• 8905 Citations
  • 51 h-Index
1992 …2020

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Article
2012

Accumulation of Secretory Vesicles in the Lacrimal Gland Epithelia Is Related to Non-Sjögren's Type Dry Eye in Visual Display Terminal Users

Kamoi, M., Ogawa, Y., Nakamura, S., Dogru, M., Nagai, T., Obata, H., Ito, M., Kaido, M., Kawakita, T., Okada, Y., Kawakami, Y., Shimmura, S. & Tsubota, K., 2012 Sep 4, In : PloS one. 7, 9, e43688.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Characterization of cultivated murine lacrimal gland epithelial cells

Kobayashi, S., Kawakita, T., Kawashima, M., Okada, N., Mishima, K., Saito, I., Ito, M., Shimmura, S. & Tsubota, K., 2012 May 12, In : Molecular vision. 18, p. 1271-1277 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Comparison of domestic and overseas donor corneas for keratoplasty

Nishi, Y., Kawakita, T., Yasu, M., Ichihashi, Y., Matsumoto, Y., Shimmura, S. & Tsubota, K., 2012 Sep 1, In : Japanese Journal of Clinical Ophthalmology. 66, 9, p. 1337-1342 6 p.

Research output: Contribution to journalArticle

Dietary lactoferrin alleviates age-related lacrimal gland dysfunction in mice

Kawashima, M., Kawakita, T., Inaba, T., Okada, N., Ito, M., Shimmura, S., Watanabe, M., Shinmura, K. & Tsubota, K., 2012 Mar 27, In : PloS one. 7, 3, e33148.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Intraocular pressure elevation after Descemet's stripping endothelial keratoplasty

Ozeki, N., Yuki, K., Shiba, D., Shimmura, S., Murat, D. & Tsubota, K., 2012 Jul 1, In : Japanese Journal of Ophthalmology. 56, 4, p. 307-311 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Mucosal microvilli in dry eye patients with chronic GVHD

Tatematsu, Y., Ogawa, Y., Shimmura, S., Dogru, M., Yaguchi, S., Nagai, T., Yamazaki, K., Kameyama, K., Okamoto, S., Kawakami, Y. & Tsubota, K., 2012 Mar 1, In : Bone Marrow Transplantation. 47, 3, p. 416-425 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Oxidative Stress Induced Inflammation Initiates Functional Decline of Tear Production

Uchino, Y., Kawakita, T., Miyazawa, M., Ishii, T., Onouchi, H., Yasuda, K., Ogawa, Y., Shimmura, S., Ishii, N. & Tsubota, K., 2012 Oct 5, In : PloS one. 7, 10, e45805.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland

Yaguchi, S., Ogawa, Y., Shimmura, S., Hatou, S., Nakamura, S., Inaba, T., Imada, T., Ozawa, Y., Kawakami, Y., Ishida, S. & Tsubota, K., 2012 Aug, In : Investigative Ophthalmology and Visual Science. 53, 9, p. 5416-5425 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The Semaphorin 3A Inhibitor SM-345431 Accelerates Peripheral Nerve Regeneration and Sensitivity in a Murine Corneal Transplantation Model

Omoto, M., Yoshida, S., Miyashita, H., Kawakita, T., Yoshida, K., Kishino, A., Kimura, T., Shibata, S., Tsubota, K., Okano, H. & Shimmura, S., 2012 Nov 9, In : PloS one. 7, 11, e47716.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2013

Angiotensin II Type 1 Receptor Antagonist Attenuates Lacrimal Gland, Lung, and Liver Fibrosis in a Murine Model of Chronic Graft-Versus-Host Disease

Yaguchi, S., Ogawa, Y., Shimmura, S., Kawakita, T., Hatou, S., Satofuka, S., Nakamura, S., Imada, T., Miyashita, H., Yoshida, S., Yaguchi, T., Ozawa, Y., Mori, T., Okamoto, S., Kawakami, Y., Ishida, S. & Tsubota, K., 2013 Jun 6, In : PloS one. 8, 6, e64724.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Aquaporin 1-positive stromal niche-like cells directly interact with N-cadherin-positive clusters in the basal limbal epithelium

Higa, K., Kato, N., Yoshida, S., Ogawa, Y., Shimazaki, J., Tsubota, K. & Shimmura, S., 2013 Mar 1, In : Stem Cell Research. 10, 2, p. 147-155 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Comparison of long-term outcome of penetrating and deep anterior lamellar keratoplasty

Adachi, S., Ichihashi, Y., Kawakita, T., Matsumoto, Y., Uchino, M., Shimmura, S. & Tsubota, K., 2013 Jan 1, In : Japanese Journal of Clinical Ophthalmology. 67, 1, p. 85-89 5 p.

Research output: Contribution to journalArticle

Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice

Narimatsu, T., Ozawa, Y., Miyake, S., Kubota, S., Hirasawa, M., Nagai, N., Shimmura, S. & Tsubota, K., 2013 Jul 15, In : Investigative Ophthalmology and Visual Science. 54, 7, p. 4555-4562 8 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Effects of dietary supplementation with fish oil on dry eye syndrome subjects: Randomized controlled trial

Kawakita, T., Kawabata, F., Tsuji, T., Kawashima, M., Shimmura, S. & Tsubota, K., 2013 Nov 11, In : Biomedical Research (Japan). 34, 5, p. 215-220 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Expression and distribution of claudin subtypes in human corneal endothelium

Inagaki, E., Hatou, S., Yoshida, S., Miyashita, H., Tsubota, K. & Shimmura, S., 2013 Oct 10, In : Investigative Ophthalmology and Visual Science. 54, 12, p. 7258-7265 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease

Kawai, M., Ogawa, Y., Shimmura, S., Ohta, S., Suzuki, T., Kawamura, N., Kuwana, M., Kawakami, Y. & Tsubota, K., 2013 Aug 29, In : Scientific reports. 3, 2455.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/β-catenin signaling

Hatou, S., Yoshida, S., Higa, K., Miyashita, H., Inagaki, E., Okano, H., Tsubota, K. & Shimmura, S., 2013 Mar 1, In : Stem Cells and Development. 22, 5, p. 828-839 12 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ

Hirayama, M., Ogawa, M., Oshima, M., Sekine, Y., Ishida, K., Yamashita, K., Ikeda, K., Shimmura, S., Kawakita, T., Tsubota, K. & Tsuji, T., 2013 Oct 14, In : Nature communications. 4, 2497.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Keratoplasty postoperative treatment update

Shimmura-Tomita, M., Shimmura, S., Satake, Y., Shimazaki-Den, S., Omoto, M., Tsubota, K. & Shimazaki, J., 2013 Nov 1, In : Cornea. 32, 11 SUPPL, p. S60-S64

Research output: Contribution to journalArticle

9 Citations (Scopus)

Long-term maintenance of limbal epithelial progenitor cells using rho kinase inhibitor and keratinocyte growth factor

Miyashita, H., Yokoo, S., Yoshida, S., Kawakita, T., Yamagami, S., Tsubota, K. & Shimmura, S., 2013 Oct, In : Stem Cells Translational Medicine. 2, 10, p. 758-765 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Long-term results of amniotic membrane transplantation for partial limbal deficiency

Konomi, K., Satake, Y., Shimmura, S., Tsubota, K. & Shimazaki, J., 2013 Aug 1, In : Cornea. 32, 8, p. 1110-1115 6 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Validation of Na,k-ATPase pump function of corneal endothelial cells for corneal regenerative medicine

Hatou, S., Higa, K., Inagaki, E., Yoshida, S., Kimura, E., Hayashi, R., Tsujikawa, M., Tsubota, K., Nishida, K. & Shimmura, S., 2013 Dec 1, In : Tissue Engineering - Part C: Methods. 19, 12, p. 901-910 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2014

AMPK-NF-κB axis in the photoreceptor disorder during retinal inflammation

Kamoshita, M., Ozawa, Y., Kubota, S., Miyake, S., Tsuda, C., Nagai, N., Yuki, K., Shimmura, S., Umezawa, K. & Tsubota, K., 2014 Jul 21, In : PloS one. 9, 7, e103013.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Clinical backgrounds of postoperative keratoplasty patients with spontaneous wound dehiscence or gaps after suture removal

Fujii, S., Matsumoto, Y., Fukui, M., Fujitake, J., Kawakita, T., Shimmura, S. & Tsubota, K., 2014 Jan 1, In : Cornea. 33, 12, p. 1320-1323 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Multivariable logistic regression model: A novel mathematical model that predicts visual field sensitivity from macular ganglion cell complex thickness in glaucoma

Shiba, D., Hatou, S., Ono, T., Hosoda, S., Tanabe, S., Ozeki, N., Yuki, K., Shimoyama, M., Fukagawa, K., Shimmura, S. & Tsubota, K., 2014 Aug 18, In : PloS one. 9, 8, e104126.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Ocular surface reconstruction by cultivated epithelial sheet transplantation

Satake, Y., Yamaguchi, T., Hirayama, M., Higa, K., Shimazaki-Den, S., Dogru, M., Kawakita, T., Kawashima, M., Shimmura, S., Tsubota, K. & Shimazaki, J., 2014 Nov, In : Cornea. 33, p. S42-S46

Research output: Contribution to journalArticle

11 Citations (Scopus)

The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa

Yoshida, T., Ozawa, Y., Suzuki, K., Yuki, K., Ohyama, M., Akamatsu, W., Matsuzaki, Y., Shimmura, S., Mitani, K., Tsubota, K. & Okano, H., 2014 Jun 16, In : Molecular brain. 7, 1, 45.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2015

Development of a transgenic mouse with R124H human TGFBI mutation associated with granular corneal dystrophy type 2

Yamazoe, K., Yoshida, S., Yasuda, M., Hatou, S., Inagaki, E., Ogawa, Y., Tsubota, K. & Shimmura, S., 2015 Jul 21, In : PloS one. 10, 7, e0133397.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Effect of Oral Pilocarpine in Treating Severe Dry Eye in Patients With Sjögren Syndrome

Kawakita, T., Shimmura, S. & Tsubota, K., 2015 Mar 1, In : Asia-Pacific Journal of Ophthalmology. 4, 2, p. 101-105 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Factors Affecting Outcomes of Repeated Penetrating Keratoplasty

Yamamoto, S., Shimmura-Tomita, M., Satake, Y., Shimazaki-Den, S., Shimmura, S. & Shimazaki, J., 2015 Sep 1, In : Nippon Ganka Gakkai zasshi. 119, 9, p. 625-631 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Possible involvement of epithelial-mesenchymal transition in fibrosis associated with IgG4-related Mikulicz's disease

Fukui, M., Ogawa, Y., Shimmura, S., Hatou, S., Ichihashi, Y., Yaguchi, S., Hirayama, M., Kawakita, T. & Tsubota, K., 2015 Sep 3, In : Modern Rheumatology. 25, 5, p. 737-743 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Tissue renin-angiotensin system in lacrimal gland fibrosis in a murine model of chronic graft-versus-host disease

Yaguchi, S., Ogawa, Y., Kawakita, T., Shimmura, S. & Tsubota, K., 2015 Oct 9, In : Cornea. 34, p. S142-S152

Research output: Contribution to journalArticle

4 Citations (Scopus)

Wickerhamomyces anomalus fungal keratitis responds to topical treatment with antifungal micafungin

Kamoshita, M., Matsumoto, Y., Nishimura, K., Katono, Y., Murata, M., Ozawa, Y., Shimmura, S. & Tsubota, K., 2015 Feb 1, In : Journal of Infection and Chemotherapy. 21, 2, p. 141-143 3 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

A Clinical Case Report Including In Vivo Laser Confocal Microscopic Findings of Keratitis Complicated with Takayasu's Arteritis

Matsumoto, Y., Yasuoka, H., Ichihashi, Y., Kawakita, T., Shimmura, S. & Tsubota, K., 2016 Feb 1, In : Nippon Ganka Gakkai zasshi. 120, 2, p. 114-119 6 p.

Research output: Contribution to journalArticle

Challenges and Strategies for Regenerating the Lacrimal Gland

Hirayama, M., Kawakita, T., Tsubota, K. & Shimmura, S., 2016 Apr 1, In : Ocular Surface. 14, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Comparison of Long-Term Outcomes of Visual Function and Endothelial Cell Survival After Descemet Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty Using Mixed-Effects Models

Ishiyama, S., Mori, Y., Nejima, R., Tokudome, T., Shimmura, S., Miyata, K. & Amano, S., 2016 Aug 24, (Accepted/In press) In : Cornea.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Cytokeratin expression in mouse lacrimal gland germ epithelium

Hirayama, M., Liu, Y., Kawakita, T., Shimmura, S. & Tsubota, K., 2016 May 1, In : Experimental Eye Research. 146, p. 54-59 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model

Ogawa, Y., Morikawa, S., Okano, H., Mabuchi, Y., Suzuki, S., Yaguchi, T., Sato, Y., Mukai, S., Yaguchi, S., Inaba, T., Okamoto, S., Kawakami, Y., Tsubota, K., Matsuzaki, Y. & Shimmura, S., 2016 Jan 26, In : eLife. 5, JANUARY2016, e09394.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Penetrating Keratoplasty Performed by Residents Compared With an Experienced Cornea Transplant Surgeon

Shimmura-Tomita, M., Shimmura, S., Tsubota, K. & Shimazaki, J., 2016, (Accepted/In press) In : Journal of Surgical Education.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Successful treatment of Beauveria bassiana fungal keratitis with topical voriconazole

Ogawa, A., Matsumoto, Y., Yaguchi, T., Shimmura, S. & Tsubota, K., 2016 Apr 1, In : Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 22, 4, p. 257-260 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells

Hirayama, M., Ko, S., Kawakita, T., Akiyama, T., Goparaju, S. K., Soma, A., Nakatake, Y., Sakota, M., Chikazawa-Nohtomi, N., Shimmura, S., Tsubota, K. & Ko, M. S. H., 2017 Dec 1, In : npj Aging and Mechanisms of Disease. 3, 1, 1.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Long-term homeostasis and wound healing in an in vitro epithelial stem cell niche model

Miyashita, H., Niwano, H., Yoshida, S., Hatou, S., Inagaki, E., Tsubota, K. & Shimmura, S., 2017 Feb 24, In : Scientific Reports. 7, 43557.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Skin-derived precursors as a source of progenitors for corneal endothelial regeneration

Inagaki, E., Hatou, S., Higa, K., Yoshida, S., Shibata, S., Okano, H., Tsubota, K. & Shimmura, S., 2017 Mar 1, In : Stem cells translational medicine. 6, 3, p. 788-798 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The Semaphorin 3A inhibitor SM-345431 preserves corneal nerve and epithelial integrity in a murine dry eye model

Yamazaki, R., Yamazoe, K., Yoshida, S., Hatou, S., Inagaki, E., Okano, H., Tsubota, K. & Shimmura, S., 2017 Dec 1, In : Scientific reports. 7, 1, 15584.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2018

A Rabbit Corneal Endothelial Dysfunction Model Using Endothelial-Mesenchymal Transformed Cells

Yamashita, K., Hatou, S., Inagaki, E., Higa, K., Tsubota, K. & Shimmura, S., 2018 Dec 1, In : Scientific Reports. 8, 1, 16868.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Cataract surgery after deep anterior lamellar keratoplasty and penetrating keratoplasty in age- and disease-matched eyes

Den, S., Shimmura, S. & Shimazaki, J., 2018 Apr, In : Journal of Cataract and Refractive Surgery. 44, 4, p. 496-503 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Corneal Endothelial Regeneration Using Mesenchymal Stem Cells Derived from Human Umbilical Cord

Yamashita, K., Inagaki, E., Hatou, S., Higa, K., Ogawa, A., Miyashita, H., Tsubota, K. & Shimmura, S., 2018 Aug 15, In : Stem Cells and Development. 27, 16, p. 1097-1108 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Functional Role of Lacrimal Gland Fibroblasts in a Mouse Model of Chronic Graft-Versus-Host Disease

Yamane, M., Ogawa, Y., Mukai, S., Yaguchi, S., Kamijuku, H., Inaba, T., Asai, K., Morikawa, S., Kawakami, Y., Shimmura, S. & Tsubota, K., 2018 Jan 1, In : Cornea. 37, 1, p. 102-108 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Prognosis after lamellar keratoplasty for limbal dermoids using preserved corneas

Yamashita, K., Hatou, S., Uchino, Y., Tsubota, K. & Shimmura, S., 2018 Jan 1, (Accepted/In press) In : Japanese Journal of Ophthalmology.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

Global consensus on definition, classification, diagnosis, and staging of limbal stem cell deficiency

Deng, S. X., Borderie, V., Chan, C. C., Dana, R., Figueiredo, F. C., Gomes, J. A. P., Pellegrini, G., Shimmura, S. & Kruse, F. E., 2019 Mar 1, In : Cornea. 38, 3, p. 364-375 12 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)