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2020

MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells

Ishiguro, K. I., Matsuura, K., Tani, N., Takeda, N., Usuki, S., Yamane, M., Sugimoto, M., Fujimura, S., Hosokawa, M., Chuma, S., Ko, M. S. H., Araki, K. & Niwa, H., 2020 Feb 24, In : Developmental Cell. 52, 4, p. 429-445.e10

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M., Tada, N., Okano, H. & Akamatsu, W., 2019 Feb 12, In : Stem Cell Reports. 12, 2, p. 305-318 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors

Hiratsuka, K., Monkawa, T., Akiyama, T., Nakatake, Y., Oda, M., Goparaju, S. K., Kimura, H., Chikazawa-Nohtomi, N., Sato, S., Ishiguro, K., Yamaguchi, S., Suzuki, S., Morizane, R., Ko, S., Itoh, H. & Ko, M., 2019 Dec 1, In : Scientific Reports. 9, 1, 913.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2018

Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing

Akiyama, T., Sato, S., Chikazawa-Nohtomi, N., Soma, A., Kimura, H., Wakabayashi, S., Ko, S. & Ko, M., 2018 Dec 1, In : Scientific Reports. 8, 1, 1189.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors 10 Technology 1004 Medical Biotechnology

Ida, H., Akiyama, T., Ishiguro, K., Goparaju, S. K., Nakatake, Y., Chikazawa-Nohtomi, N., Sato, S., Kimura, H., Yokoyama, Y., Nagino, M., Ko, M. S. H. & Ko, S. B. H., 2018 Oct 25, In : Stem Cell Research and Therapy. 9, 1, 277.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos

Ishiguro, K. I., Nakatake, Y., Chikazawa-Nohtomi, N., Kimura, H., Akiyama, T., Oda, M., Ko, S. B. H. & Ko, M. S. H., 2017 Feb 1, In : In Vitro Cellular and Developmental Biology - Animal. 53, 2, p. 179-190 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells

Hirayama, M., Ko, S., Kawakita, T., Akiyama, T., Goparaju, S. K., Soma, A., Nakatake, Y., Sakota, M., Chikazawa-Nohtomi, N., Shimmura, S., Tsubota, K. & Ko, M., 2017 Dec 1, In : npj Aging and Mechanisms of Disease. 3, 1, 1.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors

Matsushita, M., Nakatake, Y., Arai, I., Ibata, K., Kohda, K., Goparaju, S. K., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S., Kanai, T., Yuzaki, M. & Ko, M., 2017 May 31, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors

Goparaju, S. K., Kohda, K., Ibata, K., Soma, A., Nakatake, Y., Akiyama, T., Wakabayashi, S., Matsushita, M., Sakota, M., Kimura, H., Yuzaki, M., Ko, S. & Ko, M., 2017 Feb 13, In : Scientific Reports. 7, 42367.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells

Arai, Y., Takahashi, D., Asano, K., Tanaka, M., Oda, M., Ko, S., Ko, M., Mandai, S., Nomura, N., Rai, T., Uchida, S. & Sohara, E., 2017 Jan 1, In : Scientific Reports. 7, 46580.

Research output: Contribution to journalArticle

SCODE: An efficient regulatory network inference algorithm from single-cell RNA-Seq during differentiation

Matsumoto, H., Kiryu, H., Furusawa, C., Ko, M., Ko, S., Gouda, N., Hayashi, T. & Nikaido, I., 2017 Aug 1, In : Bioinformatics. 33, 15, p. 2314-2321 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Zscan4 is expressed specifically during late meiotic prophase in both spermatogenesis and oogenesis

Ishiguro, K. I., Monti, M., Akiyama, T., Kimura, H., Chikazawa-Nohtomi, N., Sakota, M., Sato, S., Redi, C. A., Ko, S. B. H. & Ko, M. S. H., 2017 Feb 1, In : In Vitro Cellular and Developmental Biology - Animal. 53, 2, p. 167-178 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

Emergence of undifferentiated colonies from mouse embryonic stem cells undergoing differentiation by retinoic acid treatment

Sharova, L. V., Sharov, A. A., Piao, Y., Stagg, C. A., Amano, T., Qian, Y., Dudekula, D., Schlessinger, D. & Ko, M., 2016 Apr 29, (Accepted/In press) In : In Vitro Cellular and Developmental Biology - Animal. p. 1-9 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Gene array analysis of neural crest cells identifies transcription factors necessary for direct conversion of embryonic fibroblasts into neural crest cells

Motohashi, T., Watanabe, N., Nishioka, M., Nakatake, Y., Yulan, P., Mochizuki, H., Kawamura, Y., Ko, M., Goshima, N. & Kunisada, T., 2016 Mar 15, In : Biology Open. 5, 3, p. 311-322 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Generation and gene expression profiling of 48 transcription-factor-inducible mouse embryonic stem cell lines

Yamamizu, K., Sharov, A. A., Piao, Y., Amano, M., Yu, H., Nishiyama, A., Dudekula, D. B., Schlessinger, D. & Ko, M., 2016 May 6, In : Scientific Reports. 6, 25667.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Induction of specific neuron types by overexpression of single transcription factors

Teratani-Ota, Y., Yamamizu, K., Piao, Y., Sharova, L., Amano, M., Yu, H., Schlessinger, D., Ko, M. & Sharov, A. A., 2016 Jun 1, (Accepted/In press) In : In Vitro Cellular and Developmental Biology - Animal. p. 1-13 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells

Akiyama, T., Wakabayashi, S., Soma, A., Sato, S., Nakatake, Y., Oda, M., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S. & Ko, M., 2016 Oct 15, In : Development (Cambridge). 143, 20, p. 3674-3685 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
20 Citations (Scopus)
2015

Correction of Down syndrome and Edwards syndrome aneuploidies in human cell cultures

Amano, T., Jeffries, E., Amano, M., Ko, A. C., Yu, H. & Ko, M., 2015 May 6, In : DNA Research. 22, 5, p. 331-342 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

ExAtlas: An interactive online tool for meta-analysis of gene expression data

Sharov, A. A., Schlessinger, D. & Ko, M., 2015 Dec 1, In : Journal of Bioinformatics and Computational Biology. 13, 6, 1550019.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells

Akiyama, T., Xin, L., Oda, M., Sharov, A. A., Amano, M., Piao, Y., Cadet, J. S., Dudekula, D. B., Qian, Y., Wang, W., Ko, S. & Ko, M., 2015 May 6, In : DNA Research. 22, 5, p. 307-318 12 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2014

A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development

Sherman-Baust, C. A., Kuhn, E., Valle, B. L., Shih, I. M., Kurman, R. J., Wang, T. L., Amano, T., Ko, M. S., Miyoshi, I., Araki, Y., Lehrmann, E., Zhang, Y., Becker, K. G. & Morin, P. J., 2014 Jul, In : Journal of Pathology. 233, 3, p. 228-237 10 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Chromatin properties of regulatory DNA probed by manipulation of transcription factors

Sharov, A. A., Nishiyama, A., Qian, Y., Dudekula, D. B., Longo, D. L., Schlessinger, D. & Ko, M. S. H., 2014 Aug 1, In : Journal of Computational Biology. 21, 8, p. 569-577 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Efficient generation of integration-free human induced pluripotent stem cells from keratinocytes by simple transfection of episomal vectors

Piao, Y., Hung, S. S. C., Lim, S. Y., Wong, R. C. B. & Ko, M. S. H., 2014, In : Stem Cells Translational Medicine. 3, 7, p. 787-791 5 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1)

Yamamizu, K., Schlessinger, D. & Ko, M. S. H., 2014 Nov 1, In : Development (Cambridge). 141, 22, p. 4254-4266 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2013

A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance

Livigni, A., Peradziryi, H., Sharov, A. A., Chia, G., Hammachi, F., Migueles, R. P., Sukparangsi, W., Pernagallo, S., Bradley, M., Nichols, J., Ko, M. S. H. & Brickman, J. M., 2013 Nov 18, In : Current Biology. 23, 22, p. 2233-2244 12 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Developmental arrest and mouse antral not-surrounded nucleolus oocytes

Monti, M., Zanoni, M., Calligaro, A., Ko, M. S. H., Mauri, P. & Redi, C. A., 2013 Jan 1, In : Biology of reproduction. 88, 1, 2.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Identification of transcription factors for lineage-specific ESC differentiation

Yamamizu, K., Piao, Y., Sharov, A. A., Zsiros, V., Yu, H., Nakazawa, K., Schlessinger, D. & Ko, M. S. H., 2013 Dec 17, In : Stem cell reports. 1, 6, p. 545-559 15 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas

Ko, S. B. H., Azuma, S., Yokoyama, Y., Yamamoto, A., Kyokane, K., Niida, S., Ishiguro, H. & Ko, M. S. H., 2013 Jun 16, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 12, p. G1103-G1116

Research output: Contribution to journalArticle

8 Citations (Scopus)

Repression of global protein synthesis by Eif1a-like genes that are expressed specifically in the two-cell embryos and the transient Zscan4-positive state of embryonic stem cells

Hung, S. S. C., Wong, R. C. B., Sharov, A. A., Nakatake, Y., Yu, H. & Ko, M. S. H., 2013 Aug 1, In : DNA Research. 20, 4, p. 391-401 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells

Nishiyama, A., Sharov, A. A., Piao, Y., Amano, M., Amano, T., Hoang, H. G., Binder, B. Y., Tapnio, R., Bassey, U., Malinou, J. N., Correa-Cerro, L. S., Yu, H., Xin, L., Meyers, E., Zalzman, M., Nakatake, Y., Stagg, C., Sharova, L., Qian, Y., Dudekula, D. & 9 others, Sheer, S., Cadet, J. S., Hirata, T., Yang, H. T., Goldberg, I., Evans, M. K., Longo, D. L., Schlessinger, D. & Ko, M. S. H., 2013 Mar 25, In : Scientific reports. 3, 1390.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation

Xu, D., Shen, W., Guo, R., Xue, Y., Peng, W., Sima, J., Yang, J., Sharov, A., Srikantan, S., Yang, J., Fox, D., Qian, Y., Martindale, J. L., Piao, Y., Machamer, J., Joshi, S. R., Mohanty, S., Shaw, A. C., Lloyd, T. E., Brown, G. W. & 4 others, Ko, M. S. H., Gorospe, M., Zou, S. & Wang, W., 2013 Sep 1, In : Nature Neuroscience. 16, 9, p. 1238-1247 10 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions

Morgani, S. M., Canham, M. A., Nichols, J., Sharov, A. A., Migueles, R. P., Ko, M. S. H. & Brickman, J. M., 2013 Mar 27, In : Cell Reports. 3, 6, p. 1945-1957 13 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)

Zscan4 restores the developmental potency of embryonic stem cells

Amano, T., Hirata, T., Falco, G., Monti, M., Sharova, L. V., Amano, M., Sheer, S., Hoang, H. G., Piao, Y., Stagg, C. A., Yamamizu, K., Akiyama, T. & Ko, M. S. H., 2013 Jun 6, In : Nature communications. 4, 1966.

Research output: Contribution to journalArticle

Open Access
57 Citations (Scopus)
2012

Activation of JNK triggers release of Brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stress

Nishiyama, A., Dey, A., Tamura, T., Ko, M. & Ozato, K., 2012 May 2, In : PloS one. 7, 5, e34719.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1

Cui, C. Y., Childress, V., Piao, Y., Michel, M., Johnson, A. A., Kunisada, M., Ko, M. S. H., Kaestner, K. H., Marmorstein, A. D. & Schlessinger, D., 2012 Jan 24, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 4, p. 1199-1203 5 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Molecular mechanisms of pancreatic stone formation in chronic pancreatitis

Ko, S. B. H., Azuma, S., Yoshikawa, T., Yamamoto, A., Kyokane, K., Ko, M. S. H. & Ishiguro, H., 2012 Dec 17, In : Frontiers in Physiology. 3 NOV, Article 415.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Prenatal arsenic exposure alters gene expression in the adult liver to a proinflammatory state contributing to accelerated atherosclerosis

States, J. C., Singh, A. V., Knudsen, T. B., Rouchka, E. C., Ngalame, N. O., Arteel, G. E., Piao, Y. & Ko, M. S. H., 2012 Jun 15, In : PloS one. 7, 6, e38713.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration

Xie, H., Sun, X., Piao, Y., Jegga, A. G., Handwerger, S., Ko, M. S. H. & Dey, S. K., 2012 Sep 14, In : Journal of Biological Chemistry. 287, 38, p. 32288-32297 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Stochastic modeling for the expression of a gene regulated by competing transcription factors

Yang, H. T. & Ko, M. S. H., 2012 Mar 14, In : PloS one. 7, 3, e32376.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Transcriptional Activation by Oct4 Is Sufficient for the Maintenance and Induction of Pluripotency

Hammachi, F., Morrison, G. M., Sharov, A. A., Livigni, A., Narayan, S., Papapetrou, E. P., O'Malley, J., Kaji, K., Ko, M. S. H., Ptashne, M. & Brickman, J. M., 2012 Feb 23, In : Cell Reports. 1, 2, p. 99-109 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Zscan4 transiently reactivates early embryonic genes during the generation of induced pluripotent stem cells

Hirata, T., Amano, T., Nakatake, Y., Amano, M., Piao, Y., Hoang, H. G. & Ko, M. S. H., 2012 Apr 19, In : Scientific reports. 2, 208.

Research output: Contribution to journalArticle

57 Citations (Scopus)
2011

Generation of mouse ES cell lines engineered for the forced induction of transcription factors

Correa-Cerro, L. S., Piao, Y., Sharov, A. A., Nishiyama, A., Cadet, J. S., Yu, H., Sharova, L. V., Xin, L., Hoang, H. G., Thomas, M., Qian, Y., Dudekula, D. B., Meyers, E., Binder, B. Y., Mowrer, G., Bassey, U., Longo, D. L., Schlessinger, D. & Ko, M. S. H., 2011 Dec 1, In : Scientific reports. 1, 167.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells

Kim, Y., Sharov, A. A., McDole, K., Cheng, M., Hao, H., Fan, C. M., Gaiano, N., Ko, M. S. H. & Zheng, Y., 2011 Dec 23, In : Science. 334, 6063, p. 1706-1710 5 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)

Responsiveness of genes to manipulation of transcription factors in ES cells is associated with histone modifications and tissue specificity

Sharov, A. A., Nishiyama, A., Piao, Y., Correa-Cerro, L. S., Amano, T., Thomas, M., Mehta, S. & Ko, M. S. H., 2011 Feb 9, In : BMC Genomics. 12, 102.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2010

A role for borg5 during trophectoderm differentiation.

Vong, Q. P., Liu, Z., Yoo, J. G., Chen, R., Xie, W., Sharov, A. A., Fan, C. M., Liu, C., Ko, M. S. H. & Zheng, Y., 2010 Jun, In : Stem cells (Dayton, Ohio). 28, 6, p. 1030-1038 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Changes in global gene expression during in vitro decidualization of rat endometrial stromal cells

Vallejo, G., Maschi, D., Mestre-Citrinovitz, A. C., Aiba, K., Maronna, R., Yohai, V., Ko, M. S. H., Beato, M. & Saragüeta, P., 2010 Jan 1, In : Journal of Cellular Physiology. 222, 1, p. 127-137 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Dkk4 and eda regulate distinctive developmental mechanisms for subtypes of mouse hair

Cui, C. Y., Kunisada, M., Piao, Y., Childress, V., Ko, M. S. H. & Schlessinger, D., 2010 Sep 10, In : PloS one. 5, 4, e10009.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript

Canham, M. A., Sharov, A. A., Ko, M. S. H. & Brickman, J. M., 2010 May 1, In : PLoS biology. 8, 5

Research output: Contribution to journalArticle

172 Citations (Scopus)

Zscan4 regulates telomere elongation and genomic stability in ES cells

Zalzman, M., Falco, G., Sharova, L. V., Nishiyama, A., Thomas, M., Lee, S. L., Stagg, C. A., Hoang, H. G., Yang, H. T., Indig, F. E., Wersto, R. P. & Ko, M. S. H., 2010 Apr 8, In : Nature. 464, 7290, p. 858-863 6 p.

Research output: Contribution to journalArticle

213 Citations (Scopus)