Takako Hishiki

2018

Biochemical, metabolomic, and genetic analyses of dephospho coenzyme a kinase involved in coenzyme a biosynthesis in the human enteric parasite entamoeba histolytica

Nurkanto, A., Jeelani, G., Yamamoto, T., Hishiki, T., Naito, Y., Suematsu, M., Hashimoto, T. & Nozaki, T., 2018 Nov 30, In : Frontiers in Microbiology. 9, NOV, 2902.

Research output: Contribution to journal › Article

Entamoeba histolytica

Metabolomics

Coenzymes

Molecular Biology

Parasites

2 Citations (Scopus)

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target

Nurkanto, A., Jeelani, G., Yamamoto, T., Naito, Y., Hishiki, T., Mori, M., Suematsu, M., Shiomi, K., Hashimoto, T. & Nozaki, T., 2018 Apr 1, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 1, p. 125-136 12 p.

Research output: Contribution to journal › Article

Entamoeba histolytica

Coenzyme A

Pharmaceutical Preparations

Enzymes

Amebiasis

7 Citations (Scopus)

Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera

Kabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., Minegishi, N., Hozawa, A., Murakami, Y., Kubo, M., Itonaga, M. & Handa, H., 2018 Oct 1, In : Clinical Chemistry. 64, 10, p. 1463-1473 11 p.

Research output: Contribution to journal › Article

Exosomes

Equipment and Supplies

CD147 Antigens

Serum

Flow cytometry

5 Citations (Scopus)

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: Evidence from fatty acid-binding protein-4 and-5 knockout mice

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Yamaguchi, A., Hanaoka, H., Hishiki, T., Nagahata-Naito, Y., Obinata, H., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Jul 1, In : Cardiovascular Research. 114, 8, p. 1132-1144 13 p.

Research output: Contribution to journal › Article

Fatty Acid-Binding Proteins

Constriction

Knockout Mice

Biomass

Pressure

17 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journal › Article

Raman Spectrum Analysis

Oxidants

Gold

Raman spectroscopy

tumors

4 Citations (Scopus)

Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Obinata, H., Yamaguchi, A., Hanaoka, H., Hishiki, T., Hayakawa, N., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Dec 1, In : Scientific Reports. 8, 1, 12035.

Research output: Contribution to journal › Article

Constriction

Energy Metabolism

Fatty Acids

Heart Failure

Pressure

4 Citations (Scopus)

Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway

Mashima, K., Takahashi, S., Minami, K., Izawa, Y., Abe, T., Tsukada, N., Hishiki, T., Suematsu, M., Kajimura, M. & Suzuki, N., 2018 May 1, In : ASN Neuro. 10

Research output: Contribution to journal › Article

Pentose Phosphate Pathway

Astrocytes

Parkinson Disease

Dopamine

Oxidative Stress

2017

7 Citations (Scopus)

Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice

Umbarawan, Y., Syamsunarno, M. R. A. A., Obinata, H., Yamaguchi, A., Sunaga, H., Matsui, H., Hishiki, T., Matsuura, T., Koitabashi, N., Obokata, M., Hanaoka, H., Haque, A., Kunimoto, F., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2017 Dec 1, In : Metabolism: Clinical and Experimental. 77, p. 47-57 11 p.

Research output: Contribution to journal › Article

Lipopolysaccharides

Glucose

Fatty Acids

Ketone Bodies

Injections

3 Citations (Scopus)

Targeting oxygen-sensing prolyl hydroxylase for metformin-associated lactic acidosis treatment

Toramaru, T., Suhara, T., Hayakawa, N., Nakamura, T., Kubo, A., Minamishima, S., Yamaguchi, K., Hishiki, T., Morisaki, H., Suematsu, M. & Minamishima, Y. A., 2017 Aug 1, In : Molecular and Cellular Biology. 37, 16, e00248-17.

Research output: Contribution to journal › Article

Prolyl Hydroxylases

Lactic Acidosis

Metformin

Oxygen

Prolyl-Hydroxylase Inhibitors

9 Citations (Scopus)

The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure

Ono, T., Kamimura, N., Matsuhashi, T., Nagai, T., Nishiyama, T., Endo, J., Hishiki, T., Nakanishi, T., Shimizu, N., Tanaka, H., Ohta, S., Suematsu, M., Ieda, M., Sano, M., Fukuda, K. & Kaneda, R., 2017 Jan 4, In : Scientific Reports. 7, 39752.

Research output: Contribution to journal › Article

Methyltransferases

Histones

Lysine

Heart Failure

Salts

2016

21 Citations (Scopus)

A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system

Iizumi, T., Takahashi, S., Mashima, K., Minami, K., Izawa, Y., Abe, T., Hishiki, T., Suematsu, M., Kajimura, M. & Suzuki, N., 2016 May 4, In : Journal of Neuroinflammation. 13, 1, 99.

Research output: Contribution to journal › Article

Pentose Phosphate Pathway

Microglia

Lipopolysaccharides

Nitric Oxide

Toll-Like Receptor 4

54 Citations (Scopus)

Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells

Tohyama, S., Fujita, J., Hishiki, T., Matsuura, T., Hattori, F., Ohno, R., Kanazawa, H., Seki, T., Nakajima, K., Kishino, Y., Okada, M., Hirano, A., Kuroda, T., Yasuda, S., Sato, Y., Yuasa, S., Sano, M., Suematsu, M. & Fukuda, K., 2016 Apr 12, In : Cell Metabolism. 23, 4, p. 663-674 12 p.

Research output: Contribution to journal › Article

Pluripotent Stem Cells

Glutamine

Pyruvic Acid

Oxidative Phosphorylation

Adenosine Triphosphate

2015

13 Citations (Scopus)

Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart

Matsuhashi, T., Hishiki, T., Zhou, H., Ono, T., Kaneda, R., Iso, T., Yamaguchi, A., Endo, J., Katsumata, Y., Anzai, A., Yamamoto, T., Shirakawa, K., Yan, X., Shinmura, K., Suematsu, M., Fukuda, K. & Sano, M., 2015 May 1, In : Journal of Molecular and Cellular Cardiology. 82, p. 116-124 9 p.

Research output: Contribution to journal › Article

Pyruvic Acid

Epigenomics

Oxidoreductases

Histones

Citric Acid Cycle

18 Citations (Scopus)

Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions

Nakano, S., Ishii, I., Shinmura, K., Tamaki, K., Hishiki, T., Akahoshi, N., Ida, T., Nakanishi, T., Kamata, S., Kumagai, Y., Akaike, T., Fukuda, K., Sano, M. & Suematsu, M., 2015 Mar 6, (Accepted/In press) In : Journal of Molecular Medicine.

Research output: Contribution to journal › Article

Hydrogen Sulfide

Hyperhomocysteinemia

Homocysteine

Biological Availability

Reperfusion

13 Citations (Scopus)

Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry

Ohmura, M., Hishiki, T., Yamamoto, T., Nakanishi, T., Kubo, A., Tsuchihashi, K., Tamada, M., Toue, S., Kabe, Y., Saya, H. & Suematsu, M., 2015 Apr 30, In : Nitric Oxide - Biology and Chemistry. 46, p. 102-113 12 p.

Research output: Contribution to journal › Article

Mass spectrometry

Tumors

Mass Spectrometry

Cells

Imaging techniques

18 Citations (Scopus)

Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle

Suhara, T., Hishiki, T., Kasahara, M., Hayakawa, N., Toramaru, T., Nakanishi, T., Kubo, A., Morisaki, H., Kaelin, W. G., Suematsu, M. & Minamishima, Y. A., 2015 Sep 15, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, p. 11642-11647 6 p.

Research output: Contribution to journal › Article

Prolyl Hydroxylases

Lactic Acidosis

Lactic Acid

Oxygen

Liver

12 Citations (Scopus)

Involvement of the yciW gene in l-cysteine and l-methionine metabolism in Escherichia coli

Kawano, Y., Ohtsu, I., Tamakoshi, A., Shiroyama, M., Tsuruoka, A., Saiki, K., Takumi, K., Nonaka, G., Nakanishi, T., Hishiki, T., Suematsu, M. & Takagi, H., 2015 Mar 1, In : Journal of Bioscience and Bioengineering. 119, 3, p. 310-313 4 p.

Research output: Contribution to journal › Article

Sulfur

Metabolism

Methionine

Escherichia coli

Cysteine

15 Citations (Scopus)

Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia

Takenouchi, T., Sugiura, Y., Morikawa, T., Nakanishi, T., Nagahata, Y., Sugioka, T., Honda, K., Kubo, A., Hishiki, T., Matsuura, T., Hoshino, T., Takahashi, T., Suematsu, M. & Kajimura, M., 2015 May 5, In : Journal of Cerebral Blood Flow and Metabolism. 35, 5, p. 794-805 12 p.

Research output: Contribution to journal › Article

Induced Hypothermia

Carnitine

Hypothermia

Acetylcholine

Ischemia

2014

40 Citations (Scopus)

Large-area surface-enhanced raman spectroscopy imaging of brain ischemia by gold nanoparticles grown on random nanoarrays of transparent boehmite

Yamazoe, S., Naya, M., Shiota, M., Morikawa, T., Kubo, A., Tani, T., Hishiki, T., Horiuchi, T., Suematsu, M. & Kajimura, M., 2014 Jun 24, In : ACS Nano. 8, 6, p. 5622-5632 11 p.

Research output: Contribution to journal › Article

ischemia

Gold

brain

Raman spectroscopy

Brain

9 Citations (Scopus)

Neutral aminoaciduria in cystathionine β-synthase-deficient mice, an animal model of homocystinuria

Akahoshi, N., Kamata, S., Kubota, M., Hishiki, T., Nagahata, Y., Matsuura, T., Yamazaki, C., Yoshida, Y., Yamada, H., Ishizaki, Y., Suematsu, M., Kasahara, T. & Ishii, I., 2014 Jun 15, In : American Journal of Physiology - Renal Physiology. 306, 12

Research output: Contribution to journal › Article

Cystathionine

Homocystinuria

Neutral Amino Acids

Animal Models

Kidney

89 Citations (Scopus)

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

Yamamoto, T., Takano, N., Ishiwata, K., Ohmura, M., Nagahata, Y., Matsuura, T., Kamata, A., Sakamoto, K., Nakanishi, T., Kubo, A., Hishiki, T. & Suematsu, M., 2014 Mar 17, In : Nature Communications. 5, 3480.

Research output: Contribution to journal › Article

pentose

Pentoses

Pentose Phosphate Pathway

methylation

Methylation

2013

29 Citations (Scopus)

A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting

Syamsunarno, M. R. A. A., Iso, T., Hanaoka, H., Yamaguchi, A., Obokata, M., Koitabashi, N., Goto, K., Hishiki, T., Nagahata, Y., Matsui, H., Sano, M., Kobayashi, M., Kikuchi, O., Sasaki, T., Maeda, K., Murakami, M., Kitamura, T., Suematsu, M., Tsushima, Y., Endo, K. & 2 others, Hotamisligil, G. S. & Kurabayashi, M., 2013 Nov 14, In : PLoS One. 8, 11, e79386.

Research output: Contribution to journal › Article

fatty acid-binding proteins

Fatty Acid-Binding Proteins

fasting

Fasting

Fatty Acids

54 Citations (Scopus)

Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle

Iso, T., Maeda, K., Hanaoka, H., Suga, T., Goto, K., Syamsunarno, M. R. A. A., Hishiki, T., Nagahata, Y., Matsui, H., Arai, M., Yamaguchi, A., Abumrad, N. A., Sano, M., Suematsu, M., Endo, K., Hotamisligil, G. S. & Kurabayashi, M., 2013 Nov, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 11, p. 2549-2557 9 p.

Research output: Contribution to journal › Article

Fatty Acid-Binding Proteins

Myocardium

Skeletal Muscle

Fatty Acids

Fasting

315 Citations (Scopus)

Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes

Tohyama, S., Hattori, F., Sano, M., Hishiki, T., Nagahata, Y., Matsuura, T., Hashimoto, H., Suzuki, T., Yamashita, H., Satoh, Y., Egashira, T., Seki, T., Muraoka, N., Yamakawa, H., Ohgino, Y., Tanaka, T., Yoichi, M., Yuasa, S., Murata, M., Suematsu, M. & 1 others, Fukuda, K., 2013 Jan 3, In : Cell Stem Cell. 12, 1, p. 127-137 11 p.

Research output: Contribution to journal › Article

Pluripotent Stem Cells

Cardiac Myocytes

Heart Diseases

Lactic Acid

Glucose

36 Citations (Scopus)

Energy management by enhanced glycolysis in G₁-phase in human colon cancer cells in vitro and in vivo

Bao, Y., Mukai, K., Hishiki, T., Kubo, A., Ohmura, M., Sugiura, Y., Matsuura, T., Nagahata, Y., Hayakawa, N., Yamamoto, T., Fukuda, R., Saya, H., Suematsu, M. & Minamishima, Y. A., 2013 Sep, In : Molecular Cancer Research. 11, 9, p. 973-985 13 p.

Research output: Contribution to journal › Article

G1 Phase

Glycolysis

Colonic Neoplasms

Cell Division

Cell Cycle

2012

19 Citations (Scopus)

Carbon monoxide: Impact on remethylation/transsulfuration metabolism and its pathophysiologic implications

Hishiki, T., Yamamoto, T., Morikawa, T., Kubo, A., Kajimura, M. & Suematsu, M., 2012 Mar, In : Journal of Molecular Medicine. 90, 3, p. 245-254 10 p.

Research output: Contribution to journal › Article

Carbon Monoxide

Gasotransmitters

Gases

Cystathionine

Heme Oxygenase (Decyclizing)

23 Citations (Scopus)

Gas biology: Tiny molecules controlling metabolic systems

Kajimura, M., Nakanishi, T., Takenouchi, T., Morikawa, T., Hishiki, T., Yukutake, Y. & Suematsu, M., 2012 Nov 15, In : Respiratory Physiology and Neurobiology. 184, 2, p. 139-148 10 p.

Research output: Contribution to journal › Article

Gases

Mass Spectrometry

Metalloproteins

Metabolomics

Capillary Electrophoresis

142 Citations (Scopus)

Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway

Morikawa, T., Kajimura, M., Nakamura, T., Hishiki, T., Nakanishi, T., Yukutake, Y., Nagahata, Y., Ishikawa, M., Hattori, K., Takenouchi, T., Takahashi, T., Ishii, I., Matsubara, K., Kabe, Y., Uchiyama, S., Nagata, E., Gadalla, M. M., Snyder, S. H. & Suematsu, M., 2012 Jan 24, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 4, p. 1293-1298 6 p.

Research output: Contribution to journal › Article

Hydrogen Sulfide

Carbon Monoxide

Microcirculation

Vasodilation

Brain Hypoxia

42 Citations (Scopus)

Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria

Yamada, H., Akahoshi, N., Kamata, S., Hagiya, Y., Hishiki, T., Nagahata, Y., Matsuura, T., Takano, N., Mori, M., Ishizaki, Y., Izumi, T., Kumagai, Y., Kasahara, T., Suematsu, M. & Ishii, I., 2012 May 1, In : Free Radical Biology and Medicine. 52, 9, p. 1716-1726 11 p.

Research output: Contribution to journal › Article

Cystathionine

Lyases

Nutrition

Methionine

Hepatitis

197 Citations (Scopus)

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

Imaizumi, Y., Okada, Y., Akamatsu, W., Koike, M., Kuzumaki, N., Hayakawa, H., Nihira, T., Kobayashi, T., Ohyama, M., Sato, S., Takanashi, M., Funayama, M., Hirayama, A., Soga, T., Hishiki, T., Suematsu, M., Yagi, T., Ito, D., Kosakai, A., Hayashi, K. & 10 others, Shouji, M., Nakanishi, A., Suzuki, N., Mizuno, Y., Mizushima, N., Amagai, M., Uchiyama, Y., Mochizuki, H., Hattori, N. & Okano, H., 2012, In : Molecular Brain. 5, 1, 35.

Research output: Contribution to journal › Article

Synucleins

Induced Pluripotent Stem Cells

Oxidative Stress

Neurons

Brain

2011

31 Citations (Scopus)

Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice

Ochiai, D., Goda, N., Hishiki, T., Kanai, M., Senoo-Matsuda, N., Soga, T., Johnson, R. S., Yoshimura, Y. & Suematsu, M., 2011 Nov 25, In : Biochemical and Biophysical Research Communications. 415, 3, p. 445-449 5 p.

Research output: Contribution to journal › Article

Nutrition

Metabolism

Hepatocytes

Obesity

Diet

17 Citations (Scopus)

Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria

Ikeda, K., Kubo, A., Akahoshi, N., Yamada, H., Miura, N., Hishiki, T., Nagahata, Y., Matsuura, T., Suematsu, M., Taguchi, R. & Ishii, I., 2011 Jun, In : Analytical and Bioanalytical Chemistry. 400, 7, p. 1853-1863 11 p.

Research output: Contribution to journal › Article

Cystathionine beta-Synthase

Homocystinuria

Fatty Liver

Liver

Phospholipids

20 Citations (Scopus)

Use of serum and urine metabolome analysis for the detection of metabolic changes in patients with stage 1-2 chronic kidney disease

Hayashi, K., Sasamura, H., Hishiki, T., Suematsu, M., Ikeda, S., Soga, T. & Itoh, H., 2011, In : Nephro-Urology Monthly. 3, 3, p. 164-171 8 p.

Research output: Contribution to journal › Article

Metabolome

Chronic Renal Insufficiency

Urine

Metabolomics

Serum

2010

84 Citations (Scopus)

4-Hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway

Zhang, Y., Sano, M., Shinmura, K., Tamaki, K., Katsumata, Y., Matsuhashi, T., Morizane, S., Ito, H., Hishiki, T., Endo, J., Zhou, H., Yuasa, S., Kaneda, R., Suematsu, M. & Fukuda, K., 2010 Oct, In : Journal of Molecular and Cellular Cardiology. 49, 4, p. 576-586 11 p.

Research output: Contribution to journal › Article

NF-E2-Related Factor 2

Reperfusion Injury

Cardiac Myocytes

Aldehydes

Ligases

22 Citations (Scopus)

Hypotaurine is an energy-saving hepatoprotective compound against ischemia-reperfusion injury of the rat liver

Sakuragawa, T., Hishiki, T., Ueno, Y., Ikeda, S., Soga, T., Yachie-Kinoshita, A., Kajimura, M. & Suematsu, M., 2010 Mar, In : Journal of Clinical Biochemistry and Nutrition. 46, 2, p. 126-134 9 p.

Research output: Contribution to journal › Article

Reperfusion Injury

Liver

Rats

Energy conservation

Taurine

69 Citations (Scopus)

Paradoxical ATP elevation in ischemic penumbra revealed by quantitative imaging mass spectrometry

Hattori, K., Kajimura, M., Hishiki, T., Nakanishi, T., Kubo, A., Nagahata, Y., Ohmura, M., Yachie-Kinoshita, A., Matsuura, T., Morikawa, T., Nakamura, T., Setou, M. & Suematsu, M., 2010 Oct 15, In : Antioxidants and Redox Signaling. 13, 8, p. 1157-1167 11 p.

Research output: Contribution to journal › Article

Mass spectrometry

Mass Spectrometry

Adenosine Triphosphate

Imaging techniques

NAD

8 Citations (Scopus)

Phosphorescence-assisted microvascular O₂ measurements reveal alterations of oxygen demand in human metastatic colon cancer in the liver of superimmunodeficient NOG mice

Handa, K., Ohmura, M., Nishime, C., Hishiki, T., Nagahata, Y., Kawai, K., Suemizu, H., Nakamura, M., Wakui, M., Kitagawa, Y., Suematsu, M. & Tsukada, K., 2010, Advances in Experimental Medicine and Biology. Vol. 662. p. 423-429 7 p. (Advances in Experimental Medicine and Biology; vol. 662).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Phosphorescence

Liver Neoplasms

Liver

Colonic Neoplasms

Tumors

3 Citations (Scopus)

Reduced CD73 expression and its association with altered purine nucleotide metabolism in colorectal cancer cells robustly causing liver metastases

Matsuyama, M., Wakui, M., Monnai, M., Mizushima, T., Nishime, C., Kawai, K., Ohmura, M., Suemizu, H., Hishiki, T., Suematsu, M., Murata, M., Chijiwa, T., Furukawa, D., Ogoshi, K., Makuuchi, H. & Nakamura, M., 2010 May, In : Oncology Letters. 1, 3, p. 431-436 6 p.

Research output: Contribution to journal › Article

Purine Nucleotides

Colorectal Neoplasms

Neoplasm Metastasis

Liver

Neoplasms

5 Citations (Scopus)

T-state stabilization of hemoglobin by nitric oxide to form α-nitrosyl heme causes constitutive release of ATP from human erythrocytes

Akatsu, T., Tsukada, K., Hishiki, T., Suga-Numa, K., Tanabe, M., Shimazu, M., Kitagawa, Y., Yachie-Kinoshita, A. & Suematsu, M., 2010, Advances in Experimental Medicine and Biology. Vol. 662. p. 109-114 6 p. (Advances in Experimental Medicine and Biology; vol. 662).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Heme

Nitric Oxide

Stabilization

Adenosine Triphosphate

Erythrocytes

2009

79 Citations (Scopus)

Cystathionine β-synthase as a carbon monoxide-sensitive regulator of bile excretion

Shintani, T., Iwabuchi, T., Soga, T., Kato, Y., Yamamoto, T., Takano, N., Hishiki, T., Ueno, Y., Ikeda, S., Sakuragawa, T., Ishikawa, K., Goda, N., Kitagawa, Y., Kajimura, M., Matsumoto, K. & Suematsu, M., 2009, In : Hepatology. 49, 1, p. 141-150 10 p.

Research output: Contribution to journal › Article

Cystathionine

Carbon Monoxide

Bile

Heme Oxygenase (Decyclizing)

Metabolome

40 Citations (Scopus)

HIF-1α is necessary to support gluconeogenesis during liver regeneration

Tajima, T., Goda, N., Fujiki, N., Hishiki, T., Nishiyama, Y., Senoo-Matsuda, N., Shimazu, M., Soga, T., Yoshimura, Y., Johnson, R. S. & Suematsu, M., 2009 Oct 2, In : Biochemical and Biophysical Research Communications. 387, 4, p. 789-794 6 p.

Research output: Contribution to journal › Article

Hypoxia-Inducible Factor 1

Liver Regeneration

Gluconeogenesis

Liver

Hepatectomy

92 Citations (Scopus)

Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart

Endo, J., Sano, M., Katayama, T., Hishiki, T., Shinmura, K., Morizane, S., Matsuhashi, T., Katsumata, Y., Zhang, Y., Ito, H., Nagahata, Y., Marchitti, S., Nishimaki, K., Wolf, A. M., Nakanishi, H., Hattori, F., Vasiliou, V., Adachi, T., Ohsawa, I., Taguchi, R. & 5 others, Hirabayashi, Y., Ohta, S., Suematsu, M., Ogawa, S. & Fukuda, K., 2009 Nov, In : Circulation Research. 105, 11, p. 1118-1127 10 p.

Research output: Contribution to journal › Article

Aldehydes

Oxidative Stress

Glutathione

NADP

Transgenic Mice

10 Citations (Scopus)

Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis

Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanabe, H., Kataoka, K., Suematsu, M. & Handa, H., 2009, In : Toxicological Sciences. 109, 1, p. 143-151 9 p.

Research output: Contribution to journal › Article

Glycogen Debranching Enzyme System

Glycogen

Metabolism

Testis

Rats

2007

68 Citations (Scopus)

Roles of hemoglobin allostery in hypoxia-induced metabolic alterations in erythrocytes: Simulation and its verification by metabolome analysis

Kinoshita, A., Tsukada, K., Soga, T., Hishiki, T., Ueno, Y., Nakayama, Y., Tomita, M. & Suematsu, M., 2007 Apr 6, In : Journal of Biological Chemistry. 282, 14, p. 10731-10741 11 p.

Research output: Contribution to journal › Article

Metabolome

Hemoglobins

Erythrocytes

2,3-Diphosphoglycerate

Glycolysis

2004

7 Citations (Scopus)

Refolding processes of cytochrome P450_cam from ferric and ferrous acid forms to the native conformation. Formations of folding intermediates with non-native heme coordination state

Egawa, T., Hishiki, T., Ichikawa, Y., Kanamori, Y., Shimada, H., Takahashi, S., Kitagawa, T. & Ishimura, Y., 2004 Jul 30, In : Journal of Biological Chemistry. 279, 31, p. 32008-32017 10 p.

Research output: Contribution to journal › Article

Camphor 5-Monooxygenase

Cytochromes

Heme

Conformations

Acids

2003

48 Citations (Scopus)

Infrared Spectroscopic and Mutational Studies on Putidaredoxin-Induced Conformational Changes in Ferrous CO-P450cam

Nagano, S., Shimada, H., Tarumi, A., Hishiki, T., Kimata-Ariga, Y., Egawa, T., Suematsu, M., Park, S. Y., Adachi, S. I., Shiro, Y. & Ishimura, Y., 2003 Dec 16, In : Biochemistry. 42, 49, p. 14507-14514 8 p.

Research output: Contribution to journal › Article

Camphor 5-Monooxygenase

Cytochromes

Infrared radiation

Carbon Monoxide

Electrons

2000

48 Citations (Scopus)

X-ray crystal structure and catalytic properties of Thr252Ile mutant of cytochrome P450cam: Roles of Thr252 and water in the active center

Hishiki, T., Shimada, H., Nagano, S., Egawa, T., Kanamori, Y., Makino, R., Park, S. Y., Adachi, S. I., Shiro, Y. & Ishimura, Y., 2000, In : Journal of Biochemistry. 128, 6, p. 965-974 10 p.

Research output: Contribution to journal › Article

Camphor 5-Monooxygenase

Cytochromes

Camphor

Crystal structure

X-Rays

1999

38 Citations (Scopus)

Putidaredoxin-cytochrome P450(cam) interaction: Spin state of the heme iron modulates putidaredoxin structure

Shimada, H., Nagano, S., Ariga, Y., Unno, M., Egawa, T., Hishiki, T., Ishimura, Y., Masuya, F., Obata, T. & Hori, H., 1999 Apr 2, In : Journal of Biological Chemistry. 274, 14, p. 9363-9369 7 p.

Research output: Contribution to journal › Article

Camphor 5-Monooxygenase

Heme

Cams

Iron

Ligands