• 1697 Citations
  • 16 h-Index
20032019
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Research Output 2003 2019

  • 1697 Citations
  • 16 h-Index
  • 20 Article
  • 2 Review article
  • 1 Short survey
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Article
2019
2 Citations (Scopus)

Methylene blue inhibits formation of tau fibrils but not of granular tau oligomers: A plausible key to understanding failure of a clinical trial for Alzheimer's disease

Soeda, Y., Saito, M., Maeda, S., Ishida, K., Nakamura, A., Kojima, S. & Takashima, A., 2019 Jan 1, In : Journal of Alzheimer's Disease. 68, 4, p. 1677-1686 10 p.

Research output: Contribution to journalArticle

Methylene Blue
Alzheimer Disease
Clinical Trials
Phase III Clinical Trials
Tauopathies

Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs

Nakamura, M., Shiozawa, S., Tsuboi, D., Amano, M., Watanabe, H., Maeda, S., Kimura, T., Yoshimatsu, S., Kisa, F., Karch, C. M., Miyasaka, T., Takashima, A., Sahara, N., Hisanaga, S. I., Ikeuchi, T., Kaibuchi, K. & Okano, H., 2019 Oct 8, In : Stem cell reports. 13, 4, p. 684-699 16 p.

Research output: Contribution to journalArticle

Open Access
tau Proteins
Frontotemporal Dementia
Pathology
Neurons
Clustered Regularly Interspaced Short Palindromic Repeats
2018
2 Citations (Scopus)

Frontotemporal dementia with Parkinsonism linked to chromosome-17 mutations enhance tau oligomer formation

Maeda, S., Sato, Y. & Takashima, A., 2018 Sep 1, In : Neurobiology of Aging. 69, p. 26-32 7 p.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Chromosomes, Human, Pair 17
Mutation
tau Proteins
Microtubule-Associated Proteins
4 Citations (Scopus)

Neuronal levels and sequence of tau modulate the power of brain rhythms

Das, M., Maeda, S., Hu, B., Yu, G. Q., Guo, W., Lopez, I., Yu, X., Tai, C., Wang, X. & Mucke, L., 2018 Sep 1, In : Neurobiology of Disease. 117, p. 181-188 8 p.

Research output: Contribution to journalArticle

etiracetam
Brain
Alzheimer Disease
Transgenic Mice
Tauopathies
2016
43 Citations (Scopus)

Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice

Maeda, S., Djukic, B., Taneja, P., Yu, G. Q., Lo, I., Davis, A., Craft, R., Guo, W., Wang, X., Kim, D., Ponnusamy, R., Gill, T. M., Masliah, E. & Mucke, L., 2016 Apr 1, In : EMBO Reports. 17, 4, p. 530-551 22 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Transgenic Mice
Neurodegenerative diseases
Metabolites
Amyloid
2015
174 Citations (Scopus)

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

Morris, M., Knudsen, G. M., Maeda, S., Trinidad, J. C., Ioanoviciu, A., Burlingame, A. L. & Mucke, L., 2015 Aug 30, In : Nature Neuroscience. 18, 8, p. 1183-1189 7 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Post Translational Protein Processing
Transgenic Mice
Lysine
Alzheimer Disease
34 Citations (Scopus)

Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups

Soeda, Y., Yoshikawa, M., Almeida, O. F. X., Sumioka, A., Maeda, S., Osada, H., Kondoh, Y., Saito, A., Miyasaka, T., Kimura, T., Suzuki, M., Koyama, H., Yoshiike, Y., Sugimoto, H., Ihara, Y. & Takashima, A., 2015 Dec 16, In : Nature Communications. 6, 10216.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Poisons
cysteine
oligomers
Oligomers
2012
9 Citations (Scopus)

Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes

Yoshiike, Y., Yamashita, S., Mizoroki, T., Maeda, S., Murayama, M., Kimura, T., Sahara, N., Soeda, Y. & Takashima, A., 2012 Feb, In : Aging Cell. 11, 1, p. 51-62 12 p.

Research output: Contribution to journalArticle

Tauopathies
Alloxan
Oxidative Stress
Phenotype
JNK Mitogen-Activated Protein Kinases
68 Citations (Scopus)

Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive Deficits

Harris, J. A., Koyama, A., Maeda, S., Ho, K., Devidze, N., Dubal, D. B., Yu, G. Q., Masliah, E. & Mucke, L., 2012 Sep 24, In : PLoS One. 7, 9, e45881.

Research output: Contribution to journalArticle

Entorhinal Cortex
Pathology
Neurons
cortex
Agglomeration
2010
53 Citations (Scopus)

Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss

Kimura, T., Fukuda, T., Sahara, N., Yamashita, S., Murayama, M., Mizoroki, T., Yoshiike, Y., Lee, B., Sotiropoulos, I., Maeda, S. & Takashima, A., 2010 Dec 3, In : Journal of Biological Chemistry. 285, 49, p. 38692-38699 8 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Detergents
Agglomeration
Memory Disorders
Neurodegenerative Diseases
2009
68 Citations (Scopus)

A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid β proteins in vitro and in vivo

Fujiwara, H., Tabuchi, M., Yamaguchi, T., Iwasaki, K., Furukawa, K., Sekiguchi, K., Ikarashi, Y., Kudo, Y., Higuchi, M., Saido, T. C., Maeda, S., Takashima, A., Hara, M., Yaegashi, N., Kase, Y. & Arai, H., 2009 Jun, In : Journal of Neurochemistry. 109, 6, p. 1648-1657 10 p.

Research output: Contribution to journalArticle

Paeonia
Amyloidogenic Proteins
Rubiaceae
Medicinal Plants
Agglomeration
2007
56 Citations (Scopus)

A ganglioside-induced toxic soluble Aβ assembly: Its enhanced formation from Aβ bearing the arctic mutation

Yamamoto, N., Matsubara, E., Maeda, S., Minagawa, H., Takashima, A., Maruyama, W., Michikawa, M. & Yanagisawa, K., 2007 Jan 26, In : Journal of Biological Chemistry. 282, 4, p. 2646-2655 10 p.

Research output: Contribution to journalArticle

Bearings (structural)
Gangliosides
Poisons
G(M1) Ganglioside
Alzheimer Disease
45 Citations (Scopus)

Aluminum induces tau aggregation in vitro but not in vivo

Mizoroki, T., Meshitsuka, S., Maeda, S., Murayama, M., Sahara, N. & Takashima, A., 2007, In : Journal of Alzheimer's Disease. 11, 4, p. 419-427 9 p.

Research output: Contribution to journalArticle

Aluminum
Alzheimer Disease
Neurofibrillary Tangles
In Vitro Techniques
Cell Line
106 Citations (Scopus)

Assembly of two distinct dimers and higher-order oligomers from full-length tau

Sahara, N., Maeda, S., Murayama, M., Suzuki, T., Dohmae, N., Yen, S. H. & Takashima, A., 2007 May, In : European Journal of Neuroscience. 25, 10, p. 3020-3029 10 p.

Research output: Contribution to journalArticle

Cysteine
COS Cells
Tauopathies
Microtubules
Disulfides
173 Citations (Scopus)

Granular tau oligomers as intermediates of tau filaments

Maeda, S., Sahara, N., Saito, Y., Murayama, M., Yoshiike, Y., Kim, H., Miyasaka, T., Murayama, S., Ikai, A. & Takashima, A., 2007 Mar 27, In : Biochemistry. 46, 12, p. 3856-3861 6 p.

Research output: Contribution to journalArticle

Tauopathies
Neurofibrillary Tangles
Intermediate Filaments
Oligomers
Alzheimer Disease
56 Citations (Scopus)

Molecular chaperone-mediated tau protein metabolism counteracts the formation of granular tau oligomers in human brain

Sahara, N., Maeda, S., Yoshiike, Y., Mizoroki, T., Yamashita, S., Murayama, M., Park, J. M., Saito, Y., Murayama, S. & Takashima, A., 2007 Nov 1, In : Journal of Neuroscience Research. 85, 14, p. 3098-3108 11 p.

Research output: Contribution to journalArticle

Tauopathies
tau Proteins
Molecular Chaperones
Neurofibrillary Tangles
Heat-Shock Proteins
6 Citations (Scopus)

Novel conformation-sensitive antibodies specific to three- and four-repeat tau

Ueno, H., Murayama, O., Maeda, S., Sahara, N., Park, J. M., Murayama, M., Sanda, A., Iwahashi, K., Matsuda, M. & Takashima, A., 2007 Jun 29, In : Biochemical and Biophysical Research Communications. 358, 2, p. 602-607 6 p.

Research output: Contribution to journalArticle

Conformations
Protein Isoforms
Antibodies
Tauopathies
Antigens
2006
171 Citations (Scopus)

Increased levels of granular tau oligomers: An early sign of brain aging and Alzheimer's disease

Maeda, S., Sahara, N., Saito, Y., Murayama, S., Ikai, A. & Takashima, A., 2006 Mar, In : Neuroscience Research. 54, 3, p. 197-201 5 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Brain Diseases
Alzheimer Disease
Frontal Lobe
Neurodegenerative Diseases
73 Citations (Scopus)

Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's β-amyloid proteins

Fujiwara, H., Iwasaki, K., Furukawa, K., Seki, T., He, M., Maruyama, M., Tomita, N., Kudo, Y., Higuchi, M., Saido, T. C., Maeda, S., Takashima, A., Hara, M., Ohizumi, Y. & Arai, H., 2006 Aug 1, In : Journal of Neuroscience Research. 84, 2, p. 427-433 7 p.

Research output: Contribution to journalArticle

Uncaria
Amyloidogenic Proteins
Medicinal Plants
Alzheimer Disease
Serum Amyloid A Protein
2003
19 Citations (Scopus)

Frequency shift feedback imaging in liquid for biological molecules

Sekiguchi, H., Okajima, T., Arakawa, H., Maeda, S., Takashima, A. & Ikai, A., 2003 Mar 31, In : Applied Surface Science. 210, 1-2 SPEC., p. 61-67 7 p.

Research output: Contribution to journalArticle

frequency shift
proteins
Proteins
Feedback
Imaging techniques