• 483 Citations
  • 14 h-Index
20042020

Research output per year

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Research Output

  • 483 Citations
  • 14 h-Index
  • 31 Article
  • 2 Review article
  • 1 Conference contribution
2004

Endovascular surgery as the first-choice treatment for ruptured cerebral aneurysms: How far has it come?

Tone, O., Tomita, H., Tamaki, M., Satoh, Y., Matsuoka, Y., Sampetrean, O., Nakabayaashi, M., Katsumi, A. & Suzaki, S., 2004 Dec 1, In : Interventional Neuroradiology. 10, SUPPL. 2, p. 41-47 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2006

Coil embolization for ruptured cerebral aneurysms fo 2x3 mm diameter

Tone, O., Tomita, H., Tamaki, M., Akimoto, H., Shigeta, K., Sampetrean, O. & Fujii, M., 2006 Jan 1, In : Interventional Neuroradiology. 12, SUPPL. 1, p. 97-100 4 p.

Research output: Contribution to journalArticle

Rapidly growing dysembryoplastic neuroepithelial tumor: Case report

Sampetrean, O., Maehara, T., Arai, N. & Nemoto, T., 2006 Dec 1, In : Neurosurgery. 59, 6, p. E1337-E1338

Research output: Contribution to journalArticle

16 Citations (Scopus)
2008

Endosaccular embolization of an intrasellar aneurysm with hypopituitarism: Case report

Fujii, M., Tone, O., Tomita, H., Tamaki, M., Akimoto, H., Shigeta, K., Sampetrean, O., Kanno, K. & Matsushita, M., 2008 Apr 1, In : Neurological Surgery. 36, 4, p. 329-337 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2009

[Mitotic regulation and carcinogenesis].

Saya, H., Zhang, D. & Oltea, S., 2009 Mar 1, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 54, 4 Suppl, p. 561-567 7 p.

Research output: Contribution to journalReview article

Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model

Kai, K., Nagano, O., Sugihara, E., Arima, Y., Sampetrean, O., Ishimoto, T., Nakanishi, M., Ueno, N. T., Iwase, H. & Saya, H., 2009 Dec 1, In : Cancer science. 100, 12, p. 2275-2282 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Reversible whole-organism cell cycle arrest in a living vertebrate

Sampetrean, O., Lida, S. I., Makino, S., Matsuzaki, Y., Ohno, K. & Saya, H., 2009 Feb 15, In : Cell Cycle. 8, 4, p. 620-627 8 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)
2011

Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells

Sampetrean, O., Saga, I., Nakanishi, M., Sugihara, E., Fukaya, R., Onishi, N., Osuka, S., Akahata, M., Kai, K., Sugimoto, H., Hirao, A. & Saya, H., 2011 Sep, In : Neoplasia. 13, 9, p. 784-791 8 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2013

A microfluidic invasion assay for glioma-initiating cells in three-dimensional culture

Fujioka, S., Oltea, S., Saya, H. & Sudo, R., 2013 Jan 1, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, p. 1075-1077 3 p. (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; vol. 2).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Characteristics of glioma stem cells

Sampetrean, O. & Saya, H., 2013 Oct 1, In : Brain tumor pathology. 30, 4, p. 209-214 6 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells

Osuka, S., Sampetrean, O., Shimizu, T., Saga, I., Onishi, N., Sugihara, E., Okubo, J., Fujita, S., Takano, S., Matsumura, A. & Saya, H., 2013 Apr 1, In : Stem Cells. 31, 4, p. 627-640 14 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)
2014

Basic biology of gliomas

Saya, H., Shibao, S. & Sampetrean, O., 2014 Jan 1, In : Japanese Journal of Neurosurgery. 23, 7, p. 541-546 6 p.

Research output: Contribution to journalArticle

Open Access

Integrated analysis identifies different metabolic signatures for tumor-initiating cells in a murine glioblastoma model

Saga, I., Shibao, S., Okubo, J., Osuka, S., Kobayashi, Y., Yamada, S., Fujita, S., Urakami, K., Kusuhara, M., Yoshida, K., Saya, H. & Sampetrean, O., 2014 Aug, In : Neuro-oncology. 16, 8, p. 1048-1056 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2015

Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression

Kozono, D., Li, J., Nitta, M., Sampetrean, O., Gonda, D., Kushwaha, D. S., Merzon, D., Ramakrishnan, V., Zhu, S., Zhu, K., Matsui, H., Harismendy, O., Hua, W., Mao, Y., Kwon, C. H., Saya, H., Nakano, I., Pizzo, D. P., Van Den Berg, S. R. & Chen, C. C., 2015 Jul 28, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 30, p. E4055-E4064

Research output: Contribution to journalArticle

29 Citations (Scopus)
2016

Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts

Umeyama, K., Watanabe, K., Watanabe, M., Horiuchi, K., Nakano, K., Kitashiro, M., Matsunari, H., Kimura, T., Arima, Y., Sampetrean, O., Nagaya, M., Saito, M., Saya, H., Kosaki, K., Nagashima, H. & Matsumoto, M., 2016 Apr 14, In : Scientific Reports. 6, 24413.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Histopathological investigation of glioblastomas resected under bevacizumab treatment

Tamura, R., Tanaka, T., Miyake, K., Tabei, Y., Ohara, K., Sampetrean, O., Kono, M., Mizutani, K., Yamamoto, Y., Murayama, Y., Tamiya, T., Yoshida, K. & Sasaki, H., 2016 Aug 1, In : Oncotarget. 7, 32, p. 52423-52435 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)

Tsuchihashi, K., Okazaki, S., Ohmura, M., Ishikawa, M., Sampetrean, O., Onishi, N., Wakimoto, H., Yoshikawa, M., Seishima, R., Iwasaki, Y., Morikawa, T., Abe, S., Takao, A., Shimizu, M., Masuko, T., Nagane, M., Furnari, F. B., Akiyama, T., Suematsu, M., Baba, E. & 3 others, Akashi, K., Saya, H. & Nagano, O., 2016 May 15, In : Cancer Research. 76, 10, p. 2954-2963 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2017

Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma

Sato, A., Mizobuchi, Y., Nakajima, K., Shono, K., Fujihara, T., Kageji, T., Kitazato, K., Matsuzaki, K., Mure, H., Kuwayama, K., Sumi, A., Saya, H., Sampetrean, O. & Nagahirao, S., 2017 Apr 1, In : Journal of Neuro-Oncology. 132, 2, p. 231-238 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Convection-enhanced delivery of sulfasalazine prolongs survival in a glioma stem cell brain tumor model

Haryu, S., Saito, R., Jia, W., Shoji, T., Mano, Y., Sato, A., Kanamori, M., Sonoda, Y., Sampetrean, O., Saya, H. & Tominaga, T., 2017 Sep 19, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

Kitagawa, M., Liao, P. J., Lee, K. H., Wong, J., Shang, S. C., Minami, N., Sampetrean, O., Saya, H., Lingyun, D., Prabhu, N., Diam, G. K., Sobota, R., Larsson, A., Nordlund, P., McCormick, F., Ghosh, S., Epstein, D. M., Dymock, B. W. & Lee, S. H., 2017 Dec 1, In : Nature Communications. 8, 1, 2200.

Research output: Contribution to journalArticle

23 Citations (Scopus)
17 Citations (Scopus)

Functional analysis of the DEPDC1 oncoantigen in malignant glioma and brain tumor initiating cells

Kikuchi, R., Sampetrean, O., Saya, H., Yoshida, K. & Toda, M., 2017 May 29, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-11 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Organotypic brain explant culture as a drug evaluation system for malignant brain tumors

Minami, N., Maeda, Y., Shibao, S., Arima, Y., Ohka, F., Kondo, Y., Maruyama, K., Kusuhara, M., Sasayama, T., Kohmura, E., Saya, H. & Sampetrean, O., 2017 Nov, In : Cancer medicine. 6, 11, p. 2635-2645 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

RNA Sequencing Analysis Reveals Interactions between Breast Cancer or Melanoma Cells and the Tissue Microenvironment during Brain Metastasis

Sato, R., Nakano, T., Hosonaga, M., Sampetrean, O., Harigai, R., Sasaki, T., Koya, I., Okano, H., Kudo, J., Saya, H. & Arima, Y., 2017, In : BioMed Research International. 2017, 8032910.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2018

CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake

Kobayashi, N., Okazaki, S., Sampetrean, O., Irie, J., Itoh, H. & Saya, H., 2018 Dec 1, In : Scientific Reports. 8, 1, 2785.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate–sensitive glutamate receptor signaling

Suina, K., Tsuchihashi, K., Yamasaki, J., Kamenori, S., Shintani, S., Hirata, Y., Okazaki, S., Sampetrean, O., Baba, E., Akashi, K., Mitsuishi, Y., Takahashi, F., Takahashi, K., Saya, H. & Nagano, O., 2018 Dec, In : Cancer science. 109, 12, p. 3874-3882 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journalArticle

26 Citations (Scopus)

HER2 heterogeneity is associated with poor survival in HER2-positive breast cancer

Hosonaga, M., Arima, Y., Sampetrean, O., Komura, D., Koya, I., Sasaki, T., Sato, E., Okano, H., Kudoh, J., Ishikawa, S., Saya, H. & Ishikawa, T., 2018 Aug, In : International journal of molecular sciences. 19, 8, 2158.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model

Shibao, S., Minami, N., Koike, N., Fukui, N., Yoshida, K., Saya, H. & Sampetrean, O., 2018 Feb 19, In : Neuro-Oncology. 20, 3, p. 343-354 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Modeling phenotypes of malignant gliomas

Sampetrean, O. & Saya, H., 2018 Jan 1, In : Cancer Science. 109, 1, p. 6-14 9 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells

Harigai, R., Sakai, S., Nobusue, H., Hirose, C., Sampetrean, O., Minami, N., Hata, Y., Kasama, T., Hirose, T., Takenouchi, T., Kosaki, K., Kishi, K., Saya, H. & Arima, Y., 2018 Dec 1, In : Scientific reports. 8, 1, 6069.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2019

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Kofuji, S., Hirayama, A., Eberhardt, A. O., Kawaguchi, R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yoshino, H., Yamashita, D., Sumita, K., Wolfe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S. & 37 others, Ban, Y., Asano, M., Flanary, V. L., Ramkissoon, A., Chow, L. M. L., Kiyokawa, J., Mashimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E. P., Anastasiou, D., Wakimoto, H., Holland, E. C., Yong, W. H., Horbinski, C., Nakano, I., DeBerardinis, R. J., Bachoo, R. M., Mischel, P. S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H. & Sasaki, A. T., 2019 Aug 1, In : Nature Cell Biology. 21, 8, p. 1003-1014 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Visualization of spatiotemporal dynamics of human glioma stem cell invasion

Tamura, R., Miyoshi, H., Sampetrean, O., Shinozaki, M., Morimoto, Y., Iwasawa, C., Fukaya, R., Mine, Y., Masuda, H., Maruyama, T., Narita, M., Saya, H., Yoshida, K., Okano, H. & Toda, M., 2019 May 6, In : Molecular brain. 12, 1, 45.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2020

A potent blood–brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model

Machida, Y., Nakagawa, M., Matsunaga, H., Yamaguchi, M., Ogawara, Y., Shima, Y., Yamagata, K., Katsumoto, T., Hattori, A., Itoh, M., Seki, T., Nishiya, Y., Nakamura, K., Suzuki, K., Imaoka, T., Baba, D., Suzuki, M., Sampetrean, O., Saya, H., Ichimura, K. & 1 others, Kitabayashi, I., 2020 Feb, In : Molecular cancer therapeutics. 19, 2, p. 375-383 9 p.

Research output: Contribution to journalArticle