• 2242 Citations
  • 28 h-Index
1994 …2020

Research output per year

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Research Output

2010

A small-molecule inhibitor shows that pirin regulates migration of melanoma cells

Miyazaki, I., Simizu, S., Okumura, H., Takagi, S. & Osada, H., 2010 Sep, In : Nature Chemical Biology. 6, 9, p. 667-673 7 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Cleavable linker for photo-cross-linked small-molecule affinity matrix

Kanoh, N., Takayama, H., Honda, K., Moriya, T., Teruya, T., Simizu, S., Osada, H. & Iwabuchi, Y., 2010 Jan 20, In : Bioconjugate Chemistry. 21, 1, p. 182-186 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion

Miyanishi, N., Suzuki, Y., Simizu, S., Kuwabara, Y., Banno, K. & Umezawa, K., 2010 Dec 3, In : Biochemical and Biophysical Research Communications. 403, 1, p. 154-159 6 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

The application of the chemical array for biological study.

Miyazaki, I., Simizu, S. & Osada, H., 2010, In : Methods in molecular biology (Clifton, N.J.). 669, p. 95-107 13 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2009

A cell-based screening to detect inhibitors of BRAF signaling pathway

Asami, Y., Mori, M., Koshino, H., Sekiyama, Y., Teruya, T., Simizu, S., Usui, T. & Osada, H., 2009 Feb 1, In : Journal of Antibiotics. 62, 2, p. 105-107 3 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells

Simizu, S., Teruya, T., Nogawa, T., Aono, H., Ueki, M., Uramoto, M., Kobayashi, Y. & Osada, H., 2009 Jun 12, In : Biochemical and Biophysical Research Communications. 383, 4, p. 406-410 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors

Miyazaki, I., Simizu, S., Ishida, K. & Osada, H., 2009 Mar 23, In : ChemBioChem. 10, 5, p. 838-843 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin-induced apoptosis

Tamura, Y., Simizu, S., Muroi, M., Takagi, S., Kawatani, M., Watanabe, N. & Osada, H., 2009 Jan 8, In : Oncogene. 28, 1, p. 107-116 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Reck negatively regulates matrix metalloproteinase-9 transcription

Takagi, S., Simizu, S. & Osada, H., 2009 Feb 15, In : Cancer Research. 69, 4, p. 1502-1508 7 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Structure-affinity relationship study of bleomycins and shble protein by use of a chemical array

Miyazaki, I., Okumura, H., Simizu, S., Takahashi, Y., Kanoh, N., Muraoka, Y., Nonomura, Y. & Osada, H., 2009 Mar 23, In : ChemBioChem. 10, 5, p. 845-852 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2008

Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase

Lai, N. S., Simizu, S., Morisaki, D., Muroi, M. & Osada, H., 2008 Sep 10, In : Experimental Cell Research. 314, 15, p. 2834-2845 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Robust and systematic drug screening method using chemical arrays and the protein library: Identification of novel inhibitors of carbonic anhydrase II

Miyazaki, I., Simizu, S., Ichimiya, H., Kawatani, M. & Osada, H., 2008 Nov 5, In : Bioscience, Biotechnology and Biochemistry. 72, 10, p. 2739-2749 11 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2007

Involvement of disulfide bond formation in the activation of heparanase

Simizu, S., Suzuki, T., Muroi, M., Ngit, S. L., Takagi, S., Dohmae, N. & Osada, H., 2007 Aug 15, In : Cancer Research. 67, 16, p. 7841-7849 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Synthesis of (+)-vinblastine and its analogues

Miyazaki, T., Yokoshima, S., Simizu, S., Osada, H., Tokuyama, H. & Fukuyama, T., 2007 Nov 8, In : Organic Letters. 9, 23, p. 4737-4740 4 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)
2006

Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions

Kanoh, N., Asami, A., Kawatani, M., Honda, K., Kumashiro, S., Takayama, H., Simizu, S., Amemiya, T., Kondoh, Y., Hatakeyama, S., Tsuganezawa, K., Utata, R., Tanaka, A., Yokoyama, S., Tashiro, H. & Osada, H., 2006 Dec 1, In : Chemistry - An Asian Journal. 1, 6, p. 789-797 9 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2005
3 Citations (Scopus)

Forward and reverse chemical genetics utilizing naturally occurring bioprobes

Kanoh, N., Simizu, S., Usui, T. & Osada, H., 2005 Aug, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 50, 9, p. 1037-1042 6 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells

Teruya, T., Simizu, S., Kanoh, N. & Osada, H., 2005 Apr 25, In : FEBS Letters. 579, 11, p. 2463-2468 6 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics

Kanoh, N., Honda, K., Simizu, S., Muroi, M. & Osada, H., 2005 Jun 6, In : Angewandte Chemie - International Edition. 44, 23, p. 3559-3562 4 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines

Simizu, S., Takagi, S., Tamura, Y. & Osada, H., 2005 Aug 15, In : Cancer Research. 65, 16, p. 7455-7461 7 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2004

Dephosphorylation of Bcl-2 by protein phosphatase 2A results in apoptosis resistance

Simizu, S., Tamura, Y. & Osada, H., 2004 Mar 1, In : Cancer science. 95, 3, p. 266-270 5 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Exploitation of heparanase inhibitors from microbial metabolites. Using an efficient visual screening system

Ishida, K., Teruya, T., Simizu, S. & Osada, H., 2004 Feb, In : Journal of Antibiotics. 57, 2, p. 136-142 7 p.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Heparanase as a molecular target of cancer chemotherapy

Simizu, S., Ishida, K. & Osada, H., 2004 Jul 1, In : Cancer science. 95, 7, p. 553-558 6 p.

Research output: Contribution to journalReview article

64 Citations (Scopus)

Kaurene diterpene induces apoptosis in human leukemia cells partly through a caspase-8-dependent pathway

Kondoh, M., Suzuki, I., Sato, M., Nagashima, F., Simizu, S., Harada, M., Fujii, M., Osada, H., Asakawa, Y. & Watanabe, Y., 2004 Oct 1, In : Journal of Pharmacology and Experimental Therapeutics. 311, 1, p. 115-122 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Novel heparan sulfate mimetic compounds as antitumor agents

Ishida, K., Wierzba, M. K., Teruya, T., Simizu, S. & Osada, H., 2004 Mar 1, In : Chemistry and Biology. 11, 3, p. 367-377 11 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents

Ishida, K., Simizu, S., Teruya, T., Wierzba, M. K. & Osada, H., 2004 May 17, In : Bioorganic and Medicinal Chemistry Letters. 14, 10, p. 2505-2509 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Secretion of Heparanase Protein Is Regulated by Glycosylation in Human Tumor Cell Lines

Simizu, S., Ishida, K., Wierzba, M. K. & Osada, H., 2004 Jan 23, In : Journal of Biological Chemistry. 279, 4, p. 2697-2703 7 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Structure-based design of a selective heparanase inhibitor as an antimetastatic agent

Ishida, K., Hirai, G., Murakami, K., Teruya, T., Simizu, S., Sodeoka, M. & Osada, H., 2004 Sep 1, In : Molecular cancer therapeutics. 3, 9, p. 1069-1077 9 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria

Tamura, Y., Simizu, S. & Osada, H., 2004 Jul 2, In : FEBS Letters. 569, 1-3, p. 249-255 7 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)
2003

Apoptosis-inducing properties of ent-kaurene-type diterpenoids from the liverwort Jungermannia truncata

Nagashima, F., Kondoh, M., Kawase, M., Simizu, S., Osada, H., Fujii, M., Watanabe, Y., Sato, M. & Asakawa, Y., 2003 Apr 1, In : Planta Medica. 69, 4, p. 377-379 3 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Expression of heparanase in human tumor cell lines and human head and neck tumors

Simizu, S., Ishida, K., Wierzba, M. K., Sato, T. A. & Osada, H., 2003 Apr 10, In : Cancer Letters. 193, 1, p. 83-89 7 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Immobilization of Natural Products on Glass Slides by Using a Photoaffinity Reaction and the Detection of Protein-Small-Molecule Interactions

Kanoh, N., Kumashiro, S., Simizu, S., Kondoh, Y., Hatakeyama, S., Tashiro, H. & Osada, H., 2003 Nov 24, In : Angewandte Chemie - International Edition. 42, 45, p. 5584-5587 4 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis

Kawatani, M., Uchi, M., Simizu, S., Osada, H. & Imoto, M., 2003 May 15, In : Experimental Cell Research. 286, 1, p. 57-66 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2000

Bcl-2-independent induction of apoptosis by neuropeptide receptor antagonist in human small cell lung carcinoma cells

Matsumoto, Y., Kawatani, M., Simizu, S., Tanaka, T., Takada, M. & Imoto, M., 2000 Nov 9, In : Anticancer research. 20, 5, p. 3123-3129 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Bcl-2 inhibits calcineurin-mediated Fas ligand expression in antitumor drug-treated baby hamster kidney cells

Simizu, S., Shibasaki, F. & Osada, H., 2000 Jan 1, In : Japanese Journal of Cancer Research. 91, 7, p. 706-714 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Involvement of protein kinase C-regulated ceramide generation in inostamycin-induced apoptosis

Kawatani, M., Simizu, S., Osada, H., Takada, M., Arber, N. & Imoto, M., 2000 Sep 15, In : Experimental Cell Research. 259, 2, p. 389-397 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines

Simizu, S. & Osada, H., 2000 Nov 20, In : Nature Cell Biology. 2, 11, p. 852-854 3 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)
1998

Caspase-3 activation is not responsible for vinblastine-induced Bcl-2 phosphorylation and G2/M arrest in human small cell lung carcinoma Ms-1 cells

Tashiro, E., Simizu, S., Takada, M., Umezawa, K. & Imoto, M., 1998 Sep, In : Japanese Journal of Cancer Research. 89, 9, p. 940-946 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Induction of hydrogen peroxide production and bax expression by caspase- 3(-like) proteases in tyrosine kinase inhibitor-induced apoptosis in human small cell lung carcinoma cells

Simizu, S., Umezawa, K., Takada, M., Arber, N. & Imoto, M., 1998 Jan 10, In : Experimental Cell Research. 238, 1, p. 197-203 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Inhibition of cyclin D1 expression and induction of apoptosis by inostamycin in small cell lung carcinoma cells

Imoto, M., Tanabe, K., Simizu, S., Tashiro, E., Takada, M. & Umezawa, K., 1998 Mar, In : Japanese Journal of Cancer Research. 89, 3, p. 315-322 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Potentiation of paclitaxel cytotoxicity by inostamycin in human small cell lung carcinoma, Ms-1 cells

Simizu, S., Tanabe, K., Tashiro, E., Takada, M., Umezawa, K. & Imoto, M., 1998 Sep, In : Japanese Journal of Cancer Research. 89, 9, p. 970-976 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Requirement of caspase-3(-like) protease-mediated hydrogen peroxide production for apoptosis induced by various anticancer drugs

Simizu, S., Takada, M., Umezawa, K. & Imoto, M., 1998 Oct 9, In : Journal of Biological Chemistry. 273, 41, p. 26900-26907 8 p.

Research output: Contribution to journalArticle

246 Citations (Scopus)
1997

Induction of apoptotic cell death by tyrosine kinase inhibitor

Imoto, M., Simizu, S. & Umezawa, K., 1997 Jan 1, In : nippon nogeikagaku kaishi. 71, 5, p. 523-526 4 p.

Research output: Contribution to journalArticle

Open Access
1996

Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells

Simizu, S., Imoto, M., Masuda, N., Takada, M. & Umezawa, K., 1996 Nov 1, In : Cancer Research. 56, 21, p. 4978-4982 5 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
1994

Induction of Apoptosis by Erbstatin in Mouse Leukemia L1210 Cells

Simizu, S., Imoto, M. & Umezawa, K., 1994, In : Bioscience, biotechnology, and biochemistry. 58, 9, p. 1549-1552 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)