Research Output 1998 2017

  • 1720 Citations
  • 18 h-Index
  • 34 Article
  • 1 Chapter
  • 1 Review article
2017
1 Citations

Blockage of Core Fucosylation Reduces Cell-Surface Expression of PD-1 and Promotes Anti-tumor Immune Responses of T Cells

Okada, M., Chikuma, S., Kondo, T., Hibino, S., Machiyama, H., Yokosuka, T., Nakano, M. & Yoshimura, A. 2017 Aug 1 In : Cell Reports. 20, 5, p. 1017-1028 12 p.

Research output: Research - peer-reviewArticle

T-cells
Cell death
Tumors
Cell Death
T-Lymphocytes
2 Citations

CTLA-4, an essential immune-checkpoint for T-Cell activation

Chikuma, S. 2017 Jan 1 Current Topics in Microbiology and Immunology. Springer Verlag, Vol. 410, p. 99-126 28 p. (Current Topics in Microbiology and Immunology; vol. 410)

Research output: ResearchChapter

T-Lymphocytes
Antigen-Presenting Cells
Neoplasms
CD86 Antigens
Immunological Synapses
3 Citations

Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy

Kondo, T., Morita, R., Okuzono, Y., Nakatsukasa, H., Sekiya, T., Chikuma, S., Shichita, T., Kanamori, M., Kubo, M., Koga, K., Miyazaki, T., Kassai, Y. & Yoshimura, A. 2017 May 22 In : Nature Communications. 8, 15338

Research output: Research - peer-reviewArticle

Adoptive Immunotherapy
Stem Cells
T-Lymphocytes
stem cells
notches
3 Citations

Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation

Komai, K., Shichita, T., Ito, M., Kanamori, M., Chikuma, S. & Yoshimura, A. 2017 In : International Immunology. 29, 2, p. 59-70 12 p.

Research output: Research - peer-reviewArticle

Scavenger Receptors
Toll-Like Receptors
Macrophages
Class A Scavenger Receptors
Cytokines
4 Citations

Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy

Chikuma, S., Kanamori, M., Mise-Omata, S. & Yoshimura, A. 2017 Apr 1 In : Cancer Science. 108, 4, p. 574-580 7 p.

Research output: Research - peer-reviewReview article

Immunotherapy
Cytokines
T-Lymphocytes
Neoplasms
Suppressor of Cytokine Signaling Proteins
2016
12 Citations

Basics of PD-1 in self-tolerance, infection, and cancer immunity

Chikuma, S. 2016 Feb 10 (Accepted/In press) In : International Journal of Clinical Oncology. p. 1-8 8 p.

Research output: Research - peer-reviewArticle

Self Tolerance
Immunity
Infection
Neoplasms
T-Lymphocytes
2 Citations

Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22

Sakaguchi, R., Chikuma, S., Shichita, T., Morita, R., Sekiya, T., Ouyang, W., Ueda, T., Seki, H., Morisaki, H. & Yoshimura, A. 2016 May 1 In : International Immunology. 28, 5, p. 233-243 11 p.

Research output: Research - peer-reviewArticle

Interleukin-23
Endotoxins
Pneumonia
interleukin-22
Acute Lung Injury
10 Citations

Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model

Zhang, B., Chikuma, S., Hori, S., Fagarasan, S. & Honjo, T. 2016 Jul 26 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 30, p. 8490-8495 6 p.

Research output: Research - peer-reviewArticle

Immune Tolerance
Pancreatitis
T-Lymphocytes
Regulatory T-Lymphocytes
Autoimmunity
2015
175 Citations

Safety and antitumor activity of Anti-PD-1 antibody, nivolumab, in patients with platinum-resistant ovarian cancer

Hamanishi, J. , Mandai, M. , Ikeda, T. , Minami, M. , Kawaguchi, A. , Murayama, T. , Kanai, M. , Mori, Y. , Matsumoto, S. , Chikuma, S. , Matsumura, N. , Abiko, K. , Baba, T. , Yamaguchi, K. , Ueda, A. , Hosoe, Y. , Morita, S. , Yokode, M. , Shimizu, A. , Honjo, T. & 1 others Konishi, I. 2015 Dec 1 In : Journal of Clinical Oncology. 33, 34, p. 4015-4022 8 p.

Research output: Research - peer-reviewArticle

Platinum
Ovarian Neoplasms
Safety
Antibodies
nivolumab
2014
2 Citations

Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models

Nguyen, T., Xu, J., Chikuma, S., Hiai, H., Kinoshita, K., Moriya, K., Koike, K., Marcuzzi, G. P., Pfister, H., Honjo, T. & Kobayashi, M. 2014 In : International Immunology. 26, 7, p. 397-406 10 p., dxu040

Research output: Research - peer-reviewArticle

Viruses
Skin
Liver
Neoplasms
AICDA (activation-induced cytidine deaminase)
4 Citations

Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function

Stumpf, M., Zhou, X., Chikuma, S. & Bluestone, J. A. 2014 In : European Journal of Immunology. 44, 6, p. 1737-1746 10 p.

Research output: Research - peer-reviewArticle

CTLA-4 Antigen
Regulatory T-Lymphocytes
Tyrosine
Tail
T-Lymphocytes
2013
228 Citations

A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application

Okazaki, T., Chikuma, S., Iwai, Y., Fagarasan, S. & Honjo, T. 2013 Dec In : Nature Immunology. 14, 12, p. 1212-1218 7 p.

Research output: Research - peer-reviewArticle

Antigens
Autoimmune Diseases
B-Lymphocytes
T-Lymphocytes
Phenotype
18 Citations
Helper-Inducer T-Lymphocytes
Innate Immunity
Cell Death
T-Lymphocytes
Autoimmune Experimental Encephalomyelitis
2012
52 Citations

Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake

Hara-Chikuma, M., Chikuma, S., Sugiyama, Y., Kabashima, K., Verkman, A. S., Inoue, S. & Miyachi, Y. 2012 Sep In : Journal of Experimental Medicine. 209, 10, p. 1743-1752 10 p.

Research output: Research - peer-reviewArticle

Aquaporin 3
Chemokines
Hydrogen Peroxide
Cell Movement
T-Lymphocytes
44 Citations

TRIM28 prevents autoinflammatory T cell development in vivo

Chikuma, S., Suita, N., Okazaki, I. M., Shibayama, S. & Honjo, T. 2012 Jun In : Nature Immunology. 13, 6, p. 596-603 8 p.

Research output: Research - peer-reviewArticle

T-Lymphocytes
Cytokines
Phenotype
Th17 Cells
Lymphopenia
2011
26 Citations

Activation-induced cytidine deaminase expression in CD4 + T cells is associated with a unique IL-10-producing subset that increases with age

Qin, H., Suzuki, K., Nakata, M., Chikuma, S., Izumi, N., Thi Huong, L., Maruya, M., Fagarasan, S., Busslinger, M., Honjo, T. & Nagaoka, H. 2011 Dec 28 In : PLoS One. 6, 12, e29141

Research output: Research - peer-reviewArticle

Interleukin-10
B-Lymphocytes
T-Lymphocytes
AICDA (activation-induced cytidine deaminase)
interleukin-10
104 Citations

IFN-α directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity

Terawaki, S., Chikuma, S., Shibayama, S., Hayashi, T., Yoshida, T., Okazaki, T. & Honjo, T. 2011 Mar 1 In : Journal of Immunology. 186, 5, p. 2772-2779 8 p.

Research output: Research - peer-reviewArticle

Cellular Immunity
Cell Death
T-Lymphocytes
Response Elements
Neoplasms
2010
45 Citations

PD-1 deficiency results in the development of fatal myocarditis in MRL mice

Wang, J., Okazaki, I. M., Yoshida, T., Chikuma, S., Kato, Y., Nakaki, F., Hiai, H., Honjo, T. & Okazaki, T. 2010 Apr 21 In : International Immunology. 22, 6, p. 443-452 10 p.

Research output: Research - peer-reviewArticle

Myocarditis
Myeloid Cells
T-Lymphocytes
CTLA-4 Antigen
Autoimmunity
2009
5 Citations

Identification of QTLs that modify peripheral neuropathy in NOD. H2b - Pdcd1-/- mice

Jiang, F., Yoshida, T., Nakaki, F., Terawaki, S., Chikuma, S., Kato, Y., Okazaki, I. M., Honjo, T. & Okazaki, T. 2009 In : International Immunology. 21, 5, p. 499-509 11 p.

Research output: Research - peer-reviewArticle

Quantitative Trait Loci
Peripheral Nervous System Diseases
Phenotype
Sialadenitis
Inbred NOD Mouse
50 Citations

PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo

Chikuma, S., Terawaki, S., Hayashi, T., Nabeshima, R., Yoshida, T., Shibayama, S., Okazaki, T. & Honjo, T. 2009 Jun 1 In : Journal of Immunology. 182, 11, p. 6682-6689 8 p.

Research output: Research - peer-reviewArticle

Interleukin-2
T-Lymphocytes
Theoretical Models
Down-Regulation
Maintenance
25 Citations

The expression of differentiation markers in aquaporin-3 deficient epidermis

Hara-Chikuma, M., Takahashi, K., Chikuma, S., Verkman, A. S. & Miyachi, Y. 2009 Mar In : Archives of Dermatological Research. 301, 3, p. 245-252 8 p.

Research output: Research - peer-reviewArticle

Aquaporin 3
Differentiation Antigens
Keratinocytes
Proteins
Tretinoin
2007
18 Citations

Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease

Chikuma, S. & Bluestone, J. A. 2007 May In : European Journal of Immunology. 37, 5, p. 1285-1289 5 p.

Research output: Research - peer-reviewArticle

Bone Marrow
Disease Attributes
Regulatory T-Lymphocytes
Lymphocytes
T-Lymphocytes
2005
44 Citations

B7-independent inhibition of T cells by CTLA-4

Chikuma, S., Abbas, A. K. & Bluestone, J. A. 2005 Jul 1 In : Journal of Immunology. 175, 1, p. 177-181 5 p.

Research output: Research - peer-reviewArticle

T-Lymphocytes
Ligands
Cell Differentiation
Cell Proliferation
Cytokines
2003
62 Citations

CTLA-4 and Tolerance: The Biochemical Point of View

Chikuma, S. & Bluestone, J. A. 2003 In : Immunologic Research. 28, 3, p. 241-253 13 p.

Research output: Research - peer-reviewArticle

T-Lymphocytes
Immunological Synapses
Lymphocyte Activation
Knockout Mice
Thymus Gland
202 Citations

Impairment of NK cell function by NKG2D modulation in NOD mice

Ogasawara, K., Hamerman, J. A., Hsin, H., Chikuma, S., Bour-Jordan, H., Chen, T., Pertel, T., Carnaud, C., Bluestone, J. A. & Lanier, L. L. 2003 Jan 1 In : Immunity. 18, 1, p. 41-51 11 p.

Research output: Research - peer-reviewArticle

Inbred NOD Mouse
Natural Killer Cells
Ligands
NK Cell Lectin-Like Receptor Subfamily K
1-Phosphatidylinositol 4-Kinase
92 Citations

Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4

Chikuma, S., Imboden, J. B. & Bluestone, J. A. 2003 Jan In : Journal of Experimental Medicine. 197, 1, p. 129-135 7 p.

Research output: Research - peer-reviewArticle

CTLA-4 Antigen
T-Cell Antigen Receptor
Lipids
T-Lymphocytes
Immunological Synapses
2002
13 Citations

CTLA-4: acting at the synapse.

Chikuma, S. & Bluestone, J. A. 2002 Jul In : Molecular Interventions. 2, 4, p. 205-208 4 p.

Research output: Research - peer-reviewArticle

CD28 Antigens
CD Antigens
Differentiation Antigens
T-Cell Antigen Receptor
Synapses
2001
18 Citations

Long-term acceptance of allografts by in vivo gene transfer of regulatable adenovirus vector containing CTLA4IgG and loxP

Takehara, M., Murakami, M., Inobe, M., Tanaka, K., Chikuma, S., Saito, I., Kanegae, Y., Yasunami, Y., Nakano, M., Yamashita, K., Todo, S. & Uede, T. 2001 In : Human Gene Therapy. 12, 4, p. 415-426 12 p.

Research output: Research - peer-reviewArticle

Adenoviridae
Allografts
Genes
Complementary DNA
Serum
31 Citations

Successful gene therapy via intraarticular injection of adenovirus vector containing CTLA4IgG in a murine model of type II collagen-induced arthritis

Ijima, K., Murakami, M., Okamoto, H., Inobe, M., Chikuma, S., Saito, I., Kanegae, Y., Kawaguchi, Y., Kitabatake, A. & Uede, T. 2001 In : Human Gene Therapy. 12, 9, p. 1063-1077 15 p.

Research output: Research - peer-reviewArticle

Intra-Articular Injections
Adenoviridae
Genetic Therapy
Serum
Antigens
2000
87 Citations

Antibodies to different peptides in osteopontin reveal complexities in the various secreted forms

Kon, S., Maeda, M., Segawa, T., Hagiwara, Y., Horikoshi, Y., Chikuma, S., Tanaka, K., Rashid, M. M., Inobe, M., Chambers, A. F. & Uede, T. 2000 In : Journal of Cellular Biochemistry. 77, 3, p. 487-498 12 p.

Research output: Research - peer-reviewArticle

Osteopontin
Peptides
Antibodies
Assays
Enzymes
3 Citations

Involvement of CD28/CTLA4-B7 Costimulatory Pathway in the Development of Lymphadenopathy and Splenomegaly in MRL/lpr Mice

Takiguchi, M., Murakami, M., Nakagawa, I., Rashid, M. M., Tosa, N., Chikuma, S., Hashimoto, A. & Uede, T. 2000 Jan In : Journal of Veterinary Medical Science. 62, 1, p. 29-36 8 p.

Research output: Research - peer-reviewArticle

Inbred MRL lpr Mouse
Splenomegaly
T-Lymphocytes
Lymphadenopathy
splenomegaly
16 Citations
Janus Kinase 2
Cytotoxic T-Lymphocytes
Tyrosine
T-cells
Molecules
1999
28 Citations

Blockade of CD28/CTLA4-B7 pathway prevented autoantibody-related- diseases but not lung disease in MRL/Ipr mice

Takiguchi, M., Murakami, M., Nakagawa, I., Yamada, A., Chikuma, S., Kawaguchi, Y., Hashimoto, A. & Uede, T. 1999 In : Laboratory Investigation. 79, 3, p. 317-326 10 p.

Research output: Research - peer-reviewArticle

Autoantibodies
Lung Diseases
T-Lymphocytes
Therapeutics
Rheumatoid Factor
236 Citations

CD44 variants but not CD44s cooperate with β1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine- aspartic acid, thereby stimulating cell motility and chemotaxis

Katagiri, Y. U., Sleeman, J., Fujii, H., Herrlich, P., Hotta, H., Tanaka, K., Chikuma, S., Yagita, H., Okumura, K., Murakami, M., Saiki, I., Chambers, A. F. & Uede, T. 1999 Jan 1 In : Cancer Research. 59, 1, p. 219-226 8 p.

Research output: Research - peer-reviewArticle

Osteopontin
Chemotaxis
Aspartic Acid
Integrins
Glycine
1998

Blockade of CD28/CTLA4 pathway prevented almost diseases and lymphadenopathy but not lung disease in MRL/lpr mice

Takiguchi, M., Murakami, M., Nakagawa, I., Yamada, A., Chikuma, S. & Uede, T. 1998 Mar 20 In : FASEB Journal. 12, 5

Research output: Research - peer-reviewArticle

Inbred MRL lpr Mouse
Lung Diseases
T-Lymphocytes
Lymphadenopathy
lymphatic diseases
55 Citations

Persistent and secondary adenovirus-mediated hepatic gene expression using adenovirus vector containing CTLA4IgG

Nakagawa, I., Murakami, M., Ijima, K., Chikuma, S., Saito, I., Kanegae, Y., Ishikura, H., Yoshiki, T., Okamoto, H., Kitabatake, A. & Uede, T. 1998 Aug 10 In : Human Gene Therapy. 9, 12, p. 1739-1745 7 p.

Research output: Research - peer-reviewArticle

Adenoviridae
Gene Expression
Liver
Serum
Genes