• 2647 Citations
  • 17 h-Index
20062020

Research output per year

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Research Output

  • 2647 Citations
  • 17 h-Index
  • 33 Article
  • 6 Review article
2020

Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity

Kimura, S., Nakamura, Y., Kobayashi, N., Shiroguchi, K., Kawakami, E., Mutoh, M., Takahashi-Iwanaga, H., Yamada, T., Hisamoto, M., Nakamura, M., Udagawa, N., Sato, S., Kaisho, T., Iwanaga, T. & Hase, K., 2020 Dec 1, In : Nature communications. 11, 1, 234.

Research output: Contribution to journalArticle

Open Access
2019

Airway M Cells arise in the lower airway due to RANKL signaling and reside in the bronchiolar epithelium associated with iBALT in murine models of respiratory disease

Kimura, S., Mutoh, M., Hisamoto, M., Saito, H., Takahashi, S., Asakura, T., Ishii, M., Nakamura, Y., Iida, J., Hase, K. & Iwanaga, T., 2019 Jan 1, In : Frontiers in Immunology. 10, JUN, 1323.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis

Nishida, K., Hasegawa, A., Yamasaki, S., Uchida, R., Ohashi, W., Kurashima, Y., Kunisawa, J., Kimura, S., Iwanaga, T., Watarai, H., Hase, K., Ogura, H., Nakayama, M., Kashiwakura, J. I., Okayama, Y., Kubo, M., Ohara, O., Kiyono, H., Koseki, H., Murakami, M. & 1 others, Hirano, T., 2019 Dec 1, In : Scientific reports. 9, 1, 10842.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Sox8 is essential for M cell maturation to accelerate IgA response at the early stage after weaning in mice

Kimura, S., Kobayashi, N., Nakamura, Y., Kanaya, T., Takahashi, D., Fujiki, R., Mutoh, M., Obata, Y., Iwanaga, T., Nakagawa, T., Kato, N., Sato, S., Kaisho, T., Ohno, H. & Hase, K., 2019 Apr 1, In : The Journal of experimental medicine. 216, 4, p. 831-846 16 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases

Kobayashi, N., Takahashi, D., Takano, S., Kimura, S. & Hase, K., 2019 Oct 9, In : Frontiers in Immunology. 10, 2345.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)
2018

Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling

Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R. & Ohno, H., 2018 Feb 1, In : Journal of Experimental Medicine. 215, 2, p. 501-519 19 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Histochemical characteristics of regressing vessels in the hyaloid vascular system of neonatal mice: Novel implication for vascular atrophy

Kishimoto, A., Kimura, S., Nio-Kobayashi, J., Takahashi-Iwanaga, H., Park, A. M. & Iwanaga, T., 2018 Jul 1, In : Experimental Eye Research. 172, p. 1-9 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Intestinal Lymphatic Endothelial Cells Produce R-Spondin3

Ogasawara, R., Hashimoto, D., Kimura, S., Hayase, E., Ara, T., Takahashi, S., Ohigashi, H., Yoshioka, K., Tateno, T., Yokoyama, E., Ebata, K., Kondo, T., Sugita, J., Onozawa, M., Iwanaga, T. & Teshima, T., 2018 Dec 1, In : Scientific reports. 8, 1, 10719.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
10 Citations (Scopus)
2017

Enhanced gap junction intercellular communication inhibits catabolic and pro-inflammatory responses in tenocytes against heat stress

Maeda, E., Kimura, S., Yamada, M., Tashiro, M. & Ohashi, T., 2017 Dec 1, In : Journal of Cell Communication and Signaling. 11, 4, p. 369-380 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Intrarenal signaling mediated by CCK plays a role in salt intake-induced natriuresis

Takahashi-Iwanaga, H., Kimura, S., Konno, K., Watanabe, M. & Iwanaga, T., 2017 Jan 1, In : American Journal of Physiology - Renal Physiology. 313, 1, p. F20-F29

Research output: Contribution to journalArticle

Tunneling nanotubes and gap junctions–their role in long-range intercellular communication during development, health, and disease conditions

Ariazi, J., Benowitz, A., De Biasi, V., Den Boer, M. L., Cherqui, S., Cui, H., Douillet, N., Eugenin, E. A., Favre, D., Goodman, S., Gousset, K., Hanein, D., Israel, D. I., Kimura, S., Kirkpatrick, R. B., Kuhn, N., Jeong, C., Lou, E., Mailliard, R., Maio, S. & 13 others, Okafo, G., Osswald, M., Pasquier, J., Polak, R., Pradel, G., de Rooij, B., Schaeffer, P., Skeberdis, V. A., Smith, I. F., Tanveer, A., Volkmann, N., Wu, Z. & Zurzolo, C., 2017 Oct 17, In : Frontiers in Molecular Neuroscience. 10, 333.

Research output: Contribution to journalReview article

Open Access
47 Citations (Scopus)
2016

Distinct Roles for the N-and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation

Kimura, S., Yamashita, M., Yamakami-Kimura, M., Sato, Y., Yamagata, A., Kobashigawa, Y., Inagaki, F., Amada, T., Hase, K., Iwanaga, T., Ohno, H. & Fukai, S., 2016 Sep 15, In : Scientific reports. 6, 33548.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Diversity of the intestinal microbiota differently affects non-neuronal and atropine-sensitive ileal contractile responses to short-chain fatty acids in mice

Yajima, M., Karaki, S. I., Tsuruta, T., Kimura, S., Nio-Kobayashi, J., Kuwahara, A. & Yajima, T., 2016 Jan 1, In : Biomedical Research (Japan). 37, 5, p. 319-328 10 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Epithelium-intrinsic MicroRNAs contribute to mucosal immune homeostasis by promoting M-cell maturation

Nakato, G., Hase, K., Sato, T., Kimura, S., Sakakibara, S., Sugiyama, M., Obata, Y., Hanazato, M., Iwanaga, T. & Ohno, H., 2016 Mar 1, In : PLoS One. 11, 3, e0150379.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon

Kaji, I., Akiba, Y., Konno, K., Watanabe, M., Kimura, S., Iwanaga, T., Kuri, A., Iwamoto, K. I., Kuwahara, A. & Kaunitz, J. D., 2016 Jun 15, In : Journal of Physiology. 594, 12, p. 3339-3352 14 p.

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)

Non-neuronal, but atropine-sensitive ileal contractile responses to short-chain fatty acids: Age-dependent desensitization and restoration under inflammatory conditions in mice

Yajima, M., Kimura, S., Karaki, S., Nio-Kobayashi, J., Tsuruta, T., Kuwahara, A., Yajima, T. & Iwanaga, T., 2016 Apr 1, In : Physiological Reports. 4, 7, p. 1-11 11 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Potential role of the formation of tunneling nanotubes in HIV-1 spread in macrophages

Hashimoto, M., Bhuyan, F., Hiyoshi, M., Noyori, O., Nasser, H., Miyazaki, M., Saito, T., Kondoh, Y., Osada, H., Kimura, S., Hase, K., Ohno, H. & Suzu, S., 2016 Feb 15, In : Journal of Immunology. 196, 4, p. 1832-1841 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

RANKL regulates differentiation of microfold cells in mouse nasopharynx-associated lymphoid tissue (NALT)

Mutoh, M., Kimura, S., Takahashi-Iwanaga, H., Hisamoto, M., Iwanaga, T. & Iida, J., 2016 Apr 1, In : Cell and Tissue Research. 364, 1, p. 175-184 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The broad distribution of GP2 in mucous glands and secretory products

Kimura, S., Nio-Kobayashi, J., Kishimoto, A. & Iwanaga, T., 2016 Jan 1, In : Biomedical Research (Japan). 37, 6, p. 351-358 8 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

The selective distribution of LYVE-1-expressing endothelial cells and reticular cells in the reticulo-endothelial system (RES)

Zheng, M., Kimura, S., Nio-Kobayashi, J. & Iwanaga, T., 2016 Jan 1, In : Biomedical Research (Japan). 37, 3, p. 187-198 12 p.

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress

Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irié, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K. & Fukada, T., 2016 Oct 1, In : PLoS Genetics. 12, 10, e1006349.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2015

GP2-expressing cells in the conjunctiva and tear ducts of mice: Identification of a novel type of cells in the squamous stratified epithelium

Kimura, S., Kishimoto, A., Mutoh, M., Takahashi-Iwanaga, H. & Iwanaga, T., 2015 Aug 22, In : Biomedical Research (Japan). 36, 4, p. 263-272 10 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Regulated C-C motif ligand 2 (CCL2) in luteal cells contributes to macrophage infiltration into the human corpus luteum during luteolysis

Nio-Kobayashi, J., Kudo, M., Sakuragi, N., Kimura, S., Iwanaga, T. & Colin Duncan, W., 2015 Mar 10, In : Molecular Human Reproduction. 21, 8, p. 645-654 10 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Visualization of the entire differentiation process of murine M cells: Suppression of their maturation in cecal patches

Kimura, S., Yamakami-Kimura, M., Obata, Y., Hase, K., Kitamura, H., Ohno, H. & Iwanaga, T., 2015 May 8, In : Mucosal Immunology. 8, 3, p. 650-660 11 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2014

A novel type of cells expressing GP2 in the respiratory epithelium of the paranasal sinuses in mice

Kimura, S., Muto, M., Hisamoto, M., Zheng, M. & Iwanaga, T., 2014 Jan 1, In : Biomedical Research (Japan). 35, 5, p. 329-337 9 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues

Obata, Y., Kimura, S., Nakato, G., Iizuka, K., Miyagawa, Y., Nakamura, Y., Furusawa, Y., Sugiyama, M., Suzuki, K., Ebisawa, M., Fujimura, Y., Yoshida, H., Iwanaga, T., Hase, K. & Ohno, H., 2014 Dec 1, In : EMBO Reports. 15, 12, p. 1297-1304 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Three types of macrophagic cells in the mesentery of mice with special reference to LYVE-1-immunoreactive cells

Zheng, M., Kimura, S., Nio-Kobayashi, J., Takahashi-Iwanaga, H. & Iwanaga, T., 2014 Mar 4, In : Biomedical Research (Japan). 35, 1, p. 37-45 9 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)
2013

The molecular basis of induction and formation of tunneling nanotubes

Kimura, S., Hase, K. & Ohno, H., 2013 Apr 1, In : Cell and Tissue Research. 352, 1, p. 67-76 10 p.

Research output: Contribution to journalReview article

33 Citations (Scopus)

Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation

Kitamura, H., Kimura, S., Shimamoto, Y., Okabe, J., Ito, M., Miyamoto, T., Naoe, Y., Kikuguchi, C., Meek, B., Toda, C., Okamoto, S., Kanehira, K., Hase, K., Watarai, H., Ishizuka, M., El-Osta, A., Ohara, O. & Miyoshi, I., 2013 Dec 1, In : FASEB Journal. 27, 12, p. 4940-4953 14 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2012

Tunneling nanotubes: Emerging view of their molecular components and formation mechanisms

Kimura, S., Hase, K. & Ohno, H., 2012 Aug 15, In : Experimental Cell Research. 318, 14, p. 1699-1706 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
2011

The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice

Takahashi, D., Hase, K., Kimura, S., Nakatsu, F., Ohmae, M., Mandai, Y., Sato, T., Date, Y., Ebisawa, M., Kato, T., Obata, Y., Fukuda, S., Kawamura, Y. I., Dohi, T., Katsuno, T., Yokosuka, O., Waguri, S. & Ohno, H., 2011 Aug, In : Gastroenterology. 141, 2, p. 621-632 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2010

M-Sec: Emerging secrets of tunneling nanotube formation

Ohno, H., Hase, K. & Kimura, S., 2010 May 1, In : Communicative and Integrative Biology. 3, 3, p. 231-233 3 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2009

Chapter 1 Monitoring Autophagy in Mammalian Cultured Cells through the Dynamics of LC3

Kimura, S., Fujita, N., Noda, T. & Yoshimori, T., 2009 Feb 9, In : Methods in Enzymology. 451, C, p. 1-12 12 p.

Research output: Contribution to journalReview article

178 Citations (Scopus)

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

Hase, K., Kimura, S., Takatsu, H., Ohmae, M., Kawano, S., Kitamura, H., Ito, M., Watarai, H., Hazelett, C. C., Yeaman, C. & Ohno, H., 2009 Dec 1, In : Nature Cell Biology. 11, 12, p. 1427-1432 6 p.

Research output: Contribution to journalArticle

153 Citations (Scopus)

Uptake through glycoprotein 2 of FimH + bacteria by M cells initiates mucosal immune response

Hase, K., Kawano, K., Nochi, T., Pontes, G. S., Fukuda, S., Ebisawa, M., Kadokura, K., Tobe, T., Fujimura, Y., Kawano, S., Yabashi, A., Waguri, S., Nakato, G., Kimura, S., Murakami, T., Iimura, M., Hamura, K., Fukuoka, S. I., Lowe, A. W., Itoh, K. & 2 others, Kiyono, H. & Ohno, H., 2009 Nov 12, In : Nature. 462, 7270, p. 226-230 5 p.

Research output: Contribution to journalArticle

367 Citations (Scopus)
2008

Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes.

Kimura, S., Noda, T. & Yoshimori, T., 2008, In : Cell structure and function. 33, 1, p. 109-122 14 p.

Research output: Contribution to journalArticle

Open Access
243 Citations (Scopus)
2007

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

Kimura, S., Noda, T. & Yoshimori, T., 2007 Jan 1, In : Autophagy. 3, 5, p. 452-460 9 p.

Research output: Contribution to journalArticle

1225 Citations (Scopus)
2006

Autophagic degradation of unfolding proteins

Kimura, S., Kamimoto, T. & Yoshimori, T., 2006 Aug 1, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.. 51, 10 Suppl, p. 1494-1498 5 p.

Research output: Contribution to journalReview article