• 407 Citations
  • 11 h-Index
20102019
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Research Output 2010 2019

  • 407 Citations
  • 11 h-Index
  • 29 Article
2019
1 Citation (Scopus)

A phase II trial of induction of erlotinib followed by cytotoxic chemotherapy for EGFR mutation-positive non-squamous non-small cell lung cancer patients

Tani, T., Naoki, K., Yasuda, H., Arai, D., Ishioka, K., Ohgino, K., Yoda, S., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T. & Soejima, K., 2019 Jan 1, (Accepted/In press) In : Cancer Chemotherapy and Pharmacology.

Research output: Contribution to journalArticle

Chemotherapy
Non-Small Cell Lung Carcinoma
Cells
Drug Therapy
Mutation
6 Citations (Scopus)

Efficacy of afatinib or osimertinib plus cetuximab combination therapy for non-small-cell lung cancer with EGFR exon 20 insertion mutations

Hasegawa, H., Yasuda, H., Hamamoto, J., Masuzawa, K., Tani, T., Nukaga, S., Hirano, T., Kobayashi, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Lung Cancer. 127, p. 146-152 7 p.

Research output: Contribution to journalArticle

Insertional Mutagenesis
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Exons
Therapeutics

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

Ikemura, S., Yasuda, H., Matsumoto, S., Kamada, M., Hamamoto, J., Masuzawa, K., Kobayashi, K., Manabe, T., Arai, D., Nakachi, I., Kawada, I., Ishioka, K., Nakamura, M., Namkoong, H., Naoki, K., Ono, F., Araki, M., Kanada, R., Ma, B., Hayashi, Y. & 8 others, Mimaki, S., Yoh, K., Kobayashi, S. S., Kohno, T., Okuno, Y., Goto, K., Tsuchihara, K. & Soejima, K., 2019 May 14, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10025-10030 6 p.

Research output: Contribution to journalArticle

Open Access
Molecular Dynamics Simulation
Lung Neoplasms
Mutation
Pharmaceutical Preparations
Protein-Tyrosine Kinases

Monomer preference of EGFR tyrosine kinase inhibitors influences the synergistic efficacy of combination therapy with cetuximab

Oashi, A., Yasuda, H., Kobayashi, K., Tani, T., Hamamoto, J., Masuzawa, K., Manabe, T., Terai, H., Ikemura, S., Kawada, I., Naoki, K. & Soejima, K., 2019 Jan 1, In : Molecular cancer therapeutics. 18, 9, p. 1593-1601 9 p.

Research output: Contribution to journalArticle

Dimerization
Protein-Tyrosine Kinases
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Therapeutics
2018
5 Citations (Scopus)

A case of pulmonary adenocarcinoma showing rapid progression of peritoneal dissemination after immune checkpoint inhibitor therapy

Shinozaki, T., Iwami, E., Ikemura, S., Matsuzaki, T., Nakajima, T., Hashimoto, K. & Terashima, T., 2018 May 31, In : BMC Cancer. 18, 1, 620.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Skin Diseases
Ascites
Non-Small Cell Lung Carcinoma

Lymph node collision tumor consisting of metastatic pulmonary adenocarcinoma and diffuse large b-cell lymphoma

Ikemura, S., Moriyama, M., Matsumoto, K., Nakayama, S., Matsuzaki, T., Nakajima, T., Sasaki, A., Miyauchi, J. & Terashima, T., 2018 Jan 1, In : Internal Medicine. 57, 8, p. 1135-1139 5 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Lymph Nodes
Liver
Bone Marrow
Neoplasm Metastasis
2017
35 Citations (Scopus)

Amplification of EGFR wild-type alleles in non-small cell lung cancer cells confers acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors

Nukaga, S., Yasuda, H., Tsuchihara, K., Hamamoto, J., Masuzawa, K., Kawada, I., Naoki, K., Matsumoto, S., Mimaki, S., Ikemura, S., Goto, K., Betsuyaku, T. & Soejima, K., 2017 Apr 15, In : Cancer Research. 77, 8, p. 2078-2089 12 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Alleles
Mutation
Lung Neoplasms
2 Citations (Scopus)

Changes in the tumor microenvironment during lymphatic metastasis of lung squamous cell carcinoma

Ikemura, S., Aramaki, N., Fujii, S., Kirita, K., Umemura, S., Matsumoto, S., Yoh, K., Niho, S., Ohmatsu, H., Kuwata, T., Kojima, M., Ochiai, A., Betsuyaku, T., Tsuboi, M., Goto, K. & Ishii, G., 2017 Jan 1, In : Cancer Science. 108, 1, p. 136-142 7 p.

Research output: Contribution to journalArticle

Lymphatic Metastasis
Tumor Microenvironment
Squamous Cell Carcinoma
Lymph Nodes
Lung

The prognostic factors for long-term (≥5 Years) survival in stage IV Non-small cell lung cancer

Matsuzaki, T., Ikemura, S., Chubachi, S., Nakayama, S., Iwami, E., Sato, M., Nakajima, T., Eguchi, K. & Terashima, T., 2017 Apr 20, In : Japanese Journal of Lung Cancer. 57, 2, p. 88-95 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Survival
Pharmaceutical Preparations
Disease-Free Survival
Retrospective Studies
2016

A Case of Small Cell Lung Cancer Treated with Concurrent Chemoradiotherapy with Carboplatin plus Etoposide in a Hemodialysis Patient

Terashima, T., Iwami, E., Chubachi, S., Ikemura, S., Nakajima, T., Matsuzaki, T. & Aoyagi, H., 2016 Jan 1, In : Gan to kagaku ryoho. Cancer & chemotherapy. 43, 1, p. 99-101 3 p.

Research output: Contribution to journalArticle

Carboplatin
Small Cell Lung Carcinoma
Chemoradiotherapy
Etoposide
Renal Dialysis
17 Citations (Scopus)

Aggressive tumor microenvironment of solid predominant lung adenocarcinoma subtype harboring with epidermal growth factor receptor mutations

Saruwatari, K., Ikemura, S., Sekihara, K., Kuwata, T., Fujii, S., Umemura, S., Kirita, K., Matsumoto, S., Yoh, K., Niho, S., Ohmatsu, H., Ochiai, A., Kohrogi, H., Tsuboi, M., Goto, K. & Ishii, G., 2016 Jan 1, In : Lung Cancer. 91, p. 7-14 8 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Epidermal Growth Factor Receptor
Adenocarcinoma
Mutation
Neoplasms
1 Citation (Scopus)

The association of intravascular stromal cells with prognosis in high-grade neuroendocrine carcinoma of the lung

Sekihara, K., Hishida, T., Ikemura, S., Saruwatari, K., Morise, M., Kuwata, T., Fujii, S., Kojima, M., Ochiai, A., Funai, K., Aokage, K., Yoshida, J., Tsuboi, M. & Ishii, G., 2016 May 1, In : Journal of Cancer Research and Clinical Oncology. 142, 5, p. 905-912 8 p.

Research output: Contribution to journalArticle

Neuroendocrine Carcinoma
Stromal Cells
Blood Vessels
Lung
Recurrence
2015
6 Citations (Scopus)

A phase II study of biweekly paclitaxel and carboplatin in elderly patients with advanced non-small cell lung cancer

Soejima, K., Naoki, K., Ishioka, K., Nakamura, M., Nakatani, M., Kawada, I., Watanabe, H., Nakachi, I., Yasuda, H., Satomi, R., Nakayama, S., Yoda, S., Ikemura, S., Terai, H., Sato, T., Ohgino, K., Arai, D., Tani, T., Kuroda, A., Nishino, M. & 1 others, Betsuyaku, T., 2015, In : Cancer Chemotherapy and Pharmacology. 75, 3, p. 513-519 7 p.

Research output: Contribution to journalArticle

Carboplatin
Paclitaxel
Non-Small Cell Lung Carcinoma
Chemotherapy
Cells
3 Citations (Scopus)

A Phase II study of S-1 and irinotecan combination therapy in previously treated patients with advanced non-small cell lung cancer

Ikemura, S., Naoki, K., Yasuda, H., Kawada, I., Yoda, S., Terai, H., Sato, T., Ishioka, K., Arai, D., Ohgino, K., Kamata, H., Miyata, J., Kabata, H., Betsuyaku, T. & Soejima, K., 2015 Apr 1, In : Japanese Journal of Clinical Oncology. 45, 4, p. 356-361 6 p.

Research output: Contribution to journalArticle

irinotecan
Non-Small Cell Lung Carcinoma
Body Surface Area
Therapeutics
Disease-Free Survival
16 Citations (Scopus)

FOXD1 expression is associated with poor prognosis in non-small cell lung cancer

Nakayama, S., Soejima, K., Yasuda, H., Yoda, S., Satomi, R., Ikemura, S., Terai, H., Sato, T., Yamaguchi, N., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Naoki, K. & Betsuyaku, T., 2015 Jan 1, In : Anticancer Research. 35, 1, p. 261-268 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lung Neoplasms
Cell Proliferation
Cell Line
Messenger RNA
5 Citations (Scopus)

Long-term exposure to gefitinib induces acquired resistance through DNA methylation changes in the EGFR-mutant PC9 lung cancer cell line

Terai, H., Soejima, K., Yasuda, H., Sato, T., Naoki, K., Ikemura, S., Arai, D., Ohgino, K., Ishioka, K., Hamamoto, J., Kanai, Y. & Betsuyaku, T., 2015 Jan 1, In : International Journal of Oncology. 46, 1, p. 430-436 7 p.

Research output: Contribution to journalArticle

DNA Methylation
Lung Neoplasms
Cell Line
Genes
Messenger RNA
11 Citations (Scopus)

Methylation-induced downregulation of TFPI-2 causes TMPRSS4 overexpression and contributes to oncogenesis in a subset of non-small-cell lung carcinoma

Hamamoto, J., Soejima, K., Naoki, K., Yasuda, H., Hayashi, Y., Yoda, S., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T., Arai, D., Ishioka, K., Ohgino, K. & Betsuyaku, T., 2015 Jan 1, In : Cancer Science. 106, 1, p. 34-42 9 p.

Research output: Contribution to journalArticle

Serine Proteases
Non-Small Cell Lung Carcinoma
Methylation
Carcinogenesis
Down-Regulation
2014
24 Citations (Scopus)

Claudin-1 is a novel target of miR-375 in non-small-cell lung cancer

Yoda, S., Soejima, K., Hamamoto, J., Yasuda, H., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T., Naoki, K. & Betsuyaku, T., 2014, In : Lung Cancer. 85, 3, p. 366-372 7 p.

Research output: Contribution to journalArticle

Claudin-1
Non-Small Cell Lung Carcinoma
Luciferases
Cell Line
Squamous Cell Carcinoma
25 Citations (Scopus)

Expression of fibroblast growth factor 9 is associated with poor prognosis in patients with resected non-small cell lung cancer

Ohgino, K., Soejima, K., Yasuda, H., Hayashi, Y., Hamamoto, J., Naoki, K., Arai, D., Ishioka, K., Sato, T., Terai, H., Ikemura, S., Yoda, S., Tani, T., Kuroda, A. & Betsuyaku, T., 2014 Jan, In : Lung Cancer. 83, 1, p. 90-96 7 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Non-Small Cell Lung Carcinoma
Fibroblast Growth Factors
Lung
Oligonucleotide Array Sequence Analysis
2013

[Evaluation of the characteristics of tuberculosis patients in Ashikaga Red Cross Hospital, Tochigi Prefecture, Japan (2007-2011)].

Shimada, M., Kameyama, Y. & Ikemura, S., 2013 Jul 1, In : Kekkaku : [Tuberculosis]. 88, 7, p. 589-593 5 p.

Research output: Contribution to journalArticle

Red Cross
Japan
Tuberculosis
Latent Tuberculosis
Sputum
113 Citations (Scopus)

Activation of the FGF2-FGFR1 autocrine pathway: A novel mechanism of acquired resistance to gefitinib in NSCLC

Terai, H., Soejima, K., Yasuda, H., Nakayama, S., Hamamoto, J., Arai, D., Ishioka, K., Ohgino, K., Ikemura, S., Sato, T., Yoda, S., Satomi, R., Naoki, K. & Betsuyaku, T., 2013 Jul, In : Molecular Cancer Research. 11, 7, p. 759-767 9 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Non-Small Cell Lung Carcinoma
Epidermal Growth Factor Receptor
Cell Line
gefitinib
44 Citations (Scopus)

Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma

Hamamoto, J., Soejima, K., Yoda, S., Naoki, K., Nakayama, S., Satomi, R., Terai, H., Ikemura, S., Sato, T., Yasuda, H., Hayashi, Y., Sakamoto, M., Takebayashi, T. & Betsuyaku, T., 2013 Aug, In : Molecular Medicine Reports. 8, 2, p. 456-462 7 p.

Research output: Contribution to journalArticle

MicroRNAs
Squamous Cell Carcinoma
Non-Small Cell Lung Carcinoma
Lung
Adenocarcinoma
2012

A case of elderly advanced squamous cell lung carcinoma successfully treated with nedaplatin and S-1 combination chemotherapy

Terai, H., Soejima, K., Naoki, K., Ikemura, S., Ogura-Tomomatsu, H., Sato, T., Asano, K. & Betsuyaku, T., 2012 Mar, In : Japanese Journal of Cancer and Chemotherapy. 39, 3, p. 429-432 4 p.

Research output: Contribution to journalArticle

Combination Drug Therapy
Squamous Cell Carcinoma
Lung
Thorax
Neoplasm Metastasis
2011
2 Citations (Scopus)

A phase i study of S-1 and irinotecan combination therapy in previously treated advanced non-small cell lung cancer patients

Yoda, S., Soejima, K., Yasuda, H., Naoki, K., Kawada, I., Watanabe, H., Nakachi, I., Satomi, R., Nakayama, S., Ikemura, S., Terai, H., Sato, T., Morosawa, M. & Asano, K., 2011 Mar, In : Cancer Chemotherapy and Pharmacology. 67, 3, p. 717-722 6 p.

Research output: Contribution to journalArticle

irinotecan
Non-Small Cell Lung Carcinoma
Cells
Toxicity
Body Surface Area
16 Citations (Scopus)

Bronchoscopic Microsampling is a Useful Complementary Diagnostic Tool for Detecting Lung Cancer

Yasuda, H., Soejima, K., Nakayama, S., Kawada, I., Nakachi, I., Yoda, S., Satomi, R., Ikemura, S., Terai, H., Sato, T., Watanabe, H., Naoki, K., Hayashi, Y. & Ishizaka, A., 2011 Apr, In : Lung Cancer. 72, 1, p. 32-38 7 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Tumor Suppressor Genes
Serum
Epigenomics
Mutation
43 Citations (Scopus)

The PCR-invader method (structure-specific 5 nuclease-based method), a sensitive method for detecting EGFR gene mutations in lung cancer specimens; Comparison with direct sequencing

Naoki, K., Soejima, K., Okamoto, H., Hamamoto, J., Hida, N., Nakachi, I., Yasuda, H., Nakayama, S., Yoda, S., Satomi, R., Ikemura, S., Terai, H., Sato, T. & Watanabe, K., 2011 Aug, In : International Journal of Clinical Oncology. 16, 4, p. 335-344 10 p.

Research output: Contribution to journalArticle

erbB-1 Genes
Lung Neoplasms
Polymerase Chain Reaction
Mutation
Non-Small Cell Lung Carcinoma
2010
13 Citations (Scopus)

Distinct epigenetic regulation of tumor suppressor genes in putative cancer stem cells of solid tumors

Yasuda, H., Soejima, K., Watanabe, H., Kawada, I., Nakachi, I., Yoda, S., Nakayama, S., Satomi, R., Ikemura, S., Terai, H., Sato, T., Suzuki, S., Matsuzaki, Y., Naoki, K. & Ishizaka, A., 2010 Dec, In : International Journal of Oncology. 37, 6, p. 1537-1546 10 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Tumor Suppressor Genes
Epigenomics
Chromatin
Neoplasms

FDG-PET imaging of benign pulmonary diseases

Terai, H., Soejima, K., Naoki, K., Kawada, I., Nakachi, I., Satomi, R., Nakayama, S., Yoda, S., Ikemura, S., Sato, T., Ishizaka, A. & Yasuda, H., 2010, In : Japanese Journal of Clinical Radiology. 55, 1, p. 163-172 10 p.

Research output: Contribution to journalArticle

Positron-Emission Tomography
Lung Diseases
Mediastinal Diseases
Radiation Pneumonitis
Pneumoconiosis
19 Citations (Scopus)

The combination of multiple receptor tyrosine kinase inhibitor and mammalian target of rapamycin inhibitor overcomes erlotinib resistance in lung cancer cell lines through c-met inhibition

Nakachi, I., Naoki, K., Soejima, K., Kawada, I., Watanabe, H., Yasuda, H., Nakayama, S., Yoda, S., Satomi, R., Ikemura, S., Terai, H., Sato, T. & Ishizaka, A., 2010 Aug, In : Molecular Cancer Research. 8, 8, p. 1142-1151 10 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Sirolimus
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Cell Line