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Research Output 1994 2019

  • 2111 Citations
  • 27 h-Index
  • 88 Article
  • 3 Short survey
  • 1 Letter
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Article
2019
1 Citation (Scopus)

C‑mannosylation of R‑spondin2 activates Wnt/β‑catenin signaling and migration activity in human tumor cells

Mizuta, H., Kuga, K., Suzuki, T., Niwa, Y., Dohmae, N. & Simizu, S., 2019 Jun 1, In : International journal of oncology. 54, 6, p. 2127-2138 12 p.

Research output: Contribution to journalArticle

Catenins
Human Activities
Neoplasms
Wnt Signaling Pathway
Fibrosarcoma

Identification and characterization of collagen-like glycosylation and hydroxylation of CCN1

Ishizawa, Y., Niwa, Y., Suzuki, T., Kawahara, R., Dohmae, N. & Simizu, S., 2019 Sep 20, In : Glycobiology. 29, 10, p. 696-704 9 p.

Research output: Contribution to journalArticle

Glycosylation
Hydroxylation
Collagen
CCN Intercellular Signaling Proteins
Glucosyltransferases

Identification of topoisomerases as molecular targets of cytosporolide C and its analog

Otake, K., Yamada, K., Miura, K., Sasazawa, Y., Miyazaki, S., Niwa, Y., Ogura, A., Takao, K. & Simizu, S., 2019 Jan 1, In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Type II DNA Topoisomerase
Cells
Neoplasms
Biomimetics
1 Citation (Scopus)

Unified Total Synthesis of Madangamine Alkaloids

Suto, T., Yanagita, Y., Nagashima, Y., Takikawa, S., Kurosu, Y., Matsuo, N., Miura, K., Simizu, S., Satou, T. & Chida, N., 2019 Jan 1, In : Bulletin of the Chemical Society of Japan. 92, 3, p. 545-571 27 p.

Research output: Contribution to journalArticle

Alkaloids
Cyclization
Alkylation
Cells
2018
4 Citations (Scopus)

Integrin β1 is an essential factor in vasculogenic mimicry of human cancer cells

Kawahara, R., Niwa, Y. & Simizu, S., 2018 Jan 1, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Integrins
Neoplasms
Clustered Regularly Interspaced Short Palindromic Repeats
Gene Deletion
Seeds
3 Citations (Scopus)

Regulation of granulocyte colony-stimulating factor receptor-mediated granulocytic differentiation by C-mannosylation

Otani, K., Niwa, Y., Suzuki, T., Sato, N., Sasazawa, Y., Dohmae, N. & Simizu, S., 2018 Jan 1, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor Receptors
Myeloid Cells
Cytokine Receptors
Granulocyte Colony-Stimulating Factor
Cell Differentiation
4 Citations (Scopus)

Topological analysis of DPY19L3, a human C-mannosyltransferase

Niwa, Y., Nakano, Y., Suzuki, T., Yamagishi, M., Otani, K., Dohmae, N. & Simizu, S., 2018 Jan 1, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

Mannosyltransferases
Glycosylation
Endoplasmic Reticulum
Luciferases
Computer Simulation
2017
6 Citations (Scopus)

Dpy-19 like 3-mediated C-mannosylation and expression levels of RPE-spondin in human tumor cell lines

Morishita, S., Suzuki, T., Niwa, Y., Dohmae, N. & Simizu, S., 2017, In : Oncology Letters. 14, 2, p. 2537-2544 8 p.

Research output: Contribution to journalArticle

Tumor Cell Line
Colorectal Neoplasms
Mannosyltransferases
Cell Line
Mannose
8 Citations (Scopus)

Regulation of secretion and enzymatic activity of lipoprotein lipase by C-mannosylation

Okamoto, S., Murano, T., Suzuki, T., Uematsu, S., Niwa, Y., Sasazawa, Y., Dohmae, N., Bujo, H. & Simizu, S., 2017 Apr 29, In : Biochemical and Biophysical Research Communications. 486, 2, p. 558-563 6 p.

Research output: Contribution to journalArticle

Lipoprotein Lipase
Hypertriglyceridemia
Lipid Metabolism
Mass spectrometry
Mass Spectrometry
3 Citations (Scopus)

Synthesis and evaluation of biological activities of vibsanin A analogs

Matsuki, W., Miyazaki, S., Yoshida, K., Ogura, A., Sasazawa, Y., Takao, K. & Simizu, S., 2017 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 27, 19, p. 4536-4539 4 p.

Research output: Contribution to journalArticle

Bioactivity
Myeloid Cells
Acute Myeloid Leukemia
Protein Kinase C
Cell Differentiation
3 Citations (Scopus)

Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models

Umezawa, K., Kojima, I., Simizu, S., Lin, Y., Fukatsu, H., Koide, N., Nakade, Y. & Yoneda, M., 2017 Dec 16, (Accepted/In press) In : Human Cell. p. 1-7 7 p.

Research output: Contribution to journalArticle

Metabolic Diseases
Alkaloids
Neurodegenerative Diseases
Autophagy
Huntington Disease
2016
4 Citations (Scopus)

Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters

Katsuyama, S., Sugino, K., Sasazawa, Y., Nakano, Y., Aono, H., Morishita, K., Kawatani, M., Umezawa, K., Osada, H. & Simizu, S., 2016 Apr 1, In : FEBS Letters. 590, 8, p. 1152-1162 11 p.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
Osteoclasts
Osteogenesis
Uridine
Osteoporosis
17 Citations (Scopus)

Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cells

Niwa, Y., Suzuki, T., Dohmae, N. & Simizu, S., 2016 Mar 1, In : Molecular Biology of the Cell. 27, 5, p. 744-756 13 p.

Research output: Contribution to journalArticle

Mannosyltransferases
Mass Spectrometry
Dolichol Phosphates
Wnt Proteins
Proteins
1 Citation (Scopus)

Identification of poly(rC) binding protein 2 (PCBP2) as a target protein of immunosuppressive agent 15-deoxyspergualin

Murahashi, M., Simizu, S., Morioka, M. & Umezawa, K., 2016 May 19, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Immunosuppressive Agents
Carrier Proteins
Proteins
STAT1 Transcription Factor
gusperimus
5 Citations (Scopus)

Identification of seco-clavilactone B as a small-molecule actin polymerization inhibitor

Miyazaki, S., Sasazawa, Y., Mogi, T., Suzuki, T., Yoshida, K., Dohmae, N., Takao, K. & Simizu, S., 2016 Apr 1, In : FEBS Letters. 590, 8, p. 1163-1173 11 p.

Research output: Contribution to journalArticle

Polymerization
Actins
Molecules
Actin Cytoskeleton
clavilactone B
5 Citations (Scopus)

N-glycosylation of R-spondin1 at Asn137 negatively regulates its secretion and Wnt/β-catenin signaling-enhancing activity

Tsuchiya, M., Niwa, Y. & Simizu, S., 2016 May 1, In : Oncology Letters. 11, 5, p. 3279-3286 8 p.

Research output: Contribution to journalArticle

Catenins
Glycosylation
Tunicamycin
Wnt Proteins
Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase
11 Citations (Scopus)

Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells

Kunii, M., Ohara-Imaizumi, M., Takahashi, N., Kobayashi, M., Kawakami, R., Kondoh, Y., Shimizu, T., Simizu, S., Lin, B., Nunomura, K., Aoyagi, K., Ohno, M., Ohmuraya, M., Sato, T., Yoshimura, S. I., Sato, K., Harada, R., Kim, Y. J., Osada, H., Nemoto, T. & 4 others, Kasai, H., Kitamura, T., Nagamatsu, S. & Harada, A., 2016, In : Journal of Cell Biology. 215, 1, 121.

Research output: Contribution to journalArticle

Endocrine Cells
Proteins
Exocrine Pancreas
Secretory Vesicles
Islets of Langerhans
2015
6 Citations (Scopus)
Vinblastine
Caspase 3
Antineoplastic Agents
Chemical activation
Cells
18 Citations (Scopus)

C-mannosylation of thrombopoietin receptor (c-Mpl) regulates thrombopoietin-dependent JAK-STAT signaling

Sasazawa, Y., Sato, N., Suzuki, T., Dohmae, N. & Simizu, S., 2015 Dec 4, In : Biochemical and Biophysical Research Communications. 468, 1-2, p. 262-268 7 p.

Research output: Contribution to journalArticle

Thrombopoietin Receptors
Janus Kinases
Thrombopoietin
Consensus Sequence
Transcription
28 Citations (Scopus)

Conophylline protects cells in cellular models of neurodegenerative diseases by inducing Mammalian target of rapamycin (mTOR)-independent autophagy

Sasazawa, Y., Sato, N., Umezawa, K. & Simizu, S., 2015 Mar 6, In : Journal of Biological Chemistry. 290, 10, p. 6168-6178 11 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Autophagy
Sirolimus
Neurodegenerative Diseases
Huntington Disease
4 Citations (Scopus)

Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages

Iwasaki, A., Ohno, O., Katsuyama, S., Morita, M., Sasazawa, Y., Dan, S., Simizu, S., Yamori, T. & Suenaga, K., 2015 Nov 15, In : Bioorganic and Medicinal Chemistry Letters. 25, 22, p. 5295-5298 4 p.

Research output: Contribution to journalArticle

Sarcoplasmic Reticulum Calcium-Transporting ATPases
Lipopeptides
Acetylene
Macrophages
Assays
6 Citations (Scopus)

Inhibition of MMP-2-mediated mast cell invasion by NF-κB inhibitor DHMEQ in mast cells

Noma, N., Asagiri, M., Takeiri, M., Ohmae, S., Takemoto, K., Iwaisako, K., Minato, N., Maeda-Yamamoto, M., Simizu, S. & Umezawa, K., 2015 May 6, In : International Archives of Allergy and Immunology. 166, 2, p. 84-90 7 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 2
Mast Cells
Antigens
Bone Marrow Cells
Immunoglobulin E
11 Citations (Scopus)

O-fucosylation of CCN1 is required for its secretion

Niwa, Y., Suzuki, T., Dohmae, N. & Simizu, S., 2015 Oct 24, In : FEBS Letters. 589, 21, p. 3287-3293 7 p.

Research output: Contribution to journalArticle

Cysteine-Rich Protein 61
Thrombospondin 1
Mass spectrometry
Mass Spectrometry
Ligands
12 Citations (Scopus)

Pirin regulates epithelial to mesenchymal transition independently of Bcl3-Slug signaling

Komai, K., Niwa, Y., Sasazawa, Y. & Simizu, S., 2015 Mar 12, In : FEBS Letters. 589, 6, p. 738-743 6 p.

Research output: Contribution to journalArticle

Gastropoda
Epithelial-Mesenchymal Transition
Cadherins
Neoplasm Metastasis
HeLa Cells
4 Citations (Scopus)

The mammalian sterile 20-like 1 kinase controls selective CCR7-dependent functions in human dendritic cells

Torres-Bacete, J., Delgado-Martín, C., Gómez-Moreira, C., Simizu, S. & Rodríguez-Fernández, J. L., 2015 Aug 1, In : Journal of Immunology. 195, 3, p. 973-981 9 p.

Research output: Contribution to journalArticle

Dendritic Cells
Phosphotransferases
Chemotaxis
Myosins
Endocytosis
2014
20 Citations (Scopus)

C-mannosylation of human hyaluronidase 1: Possible roles for secretion and enzymatic activity

Goto, Y., Niwa, Y., Suzuki, T., Dohmae, N., Umezawa, K. & Simizu, S., 2014, In : International Journal of Oncology. 45, 1, p. 344-350 7 p.

Research output: Contribution to journalArticle

Hyaluronoglucosaminidase
Hyaluronic Acid
Glycosylation
Catalytic Domain
Proteins
6 Citations (Scopus)

Involvement of conserved tryptophan residues for secretion of TIMP-2

Ukaji, T., Sasazawa, Y., Umezawa, K. & Simizu, S., 2014, In : Oncology Letters. 7, 3, p. 631-634 4 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-2
Tryptophan
Tissue Inhibitor of Metalloproteinases
Endoplasmic Reticulum
Golgi Apparatus
4 Citations (Scopus)

Isolation of a novel paxilline analog pyrapaxilline from fungus that inhibits LPS-induced NO production

Matsui, C., Ikeda, Y., Iinuma, H., Kushida, N., Kunisada, T., Simizu, S. & Umezawa, K., 2014 Nov 1, In : Journal of Antibiotics. 67, 11, p. 787-790 4 p.

Research output: Contribution to journalArticle

Nitric Oxide
Fungi
Eupenicillium
Macrophages
Cell Line
22 Citations (Scopus)

N-glycosylation is required for secretion and enzymatic activity of human hyaluronidase1

Goto, Y., Niwa, Y., Suzuki, T., Uematsu, S., Dohmae, N. & Simizu, S., 2014, In : FEBS Open Bio. 4, p. 554-559 6 p.

Research output: Contribution to journalArticle

Glycosylation
Human Activities
Asparagine
Hyaluronic Acid
Mass spectrometry
11 Citations (Scopus)

N-Glycosylation of extracellular matrix protein 1 (ECM1) regulates its secretion, which is unrelated to lipoid proteinosis

Uematsu, S., Goto, Y., Suzuki, T., Sasazawa, Y., Dohmae, N. & Simizu, S., 2014 Aug 1, In : FEBS Open Bio. 4, p. 879-885 7 p.

Research output: Contribution to journalArticle

Glycosylation
Extracellular Matrix Proteins
Genes
Mutation
Aberrations
2013
8 Citations (Scopus)

Determination of topological structure of ARL6ip1 in cells: Identification of the essential binding region of ARL6ip1 for conophylline

Kuroda, M., Funasaki, S., Saitoh, T., Sasazawa, Y., Nishiyama, S., Umezawa, K. & Simizu, S., 2013 Nov 15, In : FEBS Letters. 587, 22, p. 3656-3660 5 p.

Research output: Contribution to journalArticle

ADP-Ribosylation Factors
Proteins
conophylline
ADP-ribosylation factor 6
Sequence Deletion
5 Citations (Scopus)

Inhibition of NO-induced β-cell death by novel NF-κB inhibitor (-)-DHMEQ via activation of Nrf2-ARE pathway

Ogasawara, A., Simizu, S., Ito, A., Kawai, T., Saisho, Y., Takei, I. & Umezawa, K., 2013 Apr, In : Biochemical and Biophysical Research Communications. 433, 2, p. 181-187 7 p.

Research output: Contribution to journalArticle

Antioxidant Response Elements
Cell death
Nitric Oxide
Cell Death
Chemical activation
8 Citations (Scopus)

Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp.

Arai, Y., Iinuma, H., Ikeda, Y., Igarashi, M., Hatano, M., Kinoshita, N., Ukaji, T., Simizu, S. & Umezawa, K., 2013 Apr, In : Journal of Antibiotics. 66, 4, p. 225-230 6 p.

Research output: Contribution to journalArticle

Streptomyces
Cell Movement
Breast Neoplasms
Neoplasms
Fibrosarcoma
1 Citation (Scopus)

Molecular targets for suppression of metastasis: Recent cellular observations

Simizu, S. & Niwa, Y., 2013, In : Forum on Immunopathological Diseases and Therapeutics. 4, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

Glycosylation
Neoplasm Metastasis
Glycosaminoglycans
Cells
Proteins
2012
26 Citations (Scopus)

Determination of cathepsin v activity and intracellular trafficking by N-glycosylation

Niwa, Y., Suzuki, T., Dohmae, N., Umezawa, K. & Simizu, S., 2012 Oct 19, In : FEBS Letters. 586, 20, p. 3601-3607 7 p.

Research output: Contribution to journalArticle

Glycosylation
Cathepsins
Cysteine Proteases
Site-Directed Mutagenesis
Lysosomes
1 Citation (Scopus)

Inhibition of lysenin-induced hemolysis by All -E -Lutein derived from the plant dalbergia latifolia

Niwa, Y., Matsui, C., Sukumwang, N., Iinuma, H., Ikeda, Y., Koyano, T., Kovitayakorn, T., Simizu, S. & Umezawa, K., 2012, In : Planta Medica. 78, 10, p. 957-961 5 p.

Research output: Contribution to journalArticle

Dalbergia
Lutein
Hemolysis
Porins
Oligochaeta
18 Citations (Scopus)

Involvement of DNA binding domain in the cellular stability and importin affinity of NF-κB component RelB

Takeiri, M., Horie, K., Takahashi, D., Watanabe, M., Horie, R., Simizu, S. & Umezawa, K., 2012 Apr 21, In : Organic and Biomolecular Chemistry. 10, 15, p. 3053-3059 7 p.

Research output: Contribution to journalArticle

Karyopherins
affinity
deoxyribonucleic acid
DNA
proteins
13 Citations (Scopus)

Involvement of NF-κB-mediated expression of galectin-3- binding protein in TNF-α-induced breast cancer cell adhesion

Noma, N., Simizu, S., Kambayashi, Y., Kabe, Y., Suematsu, M. & Umezawa, K., 2012 Jun, In : Oncology Reports. 27, 6, p. 2080-2084 5 p.

Research output: Contribution to journalArticle

Galectin 3
Cell Adhesion
Carrier Proteins
Breast Neoplasms
Neoplasms
17 Citations (Scopus)

Protein disulfide isomerase-mediated disulfide bonds regulate the gelatinolytic activity and secretion of matrix metalloproteinase-9

Khan, M. M. G., Simizu, S., Suzuki, T., Masuda, A., Kawatani, M., Muroi, M., Dohmae, N. & Osada, H., 2012 May 1, In : Experimental Cell Research. 318, 8, p. 904-914 11 p.

Research output: Contribution to journalArticle

Protein Disulfide-Isomerases
Matrix Metalloproteinase 9
Disulfides
Hemopexin
Cysteine
29 Citations (Scopus)

Suppression of cellular invasion by glybenclamide through inhibited secretion of platelet-derived growth factor in ovarian clear cell carcinoma ES-2 cells

Yasukagawa, T., Niwa, Y., Simizu, S. & Umezawa, K., 2012 May 21, In : FEBS Letters. 586, 10, p. 1504-1509 6 p.

Research output: Contribution to journalArticle

Glyburide
Platelet-Derived Growth Factor
Ovarian Neoplasms
Cells
Carcinoma
13 Citations (Scopus)

The potential of protein disulfide isomerase as a therapeutic drug target

Khan, M. M. G., Simizu, S., Kawatani, M. & Osada, H., 2012, In : Oncology Research. 19, 10-11, p. 445-453 9 p.

Research output: Contribution to journalArticle

Protein Disulfide-Isomerases
Pharmaceutical Preparations
Endoplasmic Reticulum
Therapeutics
Protein Folding
2011
16 Citations (Scopus)

Development of a Vaccinia H1-Related (VHR) Phosphatase Inhibitor with a Nonacidic Phosphate-Mimicking Core Structure

Hirai, G., Tsuchiya, A., Koyama, Y., Otani, Y., Oonuma, K., Dodo, K., Simizu, S., Osada, H. & Sodeoka, M., 2011 Apr 4, In : ChemMedChem. 6, 4, p. 617-622 6 p.

Research output: Contribution to journalArticle

Dual-Specificity Phosphatases
Cultured Tumor Cells
Molecular Mimicry
Vaccinia
NIH 3T3 Cells
36 Citations (Scopus)

Discovery of a Small Molecule PDI Inhibitor That Inhibits Reduction of HIV-1 Envelope Glycoprotein gp120

Khan, M. M. G., Simizu, S., Lai, N. S., Kawatani, M., Shimizu, T. & Osada, H., 2011 Mar 18, In : ACS Chemical Biology. 6, 3, p. 245-251 7 p.

Research output: Contribution to journalArticle

HIV Envelope Protein gp120
Protein Disulfide-Isomerases
HIV-1
Glycoproteins
Molecules
2010
52 Citations (Scopus)

A small-molecule inhibitor shows that pirin regulates migration of melanoma cells

Miyazaki, I., Simizu, S., Okumura, H., Takagi, S. & Osada, H., 2010 Sep, In : Nature Chemical Biology. 6, 9, p. 667-673 7 p.

Research output: Contribution to journalArticle

Cell Movement
Melanoma
Nuclear Proteins
Proteins
21 Citations (Scopus)

Cleavable linker for photo-cross-linked small-molecule affinity matrix

Kanoh, N., Takayama, H., Honda, K., Moriya, T., Teruya, T., Simizu, S., Osada, H. & Iwabuchi, Y., 2010 Jan 20, In : Bioconjugate Chemistry. 21, 1, p. 182-186 5 p.

Research output: Contribution to journalArticle

Molecules
Proteins
carbene
34 Citations (Scopus)

Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion

Miyanishi, N., Suzuki, Y., Simizu, S., Kuwabara, Y., Banno, K. & Umezawa, K., 2010 Dec 3, In : Biochemical and Biophysical Research Communications. 403, 1, p. 154-159 6 p.

Research output: Contribution to journalArticle

Neutralizing Antibodies
Matrix Metalloproteinases
Small Interfering RNA
Cells
Carcinoma
5 Citations (Scopus)

The application of the chemical array for biological study.

Miyazaki, I., Simizu, S. & Osada, H., 2010, In : Methods in molecular biology (Clifton, N.J.). 669, p. 95-107 13 p.

Research output: Contribution to journalArticle

Proteins
Ligands
Gene Library
Carbonic Anhydrase II
Biological Phenomena
2009
2 Citations (Scopus)

A cell-based screening to detect inhibitors of BRAF signaling pathway

Asami, Y., Mori, M., Koshino, H., Sekiyama, Y., Teruya, T., Simizu, S., Usui, T. & Osada, H., 2009 Feb, In : Journal of Antibiotics. 62, 2, p. 105-107 3 p.

Research output: Contribution to journalArticle

Antitumor Drug Screening Assays
Proto-Oncogene Proteins B-raf
Antineoplastic Antibiotics
Cyclic Peptides
Experimental Melanomas
5 Citations (Scopus)

Deamino-hydroxy-phoslactomycin B, a biosynthetic precursor of phoslactomycin, induces myeloid differentiation in HL-60 cells

Simizu, S., Teruya, T., Nogawa, T., Aono, H., Ueki, M., Uramoto, M., Kobayashi, Y. & Osada, H., 2009 Jun 12, In : Biochemical and Biophysical Research Communications. 383, 4, p. 406-410 5 p.

Research output: Contribution to journalArticle

HL-60 Cells
Protein Phosphatase 2
Okadaic Acid
Retinoic Acid Receptors
Streptomyces
6 Citations (Scopus)

On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors

Miyazaki, I., Simizu, S., Ishida, K. & Osada, H., 2009 Mar 23, In : ChemBioChem. 10, 5, p. 838-843 6 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Protein 1A
Photochemistry
Protein Array Analysis
Peptide Fragments
Photochemical reactions