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Research Output 2001 2019

  • 1641 Citations
  • 20 h-Index
  • 70 Article
  • 1 Short survey
2019
1 Citation (Scopus)
Indigo Carmine
Ulcerative Colitis
Pulmonary Hypertension
Intussusception
Liver Diseases
19 Citations (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Cho, H., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. & 2 others, Sato, T. & Kanai, T., 2019 Jan 1, (Accepted/In press) In : Nature Microbiology.

Research output: Contribution to journalArticle

Th17 Cells
Sclerosing Cholangitis
Liver Diseases
Microbiota
Bacterial Translocation
Human Herpesvirus 3
Acute Liver Failure
Hematopoietic Stem Cell Transplantation
Virus Diseases
Herpes Zoster

Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35

Koda, Y., Nakamoto, N., Chu, P. S., Ugamura, A., Mikami, Y., Teratani, T., Tsujikawa, H., Shiba, S., Taniki, N., Sujino, T., Miyamoto, K., Suzuki, T., Yamaguchi, A., Morikawa, R., Sato, K., Sakamoto, M., Yoshimoto, T. & Kanai, T., 2019 Jul 2, In : The Journal of clinical investigation. 130

Research output: Contribution to journalArticle

Open Access
Dendritic Cells
Liver
Wounds and Injuries
Acute Liver Failure
Immunosuppressive Agents
2018
12 Citations (Scopus)

Clarithromycin expands CD11b+Gr-1+cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia

Namkoong, H., Ishii, M., Fujii, H., Yagi, K., Asami, T., Asakura, T., Suzuki, S., Hegab, A. E., Kamata, H., Tasaka, S., Atarashi, K., Nakamoto, N., Iwata, S., Honda, K., Kanai, T., Hasegawa, N., Koyasu, S. & Betsuyaku, T., 2018 Apr 1, In : PLoS Pathogens. 14, 4, e1006955.

Research output: Contribution to journalArticle

Bacterial Pneumonia
Clarithromycin
Septic Shock
Human Influenza
Pneumococcal Pneumonia
2 Citations (Scopus)

Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

Murakami, Y., Sugiyama, K., Ebinuma, H., Nakamoto, N., Ojiro, K., Cho, H., Taniki, N., Saito, Y., Teratani, T., Koda, Y., Suzuki, T., Saito, K., Fukasawa, M., Ikeda, M., Kato, N., Kanai, T. & Saito, H., 2018 Jun 25, In : BMC Cancer. 18, 1, 680.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Liver Neoplasms
Hepacivirus
Hepatocytes
Virus Diseases
4 Citations (Scopus)

Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey

Takahashi, A., Moriya, K., Ohira, H., Arinaga-Hino, T., Zeniya, M., Torimura, T., Abe, M., Takaki, A., Kang, J. H., Inui, A., Fujisawa, T., Yoshizawa, K., Suzuki, Y., Nakamoto, N., Koike, K., Yoshiji, H., Goto, A., Tanaka, A., Younossi, Z. M. & Takikawa, H., 2018 Oct 1, In : PLoS One. 13, 10, e0204772.

Research output: Contribution to journalArticle

autoimmune hepatitis
hepatitis A
Autoimmune Hepatitis
quality of life
questionnaires
2 Citations (Scopus)

Intestinal barrier regulates immune responses in the liver via IL-10-producing macrophages

Taniki, N., Nakamoto, N., Cho, H., Mikami, Y., Amiya, T., Teratani, T., Suzuki, T., Tsukimi, T., Fukuda, S., Yamaguchi, A., Shiba, S., Miyake, R., Katayama, T., Ebinuma, H. & Kanai, T., 2018 Jun 21, In : JCI insight. 3, 12

Research output: Contribution to journalArticle

Open Access
Interleukin-10
Macrophages
Liver
Dextran Sulfate
Concanavalin A
5 Citations (Scopus)

Non-alcoholic fatty liver disease in patients with autoimmune hepatitis

Japan AIH Study Group (JAIHSG), 2018 Apr 1, In : JGH Open. 2, 2, p. 54-58 5 p.

Research output: Contribution to journalArticle

Open Access
Autoimmune Hepatitis
Non-alcoholic Fatty Liver Disease
Ursodeoxycholic Acid
Enzymes
Prednisolone
2017
13 Citations (Scopus)

Autoimmune hepatitis in Japan: trends in a nationwide survey

Autoimmune Hepatitis Study Group-Subgroup of the Intractable Hepato-Biliary Disease Study Group in Japan, 2017 May 1, In : Journal of Gastroenterology. 52, 5, p. 631-640 10 p.

Research output: Contribution to journalArticle

Autoimmune Hepatitis
Japan
Chronic Hepatitis
Hepatitis
Emperipolesis
17 Citations (Scopus)

Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice

Nakamoto, N., Amiya, T., Aoki, R., Taniki, N., Koda, Y., Miyamoto, K., Teratani, T., Suzuki, T., Chiba, S., Cho, H., Hayashi, A., Yamaguchi, A., Shiba, S., Miyake, R., Katayama, T., Suda, W., Mikami, Y., Kamada, N., Ebinuma, H., Saito, H. & 2 others, Hattori, M. & Kanai, T., 2017 Oct 31, In : Cell Reports. 21, 5, p. 1215-1226 12 p.

Research output: Contribution to journalArticle

Immune Tolerance
Lactobacillus
Liver
Wounds and Injuries
Dendritic Cells
3 Citations (Scopus)

Detection of bacterial DNA by in situ hybridization in patients with decompensated liver cirrhosis

Usui, S., Ebinuma, H., Cho, H., Nakamoto, N., Yamagishi, Y., Saito, H. & Kanai, T., 2017 Oct 17, In : BMC Gastroenterology. 17, 1

Research output: Contribution to journalArticle

Bacterial DNA
Liver Cirrhosis
In Situ Hybridization
Peritonitis
Bacteria
8 Citations (Scopus)

Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling

Teratani, T., Tomita, K., Suzuki, T., Furuhashi, H., Irie, R., Hida, S., Okada, Y., Kurihara, C., Ebinuma, H., Nakamoto, N., Saito, H., Hibi, T., Miura, S., Hokari, R. & Kanai, T., 2017, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Acetaminophen
Endothelial Cells
Cholesterol
Liver
6 Citations (Scopus)

Glycolysis regulates LPS-induced cytokine production in M2 polarized human macrophages

Chiba, S., Hisamatsu, T., Suzuki, H., Mori, K., Kitazume, M. T., Shimamura, K., Mizuno, S., Nakamoto, N., Matsuoka, K., Naganuma, M. & Kanai, T., 2017 Mar 1, In : Immunology Letters. 183, p. 17-23 7 p.

Research output: Contribution to journalArticle

Glycolysis
Lipopolysaccharides
Macrophages
Cytokines
Macrophage Colony-Stimulating Factor
13 Citations (Scopus)

Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis

Yamada, S., Kamada, N., Amiya, T., Nakamoto, N., Nakaoka, T., Kimura, M., Saito, Y., Ejima, C., Kanai, T. & Saito, H., 2017 Nov 29, In : BMC Gastroenterology. 17, 1, 136.

Research output: Contribution to journalArticle

High Fat Diet
Fatty Liver
Fatty Acids
Inflammation
Liver
23 Citations (Scopus)

On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon-free therapy for chronic hepatitis C

Cho, H., Nakamoto, N., Taniki, N., Ojiro, K., Amiya, T., Makita, Y., Murata, H., Yamaguchi, A., Shiba, S., Miyake, R., Katayama, T., Yoshida, A., Ikura, A., Takeda, K., Ebinuma, H., Saito, H. & Kanai, T., 2017 Jun 1, In : PLoS One. 12, 6, e0179096.

Research output: Contribution to journalArticle

chronic hepatitis C
antiviral agents
Chronic Hepatitis C
interferons
hepatoma
4 Citations (Scopus)

Recovery from anemia and leukocytopenia after abstinence in Japanese alcoholic men and their genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2

Yokoyama, A., Brooks, P. J., Yokoyama, T., Mizukami, T., Shiba, S., Nakamoto, N. & Maruyama, K., 2017, In : Japanese Journal of Clinical Oncology. 47, 4, p. 306-312 7 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Erythrocyte Indices
Alcohol Dehydrogenase
Leukopenia
Genetic Polymorphisms
2 Citations (Scopus)

Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence

Yokoyama, A., Taniki, N., Hara, S., Haysashi, E., Nakamoto, N., Mizukami, T., Maruyama, K. & Yokoyama, T., 2017 Oct 23, (Accepted/In press) In : Journal of Gastroenterology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Fatty Liver
Alcoholism
Genotype
Alcoholic Fatty Liver
Aldehyde Dehydrogenase
2016
9 Citations (Scopus)

Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis

Amiya, T., Nakamoto, N., Cho, H., Teratani, T., Nakajima, H., Fukuchi, Y., Taniki, N., Yamaguchi, A., Shiba, S., Miyake, R., Katayama, T., Ebinuma, H. & Kanai, T., 2016 Oct 11, In : Scientific Reports. 6, 35146.

Research output: Contribution to journalArticle

Concanavalin A
Macrophages
Liver
Wounds and Injuries
Bone Marrow

Current status of alcoholic hepatitis in Japan (2012)

Horie, Y., Ebinuma, H., Kikuchi, H., Shiba, S., Nakamoto, N. & Kanai, T., 2016 Apr 29, In : Acta Hepatologica Japonica. 57, 4, p. 171-177 7 p.

Research output: Contribution to journalArticle

Alcoholic Hepatitis
Japan
International Normalized Ratio
Dacarbazine
Steroids

Current status of alcoholic hepatocellular carcinoma in Japan -nation-wide survey in 2014

Horie, Y., Kikuchi, M., Ebinuma, H., Shiba, S., Taniki, N., Cho, H., Nakamoto, N. & Kanai, T., 2016, In : Acta Hepatologica Japonica. 57, 10, p. 538-547 10 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Japan
Surveys and Questionnaires
Alcohols
Early Diagnosis
18 Citations (Scopus)

Glycolytic pathway affects differentiation of human monocytes to regulatory macrophages

Suzuki, H., Hisamatsu, T., Chiba, S., Mori, K., Kitazume, M. T., Shimamura, K., Nakamoto, N., Matsuoka, K., Ebinuma, H., Naganuma, M. & Kanai, T., 2016 Aug 1, In : Immunology Letters. 176, p. 18-27 10 p.

Research output: Contribution to journalArticle

Glycolysis
Monocytes
Macrophages
Interleukin-10
Phenotype
1 Citation (Scopus)
Chemokines
Macrophages
Liver
Wounds and Injuries
Liver Diseases
3 Citations (Scopus)

Simeprevir/pegylated interferon/ribavirin triple therapy for recurrent hepatitis C after living donor liver transplantation

Shinoda, M., Ebinuma, H., Itano, O., Yamagishi, Y., Obara, H., Kitago, M., Nakamoto, N., Hibi, T., Yagi, H., Abe, Y., Matsubara, K., Cho, H., Wakayama, Y., Taniki, N., Yamaguchi, A., Amemiya, R., Miyake, R., Mizota, T., Kanai, T. & Kitagawa, Y., 2016 Oct 1, In : Hepatology Research. 46, 11, p. 1118-1128 11 p.

Research output: Contribution to journalArticle

Ribavirin
Living Donors
Hepatitis C
Liver Transplantation
Interferons
2015
Hyperbilirubinemia
Ribavirin
Chronic Hepatitis C
Serum
Therapeutics
6 Citations (Scopus)
Alcoholic Liver Cirrhosis
Hepatocellular Carcinoma
Japan
Alcohols
Diabetes Mellitus

Current status of alcoholic liver diseases in Japan

Horie, Y., Ebinuma, H., Kikuchi, M., Nakamoto, N. & Kanai, T., 2015 Jul 29, In : Acta Hepatologica Japonica. 56, 7, p. 366-368 3 p.

Research output: Contribution to journalArticle

Alcoholic Liver Diseases
Liver Cirrhosis
Japan
Alcohols
Alcoholics
1 Citation (Scopus)

Genotype-associated differential NKG2D expression on CD56+CD3+ lymphocytes predicts response to pegylated-interferon/ribavirin therapy in chronic hepatitis C

Cho, H., Ebinuma, H., Nakamoto, N., Sugiyama, K., Usui, S., Wakayama, Y., Taniki, N., Yamaguchi, A., Shiba, S., Yamagishi, Y., Wakita, T., Hibi, T., Saito, H. & Kanai, T., 2015 May 12, In : PLoS One. 10, 5, e0125664.

Research output: Contribution to journalArticle

chronic hepatitis C
Lymphocytes
Ribavirin
Chronic Hepatitis C
interferons
2014
16 Citations (Scopus)

Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice

Yokoyama, W., Kohsaka, H., Kaneko, K., Walters, M., Takayasu, A., Fukuda, S., Miyabe, C., Miyabe, Y., Love, P. E., Nakamoto, N., Kanai, T., Watanabe-Imai, K., Charvat, T. T., Penfold, M. E. T., Jaen, J., Schall, T. J., Harigai, M., Miyasaka, N. & Nanki, T., 2014, In : Arthritis Research and Therapy. 16, 1, 445.

Research output: Contribution to journalArticle

Experimental Arthritis
Rheumatoid Arthritis
Interleukin-6
Matrix Metalloproteinase 3
Tumor Necrosis Factor-alpha
4 Citations (Scopus)

Clinical features of bacteremia due to Campylobacter jejuni

Mori, T., Hasegawa, N., Sugita, K., Shinjo(H), M., Nakamoto, N., Shimizu, T., Hori, S., Iketani, O., Fujiwara, H., Takano, Y. & Iwata, S., 2014, In : Internal Medicine. 53, 17, p. 1941-1944 4 p.

Research output: Contribution to journalArticle

Campylobacter jejuni
Bacteremia
Hematologic Diseases
Fluoroquinolones
Macrolides
10 Citations (Scopus)

Induction of multiple immune regulatory pathways with differential impact in HCV/HIV coinfection

Cho, H., Kikuchi, M., Li, Y., Nakamoto, N., Amorosa, V. K., Valiga, M. E. & Chang, K. M., 2014, In : Frontiers in Immunology. 5, JUL, p. 1 1 p., Article 265.

Research output: Contribution to journalArticle

Coinfection
CTLA-4 Antigen
HIV
T-Lymphocytes
HIV Infections
9 Citations (Scopus)

Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation

Mikami, Y., Mizuno, S., Nakamoto, N., Hayashi, A., Sujino, T., Sato, T., Kamada, N., Matsuoka, K., Hisamatsu, T., Ebinuma, H., Hibi, T., Yoshimura, A. & Kanai, T., 2014 Jan 2, In : PLoS One. 9, 1, e84619.

Research output: Contribution to journalArticle

Macrophages
dendritic cells
Liver
Dendritic Cells
macrophages
19 Citations (Scopus)

Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus

Sugiyama, K., Ebinuma, H., Nakamoto, N., Sakasegawa, N., Murakami, Y., Cho, H., Usui, S., Ishibashi, Y., Wakayama, Y., Taniki, N., Murata, H., Saito, Y., Fukasawa, M., Saito, K., Yamagishi, Y., Wakita, T., Takaku, H., Hibi, T., Saito, H. & Kanai, T., 2014 Apr 9, In : PLoS One. 9, 4, e94460.

Research output: Contribution to journalArticle

Hepatitis C virus
Viruses
Hepacivirus
Cells
cell lines
59 Citations (Scopus)

Role of Toll-like receptors in immune activation and tolerance in the liver

Nakamoto, N. & Kanai, T., 2014, In : Frontiers in Immunology. 5, MAY, 221.

Research output: Contribution to journalShort survey

Immune Tolerance
Toll-Like Receptors
Liver
Antigens
Pattern Recognition Receptors
2013

A case of acute pancreatitis induced by telaprevir in the anti-HCV treatment with peginterferon and ribavirin

Matsushita, M., Ebinuma, H., Fukuhara, S., Minami, K., Minami, K., Nakamoto, N., Funakoshi, S., Kanai, T., Saito, H. & Hibi, T., 2013 May 30, In : Acta Hepatologica Japonica. 54, 5, p. 340-346 7 p.

Research output: Contribution to journalArticle

Ribavirin
Pancreatitis
Therapeutics
Gabexate
RNA
49 Citations (Scopus)

C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice

Cho, H., Nakamoto, N., Ebinuma, H., Usui, S., Saeki, K., Matsumoto, A., Mikami, Y., Sugiyama, K., Tomita, K., Kanai, T., Saito, H. & Hibi, T., 2013 Jul, In : Hepatology. 58, 1, p. 337-350 14 p.

Research output: Contribution to journalArticle

CCR Receptors
Hepatic Stellate Cells
Liver Cirrhosis
Macrophages
Liver
7 Citations (Scopus)

CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion

Nakamura, Y., Kanai, T., Saeki, K., Takabe, M., Irie, J., Miyoshi, J., Mikami, Y., Teratani, T., Suzuki, T., Miyata, N., Hisamatsu, T., Nakamoto, N., Yamagishi, Y., Higuchi, H., Ebinuma, H., Hozawa, S., Saito, H., Itoh, H. & Hibi, T., 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 8

Research output: Contribution to journalArticle

Ceruletide
Peptide Receptors
Chronic Pancreatitis
Hyperglycemia
Insulin
20 Citations (Scopus)

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

Matsumoto, A., Kanai, T., Mikami, Y., Cho, H., Nakamoto, N., Ebinuma, H., Saito, H., Sato, T., Yagita, H. & Hibi, T., 2013 Apr 23, In : PLoS One. 8, 4, e62853.

Research output: Contribution to journalArticle

hepatitis
Liver
Hepatitis
T-cells
Lymphocytes
13 Citations (Scopus)

Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier

Mizuno, S., Yamagishi, Y., Ebinuma, H., Nakamoto, N., Katahira, M., Sasaki, A., Sakamoto, M., Suzuki, H., Kanai, T. & Hibi, T., 2013, In : Clinical Journal of Gastroenterology. 6, 2, p. 188-192 5 p.

Research output: Contribution to journalArticle

Liver Failure
Renal Cell Carcinoma
Hepatitis B virus
Mycoses
Chronic Hepatitis B
2012
41 Citations (Scopus)

CCR9 + macrophages are required for acute liver inflammation in mouse models of hepatitis

Nakamoto, N., Ebinuma, H., Kanai, T., Cho, H., Ono, Y., Mikami, Y., Ojiro, K., Lipp, M., Love, P. E., Saito, H. & Hibi, T., 2012 Feb, In : Gastroenterology. 142, 2, p. 366-376 11 p.

Research output: Contribution to journalArticle

Hepatitis
Macrophages
Concanavalin A
Inflammation
Liver
24 Citations (Scopus)

CCR9+ plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice

Mizuno, S., Kanai, T., Mikami, Y., Sujino, T., Ono, Y., Hayashi, A., Handa, T., Matsumoto, A., Nakamoto, N., Matsuoka, K., Hisamatsu, T., Takaishi, H. & Hibi, T., 2012 Aug 30, In : Immunology Letters. 146, 1-2, p. 64-69 6 p.

Research output: Contribution to journalArticle

Dendritic Cells
Small Intestine
Inflammation
Colon
T-Lymphocytes
3 Citations (Scopus)

Disadvantages of peginterferon and ribavirin treatment in older patients with chronic hepatitis C: An analysis using the propensity score

Ebinuma, H., Saito, H., Tada, S., Nakamoto, N., Ohishi, T., Tsunematsu, S., Kumagai, N., Tsuchimoto, K., Tsukada, N., Inagaki, Y., Horie, Y., Takahashi, M., Atsukawa, K., Okamura, Y., Kanai, T. & Hibi, T., 2012 Oct, In : Hepatology International. 6, 4, p. 744-752 9 p.

Research output: Contribution to journalArticle

Propensity Score
Ribavirin
Chronic Hepatitis C
Therapeutics
Hemoglobins
7 Citations (Scopus)

MyD88-dependent interleukin-10 production from regulatory CD11b+Gr-1high cells suppresses development of acute cerulein pancreatitis in mice

Koike, Y., Kanai, T., Saeki, K., Nakamura, Y., Nakano, M., Mikami, Y., Yamagishi, Y., Nakamoto, N., Ebinuma, H. & Hibi, T., 2012 Dec 7, In : Immunology Letters. 148, 2, p. 172-177 6 p.

Research output: Contribution to journalArticle

Ceruletide
Pancreatitis
Interleukin-10
Toll-Like Receptors
Pancreas
2011
88 Citations (Scopus)

Evaluation of liver fibrosis by transient elastography using acoustic radiation force impulse: comparison with Fibroscan(®).

Ebinuma, H., Saito, H., Komuta, M., Ojiro, K., Wakabayashi, K., Usui, S., Cho, H., Umeda, R., Ishibashi, Y., Takayama, T., Kikuchi, M., Nakamoto, N., Yamagishi, Y., Kanai, T., Ohkuma, K., Sakamoto, M. & Hibi, T., 2011, In : Journal of Gastroenterology. 46, 10, p. 1238-1248 11 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Acoustics
Liver Cirrhosis
Radiation
Liver
2010
25 Citations (Scopus)

DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8

Kurita, S., Higuchi, H., Saito, Y., Nakamoto, N., Takaishi, H., Tada, S., Saito, H., Gores, G. J. & Hibi, T., 2010 Jun, In : Cancer Science. 101, 6, p. 1431-1439 9 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand Receptors
Caspase 8
Methyltransferases
Hepatocellular Carcinoma
Up-Regulation
20 Citations (Scopus)

MyD88-dependent pathway accelerates the liver damage of Concanavalin A-induced hepatitis

Ojiro, K., Ebinuma, H., Nakamoto, N., Wakabayashi, K., Mikami, Y., Ono, Y., Cho, H., Usui, S., Umeda, R., Takaishi, H., Yamagishi, Y., Saito, H., Kanai, T. & Hibi, T., 2010 Sep, In : Biochemical and Biophysical Research Communications. 399, 4, p. 744-749 6 p.

Research output: Contribution to journalArticle

Concanavalin A
Liver
Hepatitis
Toll-Like Receptors
Macrophages
2009
10 Citations (Scopus)

Determinants of in vitro expansion of different human virus-specific FoxP3+ regulatory CD8+ T cells in chronic hepatitis C virus infection

Billerbeck, E., Nakamoto, N., Seigel, B., Blum, H. E., Chang, K. M. & Thimme, R., 2009, In : Journal of General Virology. 90, 7, p. 1692-1701 10 p.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Virus Diseases
Regulatory T-Lymphocytes
Hepacivirus
Viruses
237 Citations (Scopus)

Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade

Nakamoto, N., Cho, H., Shaked, A., Olthoff, K., Valiga, M. E., Kaminski, M., Gostick, E., Price, D. A., Freeman, G. J., Wherry, E. J. & Chang, K. M., 2009 Feb, In : PLoS Pathogens. 5, 2, e1000313.

Research output: Contribution to journalArticle

CTLA-4 Antigen
T-Lymphocytes
Viruses
Liver
Virus Diseases
2008
195 Citations (Scopus)

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

Nakamoto, N., Kaplan, D. E., Coleclough, J., Li, Y., Valiga, M. E., Kaminski, M., Shaked, A., Olthoff, K., Gostick, E., Price, D. A., Freeman, G. J., Wherry, E. J. & Chang, K. M., 2008 Jun, In : Gastroenterology. 134, 7

Research output: Contribution to journalArticle

Hepacivirus
Cell Death
T-Lymphocytes
Ligands
CD8 Antigens
130 Citations (Scopus)

Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection

Ebinuma, H., Nakamoto, N., Li, Y., Price, D. A., Gostick, E., Levine, B. L., Tobias, J., Kwok, W. W. & Chang, K. M., 2008 May, In : Journal of Virology. 82, 10, p. 5043-5053 11 p.

Research output: Contribution to journalArticle

Interleukin-2 Receptor alpha Subunit
Hepatitis C virus
Virus Diseases
Regulatory T-Lymphocytes
Hepacivirus