• 3254 Citations
  • 27 h-Index
20032020

Research output per year

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Research Output

  • 3254 Citations
  • 27 h-Index
  • 51 Article
  • 3 Review article
2020

Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy

Otsuki, Y., Yamasaki, J., Suina, K., Okazaki, S., Koike, N., Saya, H. & Nagano, O., 2020 Jan 1, In : Cancer science. 111, 1, p. 127-136 10 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2019

Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma

Sato, T., Yoo, S., Kong, R., Sinha, A., Chandramani-Shivalingappa, P., Patel, A., Fridrikh, M., Nagano, O., Masuko, T., Beasley, M. B., Powell, C. A., Zhu, J. & Watanabe, H., 2019 Dec 15, In : Cancer Research. 79, 24, p. 6084-6100 17 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors

Suzuki, K., Miura, Y., Mochida, Y., Miyazaki, T., Toh, K., Anraku, Y., Melo, V., Liu, X., Ishii, T., Nagano, O., Saya, H., Cabral, H. & Kataoka, K., 2019 May 10, In : Journal of Controlled Release. 301, p. 28-41 14 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma

Okazaki, S., Umene, K., Yamasaki, J., Suina, K., Otsuki, Y., Yoshikawa, M., Minami, Y., Masuko, T., Kawaguchi, S., Nakayama, H., Banno, K., Aoki, D., Saya, H. & Nagano, O., 2019 Nov 1, In : Cancer science. 110, 11, p. 3453-3463 11 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)
2018

Development of a functional thyroid model based on an organoid culture system

Saito, Y., Onishi, N., Takami, H., Seishima, R., Inoue, H., Hirata, Y., Kameyama, K., Tsuchihashi, K., Sugihara, E., Uchino, S., Ito, K., Kawakubo, H., Takeuchi, H., Kitagawa, Y., Saya, H. & Nagano, O., 2018 Mar 4, In : Biochemical and Biophysical Research Communications. 497, 2, p. 783-789 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate–sensitive glutamate receptor signaling

Suina, K., Tsuchihashi, K., Yamasaki, J., Kamenori, S., Shintani, S., Hirata, Y., Okazaki, S., Sampetrean, O., Baba, E., Akashi, K., Mitsuishi, Y., Takahashi, F., Takahashi, K., Saya, H. & Nagano, O., 2018 Dec, In : Cancer science. 109, 12, p. 3874-3882 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells

Okazaki, S., Shintani, S., Hirata, Y., Suina, K., Semba, T., Yamasaki, J., Umene, K., Ishikawa, M., Saya, H. & Nagano, O., 2018 Sep 1, In : Oncotarget. 9, 73, p. 33832-33843 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2017

CD44 variant–dependent regulation of redox balance in EGFR mutation–positive non–small cell lung cancer: A target for treatment

Kawano, Y., Iwama, E., Tsuchihashi, K., Shibahara, D., Harada, T., Tanaka, K., Nagano, O., Saya, H., Nakanishi, Y. & Okamoto, I., 2017 Nov, In : Lung Cancer. 113, p. 72-78 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells

Miyano, K., Cabral, H., Miura, Y., Matsumoto, Y., Mochida, Y., Kinoh, H., Iwata, C., Nagano, O., Saya, H., Nishiyama, N., Kataoka, K. & Yamasoba, T., 2017 Sep 10, In : Journal of Controlled Release. 261, p. 275-286 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis

Jeong, S., Choi, E., Petersen, C. P., Roland, J. T., Federico, A., Ippolito, R., D'Armiento, F. P., Nardone, G., Nagano, O., Saya, H., Romano, M. & Goldenring, J. R., 2017, In : United European Gastroenterology Journal. 5, 1, p. 37-44 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression

Kasai, S., Furuichi, Y., Ando, N., Kagami, K., Abe, M., Nakane, T., Goi, K., Inukai, T., Saitoh, S., Ohno, S., Okazaki, S., Nagano, O., Saya, H. & Sugita, K., 2017 Jun 1, In : Cell death & disease. 8, 6, p. e2857

Research output: Contribution to journalArticle

5 Citations (Scopus)

Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407)

Shitara, K., Doi, T., Nagano, O., Fukutani, M., Hasegawa, H., Nomura, S., Sato, A., Kuwata, T., Asai, K., Einaga, Y., Tsuchihashi, K., Suina, K., Maeda, Y., Saya, H. & Ohtsu, A., 2017 Nov 1, In : Gastric Cancer. 20, 6, p. 1004-1009 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer

Otsubo, K., Nosaki, K., Imamura, C. K., Ogata, H., Fujita, A., Sakata, S., Hirai, F., Toyokawa, G., Iwama, E., Harada, T., Seto, T., Takenoyama, M., Ozeki, T., Mushiroda, T., Inada, M., Kishimoto, J., Tsuchihashi, K., Suina, K., Nagano, O., Saya, H. & 2 others, Nakanishi, Y. & Okamoto, I., 2017 Sep, In : Cancer science. 108, 9, p. 1843-1849 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer

Tayama, S., Motohara, T., Narantuya, D., Li, C., Fujimoto, K., Sakaguchi, I., Tashiro, H., Saya, H., Nagano, O. & Katabuchi, H., 2017, In : Oncotarget. 8, 27, p. 44312-44325 14 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2016

CD44 splice variant v8-10 as a marker of serous ovarian cancer prognosis

Sosulski, A., Horn, H., Zhang, L., Coletti, C., Vathipadiekal, V., Castro, C. M., Birrer, M. J., Nagano, O., Saya, H., Lage, K., Donahoe, P. K. & Pépin, D., 2016 Jun, In : PloS one. 11, 6, e0156595.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Development of an ErbB4 monoclonal antibody that blocks neuregulin-1-induced ErbB4 activation in cancer cells

Okazaki, S., Nakatani, F., Masuko, K., Tsuchihashi, K., Ueda, S., Masuko, T., Saya, H. & Nagano, O., 2016 Jan 29, In : Biochemical and Biophysical Research Communications. 470, 1, p. 239-244 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Shitara, K., Doi, T., Nagano, O., Imamura, C., Ozeki, T., Ishii, Y., Tsuchihashi, K., Takahashi, S., Nakajima, T. E., Hironaka, S., Fukutani, M., Hasegawa, H., Nomura, S., Sato, A., Einaga, Y., Kuwata, T., Saya, H. & Ohtsu, A., 2016 Apr 7, (Accepted/In press) In : Gastric Cancer. p. 1-9 9 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines

Wang, M., Miura, Y., Tsuchihashi, K., Miyano, K., Nagano, O., Yoshikawa, M., Tanabe, A., Makino, J., Mochida, Y., Nishiyama, N., Saya, H., Cabral, H. & Kataoka, K., 2016 May 28, In : Journal of Controlled Release. 230, p. 26-33 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Potential of sulfasalazine as a therapeutic sensitizer for CD44 splice variant 9-positive urogenital cancer

Takayama, T., Kubo, T., Morikawa, A., Morita, T., Nagano, O. & Saya, H., 2016 May 1, In : Medical Oncology. 33, 5, 45.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)

Tsuchihashi, K., Okazaki, S., Ohmura, M., Ishikawa, M., Sampetrean, O., Onishi, N., Wakimoto, H., Yoshikawa, M., Seishima, R., Iwasaki, Y., Morikawa, T., Abe, S., Takao, A., Shimizu, M., Masuko, T., Nagane, M., Furnari, F. B., Akiyama, T., Suematsu, M., Baba, E. & 3 others, Akashi, K., Saya, H. & Nagano, O., 2016 May 15, In : Cancer Research. 76, 10, p. 2954-2963 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2015

Ink4a/arf-dependent loss of parietal cells induced by oxidative stress promotes CD44-dependent gastric tumorigenesis

Seishima, R., Wada, T., Tsuchihashi, K., Okazaki, S., Yoshikawa, M., Oshima, H., Oshima, M., Sato, T., Hasegawa, H., Kitagawa, Y., Goldenring, J. R., Saya, H. & Nagano, O., 2015 Jun 1, In : Cancer Prevention Research. 8, 6, p. 492-501 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
7 Citations (Scopus)
2014

CD44s signals the acquisition of the mesenchymal phenotype required for anchorage-independent cell survival in hepatocellular carcinoma

Okabe, H., Ishimoto, T., Mima, K., Nakagawa, S., Hayashi, H., Kuroki, H., Imai, K., Nitta, H., Saito, S., Hashimoto, D., Chikamoto, A., Ishiko, T., Watanabe, M., Nagano, O., Beppu, T., Saya, H. & Baba, H., 2014 Feb 18, In : British Journal of Cancer. 110, 4, p. 958-966 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation

Ishimoto, T., Sugihara, H., Watanabe, M., Sawayama, H., Iwatsuki, M., Baba, Y., Okabe, H., Hidaka, K., Yokoyama, N., Miyake, K., Yoshikawa, M., Nagano, O., Komohara, Y., Takeya, M., Saya, H. & Baba, H., 2014 Apr, In : Carcinogenesis. 35, 5, p. 1003-1011 9 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
2013

CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence

Hirata, K., Suzuki, H., Imaeda, H., Matsuzaki, J., Tsugawa, H., Nagano, O., Asakura, K., Saya, H. & Hibi, T., 2013 Jul 23, In : British Journal of Cancer. 109, 2, p. 379-386 8 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia

Wada, T., Ishimoto, T., Seishima, R., Tsuchihashi, K., Yoshikawa, M., Oshima, H., Oshima, M., Masuko, T., Wright, N. A., Furuhashi, S., Hirashima, K., Baba, H., Kitagawa, Y., Saya, H. & Nagano, O., 2013 Oct 1, In : Cancer science. 104, 10, p. 1323-1329 7 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
6 Citations (Scopus)
27 Citations (Scopus)

Lysyl oxidase is induced by cell density-mediated cell cycle suppression via RB-E2F1-HIF-1α axis

Goto, T. M., Arima, Y., Nagano, O. & Saya, H., 2013 Jan 24, In : Cell structure and function. 38, 1, p. 9-14 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Redox regulation in stem-like cancer cells by CD44 variant isoforms

Nagano, O., Okazaki, S. & Saya, H., 2013 Oct 31, In : Oncogene. 32, 44, p. 5191-5198 8 p.

Research output: Contribution to journalReview article

162 Citations (Scopus)

XCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma

Yoshikawa, M., Tsuchihashi, K., Ishimoto, T., Yae, T., Motohara, T., Sugihara, E., Onishi, N., Masuko, T., Yoshizawa, K., Kawashiri, S., Mukai, M., Asoda, S., Kawana, H., Nakagawa, T., Saya, H. & Nagano, O., 2013 Mar 15, In : Cancer Research. 73, 6, p. 1855-1866 12 p.

Research output: Contribution to journalArticle

108 Citations (Scopus)
2012

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

Yae, T., Tsuchihashi, K., Ishimoto, T., Motohara, T., Yoshikawa, M., Yoshida, G. J., Wada, T., Masuko, T., Mogushi, K., Tanaka, H., Osawa, T., Kanki, Y., Minami, T., Aburatani, H., Ohmura, M., Kubo, A., Suematsu, M., Takahashi, K., Saya, H. & Nagano, O., 2012, In : Nature communications. 3, 883.

Research output: Contribution to journalArticle

203 Citations (Scopus)

CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma

Mima, K., Okabe, H., Ishimoto, T., Hayashi, H., Nakagawa, S., Kuroki, H., Watanabe, M., Beppu, T., Tamada, M., Nagano, O., Saya, H. & Baba, H., 2012 Jul 1, In : Cancer Research. 72, 13, p. 3414-3423 10 p.

Research output: Contribution to journalArticle

119 Citations (Scopus)

In vivo assessment of cancerous tumors using boron doped diamond microelectrode

Fierro, S., Yoshikawa, M., Nagano, O., Yoshimi, K., Saya, H. & Einaga, Y., 2012 Dec 14, In : Scientific reports. 2, 901.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells

Tamada, M., Nagano, O., Tateyama, S., Ohmura, M., Yae, T., Ishimoto, T., Sugihara, E., Onishi, N., Yamamoto, T., Yanagawa, H., Suematsu, M. & Saya, H., 2012 Mar 15, In : Cancer Research. 72, 6, p. 1438-1448 11 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)

Reactive oxygen species-induced autophagic degradation of helicobacter pylori CagA is specifically suppressed in cancer stem-like cells

Tsugawa, H., Suzuki, H., Saya, H., Hatakeyama, M., Hirayama, T., Hirata, K., Nagano, O., Matsuzaki, J. & Hibi, T., 2012 Dec 13, In : Cell Host and Microbe. 12, 6, p. 764-777 14 p.

Research output: Contribution to journalArticle

136 Citations (Scopus)
2011

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc- and Thereby Promotes Tumor Growth

Ishimoto, T., Nagano, O., Yae, T., Tamada, M., Motohara, T., Oshima, H., Oshima, M., Ikeda, T., Asaba, R., Yagi, H., Masuko, T., Shimizu, T., Ishikawa, T., Kai, K., Takahashi, E., Imamura, Y., Baba, Y., Ohmura, M., Suematsu, M., Baba, H. & 1 others, Saya, H., 2011 Mar 8, In : Cancer Cell. 19, 3, p. 387-400 14 p.

Research output: Contribution to journalArticle

598 Citations (Scopus)

Establishment of a choriocarcinoma model from immortalized normal extravillous trophoblast cells transduced with HRASV12

Kobayashi, Y., Shimizu, T., Naoe, H., Ueki, A., Ishizawa, J., Chiyoda, T., Onishi, N., Sugihara, E., Nagano, O., Banno, K., Kuninaka, S., Aoki, D. & Saya, H., 2011 Sep 1, In : American Journal of Pathology. 179, 3, p. 1471-1482 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells

Motohara, T., Masuko, S., Ishimoto, T., Yae, T., Onishi, N., Muraguchi, T., Hirao, A., Matsuzaki, Y., Tashiro, H., Katabuchi, H., Saya, H. & Nagano, O., 2011 Nov 1, In : Carcinogenesis. 32, 11, p. 1597-1606 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2010

CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis

Ishimoto, T., Oshima, H., Oshima, M., Kai, K., Torii, R., Masuko, T., Baba, H., Saya, H. & Nagano, O., 2010 Mar 1, In : Cancer science. 101, 3, p. 673-678 6 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)

The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation

Naoe, H., Araki, K., Nagano, O., Kobayashi, Y., Ishizawa, J., Chiyoda, T., Shimizu, T., Yamamura, K. I., Sasaki, Y., Saya, H. & Kuninaka, S., 2010 Aug, In : Molecular and cellular biology. 30, 16, p. 3994-4005 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Tumor necrosis factor-α regulates transforming growth factor-β-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction

Takahashi, E., Nagano, O., Ishimoto, T., Yae, T., Suzuki, Y., Shinoda, T., Nakamura, S., Niwa, S., Ikeda, S., Koga, H., Tanihara, H. & Saya, H., 2010 Feb 5, In : Journal of Biological Chemistry. 285, 6, p. 4060-4073 14 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)
2009

Maintenance of HCT116 colon cancer cell line conforms to a stochastic model but not a cancer stem cell model

Kai, K., Nagano, O., Sugihara, E., Arima, Y., Sampetrean, O., Ishimoto, T., Nakanishi, M., Ueno, N. T., Iwase, H. & Saya, H., 2009 Dec 1, In : Cancer science. 100, 12, p. 2275-2282 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress

Inumaru, J., Nagano, O., Takahashi, E., Ishimoto, T., Nakamura, S., Suzuki, Y., Niwa, S. I., Umezawa, K., Tanihara, H. & Saya, H., 2009 Jun 15, In : Genes to Cells. 14, 6, p. 703-716 14 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2008

EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding, internalization and motogenic effect of CD44

Pályi-Krekk, Z., Barok, M., Kovács, T., Saya, H., Nagano, O., Szöllosi, J. & Nagy, P., 2008 May 18, In : Cancer Letters. 263, 2, p. 231-242 12 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Involvement of NF-κB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma

Takamune, Y., Ikebe, T., Nagano, O. & Shinohara, M., 2008 Jan 11, In : Biochemical and Biophysical Research Communications. 365, 2, p. 393-398 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to- mesenchymal transition

Arima, Y., Inoue, Y., Shibata, T., Hayashi, H., Nagano, O., Saya, H. & Taya, Y., 2008 Jul 1, In : Cancer Research. 68, 13, p. 5104-5112 9 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

Role of CD44-mediated signal in cancer invasion and metastasis

Saya, H. & Nagano, O., 2008 Aug 1, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 53, 10, p. 1225-1230 6 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)
2007

ADAM-17 associated with CD44 cleavage and metastasis in oral squamous cell carcinoma

Takamune, Y., Ikebe, T., Nagano, O., Nakayama, H., Ota, K., Obayashi, T., Saya, H. & Shinohara, M., 2007 Feb 1, In : Virchows Archiv. 450, 2, p. 169-177 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)