• 2797 Citations
  • 31 h-Index
1983 …2020

Research output per year

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Research Output

  • 2797 Citations
  • 31 h-Index
  • 97 Article
  • 3 Review article
  • 1 Chapter
  • 1 Conference contribution
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Article
2020

Inhibitors of the protein–protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line

Yasuda, D., Ohe, T., Takahashi, K., Imamura, R., Kojima, H., Okabe, T., Ichimura, Y., Komatsu, M., Yamamoto, M., Nagano, T. & Mashino, T., 2020 Jan 1, (Accepted/In press) In : Free Radical Research.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine

Tateishi, Y., Ohe, T., Yasuda, D., Takahashi, K., Nakamura, S., Kazuki, Y. & Mashino, T., 2020 Apr, In : Drug Metabolism And Pharmacokinetics. 35, 2, p. 238-243 6 p.

Research output: Contribution to journalArticle

2019

N-Acetyl cysteine prevents activities of STAT3 inhibitors, Stattic and BP-1-102 independently of its antioxidant properties

Uchihara, Y., Ohe, T., Mashino, T., Kidokoro, T., Tago, K., Tamura, H. & Funakoshi-Tago, M., 2019 Dec, In : Pharmacological Reports. 71, 6, p. 1067-1078 12 p.

Research output: Contribution to journalArticle

Synthesis and antitumor activity of novel pyridinium fullerene derivatives

Yasuno, T., Ohe, T., Ikeda, H., Takahashi, K., Nakamura, S. & Mashino, T., 2019 Jan 1, In : International journal of nanomedicine. 14, p. 6325-6337 13 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2018

A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis

Niino, T., Tago, K., Yasuda, D., Takahashi, K., Mashino, T., Tamura, H. & Tago, M., 2018 Sep 1, In : Biochemical Pharmacology. 155, p. 182-197 16 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

A major component of vitamin E, α-tocopherol inhibits the anti-tumor activity of crizotinib against cells transformed by EML4-ALK

Uchihara, Y., Kidokoro, T., Tago, K., Mashino, T., Tamura, H. & Tago, M., 2018 Apr 15, In : European Journal of Pharmacology. 825, p. 1-9 9 p.

Research output: Contribution to journalArticle

Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation

Ohe, T., Umezawa, R., Kitagawara, Y., Yasuda, D., Takahashi, K., Nakamura, S., Abe, A., Sekine, S., Ito, K., Okunushi, K., Morio, H., Furihata, T., Anzai, N. & Mashino, T., 2018 Jan 1, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

Alpha-tocopherol attenuates the anti-tumor activity of crizotinib against cells transformed by NPM-ALK

Uchihara, Y., Ueda, F., Tago, K., Nakazawa, Y., Ohe, T., Mashino, T., Yokota, S., Kasahara, T., Tamura, H. & Funakoshi-Tago, M., 2017 Aug 1, In : PLoS One. 12, 8, e0183003.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor

Yasuda, D., Yuasa, A., Obata, R., Nakajima, M., Takahashi, K., Ohe, T., Ichimura, Y., Komatsu, M., Yamamoto, M., Imamura, R., Kojima, H., Okabe, T., Nagano, T. & Mashino, T., 2017 Nov 15, In : Bioorganic and Medicinal Chemistry Letters. 27, 22, p. 5006-5009 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2016

A bis-malonic acid fullerene derivative significantly suppressed IL-33-induced IL-6 expression by inhibiting NF-κB activation

Funakoshi-Tago, M., Miyagawa, Y., Ueda, F., Mashino, T., Moriwaki, Y., Tago, K., Kasahara, T. & Tamura, H., 2016 Nov 1, In : International Immunopharmacology. 40, p. 254-264 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A proline-type fullerene derivative inhibits adipogenesis by preventing PPARγ activation

Funakoshi-Tago, M., Hattori, T., Ueda, F., Tago, K., Ohe, T., Mashino, T. & Tamura, H., 2016 Mar 1, In : Biochemistry and Biophysics Reports. 5, p. 259-265 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Novel fullerene derivatives as dual inhibitors of Hepatitis C virus NS5B polymerase and NS3/4A protease

Kataoka, H., Ohe, T., Takahashi, K., Nakamura, S. & Mashino, T., 2016 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 26, 19, p. 4565-4567 3 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

P62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., Ohishi, M., Endo, K., Uemura, T., Nishito, Y., Okuda, S., Obata, M., Kouno, T., Imamura, R., Tada, Y., Obata, R. & 18 others, Yasuda, D., Takahashi, K., Fujimura, T., Pi, J., Lee, M. S., Ueno, T., Ohe, T., Mashino, T., Wakai, T., Kojima, H., Okabe, T., Nagano, T., Motohashi, H., Waguri, S., Soga, T., Yamamoto, M., Tanaka, K. & Komatsu, M., 2016 Jun 27, In : Nature Communications. 7, 12030.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Potential Suppressive Effects of Two C60 Fullerene Derivatives on Acquired Immunity

Hirai, T., Yoshioka, Y., Udaka, A., Uemura, E., Ohe, T., Aoshima, H., Gao, J. Q., Kokubo, K., Oshima, T., Nagano, K., Higashisaka, K., Mashino, T. & Tsutsumi, Y., 2016 Dec 1, In : Nanoscale Research Letters. 11, 1, 449.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Preparation and antioxidant/pro-oxidant activities of 3-monosubstituted 5-hydroxyoxindole derivatives

Yasuda, D., Takahashi, K., Ohe, T., Nakamura, S. & Mashino, T., 2016 Jan 1, In : Journal of Clinical Biochemistry and Nutrition. 59, 3, p. 165-173 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity

Yasuda, D., Nakajima, M., Yuasa, A., Obata, R., Takahashi, K., Ohe, T., Ichimura, Y., Komatsu, M., Yamamoto, M., Imamura, R., Kojima, H., Okabe, T., Nagano, T. & Mashino, T., 2016 Dec 15, In : Bioorganic and Medicinal Chemistry Letters. 26, 24, p. 5956-5959 4 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2015

Novel bioactivation pathway of benzbromarone mediated by cytochrome P450

Kitagawara, Y., Ohe, T., Tachibana, K., Takahashi, K., Nakamura, S. & Mashino, T., 2015 Sep 1, In : Drug Metabolism and Disposition. 43, 9, p. 1303-1306 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The human immunodeficiency virus-reverse transcriptase inhibition activity of novel pyridine/pyridinium-type fullerene derivatives

Yasuno, T., Ohe, T., Takahashi, K., Nakamura, S. & Mashino, T., 2015 Jul 3, In : Bioorganic and Medicinal Chemistry Letters. 25, 16, p. 3226-3229 4 p., 22776.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2014

Effect of chemical modification on the ability of pyrrolidinium fullerene to induce apoptosis of cells transformed by JAK2 V617F mutant

Funakoshi-Tago, M., Tsukada, M., Watanabe, T., Mameda, Y., Tago, K., Ohe, T., Nakamura, S., Mashino, T. & Kasahara, T., 2014 May, In : International Immunopharmacology. 20, 1, p. 258-263 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma

Watanabe, T., Nakamura, S., Ono, T., Ui, S., Yagi, S., Kagawa, H., Watanabe, H., Ohe, T., Mashino, T. & Fujimuro, M., 2014 Aug 15, In : Biochemical and Biophysical Research Communications. 451, 1, p. 93-100 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2013

Anti-Influenza Activity of C60 Fullerene Derivatives

Shoji, M., Takahashi, E., Hatakeyama, D., Iwai, Y., Morita, Y., Shirayama, R., Echigo, N., Kido, H., Nakamura, S., Mashino, T., Okutani, T. & Kuzuhara, T., 2013 Jun 13, In : PloS one. 8, 6, e66337.

Research output: Contribution to journalArticle

41 Citations (Scopus)
11 Citations (Scopus)

Synthesis, radical scavenging activity and structure-activity relationship of uric acid analogs

Yasuda, D., Takahashi, K., Kakinoki, T., Tanaka, Y., Ohe, T., Nakamura, S. & Mashino, T., 2013 Mar 1, In : MedChemComm. 4, 3, p. 527-529 3 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2012

Fullerene derivative prevents cellular transformation induced by JAK2 V617F mutant through inhibiting c-Jun N-terminal kinase pathway

Funakoshi-Tago, M., Nagata, T., Tago, K., Tsukada, M., Tanaka, K., Nakamura, S., Mashino, T. & Kasahara, T., 2012 Nov 1, In : Cellular Signalling. 24, 11, p. 2024-2034 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Impairment of heme biosynthesis induces short circadian period in body temperature rhythms in mice

Iwadate, R., Satoh, Y., Watanabe, Y., Kawai, H., Kudo, N., Kawashima, Y., Mashino, T. & Mitsumoto, A., 2012 Jul 1, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 303, 1, p. R8-R18

Research output: Contribution to journalArticle

5 Citations (Scopus)
2011

Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin

Funakoshi-Tago, M., Nakamura, K., Tago, K., Mashino, T. & Kasahara, T., 2011 Sep 1, In : International Immunopharmacology. 11, 9, p. 1150-1159 10 p.

Research output: Contribution to journalArticle

143 Citations (Scopus)

Ipso substitution of bisphenol A catalyzed by microsomal cytochrome P450 and enhancement of estrogenic activity

Nakamura, S., Tezuka, Y., Ushiyama, A., Kawashima, C., Kitagawara, Y., Takahashi, K., Ohta, S. & Mashino, T., 2011 May 30, In : Toxicology Letters. 203, 1, p. 92-95 4 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Isolation and structural identification of a direct-acting mutagen derived from N-nitroso-N-methylpentylamine and Fenton's reagent with copper ion

Miura, M., Inami, K., Yoshida, M., Yamaguchi, K., Mashino, T. & Mochizuki, M., 2011 Sep 15, In : Bioorganic and Medicinal Chemistry. 19, 18, p. 5693-5697 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2010

Biological safety of water-soluble fullerenes evaluated using tests for genotoxicity, phototoxicity, and pro-oxidant activity

Aoshima, H., Yamana, S., Nakamura, S. & Mashino, T., 2010, In : Journal of Toxicological Sciences. 35, 3, p. 401-409 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

The fixed structure of Licochalcone A by α, β-unsaturated ketone is necessary for anti-inflammatory activity through the inhibition of NF-κB activation

Funakoshi-Tago, M., Nakamura, K., Tsuruya, R., Hatanaka, M., Mashino, T., Sonoda, Y. & Kasahara, T., 2010 May 1, In : International Immunopharmacology. 10, 5, p. 562-571 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2009

Biological activities of water-soluble fullerene derivatives

Nakamura, S. & Mashino, T., 2009 Jan 1, In : Journal of Physics: Conference Series. 159, 012003.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Fullerene nanowhiskers and related fullerene nanomaterials

Miyazawa, K., Kato, R., Saito, K., Kizuka, T., Mashino, T. & Nakamura, S., 2009 Jan 1, In : Journal of Physics: Conference Series. 159, 012007.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-κB p65 in LPS signaling pathway

Furusawa, J. I., Funakoshi-Tago, M., Mashino, T., Tago, K., Inoue, H., Sonoda, Y. & Kasahara, T., 2009 Apr 1, In : International Immunopharmacology. 9, 4, p. 499-507 9 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

In vitro free radical scavenging activity of platinum nanoparticles

Watanabe, A., Kajita, M., Kim, J., Kanayama, A., Takahashi, K., Mashino, T. & Miyamoto, Y., 2009 Nov 9, In : Nanotechnology. 20, 45, 455105.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Licochalcone A potently inhibits tumor necrosis factor α-induced nuclear factor-κB activation through the direct inhibition of IκB kinase complex activation

Funakoshi-Tago, M., Tanabe, S., Tago, K., Itoh, H., Mashino, T., Sonoda, Y. & Kasahara, T., 2009 Oct 1, In : Molecular Pharmacology. 76, 4, p. 745-753 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-κB p65 phosphorylation at serine 276

Furusawa, J. I., Funakoshi-Tago, M., Tago, K., Mashino, T., Inoue, H., Sonoda, Y. & Kasahara, T., 2009 May 1, In : Cellular Signalling. 21, 5, p. 778-785 8 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Pyrrolidinium-type fullerene derivative-induced apoptosis by the generation of reactive oxygen species in HL-60 cells

Nishizawa, C., Hashimoto, N., Yokoo, S., Funakoshi-Tago, M., Kasahara, T., Takahashi, K., Nakamura, S. & Mashino, T., 2009, In : Free Radical Research. 43, 12, p. 1240-1247 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2008

2,2′-Pyridoin derivatives protect HL-60 cells against oxidative stress

Hatanaka, M., Nishizawa, C., Kakinoki, T., Takahashi, K., Nakamura, S. & Mashino, T., 2008 Oct 1, In : Bioorganic and Medicinal Chemistry Letters. 18, 19, p. 5290-5293 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

C60 nanowhisker field-effect-transistor application for nano-electronics

Ogawa, K. I., Aoki, N., Miyazawa, K., Nakamura, S., Mashino, T., Bird, J. P. & Ochiai, Y., 2008 Jan 22, In : Japanese journal of applied physics. 47, 1 PART 2, p. 501-504 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Licochalcone A is a potent inhibitor of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation

Funakoshi-Tago, M., Tago, K., Nishizawa, C., Takahashi, K., Mashino, T., Iwata, S., Inoue, H., Sonoda, Y. & Kasahara, T., 2008 Dec 15, In : Biochemical Pharmacology. 76, 12, p. 1681-1693 13 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2007

DMPO-OH radical formation from 5,5-dimethyl-1-pyrroline N-oxide (DMPO) in hot water

Shoji, T., Li, L., Abe, Y., Ogata, M., Ishimoto, Y., Gonda, R., Mashino, T., Mochizuki, M., Uemoto, M. & Miyata, N., 2007 Feb, In : Analytical Sciences. 23, 2, p. 219-221 3 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Iron-chelating agents never suppress Fenton reaction but participate in quenching spin-trapped radicals

Li, L., Abe, Y., Kanagawa, K., Shoji, T., Mashino, T., Mochizuki, M., Tanaka, M. & Miyata, N., 2007 Sep 19, In : Analytica Chimica Acta. 599, 2, p. 315-319 5 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Novel metabolic pathways of p-n-nonylphenol catalyzed by cytochrome P450 and estrogen receptor binding activity of new metabolites

Tezuka, Y., Takahashi, K., Suzuki, T., Kitamura, S., Ohta, S., Nakamura, S. & Mashino, T., 2007 Oct 1, In : Journal of Health Science. 53, 5, p. 552-561 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid

Ogata, M., Oka, K., Seki, M., Hoshi, M., Takatsu, H., Mashino, T., Urano, S. & Endo, T., 2007 Aug 1, In : Biological and Pharmaceutical Bulletin. 30, 8, p. 1565-1568 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2006

Metabolic conversion of 24-methyl-Δ25-cholesterol to 24-methylcholesterol in higher plants

Takahashi, K., Nasu, K., Mashino, T., Morisaki, M., Hara, N. & Fujimoto, Y., 2006 Feb 1, In : Bioorganic and Medicinal Chemistry. 14, 3, p. 732-738 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Structural characterization of room-temperature synthesized fullerene nanowhiskers

Miyazawa, K., Minato, J. I., Mashino, T., Nakamura, S., Fujino, M. & Suga, T., 2006 Jun 14, In : Nukleonika. 51, SUPPL. 1, p. S41-S48

Research output: Contribution to journalArticle

10 Citations (Scopus)
2005

Biodegradable polymers in chondrogenesis of human articular chondrocytes

Banu, N., Banu, Y., Sakai, M., Mashino, T. & Tsuchiya, T., 2005 Sep 1, In : Journal of Artificial Organs. 8, 3, p. 184-191 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives

Mashino, T., Shimotohno, K., Ikegami, N., Nishikawa, D., Okuda, K., Takahashi, K., Nakamura, S. & Mochizuki, M., 2005 Feb 15, In : Bioorganic and Medicinal Chemistry Letters. 15, 4, p. 1107-1109 3 p.

Research output: Contribution to journalArticle

140 Citations (Scopus)

Preparation and antioxidant activity of α-pyridoin and its derivatives

Hatanaka, M., Takahashi, K., Nakamura, S. & Mashino, T., 2005 Dec 15, In : Bioorganic and Medicinal Chemistry. 13, 24, p. 6763-6770 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2004

An HPLC assay of hydroxyl radicals by the hydroxylation reaction of terephthalic acid

Linxiang, L., Abe, Y., Nagasawa, Y., Kudo, R., Usui, N., Imai, K., Mashino, T., Mochizuki, M. & Miyata, N., 2004 Sep 1, In : Biomedical Chromatography. 18, 7, p. 470-474 5 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)