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Research Output 1999 2019

  • 2139 Citations
  • 25 h-Index
  • 79 Article
  • 1 Letter
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Article
2019
1 Citation (Scopus)
Open Access
Aquaporin 4
Synaptic Transmission
Fatigue
Retina
Knockout Mice

Dietary spirulina supplementation protects visual function from photostress by suppressing retinal neurodegeneration in mice

Okamoto, T., Kawashima, H., Osada, H., Toda, E., Homma, K., Nagai, N., Imai, Y., Tsubota, K. & Ozawa, Y., 2019 Nov, In : Translational Vision Science and Technology. 8, 6, 20.

Research output: Contribution to journalArticle

Open Access
Spirulina
Dietary Supplements
Proteins
Oxygen
Reactive Oxygen Species

Dynamic changes in choroidal conditions during anti-vascular endothelial growth factor therapy in polypoidal choroidal vasculopathy

Nagai, N., Suzuki, M., Minami, S., Kurihara, T., Kamoshita, M., Sonobe, H., Watanabe, K., Uchida, A., Shinoda, H., Tsubota, K. & Ozawa, Y., 2019 Dec 1, In : Scientific reports. 9, 1, 11389.

Research output: Contribution to journalArticle

Open Access
Vascular Endothelial Growth Factor A
Therapeutics
Injections
Choroid
Optical Coherence Tomography
Open Access
Retinal Perforations
Retinoschisis
Neurodegenerative Diseases
Optical Coherence Tomography
Retina

Effect of axial length and age on the visual outcome of patients with idiopathic epiretinal membrane after pars plana vitrectomy

Minami, S., Shinoda, H., Shigeno, Y., Nagai, N., Kurihara, T., Watanabe, K., Sonobe, H., Takagi, H., Tsubota, K. & Ozawa, Y., 2019 Dec 1, In : Scientific reports. 9, 1, 19056.

Research output: Contribution to journalArticle

Open Access
Epiretinal Membrane
Temazepam
Vitrectomy
Visual Acuity
Confidence Intervals
Open Access
Retinal Vein Occlusion
Macular Edema
Vascular Endothelial Growth Factor A
Visual Acuity
Recurrence

QD laser eyewear as a visual field aid in a visual field defect model

Iyama, C., Shigeno, Y., Hirano, E., Kamoshita, M., Nagai, N., Suzuki, M., Minami, S., Kurihara, T., Sonobe, H., Watanabe, K., Shinoda, H., Tsubota, K. & Ozawa, Y., 2019 Dec 1, In : Scientific Reports. 9, 1, 1010.

Research output: Contribution to journalArticle

Audiovisual Aids
Visual Fields
Lasers
Equipment and Supplies
Optical Devices
Retinal Perforations
Inflammation
Recurrence
Temazepam
Fluorescein Angiography

Spatial-sweep steady-state pattern electroretinography can detect subtle differences in visual function among healthy adults

Minami, S., Nagai, N., Suzuki, M., Kurihara, T., Sonobe, H., Watanabe, K., Shinoda, H., Takagi, H., Tsubota, K. & Ozawa, Y., 2019 Dec 1, In : Scientific reports. 9, 1, 18119.

Research output: Contribution to journalArticle

Open Access
Electroretinography
Signal-To-Noise Ratio
Eye Diseases
Optical Coherence Tomography
Fourier Analysis
1 Citation (Scopus)

Suppression of Blue Light at Night Ameliorates Metabolic Abnormalities by Controlling Circadian Rhythms

Nagai, N., Ayaki, M., Yanagawa, T., Hattori, A., Negishi, K., Mori, T., Nakamura, T. J. & Tsubota, K., 2019 Sep 3, In : Investigative ophthalmology & visual science. 60, 12, p. 3786-3793 8 p.

Research output: Contribution to journalArticle

Open Access
Circadian Rhythm
Light
Suprachiasmatic Nucleus
Blue Cross Blue Shield Insurance Plans
Sleep
2018
2 Citations (Scopus)

Benefits of aflibercept treatment for age-related macular degeneration patients with good best-corrected visual acuity at baseline

Minami, S., Nagai, N., Suzuki, M., Kurihara, T., Sonobe, H., Kamoshita, M., Uchida, A., Shinoda, H., Takagi, H., Sonoda, S., Sakamoto, T., Tsubota, K. & Ozawa, Y., 2018 Dec 1, In : Scientific Reports. 8, 1, 58.

Research output: Contribution to journalArticle

Macular Degeneration
Visual Acuity
Therapeutics
Optical Coherence Tomography
aflibercept
1 Citation (Scopus)
Hemianopsia
Optic Nerve Diseases
Retinal Perforations
Temazepam
Vitrectomy
2017
4 Citations (Scopus)

Absolute and estimated values of macular pigment optical density in young and aged Asian participants with or without age-related macular degeneration

Ozawa, Y., Shigeno, Y., Nagai, N., Suzuki, M., Kurihara, T., Minami, S., Hirano, E., Shinoda, H., Kobayashi, S. & Tsubota, K., 2017 Aug 29, In : BMC Ophthalmology. 17, 1, 161.

Research output: Contribution to journalArticle

Macular Degeneration
Lutein
Macular Pigment
Visual Acuity
Photometry
1 Citation (Scopus)
Endothelial Growth Factors
Intravitreal Injections
Macular Degeneration
Exanthema
Vascular Endothelial Growth Factor A
11 Citations (Scopus)

Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina

Osada, H., Okamoto, T., Kawashima, H., Toda, E., Miyake, S., Nagai, N., Kobayashi, S., Tsubota, K. & Ozawa, Y., 2017 Jun 1, In : PLoS One. 12, 6, e0178627.

Research output: Contribution to journalArticle

Vaccinium myrtillus
bilberries
neuroprotective effect
Neuroprotective Agents
retina
7 Citations (Scopus)

Predictive factors of better outcomes by monotherapy of an antivascular endothelial growth factor drug, ranibizumab, for diabetic macular edema in clinical practice

Sato, S., Shinoda, H., Nagai, N., Suzuki, M., Uchida, A., Kurihara, T., Kamoshita, M., Tomita, Y., Iyama, C., Minami, S., Yuki, K., Tsubota, K. & Ozawa, Y., 2017, In : Medicine (United States). 96, 16, e6459.

Research output: Contribution to journalArticle

Endothelial Growth Factors
Macular Edema
Visual Acuity
Pharmaceutical Preparations
Light Coagulation
2016
7 Citations (Scopus)

Distinct Responsiveness to Intravitreal Ranibizumab Therapy in Polypoidal Choroidal Vasculopathy with Single or Multiple Polyps

Suzuki, M., Nagai, N., Shinoda, H., Uchida, A., Kurihara, T., Tomita, Y., Kamoshita, M., Iyama, C., Tsubota, K. & Ozawa, Y., 2016 Jun 1, In : American Journal of Ophthalmology. 166, p. 52-59 8 p.

Research output: Contribution to journalArticle

Polyps
Visual Acuity
Therapeutics
Optical Coherence Tomography
Ranibizumab

Distinct Responsiveness to Intravitreal Ranibizumab Therapy in Polypoidal Choroidal Vasculopathy With Single or Multiple Polyps

Suzuki, M., Nagai, N., Shinoda, H., Uchida, A., Kurihara, T., Tomita, Y., Kamoshita, M., Iyama, C., Tsubota, K. & Ozawa, Y., 2016, (Accepted/In press) In : American Journal of Ophthalmology.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Effects of Constant Intake of Lutein-rich Spinach on Macular Pigment Optical Density: a Pilot Study

Ozawa, Y., Nagai, N., Suzuki, M., Kurihara, T., Shinoda, H., Watanabe, M. & Tsubota, K., 2016 Jan 1, In : Nippon Ganka Gakkai zasshi. 120, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

Lutein
Spinacia oleracea
Macular Degeneration
Food
Macular Pigment
10 Citations (Scopus)

Functional visual acuity in age-related macular degeneration

Tomita, Y., Nagai, N., Suzuki, M., Shinoda, H., Uchida, A., Mochimaru, H., Izumi-Nagai, K., Sasaki, M., Tsubota, K. & Ozawa, Y., 2016, In : Optometry and Vision Science. 93, 1, p. 70-76 7 p.

Research output: Contribution to journalArticle

Macular Degeneration
Visual Acuity
Optical Coherence Tomography
Lenses
Retina
17 Citations (Scopus)
Macular Degeneration
Visual Acuity
Therapeutics
aflibercept
Clinical Protocols
21 Citations (Scopus)

The neuroprotective effect of rapamycin as a modulator of the mTOR-NF-KB axis during retinal inflammation

Okamoto, T., Ozawa, Y., Kamoshita, M., Osada, H., Toda, E., Kurihara, T., Nagai, N., Umezawa, K. & Tsubota, K., 2016 Jan 1, In : PLoS One. 11, 1, e0146517.

Research output: Contribution to journalArticle

neuroprotective effect
Neuroprotective Agents
Sirolimus
Modulators
inflammation
2015
8 Citations (Scopus)

Association of macular pigment optical density with serum concentration of oxidized low-density lipoprotein in healthy adults

Nagai, N., Izumi-Nagai, K., Suzuki, M., Shinoda, H., Koto, T., Uchida, A., Mochimaru, H., Tomita, Y., Miyake, S., Kobayashi, S., Sasaki, M., Tsubota, K. & Ozawa, Y., 2015 Apr 1, In : Retina. 35, 4, p. 820-826 7 p.

Research output: Contribution to journalArticle

Serum
Confidence Intervals
Photometry
Macular Pigment
oxidized low density lipoprotein
16 Citations (Scopus)

Novel CCR3 Antagonists Are Effective Mono- and Combination Inhibitors of Choroidal Neovascular Growth and Vascular Permeability

Nagai, N., Ju, M., Izumi-Nagai, K., Robbie, S. J., Bainbridge, J. W., Gale, D. C., Pierre, E., Krauss, A. H. P., Adamson, P., Shima, D. T. & Ng, Y. S., 2015 Sep 1, In : American Journal of Pathology. 185, 9, p. 2534-2549 16 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Capillary Permeability
Growth
Primates
CC Chemokines
9 Citations (Scopus)

Wide-Angle Viewing System versus Conventional Indirect Ophthalmoscopy for Scleral Buckling

Tomita, Y., Kurihara, T., Uchida, A., Nagai, N., Shinoda, H., Tsubota, K. & Ozawa, Y., 2015 Sep 2, In : Scientific Reports. 5, 13256.

Research output: Contribution to journalArticle

Scleral Buckling
Ophthalmoscopy
Retinal Detachment
Temazepam
Vitrectomy
2014
14 Citations (Scopus)

AMPK-NF-κB axis in the photoreceptor disorder during retinal inflammation

Kamoshita, M., Ozawa, Y., Kubota, S., Miyake, S., Tsuda, C., Nagai, N., Yuki, K., Shimmura, S., Umezawa, K. & Tsubota, K., 2014 Jul 21, In : PLoS One. 9, 7, e103013.

Research output: Contribution to journalArticle

Ribonucleosides
ribonucleosides
AMP-activated protein kinase
Proto-Oncogene Proteins c-akt
AMP-Activated Protein Kinases
15 Citations (Scopus)

Angiotensin II type 1 receptor blockade suppresses light-induced neural damage in the mouse retina

Narimatsu, T., Ozawa, Y., Miyake, S., Nagai, N. & Tsubota, K., 2014, In : Free Radical Biology and Medicine. 71, p. 176-185 10 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Retina
Valsartan
Light
Acetylcysteine
5 Citations (Scopus)

Association of maternal age to development and progression of retinopathy of prematurity in infants of gestational age under 33 weeks

Uchida, A., Miwa, M., Shinoda, H., Koto, T., Nagai, N., Mochimaru, H., Tomita, Y., Sasaki, M., Ikeda, K., Tsubota, K. & Ozawa, Y., 2014, In : Journal of Ophthalmology. 2014, 187929.

Research output: Contribution to journalArticle

Retinopathy of Prematurity
Maternal Age
Gestational Age
Confidence Intervals
Lasers
20 Citations (Scopus)

Biological effects of blocking blue and other visible light on the mouse retina

Narimatsu, T., Ozawa, Y., Miyake, S., Kubota, S., Yuki, K., Nagai, N. & Tsubota, K., 2014, In : Clinical and Experimental Ophthalmology. 42, 6, p. 555-563 9 p.

Research output: Contribution to journalArticle

Retina
Light
Retinal Photoreceptor Cell Outer Segment
Retinal Degeneration
Messenger RNA
5 Citations (Scopus)
Retinal Perforations
Temazepam
Vitrectomy
Macular Degeneration
Fluorescein
35 Citations (Scopus)

Predictive factors for non-response to intravitreal ranibizumab treatment in age-related macular degeneration

Suzuki, M., Nagai, N., Izumi-Nagai, K., Shinoda, H., Koto, T., Uchida, A., Mochimaru, H., Yuki, K., Sasaki, M., Tsubota, K. & Ozawa, Y., 2014, In : British Journal of Ophthalmology. 98, 9, p. 1186-1191 6 p.

Research output: Contribution to journalArticle

Macular Degeneration
Visual Acuity
Logistic Models
Choroidal Neovascularization
Therapeutics
26 Citations (Scopus)
Choroidal Neovascularization
AMP-Activated Protein Kinases
Macrophages
Retinal Pigments
Retinal Pigment Epithelium
25 Citations (Scopus)

Spontaneous CNV in a novel mutant mouse is associated with early VEGF-A-driven angiogenesis and late-stage focal edema, neural cell loss, and dysfunction

Nagai, N., von Leithner, P. L., Izumi-Nagai, K., Hosking, B., Chang, B., Hurd, R., Adamson, P., Adamis, A. P., Foxton, R. H., Ng, Y. S. & Shima, D. T., 2014 May 20, In : Investigative Ophthalmology and Visual Science. 55, 6, p. 3709-3719 11 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Vascular Endothelial Growth Factor A
Edema
Macrophages
Ophthalmoscopy
24 Citations (Scopus)

Vitrectomy for myopic foveoschisis with internal limiting membrane peeling and no gas tamponade

Uchida, A., Shinoda, H., Koto, T., Mochimaru, H., Nagai, N., Tsubota, K. & Ozawa, Y., 2014 Mar, In : Retina. 34, 3, p. 455-460 6 p.

Research output: Contribution to journalArticle

Vitrectomy
Gases
Membranes
Retinal Perforations
Visual Acuity
2013
17 Citations (Scopus)

Detection of early visual impairment in patients with epiretinal membrane

Nishi, Y., Shinoda, H., Uchida, A., Koto, T., Mochimaru, H., Nagai, N., Tsubota, K. & Ozawa, Y., 2013 Aug, In : Acta Ophthalmologica. 91, 5

Research output: Contribution to journalArticle

Epiretinal Membrane
Vision Disorders
Visual Acuity
Crystalline Lens
Ophthalmology
38 Citations (Scopus)

Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice

Narimatsu, T., Ozawa, Y., Miyake, S., Kubota, S., Hirasawa, M., Nagai, N., Shimmura, S. & Tsubota, K., 2013, In : Investigative Ophthalmology and Visual Science. 54, 7, p. 4555-4562 8 p.

Research output: Contribution to journalArticle

Intercellular Junctions
Retinal Pigment Epithelium
rho-Associated Kinases
Cytokines
Acetylcysteine
1 Citation (Scopus)

Neuroprotective role of VEGF induced in response to photodynamic therapy

Ozawa, Y., Suzuki, M., Niikura, S., Kamoshita, M., Nagai, N. & Tsubota, K., 2013, In : Advances in Neuroimmune Biology. 4, 3, p. 161-165 5 p.

Research output: Contribution to journalArticle

Photochemotherapy
Vascular Endothelial Growth Factor A
Choroidal Neovascularization
Macular Degeneration
Pathologic Neovascularization
2012

Oral voriconazole induced visual disturbances that led to the diagnosis of optic radiation lesions in a patient with aplastic anemia

Horino, T., Uchida, A., Mochimaru, H., Koto, T., Nagai, N., Shinoda, H., Shinoda, K., Ohde, H., Ozawa, Y. & Tsubota, K., 2012 Dec, In : Folia Japonica de Ophthalmologica Clinica. 5, 12, p. 1129-1133 5 p.

Research output: Contribution to journalArticle

Aplastic Anemia
Radiation
Voriconazole
2011

[Effects of carteolol hydrochloride on experimental choroidal neovascularization].

Ishida, S., Mochimaru, H., Nagai, N., Noda, K. & Ozawa, Y., 2011 Apr, In : Nippon Ganka Gakkai zasshi. 115, 4, p. 355-361 7 p.

Research output: Contribution to journalArticle

Carteolol
Choroidal Neovascularization
Choroid
Retinal Pigment Epithelium
Chemokine CCL2
2010
5 Citations (Scopus)

Calcium channel blocker nilvadipine, but not diltiazem, inhibits ocular inflammation in endotoxin-induced uveitis

Ishida, S., Koto, T., Nagai, N. & Oike, Y., 2010 Nov, In : Japanese Journal of Ophthalmology. 54, 6, p. 594-601 8 p.

Research output: Contribution to journalArticle

nilvadipine
Diltiazem
Uveitis
Calcium Channel Blockers
Endotoxins
119 Citations (Scopus)

Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

Cano, M., Thimmalappula, R., Fujihara, M., Nagai, N., Sporn, M., Wang, A. L., Neufeld, A. H., Biswal, S. & Handa, J. T., 2010 Mar, In : Vision Research. 50, 7, p. 652-664 13 p.

Research output: Contribution to journalArticle

Macular Degeneration
Oxidants
Oxidative Stress
Smoking
Epidemiologic Factors
2009
115 Citations (Scopus)

(Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation

Satofuka, S., Ichihara, A., Nagai, N., Noda, K., Ozawa, Y., Fukamizu, A., Tsubota, K., Itoh, H., Oike, Y. & Ishida, S., 2009 Jul, In : Diabetes. 58, 7, p. 1625-1633 9 p.

Research output: Contribution to journalArticle

Renin-Angiotensin System
Renin
Signal Transduction
Inflammation
Angiotensin Type 1 Receptor
38 Citations (Scopus)

CTGF is increased in basal deposits and regulates matrix production through the ERK (p42/p44mapk) MAPK and the p38 MAPK signaling pathways

Nagai, N., Klimava, A., Lee, W. H., Izumi-Nagai, K. & Handa, J. T., 2009 Apr, In : Investigative Ophthalmology and Visual Science. 50, 4, p. 1903-1910 8 p.

Research output: Contribution to journalArticle

Connective Tissue Growth Factor
Mitogen-Activated Protein Kinase 1
p38 Mitogen-Activated Protein Kinases
Matrix Metalloproteinases
Laminin
1 Citation (Scopus)

New retractor capable of aspirating fluids during scleral buckling surgery

Kurihara, T., Suzuki, K., Noda, K., Kawamura, R., Nagai, N., Shinoda, H., Shinoda, K., Tsubota, K., Ishida, S. & Inoue, M., 2009 Nov, In : Retina. 29, 10, p. 1542-1544 3 p.

Research output: Contribution to journalArticle

Scleral Buckling
Intraoperative Complications
Retinal Detachment
49 Citations (Scopus)

Nrf2 is a critical modulator of the innate immune response in a model of uveitis

Nagai, N., Thimmulappa, R. K., Cano, M., Fujihara, M., Izumi-Nagai, K., Kong, X., Sporn, M. B., Kensler, T. W., Biswal, S. & Handa, J. T., 2009 Aug 1, In : Free Radical Biology and Medicine. 47, 3, p. 300-306 7 p.

Research output: Contribution to journalArticle

Uveitis
Innate Immunity
Modulators
Antioxidants
Intercellular Adhesion Molecule-1
23 Citations (Scopus)

Suppression of experimental autoimmune uveitis by angiotensin II type 1 receptor blocker telmisartan

Okunuki, Y., Usui, Y., Nagai, N., Kezuka, T., Ishida, S., Takeuchi, M. & Goto, H., 2009, In : Investigative Ophthalmology and Visual Science. 50, 5, p. 2255-2261 7 p.

Research output: Contribution to journalArticle

Angiotensin II Type 1 Receptor Blockers
Uveitis
Angiotensin Type 1 Receptor
Intercellular Adhesion Molecule-1
Peptides
2008
49 Citations (Scopus)

(Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system

Satofuka, S., Ichihara, A., Nagai, N., Noda, K., Ozawa, Y., Fukamizu, A., Tsubota, K., Itoh, H., Oike, Y. & Ishida, S., 2008 Dec, In : American Journal of Pathology. 173, 6, p. 1911-1918 8 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Renin-Angiotensin System
Renin
Signal Transduction
Angiotensin Type 1 Receptor
93 Citations (Scopus)

Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina

Kurihara, T., Ozawa, Y., Nagai, N., Shinoda, K., Noda, K., Imamura, Y., Tsubota, K., Okano, H., Oike, Y. & Ishida, S., 2008 Aug, In : Diabetes. 57, 8, p. 2191-2198 8 p.

Research output: Contribution to journalArticle

Synaptophysin
Angiotensin Type 1 Receptor
Retina
Extracellular Signal-Regulated MAP Kinases
Renin-Angiotensin System
97 Citations (Scopus)

Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice

Fujihara, M., Nagai, N., Sussan, T. E., Biswal, S. & Handa, J. T., 2008 Sep 1, In : PLoS One. 3, 9, e3119.

Research output: Contribution to journalArticle

cigarettes
smoke
Smoke
Tobacco Products
epithelial cells
57 Citations (Scopus)

Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin

Izumi-Nagai, K., Nagai, N., Ohgami, K., Satofuka, S., Ozawa, Y., Tsubota, K., Ohno, S., Oike, Y. & Ishida, S., 2008 Apr, In : Investigative Ophthalmology and Visual Science. 49, 4, p. 1679-1685 7 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Carotenoids
Anti-Inflammatory Agents
Vascular Endothelial Growth Factor Receptor
NF-kappa B