• 8995 Citations
  • 51 h-Index
1992 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2012

Mucosal microvilli in dry eye patients with chronic GVHD

Tatematsu, Y., Ogawa, Y., Shimmura, S., Dogru, M., Yaguchi, S., Nagai, T., Yamazaki, K., Kameyama, K., Okamoto, S., Kawakami, Y. & Tsubota, K., 2012 Mar 1, In : Bone Marrow Transplantation. 47, 3, p. 416-425 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Oxidative Stress Induced Inflammation Initiates Functional Decline of Tear Production

Uchino, Y., Kawakita, T., Miyazawa, M., Ishii, T., Onouchi, H., Yasuda, K., Ogawa, Y., Shimmura, S., Ishii, N. & Tsubota, K., 2012 Oct 5, In : PloS one. 7, 10, e45805.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland

Yaguchi, S., Ogawa, Y., Shimmura, S., Hatou, S., Nakamura, S., Inaba, T., Imada, T., Ozawa, Y., Kawakami, Y., Ishida, S. & Tsubota, K., 2012 Aug, In : Investigative Ophthalmology and Visual Science. 53, 9, p. 5416-5425 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The Semaphorin 3A Inhibitor SM-345431 Accelerates Peripheral Nerve Regeneration and Sensitivity in a Murine Corneal Transplantation Model

Omoto, M., Yoshida, S., Miyashita, H., Kawakita, T., Yoshida, K., Kishino, A., Kimura, T., Shibata, S., Tsubota, K., Okano, H. & Shimmura, S., 2012 Nov 9, In : PloS one. 7, 11, e47716.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2011

[Risk factors of severe peripheral corneal ulcers].

Suzuki, A., Matsumoto, Y., Uchino, Y., Kawakita, T., Shimmura, S. & Tsubota, K., 2011 Feb 1, In : Nippon Ganka Gakkai zasshi. 115, 2, p. 116-121 6 p.

Research output: Contribution to journalArticle

Clusterin promotes corneal epithelial cell growth through upregulation of hepatocyte growth factor by mesenchymal cells in vitro

Okada, N., Kawakita, T., Mishima, K., Saito, I., Miyashita, H., Yoshida, S., Shimmura, S. & Tsubota, K., 2011 May 1, In : Investigative Ophthalmology and Visual Science. 52, 6, p. 2905-2910 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Comparison of corneal thickness and haze in DSAEK and penetrating keratoplasty

Uchino, Y., Shimmura, S., Yamaguchi, T., Kawakita, T., Matsumoto, Y., Negishi, K. & Tsubota, K., 2011 Mar 1, In : Cornea. 30, 3, p. 287-290 4 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Comparison of telomere length and association with progenitor cell markers in lacrimal gland between sjögren syndrome and non-sjögren syndrome dry eye patients

Kawashima, M., Kawakita, T., Maida, Y., Kamoi, M., Ogawa, Y., Shimmura, S., Masutomi, K. & Tsubota, K., 2011 Jun 22, In : Molecular vision. 17, p. 1397-1404 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Fate of corneal epithelial cells separated from limbus in vivo

Kawakita, T., Higa, K., Shimmura, S., Tomita, M., Tsubota, K. & Shimazaki, J., 2011 Oct 1, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 8132-8137 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Four cases of corneal perforation in patients with chronic graft-versus-host disease

Inagaki, E., Ogawa, Y., Matsumoto, Y., Kawakita, T., Shimmura, S. & Tsubota, K., 2011 Mar 7, In : Molecular vision. 17, p. 598-606 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells

Yoshida, S., Yasuda, M., Miyashita, H., Ogawa, Y., Yoshida, T., Matsuzaki, Y., Tsubota, K., Okano, H. & Shimmura, S., 2011 Dec 9, In : PloS one. 6, 12, e28856.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model

Kubota, M., Shimmura, S., Kubota, S., Miyashita, H., Kato, N., Noda, K., Ozawa, Y., Usui, T., Ishida, S., Umezawa, K., Kurihara, T. & Tsubota, K., 2011 Jan, In : Investigative Ophthalmology and Visual Science. 52, 1, p. 427-433 7 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Mathematical projection model of visual loss due to fuchs corneal dystrophy

Hatou, S., Shimmura, S., Shimazaki, J., Usui, T., Amano, S., Yokogawa, H., Kobayashi, A., Zheng, X., Shiraishi, A., Ohashi, Y., Inatomi, T. & Tsubota, K., 2011 Oct, In : Investigative Ophthalmology and Visual Science. 52, 11, p. 7888-7893 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Porous silk fibroin film as a transparent carrier for cultivated corneal epithelial sheets

Higa, K., Takeshima, N., Moro, F., Kawakita, T., Kawashima, M., Demura, M., Shimazaki, J., Asakura, T., Tsubota, K. & Shimmura, S., 2011, In : Journal of Biomaterials Science, Polymer Edition. 22, 17, p. 2261-2276 16 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Prospective, randomized study of the efficacy of systemic cyclosporine in high-risk corneal transplantation

Shimazaki, J., Den, S., Omoto, M., Satake, Y., Shimmura, S. & Tsubota, K., 2011 Jul, In : American Journal of Ophthalmology. 152, 1, p. 33-39.e1

Research output: Contribution to journalArticle

39 Citations (Scopus)

Purified mesenchymal stem cells are an efficient source for iPS cell induction

Niibe, K., Kawamura, Y., Araki, D., Morikawa, S., Miura, K., Suzuki, S., Shimmura, S., Sunabori, T., Mabuchi, Y., Nagai, Y., Nakagawa, T., Okano, H. & Matsuzaki, Y., 2011, In : PloS one. 6, 3, e17610.

Research output: Contribution to journalArticle

39 Citations (Scopus)

The application of in vivo confocal scanning laser microscopy in the diagnosis and evaluation of treatment responses in mooren's ulcer

Hatou, S., Dogru, M., brahim, O. M. A., Wakamatsu, T., Sato, E. A., Shimmura, S., Negishi, K. & Tsubota, K., 2011 Aug 1, In : Investigative Ophthalmology and Visual Science. 52, 9, p. 6680-6689 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2010

Calorie restriction: A new therapeutic intervention for age-related dry eye disease in rats

Kawashima, M., Kawakita, T., Okada, N., Ogawa, Y., Murat, D., Nakamura, S., Nakashima, H., Shimmura, S., Shinmura, K. & Tsubota, K., 2010 Jul 1, In : Biochemical and Biophysical Research Communications. 397, 4, p. 724-728 5 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Comparison of anterior and posterior corneal surface irregularity in descemet stripping automated endothelial keratoplasty and penetrating keratoplasty

Yamaguchi, T., Negishi, K., Yamaguchi, K., Dogru, M., Uchino, Y., Shimmura, S. & Tsubota, K., 2010 Oct 1, In : Cornea. 29, 10, p. 1086-1090 5 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
14 Citations (Scopus)

Simultaneous deep anterior lamellar keratoplasty and limbal allograft in bilateral limbal stem cell deficiency

Omoto, M., Shimmura, S., Hatou, S., Ichihashi, Y., Kawakita, T. & Tsubota, K., 2010 Nov 1, In : Japanese Journal of Ophthalmology. 54, 6, p. 537-543 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Subepithelial corneal fibrosis partially due to epithelial-mesenchymal transition of ocular surface epithelium

Kawashima, M., Kawakita, T., Higa, K., Satake, Y., Omoto, M., Tsubota, K., Shimmura, S. & Shimazaki, J., 2010 Dec 1, In : Molecular vision. 16, p. 2727-2732 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The anti-oxidative role of ABCG2 in corneal epithelial cells

Kubota, M., Shimmura, S., Miyashita, H., Kawashima, M., Kawakita, T. & Tsubota, K., 2010 Nov 1, In : Investigative Ophthalmology and Visual Science. 51, 11, p. 5617-5622 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2009

Characteristics of Traumatic Globe Rupture after Keratoplasty

Kawashima, M., Kawakita, T., Shimmura, S., Tsubota, K. & Shimazaki, J., 2009 Nov 1, In : Ophthalmology. 116, 11, p. 2072-2076 5 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Cultivated autologous limbal epithelial transplantation for symptomatic bullous keratopathy

Satake, Y., Shimmura, S. & Shimazaki, J., 2009 Apr 14, In : BMJ case reports.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Development of mesenchymal stem cells partially originate from the neural crest

Morikawa, S., Mabuchi, Y., Niibe, K., Suzuki, S., Nagoshi, N., Sunabori, T., Shimmura, S., Nagai, Y., Nakagawa, T., Okano, H. & Matsuzaki, Y., 2009 Feb 20, In : Biochemical and Biophysical Research Communications. 379, 4, p. 1114-1119 6 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)

Effect of anterior and posterior corneal surface irregularity on vision after Descemet-stripping endothelial keratoplasty

Yamaguchi, T., Negishi, K., Yamaguchi, K., Murat, D., Uchino, Y., Shimmura, S. & Tsubota, K., 2009 Apr 1, In : Journal of Cataract and Refractive Surgery. 35, 4, p. 688-694 7 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease

Ogawa, Y., Shimmura, S., Kawakita, T., Yoshida, S., Kawakami, Y. & Tsubota, K., 2009, In : American Journal of Pathology. 175, 6, p. 2372-2381 10 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Greater growth potential of p63-positive epithelial cell clusters maintained in human limbal epithelial sheets

Kawakita, T., Shimmura, S., Higa, K., Espana, E. M., He, H., Shimazaki, J., Tsubota, K. & Tseng, S. C. G., 2009, In : Investigative Ophthalmology and Visual Science. 50, 10, p. 4611-4617 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Long-term culture and growth kinetics of murine corneal epithelial cells expanded from single corneas

Ma, X., Shimmura, S., Miyashita, H., Yoshida, S., Kubota, M., Kawakita, T. & Tsubota, K., 2009 Dec 1, In : Investigative Ophthalmology and Visual Science. 50, 6, p. 2716-2721 6 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

N-Cadherin in the maintenance of human corneal limbal epithelial progenitor cells in vitro

Higa, K., Shimmura, S., Miyashita, H., Kato, N., Ogawa, Y., Kawakita, T., Shimazaki, J. & Tsubota, K., 2009 Dec 1, In : Investigative Ophthalmology and Visual Science. 50, 10, p. 4640-4645 6 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Nucleostemin as a possible progenitor marker of corneal epithelial cells

Kawashima, M., Kawakita, T., Yoshida, S., Shimmura, S. & Tsubota, K., 2009 Jun 10, In : Molecular vision. 15, 123.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

Morikawa, S., Mabuchi, Y., Kubota, Y., Nagai, Y., Niibe, K., Hiratsu, E., Suzuki, S., Miyauchi-Hara, C., Nagoshi, N., Sunabori, T., Shimmura, S., Miyawaki, A., Nakagawa, T., Suda, T., Okano, H. & Matsuzaki, Y., 2009 Oct 26, In : Journal of Experimental Medicine. 206, 11, p. 2483-2496 14 p.

Research output: Contribution to journalArticle

481 Citations (Scopus)

Retinal phototoxicity in a novel murine model of intraocular lens implantation.

Kurihara, T., Omoto, M., Noda, K., Ebinuma, M., Kubota, S., Koizumi, H., Yoshida, S., Ozawa, Y., Shimmura, S., Ishida, S. & Tsubota, K., 2009, In : Molecular vision. 15, p. 2751-2761 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

The use of human mesenchymal stem cell-derived feeder cells for the cultivation of transplantable epithelial sheets

Omoto, M., Miyashita, H., Shimmura, S., Higa, K., Kawakita, T., Yoshida, S., Mcgrogan, M., Shimazaki, J. & Tsubota, K., 2009 Dec 1, In : Investigative Ophthalmology and Visual Science. 50, 5, p. 2109-2115 7 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)
2008

A novel NIH/3T3 duplex feeder system to engineer corneal epithelial sheets with enhanced cytokeratin 15-positive progenitor populations

Miyashita, H., Shimmura, S., Higa, K., Yoshida, S., Kawakita, T., Shimazaki, J. & Tsubota, K., 2008 Jul 1, In : Tissue Engineering - Part A.. 14, 7, p. 1275-1282 8 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Isolation of oral epithelial progenitors using collagen IV

Igarashi, T., Shimmura, S., Yoshida, S., Tonogi, M., Shinozaki, N. & Yamane, G. Y., 2008 Jul 1, In : Oral Diseases. 14, 5, p. 413-418 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Japan Ministry of Health Study on Prevalence of Dry Eye Disease Among Japanese High School Students

Uchino, M., Dogru, M., Uchino, Y., Fukagawa, K., Shimmura, S., Takebayashi, T., Schaumberg, D. A. & Tsubota, K., 2008 Dec, In : American Journal of Ophthalmology. 146, 6, p. 925-929.e2

Research output: Contribution to journalArticle

56 Citations (Scopus)

Postkeratoplasty Atopic Sclerokeratitis in Keratoconus Patients

Tomita, M., Shimmura, S., Tsubota, K. & Shimazaki, J., 2008 May 1, In : Ophthalmology. 115, 5, p. 851-856 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Prevalence of Dry Eye Disease among Japanese Visual Display Terminal Users

Uchino, M., Schaumberg, D. A., Dogru, M., Uchino, Y., Fukagawa, K., Shimmura, S., Satoh, T., Takebayashi, T. & Tsubota, K., 2008 Nov 1, In : Ophthalmology. 115, 11, p. 1982-1988 7 p.

Research output: Contribution to journalArticle

179 Citations (Scopus)
46 Citations (Scopus)

Stratified epithelial sheets engineered from a single adult murine corneal/limbal progenitor cell

Kawakita, T., Shimmura, S., Hornia, A., Higa, K. & Tseng, S. C. G., 2008 Aug, In : Journal of Cellular and Molecular Medicine. 12, 4, p. 1303-1316 14 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2

Mochimaru, H., Usui, T., Yaguchi, T., Nagahama, Y., Hasegawa, G., Usui, Y., Shimmura, S., Tsubota, K., Amano, S., Kawakami, Y. & Ishida, S., 2008 Apr, In : Investigative Ophthalmology and Visual Science. 49, 5, p. 2172-2177 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2007

Albumin rescues ocular epithelial cells from cell death in dry eye

Higuchi, A., Ueno, R., Shimmura, S., Suematsu, M., Dogru, M. & Tsubota, K., 2007 Feb 1, In : Current Eye Research. 32, 2, p. 83-88 6 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
35 Citations (Scopus)

Deep lamellar keratoplasty in severe ocular surface disease

Shimmura, S., Higa, A., Omoto, M., Shimazaki, J. & Tsubota, K., 2007 May, In : Nippon Ganka Gakkai zasshi. 111, 5, p. 391-396 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Factors Influencing Outcomes in Cultivated Limbal Epithelial Transplantation for Chronic Cicatricial Ocular Surface Disorders

Shimazaki, J., Higa, K., Morito, F., Dogru, M., Kawakita, T., Satake, Y., Shimmura, S. & Tsubota, K., 2007 Jun 1, In : American Journal of Ophthalmology. 143, 6, p. 945-953 9 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Hypoxia enhances the expansion of human limbal epithelial progenitor cells in vitro

Miyashita, H., Higa, K., Kato, N., Kawakita, T., Yoshida, S., Tsubota, K. & Shimmura, S., 2007 Aug 1, In : Investigative Ophthalmology and Visual Science. 48, 8, p. 3586-3593 8 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Immunohistochemistry and electron microscopy of retrocorneal scrolls in syphilitic interstitial keratitis

Dogru, M., Kato, N., Matsumoto, Y., Tanaka, Y., Akabane, N., Shimmura, S., Tsubota, K. & Shimazaki, J., 2007 Oct 1, In : Current Eye Research. 32, 10, p. 863-870 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Impact of the Descemet Membrane Perforation on Surgical Outcomes After Deep Lamellar Keratoplasty

Den, S., Shimmura, S., Tsubota, K. & Shimazaki, J., 2007 May 1, In : American Journal of Ophthalmology. 143, 5, p. 750-754 5 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)