• 1775 Citations
  • 22 h-Index
20012020

Research output per year

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Research Output

  • 1775 Citations
  • 22 h-Index
  • 74 Article
  • 2 Comment/debate
  • 1 Short survey
  • 1 Review article
2020

A case of intrahepatic cholangiocellular carcinoma due to thorotrast deposition, well-controlled by radiofrequency ablation therapy

Taniki, N., Nakamoto, N., Yoshida, A., Chu, P. S., Ikura, A., Yamataka, K., Morikawa, R., Shiba, S., Yamaguchi, A., Usui, S., Ojiro, K., Ebinuma, H., Saito, H., Kubota, N., Masugi, Y., Sakamto, M. & Kanai, T., 2020, In : Acta Hepatologica Japonica. 61, 5, p. 262-269 8 p.

Research output: Contribution to journalArticle

Open Access

A significant association of non-obese non-alcoholic fatty liver disease with sarcopenic obesity

Kashiwagi, K., Takayama, M., Fukuhara, K., Shimizu-Hirota, R., Chu, P. S., Nakamoto, N., Inoue, N., Iwao, Y. & Kanai, T., 2020 Aug, In : Clinical Nutrition ESPEN. 38, p. 86-93 8 p.

Research output: Contribution to journalArticle

Open Access

Associations among liver disease, serum lipid profile, body mass index, ketonuria, meal skipping, and the alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese men with alcohol dependence

Yokoyama, A., Taniki, N., Nakamoto, N., Tomita, K., Hara, S., Mizukami, T., Maruyama, K. & Yokoyama, T., 2020 May 1, In : Hepatology Research. 50, 5, p. 565-577 13 p.

Research output: Contribution to journalArticle

Clinical implications with tolvaptan on monitored bioimpedance-defined fluid status in patients with cirrhotic ascites: An observational study

Shiba, S., Chu, P. S., Nakamoto, N., Yamataka, K., Taniki, N., Ojiro, K., Yamaguchi, A., Morikawa, R., Yoshida, A., Ikura, A., Ebinuma, H., Saito, H. & Kanai, T., 2020 Mar 5, In : BMC Gastroenterology. 20, 1, 53.

Research output: Contribution to journalArticle

Open Access

Differences in autoimmune hepatitis based on inflammation localization

Takahashi, A., Ohira, H., Abe, K., Zeniya, M., Abe, M., Arinaga-Hino, T., Torimura, T., Yoshizawa, K., Takaki, A., Kang, J. H., Suzuki, Y., Nakamoto, N., Inui, A., Tanaka, A. & Takikawa, H., 2020, (Accepted/In press) In : Medical Molecular Morphology.

Research output: Contribution to journalArticle

The liver–brain–gut neural arc maintains the Treg cell niche in the gut

Teratani, T., Mikami, Y., Nakamoto, N., Suzuki, T., Harada, Y., Okabayashi, K., Hagihara, Y., Taniki, N., Kohno, K., Sibata, S., Miyamoto, K., Ishigame, H., Chu, P. S., Sujino, T., Suda, W., Hattori, M., Matsui, M., Okada, T., Okano, H., Inoue, M. & 7 others, Yada, T., Kitagawa, Y., Yoshimura, A., Tanida, M., Tsuda, M., Iwasaki, Y. & Kanai, T., 2020, (Accepted/In press) In : Nature.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2019

Adverse events in patients with ulcerative colitis treated with indigo naturalis: a Japanese nationwide survey

INDIGO survey Group, 2019 Oct 1, In : Journal of gastroenterology. 54, 10, p. 891-896 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P. S., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. & 2 others, Sato, T. & Kanai, T., 2019 Mar 1, In : Nature Microbiology. 4, 3, p. 492-503 12 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35

Koda, Y., Nakamoto, N., Chu, P. S., Ugamura, A., Mikami, Y., Teratani, T., Tsujikawa, H., Shiba, S., Taniki, N., Sujino, T., Miyamoto, K., Suzuki, T., Yamaguchi, A., Morikawa, R., Sato, K., Sakamoto, M., Yoshimoto, T. & Kanai, T., 2019 Aug 1, In : Journal of Clinical Investigation. 129, 8, p. 3201-3213 13 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2018

Clarithromycin expands CD11b+Gr-1+cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia

Namkoong, H., Ishii, M., Fujii, H., Yagi, K., Asami, T., Asakura, T., Suzuki, S., Hegab, A. E., Kamata, H., Tasaka, S., Atarashi, K., Nakamoto, N., Iwata, S., Honda, K., Kanai, T., Hasegawa, N., Koyasu, S. & Betsuyaku, T., 2018 Apr, In : PLoS Pathogens. 14, 4, e1006955.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

Murakami, Y., Sugiyama, K., Ebinuma, H., Nakamoto, N., Ojiro, K., Chu, P. S., Taniki, N., Saito, Y., Teratani, T., Koda, Y., Suzuki, T., Saito, K., Fukasawa, M., Ikeda, M., Kato, N., Kanai, T. & Saito, H., 2018 Jun 25, In : BMC cancer. 18, 1, 680.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey

Takahashi, A., Moriya, K., Ohira, H., Arinaga-Hino, T., Zeniya, M., Torimura, T., Abe, M., Takaki, A., Kang, J. H., Inui, A., Fujisawa, T., Yoshizawa, K., Suzuki, Y., Nakamoto, N., Koike, K., Yoshiji, H., Goto, A., Tanaka, A., Younossi, Z. M. & Takikawa, H., 2018 Oct, In : PloS one. 13, 10, e0204772.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Intestinal barrier regulates immune responses in the liver via IL-10-producing macrophages

Taniki, N., Nakamoto, N., Chu, P. S., Mikami, Y., Amiya, T., Teratani, T., Suzuki, T., Tsukimi, T., Fukuda, S., Yamaguchi, A., Shiba, S., Miyake, R., Katayama, T., Ebinuma, H. & Kanai, T., 2018 Jun 21, In : JCI Insight. 3, 12

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Non-alcoholic fatty liver disease in patients with autoimmune hepatitis

Japan AIH Study Group (JAIHSG), 2018 Apr 1, In : JGH Open. 2, 2, p. 54-58 5 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2017

Autoimmune hepatitis in Japan: trends in a nationwide survey

Autoimmune Hepatitis Study Group-Subgroup of the Intractable Hepato-Biliary Disease Study Group in Japan, 2017 May 1, In : Journal of gastroenterology. 52, 5, p. 631-640 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice

Nakamoto, N., Amiya, T., Aoki, R., Taniki, N., Koda, Y., Miyamoto, K., Teratani, T., Suzuki, T., Chiba, S., Chu, P. S., Hayashi, A., Yamaguchi, A., Shiba, S., Miyake, R., Katayama, T., Suda, W., Mikami, Y., Kamada, N., Ebinuma, H., Saito, H. & 2 others, Hattori, M. & Kanai, T., 2017 Oct 31, In : Cell Reports. 21, 5, p. 1215-1226 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Detection of bacterial DNA by in situ hybridization in patients with decompensated liver cirrhosis

Usui, S., Ebinuma, H., Chu, P. S., Nakamoto, N., Yamagishi, Y., Saito, H. & Kanai, T., 2017 Oct 17, In : BMC Gastroenterology. 17, 1, 106.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling

Teratani, T., Tomita, K., Suzuki, T., Furuhashi, H., Irie, R., Hida, S., Okada, Y., Kurihara, C., Ebinuma, H., Nakamoto, N., Saito, H., Hibi, T., Miura, S., Hokari, R. & Kanai, T., 2017 Oct, In : Journal of Hepatology. 67, 4, p. 780-790 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Glycolysis regulates LPS-induced cytokine production in M2 polarized human macrophages

Chiba, S., Hisamatsu, T., Suzuki, H., Mori, K., Kitazume, M. T., Shimamura, K., Mizuno, S., Nakamoto, N., Matsuoka, K., Naganuma, M. & Kanai, T., 2017 Mar 1, In : Immunology Letters. 183, p. 17-23 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis

Yamada, S., Kamada, N., Amiya, T., Nakamoto, N., Nakaoka, T., Kimura, M., Saito, Y., Ejima, C., Kanai, T. & Saito, H., 2017 Nov 29, In : BMC Gastroenterology. 17, 1, 136.

Research output: Contribution to journalArticle

19 Citations (Scopus)

On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon-free therapy for chronic hepatitis C

Chu, P. S., Nakamoto, N., Taniki, N., Ojiro, K., Amiya, T., Makita, Y., Murata, H., Yamaguchi, A., Shiba, S., Miyake, R., Katayama, T., Ugamura, A., Ikura, A., Takeda, K., Ebinuma, H., Saito, H. & Kanai, T., 2017 Jun, In : PloS one. 12, 6, e0179096.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Recovery from anemia and leukocytopenia after abstinence in Japanese alcoholic men and their genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2

Yokoyama, A., Brooks, P. J., Yokoyama, T., Mizukami, T., Shiba, S., Nakamoto, N. & Maruyama, K., 2017, In : Japanese journal of clinical oncology. 47, 4, p. 306-312 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence

Yokoyama, A., Taniki, N., Hara, S., Haysashi, E., Nakamoto, N., Mizukami, T., Maruyama, K. & Yokoyama, T., 2017 Oct 23, (Accepted/In press) In : Journal of Gastroenterology. p. 1-10 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016

Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis

Amiya, T., Nakamoto, N., Chu, P. S., Teratani, T., Nakajima, H., Fukuchi, Y., Taniki, N., Yamaguchi, A., Shiba, S., Miyake, R., Katayama, T., Ebinuma, H. & Kanai, T., 2016 Oct 11, In : Scientific reports. 6, 35146.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Current status of alcoholic hepatitis in Japan (2012)

Horie, Y., Ebinuma, H., Kikuchi, H., Shiba, S., Nakamoto, N. & Kanai, T., 2016 Apr 29, In : Acta Hepatologica Japonica. 57, 4, p. 171-177 7 p.

Research output: Contribution to journalArticle

Current status of alcoholic hepatocellular carcinoma in Japan -nation-wide survey in 2014

Horie, Y., Kikuchi, M., Ebinuma, H., Shiba, S., Taniki, N., Chu, P. S., Nakamoto, N. & Kanai, T., 2016, In : Acta Hepatologica Japonica. 57, 10, p. 538-547 10 p.

Research output: Contribution to journalArticle

Glycolytic pathway affects differentiation of human monocytes to regulatory macrophages

Suzuki, H., Hisamatsu, T., Chiba, S., Mori, K., Kitazume, M. T., Shimamura, K., Nakamoto, N., Matsuoka, K., Ebinuma, H., Naganuma, M. & Kanai, T., 2016 Aug 1, In : Immunology Letters. 176, p. 18-27 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
1 Citation (Scopus)

Simeprevir/pegylated interferon/ribavirin triple therapy for recurrent hepatitis C after living donor liver transplantation

Shinoda, M., Ebinuma, H., Itano, O., Yamagishi, Y., Obara, H., Kitago, M., Nakamoto, N., Hibi, T., Yagi, H., Abe, Y., Matsubara, K., Chu, P. S., Wakayama, Y., Taniki, N., Yamaguchi, A., Amemiya, R., Miyake, R., Mizota, T., Kanai, T. & Kitagawa, Y., 2016 Oct 1, In : Hepatology Research. 46, 11, p. 1118-1128 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2015

A case of type C chronic hepatitis with constitutional hyperbilirubinemia treated by peginterferon-alpha + ribavirin + simeprevir

Horie, Y., Ebinuma, H., Nakamoto, N. & Kanai, T., 2015 Jan 1, In : Acta Hepatologica Japonica. 56, 1, p. 13-17 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Current status of alcoholic liver diseases in Japan

Horie, Y., Ebinuma, H., Kikuchi, M., Nakamoto, N. & Kanai, T., 2015 Jul 29, In : Acta Hepatologica Japonica. 56, 7, p. 366-368 3 p.

Research output: Contribution to journalArticle

Genotype-associated differential NKG2D expression on CD56+CD3+ lymphocytes predicts response to pegylated-interferon/ribavirin therapy in chronic hepatitis C

Chu, P. S., Ebinuma, H., Nakamoto, N., Sugiyama, K., Usui, S., Wakayama, Y., Taniki, N., Yamaguchi, A., Shiba, S., Yamagishi, Y., Wakita, T., Hibi, T., Saito, H. & Kanai, T., 2015 May 12, In : PloS one. 10, 5, e0125664.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2014

Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice

Yokoyama, W., Kohsaka, H., Kaneko, K., Walters, M., Takayasu, A., Fukuda, S., Miyabe, C., Miyabe, Y., Love, P. E., Nakamoto, N., Kanai, T., Watanabe-Imai, K., Charvat, T. T., Penfold, M. E. T., Jaen, J., Schall, T. J., Harigai, M., Miyasaka, N. & Nanki, T., 2014, In : Arthritis Research and Therapy. 16, 1, 445.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Clinical features of bacteremia due to Campylobacter jejuni

Mori, T., Hasegawa, N., Sugita, K., Shinjoh, M., Nakamoto, N., Shimizu, T., Hori, S., Iketani, O., Fujiwara, H., Takano, Y. & Iwata, S., 2014 Jan 1, In : Internal Medicine. 53, 17, p. 1941-1944 4 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Induction of multiple immune regulatory pathways with differential impact in HCV/HIV coinfection

Cho, H., Kikuchi, M., Li, Y., Nakamoto, N., Amorosa, V. K., Valiga, M. E. & Chang, K. M., 2014, In : Frontiers in Immunology. 5, JUL, p. 1 1 p., Article 265.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation

Mikami, Y., Mizuno, S., Nakamoto, N., Hayashi, A., Sujino, T., Sato, T., Kamada, N., Matsuoka, K., Hisamatsu, T., Ebinuma, H., Hibi, T., Yoshimura, A. & Kanai, T., 2014 Jan 2, In : PloS one. 9, 1, e84619.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus

Sugiyama, K., Ebinuma, H., Nakamoto, N., Sakasegawa, N., Murakami, Y., Chu, P. S., Usui, S., Ishibashi, Y., Wakayama, Y., Taniki, N., Murata, H., Saito, Y., Fukasawa, M., Saito, K., Yamagishi, Y., Wakita, T., Takaku, H., Hibi, T., Saito, H. & Kanai, T., 2014 Apr 9, In : PloS one. 9, 4, e94460.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Role of Toll-like receptors in immune activation and tolerance in the liver

Nakamoto, N. & Kanai, T., 2014, In : Frontiers in Immunology. 5, MAY, 221.

Research output: Contribution to journalShort survey

63 Citations (Scopus)
2013

A case of acute pancreatitis induced by telaprevir in the anti-HCV treatment with peginterferon and ribavirin

Matsushita, M., Ebinuma, H., Fukuhara, S., Minami, K., Minami, K., Nakamoto, N., Funakoshi, S., Kanai, T., Saito, H. & Hibi, T., 2013 May 30, In : Acta Hepatologica Japonica. 54, 5, p. 340-346 7 p.

Research output: Contribution to journalArticle

C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice

Chu, P. S., Nakamoto, N., Ebinuma, H., Usui, S., Saeki, K., Matsumoto, A., Mikami, Y., Sugiyama, K., Tomita, K., Kanai, T., Saito, H. & Hibi, T., 2013 Jul 1, In : Hepatology. 58, 1, p. 337-350 14 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion

Nakamura, Y., Kanai, T., Saeki, K., Takabe, M., Irie, J., Miyoshi, J., Mikami, Y., Teratani, T., Suzuki, T., Miyata, N., Hisamatsu, T., Nakamoto, N., Yamagishi, Y., Higuchi, H., Ebinuma, H., Hozawa, S., Saito, H., Itoh, H. & Hibi, T., 2013 Jun 10, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 8, p. G700-G707

Research output: Contribution to journalArticle

7 Citations (Scopus)

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

Matsumoto, A., Kanai, T., Mikami, Y., Chu, P. S., Nakamoto, N., Ebinuma, H., Saito, H., Sato, T., Yagita, H. & Hibi, T., 2013 Apr 23, In : PloS one. 8, 4, e62853.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier

Mizuno, S., Yamagishi, Y., Ebinuma, H., Nakamoto, N., Katahira, M., Sasaki, A., Sakamoto, M., Suzuki, H., Kanai, T. & Hibi, T., 2013 Apr, In : Clinical journal of gastroenterology. 6, 2, p. 188-192 5 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2012

CCR9+ macrophages are required for acute liver inflammation in mouse models of hepatitis

Nakamoto, N., Ebinuma, H., Kanai, T., Chu, P., Ono, Y., Mikami, Y., Ojiro, K., Lipp, M., Love, P. E., Saito, H. & Hibi, T., 2012 Feb, In : Gastroenterology. 142, 2, p. 366-376 11 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

CCR9+ plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice

Mizuno, S., Kanai, T., Mikami, Y., Sujino, T., Ono, Y., Hayashi, A., Handa, T., Matsumoto, A., Nakamoto, N., Matsuoka, K., Hisamatsu, T., Takaishi, H. & Hibi, T., 2012 Aug 30, In : Immunology Letters. 146, 1-2, p. 64-69 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Disadvantages of peginterferon and ribavirin treatment in older patients with chronic hepatitis C: An analysis using the propensity score

Ebinuma, H., Saito, H., Tada, S., Nakamoto, N., Ohishi, T., Tsunematsu, S., Kumagai, N., Tsuchimoto, K., Tsukada, N., Inagaki, Y., Horie, Y., Takahashi, M., Atsukawa, K., Okamura, Y., Kanai, T. & Hibi, T., 2012 Oct 1, In : Hepatology International. 6, 4, p. 744-752 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

MyD88-dependent interleukin-10 production from regulatory CD11b+Gr-1high cells suppresses development of acute cerulein pancreatitis in mice

Koike, Y., Kanai, T., Saeki, K., Nakamura, Y., Nakano, M., Mikami, Y., Yamagishi, Y., Nakamoto, N., Ebinuma, H. & Hibi, T., 2012 Dec 7, In : Immunology Letters. 148, 2, p. 172-177 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)