• 3525 Citations
  • 30 h-Index
1991 …2020

Research output per year

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Research Output

1991

A case of pulmonary embolism effectively treated by thrombolysis with tissue-type plasminogen activator

Hasegawa, N., Ichinose, Y. & Okada, Y., 1991 Dec 1, In : Japanese Journal of Chest Diseases. 50, 12, p. 1004-1009 6 p.

Research output: Contribution to journalArticle

1992

Granulocyte colony-stimulating factor does not enhance endotoxin-induced acute lung injury in guinea pigs

Kanazawa, M., Ishizaka, A., Hasegawa, N., Suzuki, Y. & Yokoyama, T., 1992 Jan 1, In : American Review of Respiratory Disease. 145, 5, p. 1030-1035 6 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Influence of chest background on pulmonary 99mTc-DTPA clearance in interstitial lung disease

Ishizaka, A., Kanazawa, M., Suzuki, Y., Hasegawa, N., Kubo, A. & Kawashiro, T., 1992 Jan 1, In : Journal of Applied Physiology. 73, 5, p. 1820-1824 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Measurements of plasmin-α2 plasmin inhibitor complex and FDP · D dimer levels in the fibrinolytic therapy of acute pulmonary thromboembolism

Yamasawa, F., Hasegawa, N., Asano, K., Sayama, K., Fujita, H., Urano, T., Aoki, T., Ishizaka, A., Kanazawa, M., Kawashiro, T., Yokoyama, T., Kawai, Y. & Watanabe, K., 1992 Jan 1, In : Respiration and Circulation. 40, 7, p. 685-690 6 p.

Research output: Contribution to journalArticle

The Role of Recombinant Human Tissue-Type Plasminogen Activator in the Treatment of Acute Pulmonary Thromboembolism

Yamasawa, F., Okada, Y., Asano, K., Mori, M., Fujita, H., Hasegawa, N., Aoki, T., Ishizaka, A., Kanazawa, M. & Kawashiro, T., 1992 Jan 1, In : Internal Medicine. 31, 7, p. 885-892 8 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)
1993

Assessment of pulmonary aerosol deposition and epithelial permeability in 99mTc-DTPA inhalation scintigram

Kanazawa, M., Suzuki, Y., Ishizaka, A., Hasegawa, N., Fujishima, S., Kawashiro, T., Yokoyama, T., Kubo, A. & Hashimoto, S., 1993 Jan 1, In : Japanese Journal of Thoracic Diseases. 31, 5, p. 593-600 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Gastric metastasis of primary lung cancer

Hasegawa, N., Yamasawa, F., Kanazawa, M., Kawashiro, T., Kikuchi, K., Kobayashi, K., Ishihara, T., Kuramochi, S. & Mukai, M., 1993 Dec 1, In : Japanese Journal of Thoracic Diseases. 31, 11, p. 1390-1396 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Measurement of myeloperoxidase and thiobarbituric acid-reactive material in plasma and bronchoalveolar lavage in E. coli-induced acute lung injury

Hasegawa, N., Ishizaka, A., Kanazawa, M., Urano, T., Sayama, K., Suzuki, Y., Nakamura, H., Sakamaki, F., Tasaka, S. & Kawashiro, T., 1993 Jan 1, In : Japanese Journal of Thoracic Diseases. 31, 8, p. 924-931 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
1994

Clinical Significance of Measuring Myeloperoxidase, Thiobarbituric Acid Reactive Material and 7S Collagen in Plasma of Patients with Adult Respiratory Distress Syndrome

Sakamaki, F., Ishizaka, A., Hasegawa, N., Urano, T., Sayama, K., Nakamura, H., Terashima, T., Waki, Y., Tasaka, S., Fujishima, S., Kanazawa, M. & Kawashiro, T., 1994 Jan 1, In : Internal Medicine. 33, 5, p. 257-262 6 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Effects of ONO-1078, a peptide leukotriene antagonist, on endotoxin- induced acute lung injury

Ishizaka, A., Hasegawa, N., Sakamaki, F., Tasaka, S., Nakamura, H., Kishikawa, K., Yamada, A., Obata, T., Sayama, K., Urano, T. & Kanazawa, M., 1994 Jan 1, In : American journal of respiratory and critical care medicine. 150, 5 I, p. 1325-1331 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Pulmonary Infection due to Mycobacterium xenopi

Terashima, T., Sakamaki, F., Hasegawa, N., Kanazawa, M. & Kawashiro, T., 1994 Jan 1, In : Internal Medicine. 33, 9, p. 536-539 4 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Regional lung hematocrit variation and assessment of acute lung injury

Kanazawa, M., Hasegawa, N., Urano, T., Sayama, K., Tasaka, S., Sakamaki, F., Nakamura, H., Waki, Y., Terashima, T., Fujishima, S. & Ishizaka, A., 1994 Jan 1, In : Journal of Applied Physiology. 77, 2, p. 567-573 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Role of the coagulation system in ARDS

Hasegawa, N., Husari, A. W., Hart, W. T., Kandra, T. G. & Raffin, T. A., 1994 Jan 1, In : Chest. 105, 1, p. 268-277 10 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Serum concentration of 7S collagen and prognosis in patients with the adult respiratory distress syndrome

Kawamura, M., Yamasawa, F., Ishizaka, A., Kato, R., Kikuchi, K., Kobayashi, K., Aoki, T., Sakamaki, F., Hasegawa, N., Kawashiro, T. & Ishihara, T., 1994, In : Thorax. 49, 2, p. 144-146 3 p.

Research output: Contribution to journalArticle

Open Access
26 Citations (Scopus)
1995

Effects of intravascular latex injection on factors responsible for acute lung injury

Ishizaka, A., Hasegawa, N., Sayama, K., Urano, T., Sakamaki, F., Nakamura, H., Tasaka, S. & Kanazawa, M., 1995 Jan 1, In : Japanese Journal of Thoracic Diseases. 33, 9, p. 930-935 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Effects of pretreatment with SDZ MRL 953, a novel immunostimulatory lipid A analog, on endotoxin-induced acute lung injury in guinea pigs

Nakamura, H., Ishizaka, A., Urano, T., Sayama, K., Sakamaki, F., Terashima, T., Waki, Y., Soejima, K., Tasaka, S., Hasegawa, N., Fujishima, S. & Kanazawa, M., 1995, In : Clinical and Diagnostic Laboratory Immunology. 2, 6, p. 672-677 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Platelet activating factor does not participate in direct endothelial cell injury caused by tumor necrosis factor

Sayama, K., Ishizaka, A., Asano, K., Hasegawa, N., Urano, T., Kanazawa, M. & Kawashiro, T., 1995 Jan 1, In : Respiration and Circulation. 43, 1, p. 49-53 5 p.

Research output: Contribution to journalArticle

1996

Augmentation of endotoxin-induced pulmonary responses by mononuclear cell phagocytosis in the reticuloendothelial system

Ishizaka, A., Hasegawa, N., Sayama, K., Urano, T., Nakamura, H., Sakamaki, F., Soejima, K., Waki, Y., Tasaka, S., Nakamura, M., Matsubara, H. & Kanazawa, M., 1996 Jun 1, In : Critical care medicine. 24, 6, p. 1034-1040 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury

Sakamaki, F., Ishizaka, A., Urano, T., Sayama, K., Nakamura, H., Terashima, T., Waki, Y., Tasaka, S., Hasegawa, N., Sato, K., Nakagawa, N., Obata, T. & Kanazawa, M., 1996 Jan 1, In : American journal of respiratory and critical care medicine. 153, 1, p. 391-397 7 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Pulmonary capillary injury

Ishizaka, A. & Hasegawa, N., 1996 Jul 1, In : Respiration and Circulation. 44, 7, p. 691-698 8 p.

Research output: Contribution to journalArticle

The effects of recombinant human thrombomodulin on endotoxin-induced multiple-system organ failure in rats

Hasegawa, N., Kandra, T. G., Husari, A. W., Veiss, S., Hart, W. T., Hedgpeth, J., Wydro, R. & Raffin, T. A., 1996 Jan 1, In : American journal of respiratory and critical care medicine. 153, 6 I, p. 1831-1837 7 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
1997

The effects of post-treatment with lisofylline, a phosphatidic acid generation inhibitor, on sepsis-induced acute lung injury in pigs

Hasegawa, N., Oka, Y., Nakayama, M., Berry, G. J., Bursten, S., Rice, G. & Raffin, T. A., 1997 Jan 1, In : American journal of respiratory and critical care medicine. 155, 3, p. 928-936 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
1998

Attributable factors to the emergence of multidrug-resistant Mycobacterium tuberculosis based on the observation of consecutive drug resistance test results

Fujino, T., Hasegawa, N., Satou, R., Komatsu, H. & Kawada, K., 1998 Jul 1, In : Kekkaku. 73, 7, p. 471-476 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Effects of the lazaroid, tirilazad mesylate, on sepsis-induced acute lung injury in minipigs

Nakayama, M., Hasegawa, N., Oka, Y., Lutzke, B., McCall, J. M. & Raffin, T. A., 1998 Apr 8, In : Critical care medicine. 26, 3, p. 538-547 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
1999

Selective downregulation of neutrophils by a phosphatidic acid generation inhibitor in a porcine sepsis model

Oka, Y., Hasegawa, N., Nakayama, M., Murphy, G. A., Sussman, H. H. & Raffin, T. A., 1999 Feb, In : Journal of Surgical Research. 81, 2, p. 147-155 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2000

Attenuation of live E. coli-induced acute lung injury by x-ray irradiation in guinea pigs

Ishizaka, A., Sayama, K., Hasegawa, N., Fujita, H., Asano, K., Kanazawa, M. & Kubo, A., 2000 Dec 1, In : Lung. 178, 6, p. 331-340 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Genetic variants of NRAMP1 and active tuberculosis in Japanese populations

Gao, P. S., Fujishima, S., Mao, X. Q., Remus, N., Kanda, M., Enomoto, T., Dake, Y., Bottini, N., Tabuchie, M., Hasegawa, N., Yamaguchib, K., Tiemessenf, C., Hopkina, J. M., Shirakawa, T. & Kishie, F., 2000, In : Clinical Genetics. 58, 1, p. 74-76 3 p.

Research output: Contribution to journalLetter

113 Citations (Scopus)
2001

New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome

Ishizaka, A., Watanabe, M., Yamashita, T., Ogawa, Y., Koh, H., Hasegawa, N., Nakamura, H., Asano, K., Yamaguchi, K., Kotani, M., Kotani, T., Morisaki, H., Takeda, J., Kobayashi, K. & Ogawa, S., 2001 Jan 1, In : Critical care medicine. 29, 4, p. 896-898 3 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Pretreatment with FK506 improves survival rate and gas exchange in canine model of acute lung injury

Koshika, T., Ishizaka, A., Nagatomi, I., Sudo, Y., Hasegawa, N. & Goto, T., 2001 Jan 1, In : American journal of respiratory and critical care medicine. 163, 1, p. 79-84 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Usefulness of pulmonary vascular leakiness assessment in interstitial pneumonitis

Ishizaka, A., Hasegawa, N., Nakamura, K., Takagi, Y., Takano, M., Yamaguchi, K. & Kubo, A., 2001 May, In : Chest. 119, 5, p. 1455-1460 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2002

Detection of mycobacteria in patients with pulmonary tuberculosis undergoing chemotherapy using MGIT and egg-based solid medium culture systems

Hasegawa, N., Miura, T., Ishizaka, A., Yamaguchi, K. & Ishii, K., 2002 May 20, In : International Journal of Tuberculosis and Lung Disease. 6, 5, p. 447-453 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT1 antagonist, pranlukast, in Japanese patients with moderate asthma

Asano, K., Shiomi, T., Hasegawa, N., Nakamura, H., Kudo, H., Matsuzaki, T., Hakuno, H., Fukunaga, K., Suzuki, Y., Kanazawa, M. & Yamaguchi, K., 2002 Oct, In : Pharmacogenetics. 12, 7, p. 565-570 6 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

New simple and rapid test for culture confirmation of Mycobacterium tuberculosis complex: A multicenter study

Hasegawa, N., Miura, T., Ishii, K., Yamaguchi, K., Lindner, T. H., Merritt, S., Matthews, J. D. & Siddiqi, S. H., 2002, In : Journal of Clinical Microbiology. 40, 3, p. 908-912 5 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Pharmacology of acute lung injury

Tasaka, S., Hasegawa, N. & Ishizaka, A., 2002 Jan 1, In : Pulmonary Pharmacology and Therapeutics. 15, 2, p. 83-95 13 p.

Research output: Contribution to journalReview article

47 Citations (Scopus)
2003

Effect of CD14 blockade on endotoxin-induced acute lung injury in mice

Tasaka, S., Ishizaka, A., Yamada, W., Shimizu, M., Koh, H., Hasegawa, N., Adachi, Y. & Yamaguchi, K., 2003 Aug 1, In : American journal of respiratory cell and molecular biology. 29, 2, p. 252-258 7 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Effects of docetaxel dosage in combination chemotherapy with carboplatin against advanced non-small cell lung cancer

Oyamada, Y., Watanabe, H., Fukunaga, K., Nakamura, H., Asano, K., Hasegawa, N. & Yamaguchi, K., 2003 Nov, In : Gan to kagaku ryoho. Cancer & chemotherapy. 30, 12, p. 1917-1922 6 p.

Research output: Contribution to journalArticle

Reactive oxygen species and acute lung injury

Shimizu, M., Hasegawa, N. & Ishizaka, A., 2003 Jul 1, In : Respiration and Circulation. 51, 7, p. 715-720 6 p.

Research output: Contribution to journalComment/debate

2004

Contributions of high mobility group box protein in experimental and clinical acute lung injury

Ueno, H., Matsuda, T., Hashimoto, S., Amaya, F., Kitamura, Y., Tanaka, M., Kobayash, A., Maruyama, I., Yamada, S., Hasegawa, N., Soejima, J., Koh, H. & Ishizaka, A., 2004 Dec 15, In : American journal of respiratory and critical care medicine. 170, 12, p. 1310-1316 7 p.

Research output: Contribution to journalArticle

300 Citations (Scopus)

Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome

Ishizaka, A., Matsuda, T., Albertine, K. H., Koh, H., Tasaka, S., Hasegawa, N., Kohno, N., Kotani, T., Morisaki, H., Takeda, J., Nakamura, M., Fang, X., Martin, T. R., Matthay, M. A. & Hashimoto, S., 2004 Jun, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 286, 6 30-6, p. L1088-L1094

Research output: Contribution to journalArticle

128 Citations (Scopus)

High prevalence rate of Helicobacter pylori resistance to clarithromycin during long-term multiple antibiotic therapy for chronic respiratory disease caused by non-tuberculous mycobacteria

Kaneko, F., Suzuki, H., Hasegawa, N., Kurabayshi, K., Saito, H., Otani, S., Nakamizo, H., Kawata, K., Miyairi, M., Ishii, K. & Ishii, H., 2004 Jul, In : Alimentary Pharmacology and Therapeutics, Supplement. 20, 1, p. 62-67 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2005

Attenuation of endotoxin-induced acute lung injury by the Rho associated kinase inhibitor, Y-27632

Tasaka, S., Koh, H., Yamada, W., Shimizu, M., Ogawa, Y., Hasegawa, N., Yamaguchi, K., Ishii, Y., Richer, S. E., Doerschuk, C. M. & Ishizaka, A., 2005 Jun 1, In : American journal of respiratory cell and molecular biology. 32, 6, p. 504-510 7 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Introduction and outcome of DOTS projects in Japan

Hasegawa, N., 2005 Nov 1, In : Kekkaku. 80, 11, p. 709-718 10 p.

Research output: Contribution to journalArticle

SARS risk perceptions in healthcare workers, Japan

Imai, T., Takahashi, K., Hoshuyama, T., Hasegawa, N., Lim, M. K. & Koh, D., 2005 Mar 1, In : Emerging Infectious Diseases. 11, 3, p. 404-410 7 p.

Research output: Contribution to journalReview article

37 Citations (Scopus)

Usefulness of QuantiFERON®TB-2G in contact investigation of a tuberculosis outbreak in a university

Funayama, K., Tsujimoto, A., Mori, M., Yamamoto, H., Fujiwara, K., Nishimura, T., Hasegawa, N., Horiguchi, I., Mori, T. & Marui, E., 2005 Jul 1, In : Kekkaku. 80, 7, p. 527-534 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2006
2 Citations (Scopus)

Early Pulmonary Resection for Mycobacterium Avium Complex Lung Disease Treated With Macrolides and Quinolones

Watanabe, M., Hasegawa, N., Ishizaka, A., Asakura, K., Izumi, Y., Eguchi, K., Kawamura, M., Horinouchi, H. & Kobayashi, K., 2006 Jun, In : Annals of Thoracic Surgery. 81, 6, p. 2026-2030 5 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Effects of initial passage of endotoxin through the liver on the extent of acute lung injury in a rat model

Shimada, H., Hasegawa, N., Koh, H., Tasaka, S., Shimizu, M., Yamada, W., Nishimura, T., Amakawa, K., Kohno, M., Sawafuji, M., Nakamura, K., Fujishima, S., Yamaguchi, K. & Ishizaka, A., 2006 Sep 1, In : Shock. 26, 3, p. 311-315 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

New rapid detection test with a combination of polymerase chain reaction and immunochromatographic assay for Mycobacterium tuberculosis complex

Suzuki, T., Tanaka, M., Otani, S., Matsuura, S., Sakaguchi, Y., Nishimura, T., Ishizaka, A. & Hasegawa, N., 2006 Nov 1, In : Diagnostic Microbiology and Infectious Disease. 56, 3, p. 275-280 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Small cell lung cancer with Sjögren's syndrome and Lambert-Eaton myasthenic syndrome

Nishimura, T., Tasaka, S., Yamada, W., Hasegawa, N., Soejima, K., Sayama, K., Asano, K. & Ishizaka, A., 2006 Oct, In : Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 44, 10, p. 775-778 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Substantial differences in preparedness for emergency infection control measures among major hospitals in Japan: Lessons from SARS

Imai, T., Takahashi, K., Hoshuyama, T., Hasegawa, N., Chia, S. E. & Koh, D., 2006 Jun, In : Journal of Infection and Chemotherapy. 12, 3, p. 124-131 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)