 Jan, In : Experimental Gerontology. 46, 1, p. 81-85 5 p.

Research output: Contribution to journalArticle

Proteomics
Clusterin
Blood Proteins
Haptoglobins
Geriatrics
2010
31 Citations (Scopus)

The Tokyo Oldest Old Survey on Total Health (TOOTH): A longitudinal cohort study of multidimensional components of health and well-being

Arai, Y., Iinuma, T., Takayama, M., Takayama, M., Abe, Y., Fukuda, R., Andou, J., Ohta, K., Hanabusa, H., Asakura, K., Nishiwaki, Y., Gondo, Y., Akiyama, H., Komiyama, K., Gionhaku, N. & Hirose, N., 2010, In : BMC Geriatrics. 10, 35.

Research output: Contribution to journalArticle

Tokyo
Longitudinal Studies
Cohort Studies
Tooth
Health
2 Citations (Scopus)

Vitamin D deficiency and lifestyle factors in the oldest old

Sumiya, C., Arai, Y., Takayama, M., Abe, Y., Hirose, N., Asakura, K., Nishiwaki, Y. & Takebayashi, T., 2010 Nov, In : Journal of the American Geriatrics Society. 58, 11, p. 2242-2244 3 p.

Research output: Contribution to journalArticle

Vitamin D Deficiency
Life Style
2009
1 Citation (Scopus)
Tokyo
Cognition
Hypertension
Stroke
Morbidity
13 Citations (Scopus)

Cognitive function in Japanese centenarians according to the mini-mental state examination

Inagaki, H., Gondo, Y., Hirose, N., Masui, Y., Kitagawa, K., Arai, Y., Ebihara, Y., Yamamura, K., Takayama, M., Nakazawa, S., Shimizu, K. I. & Homma, A., 2009 Aug, In : Dementia and Geriatric Cognitive Disorders. 28, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

Cognition
Aptitude
Life Expectancy
Dementia
Language
24 Citations (Scopus)

The metabolic syndrome, IGF-1, and insulin action

Arai, Y., Kojima, T., Takayama, M. & Hirose, N., 2009 Feb 5, In : Molecular and Cellular Endocrinology. 299, 1, p. 124-128 5 p.

Research output: Contribution to journalArticle

Somatomedins
Insulin
Insulin Resistance
Adiponectin
Leptin
2008
50 Citations (Scopus)

Adipose endocrine function, insulin-like growth factor-1 axis, and exceptional survival beyond 100 years of age

Arai, Y., Takayama, M., Gondo, Y., Inagaki, H., Yamamura, K., Nakazawa, S., Kojima, T., Ebihara, Y., Shimizu, K., Masui, Y., Kitagawa, K., Takebayashi, T. & Hirose, N., 2008 Nov, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 63, 11, p. 1209-1218 10 p.

Research output: Contribution to journalArticle

Somatomedins
Insulin-Like Growth Factor Binding Protein 3
Mortality
Activities of Daily Living
Cognition
4 Citations (Scopus)

Relationship between physical and cognitive function, blood pressure and serum lipid concentration in centenarians

Shimizu, K., Hirose, N., Takayama, M., Arai, Y., Gondo, Y., Ebihara, Y., Yamamura, K., Nakazawa, S., Inagaki, H., Masui, Y. & Kitagawa, K., 2008 Dec, In : Geriatrics and Gerontology International. 8, 4, p. 300-302 3 p.

Research output: Contribution to journalArticle

hypertension
HDL Lipoproteins
Hyperlipidemias
Cognition
cognition
2007
50 Citations (Scopus)

Morbidity of Tokyo-area centenarians and its relationship to functional status

Takayama, M., Hirose, N., Arai, Y., Gondo, Y., Shimizu, K., Ebihara, Y., Yamamura, K., Nakazawa, S., Inagaki, H., Masui, Y. & Kitagawa, K., 2007 Jul, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 62, 7, p. 774-782 9 p.

Research output: Contribution to journalArticle

Tokyo
Morbidity
Cognition
Stroke
Chronic Disease
2006
1 Citation (Scopus)

Anti-aging mechanism in centenarians

Hirose, N., Arai, Y., Takayama, M., Nakazawa, S., Ebehara, Y., Yamamura, K., Gondo, Y. & Kojima, T., 2006, In : Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine. 95, 3, p. 447-452 6 p.

Research output: Contribution to journalArticle

Inflammation Mediators
Tokyo
Arteriosclerosis
Adiponectin
Activities of Daily Living
122 Citations (Scopus)

Functional status of centenarians in Tokyo, Japan: Developing better phenotypes of exceptional longevity

Gondo, Y., Hirose, N., Arai, Y., Inagaki, H., Masui, Y., Yamamura, K., Shimizu, K. I., Takayama, M., Ebihara, Y., Nakazawa, S. & Kitagawa, K., 2006 Mar, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 61, 3, p. 305-310 6 p.

Research output: Contribution to journalArticle

Tokyo
Japan
Phenotype
Cognition
Dementia
2005
16 Citations (Scopus)

Contribution of an affect-associated gene to human longevity: Prevalence of the long-allele genotype of the serotonin transporter-linked gene in Japanese centenarians

Gondo, Y., Hirose, N., Arai, Y., Yamamura, K., Shimizu, K. I., Takayama, M., Ebihara, Y., Nakazawa, S., Inagaki, H., Masui, Y. & Kitagawa, K., 2005 Nov, In : Mechanisms of Ageing and Development. 126, 11, p. 1178-1184 7 p.

Research output: Contribution to journalArticle

Serotonin Plasma Membrane Transport Proteins
Genes
Alleles
Genotype
Polymorphism
2004
84 Citations (Scopus)

Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways

Kojima, T., Kamei, H., Aizu, T., Arai, Y., Takayama, M., Nakazawa, S., Ebihara, Y., Inagaki, H., Masui, Y., Gondo, Y., Sakaki, Y. & Hirose, N., 2004 Nov, In : Experimental Gerontology. 39, 11-12 SPEC. ISS., p. 1595-1598 4 p.

Research output: Contribution to journalArticle

Somatomedins
Genes
Insulin
Haplotypes
Population
2003
4 Citations (Scopus)

Association analysis of the SHC1 gene locus with longevity in the Japanese population

Kamei, H., Adati, N., Arai, Y., Yamamura, K., Takayama, M., Nakazawa, S., Ebihara, Y., Gondo, Y., Akechi, M., Noguchi, T., Hirose, N., Sakaki, Y. & Kojima, T., 2003 Nov, In : Journal of Molecular Medicine. 81, 11, p. 724-728 5 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Population
Genes
Linkage Disequilibrium
3' Untranslated Regions
32 Citations (Scopus)

Deficiency of choresteryl ester transfer protein and gene polymorphisms of lipoprotein lipase and hepatic lipase are not associated with longevity

Arai, Y., Hirose, N., Yamamura, K., Nakazawa, S., Shimizu, K. I., Takayama, M., Ebihara, Y., Homma, S., Gondo, Y., Masui, Y. & Inagaki, H., 2003 Feb 1, In : Journal of Molecular Medicine. 81, 2, p. 102-109 8 p.

Research output: Contribution to journalArticle

Lipoprotein Lipase
Lipase
Cholesterol Ester Transfer Proteins
Esters
Genotype
3 Citations (Scopus)

Possible model for successful care: Burden of caregivers of centenarians [5]

Nishikawa, K., Harada, Y., Fujimori, J., Ebihara, Y., Arai, Y., Takayama, M., Yamamura, K., Nakazawa, S., Hirose, N., Gondo, Y., Inagaki, H., Masui, K. & Kitagawa, K., 2003 Apr 1, In : Journal of the American Geriatrics Society. 51, 4, p. 577-578 2 p.

Research output: Contribution to journalArticle

Activities of Daily Living
Caregivers
Fatigue
Japan
Surveys and Questionnaires
23 Citations (Scopus)

Preconditioning with heat shock further improved functional recovery in young adult but not in middle-aged rat hearts

Honma, Y., Tani, M., Yamamura, K., Takayama, M. & Hasegawa, H., 2003 Mar 1, In : Experimental Gerontology. 38, 3, p. 299-306 8 p.

Research output: Contribution to journalArticle

Rats
Young Adult
Shock
Hot Temperature
Recovery
2002
17 Citations (Scopus)

Aging abolishes the cardioprotective effect of combination heat shock and hypoxic preconditioning in reperfused rat hearts

Honma, Y., Tani, M., Takayama, M., Yamamura, K. & Hasegawa, H., 2002 Nov, In : Basic Research in Cardiology. 97, 6, p. 489-495 7 p.

Research output: Contribution to journalArticle

Shock
Hot Temperature
Protein Kinase C
Cytosol
Heat-Shock Proteins
2001
13 Citations (Scopus)
Inbred F344 Rats
Phorbol Esters
Cardiac Myocytes
Protein Kinase C
Young Adult
34 Citations (Scopus)

Lipoprotein metabolism in Japanese centenarians: Effects of apolipoprotein E polymorphism and nutritional status

Arai, Y., Hirose, N., Nakazawa, S., Yamamura, K., Shimizu, K. I., Takayama, M., Ebihara, Y., Osono, Y. & Homma, S., 2001, In : Journal of the American Geriatrics Society. 49, 11, p. 1434-1441 8 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Nutritional Status
Lipoproteins
HDL Cholesterol
Apolipoproteins B
46 Citations (Scopus)

Serum insulin-like growth factor-1 in centenarians: Implications of IGF-1 as a rapid turnover protein

Arai, Y., Hirose, N., Yamamura, K., Shimizu, K. I., Takayama, M., Ebihara, Y. & Osono, Y., 2001, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 56, 2

Research output: Contribution to journalArticle

Somatomedins
Insulin-Like Growth Factor I
Serum
Dementia
Retinol-Binding Proteins
5 Citations (Scopus)

Suggestions from a centenarian study--aging and inflammation

Hirose, N., Arai, Y., Yamamura, K., Nakazawa, S., Takayama, M., Ebihara, Y., Homma, S. & Shimizu, K., 2001 Mar, In : Japanese Journal of Geriatrics. 38, 2, p. 121-124 4 p.

Research output: Contribution to journalArticle

Homocysteine
Inflammation
Nutritional Status
Albumins
Tokyo