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Research Output 1999 2018

  • 1908 Citations
  • 22 h-Index
  • 46 Article
  • 2 Conference contribution
2018
2 Citations (Scopus)

Biochemical, metabolomic, and genetic analyses of dephospho coenzyme a kinase involved in coenzyme a biosynthesis in the human enteric parasite entamoeba histolytica

Nurkanto, A., Jeelani, G., Yamamoto, T., Hishiki, T., Naito, Y., Suematsu, M., Hashimoto, T. & Nozaki, T., 2018 Nov 30, In : Frontiers in Microbiology. 9, NOV, 2902.

Research output: Contribution to journalArticle

Entamoeba histolytica
Metabolomics
Coenzymes
Molecular Biology
Parasites
2 Citations (Scopus)

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target

Nurkanto, A., Jeelani, G., Yamamoto, T., Naito, Y., Hishiki, T., Mori, M., Suematsu, M., Shiomi, K., Hashimoto, T. & Nozaki, T., 2018 Apr 1, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 1, p. 125-136 12 p.

Research output: Contribution to journalArticle

Entamoeba histolytica
Coenzyme A
Pharmaceutical Preparations
Enzymes
Amebiasis
7 Citations (Scopus)

Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera

Kabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., Minegishi, N., Hozawa, A., Murakami, Y., Kubo, M., Itonaga, M. & Handa, H., 2018 Oct 1, In : Clinical Chemistry. 64, 10, p. 1463-1473 11 p.

Research output: Contribution to journalArticle

Exosomes
Equipment and Supplies
CD147 Antigens
Serum
Flow cytometry
5 Citations (Scopus)

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: Evidence from fatty acid-binding protein-4 and-5 knockout mice

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Yamaguchi, A., Hanaoka, H., Hishiki, T., Nagahata-Naito, Y., Obinata, H., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Jul 1, In : Cardiovascular Research. 114, 8, p. 1132-1144 13 p.

Research output: Contribution to journalArticle

Fatty Acid-Binding Proteins
Constriction
Knockout Mice
Biomass
Pressure
17 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journalArticle

Raman Spectrum Analysis
Oxidants
Gold
Raman spectroscopy
tumors
4 Citations (Scopus)

Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Obinata, H., Yamaguchi, A., Hanaoka, H., Hishiki, T., Hayakawa, N., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Dec 1, In : Scientific Reports. 8, 1, 12035.

Research output: Contribution to journalArticle

Constriction
Energy Metabolism
Fatty Acids
Heart Failure
Pressure
4 Citations (Scopus)

Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway

Mashima, K., Takahashi, S., Minami, K., Izawa, Y., Abe, T., Tsukada, N., Hishiki, T., Suematsu, M., Kajimura, M. & Suzuki, N., 2018 May 1, In : ASN Neuro. 10

Research output: Contribution to journalArticle

Pentose Phosphate Pathway
Astrocytes
Parkinson Disease
Dopamine
Oxidative Stress
2017
7 Citations (Scopus)

Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice

Umbarawan, Y., Syamsunarno, M. R. A. A., Obinata, H., Yamaguchi, A., Sunaga, H., Matsui, H., Hishiki, T., Matsuura, T., Koitabashi, N., Obokata, M., Hanaoka, H., Haque, A., Kunimoto, F., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2017 Dec 1, In : Metabolism: Clinical and Experimental. 77, p. 47-57 11 p.

Research output: Contribution to journalArticle

Lipopolysaccharides
Glucose
Fatty Acids
Ketone Bodies
Injections
3 Citations (Scopus)

Targeting oxygen-sensing prolyl hydroxylase for metformin-associated lactic acidosis treatment

Toramaru, T., Suhara, T., Hayakawa, N., Nakamura, T., Kubo, A., Minamishima, S., Yamaguchi, K., Hishiki, T., Morisaki, H., Suematsu, M. & Minamishima, Y. A., 2017 Aug 1, In : Molecular and Cellular Biology. 37, 16, e00248-17.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Lactic Acidosis
Metformin
Oxygen
Prolyl-Hydroxylase Inhibitors
9 Citations (Scopus)

The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure

Ono, T., Kamimura, N., Matsuhashi, T., Nagai, T., Nishiyama, T., Endo, J., Hishiki, T., Nakanishi, T., Shimizu, N., Tanaka, H., Ohta, S., Suematsu, M., Ieda, M., Sano, M., Fukuda, K. & Kaneda, R., 2017 Jan 4, In : Scientific Reports. 7, 39752.

Research output: Contribution to journalArticle

Methyltransferases
Histones
Lysine
Heart Failure
Salts
2016
21 Citations (Scopus)

A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system

Iizumi, T., Takahashi, S., Mashima, K., Minami, K., Izawa, Y., Abe, T., Hishiki, T., Suematsu, M., Kajimura, M. & Suzuki, N., 2016 May 4, In : Journal of Neuroinflammation. 13, 1, 99.

Research output: Contribution to journalArticle

Pentose Phosphate Pathway
Microglia
Lipopolysaccharides
Nitric Oxide
Toll-Like Receptor 4
54 Citations (Scopus)

Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells

Tohyama, S., Fujita, J., Hishiki, T., Matsuura, T., Hattori, F., Ohno, R., Kanazawa, H., Seki, T., Nakajima, K., Kishino, Y., Okada, M., Hirano, A., Kuroda, T., Yasuda, S., Sato, Y., Yuasa, S., Sano, M., Suematsu, M. & Fukuda, K., 2016 Apr 12, In : Cell Metabolism. 23, 4, p. 663-674 12 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Glutamine
Pyruvic Acid
Oxidative Phosphorylation
Adenosine Triphosphate
2015
13 Citations (Scopus)

Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart

Matsuhashi, T., Hishiki, T., Zhou, H., Ono, T., Kaneda, R., Iso, T., Yamaguchi, A., Endo, J., Katsumata, Y., Anzai, A., Yamamoto, T., Shirakawa, K., Yan, X., Shinmura, K., Suematsu, M., Fukuda, K. & Sano, M., 2015 May 1, In : Journal of Molecular and Cellular Cardiology. 82, p. 116-124 9 p.

Research output: Contribution to journalArticle

Pyruvic Acid
Epigenomics
Oxidoreductases
Histones
Citric Acid Cycle
18 Citations (Scopus)

Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions

Nakano, S., Ishii, I., Shinmura, K., Tamaki, K., Hishiki, T., Akahoshi, N., Ida, T., Nakanishi, T., Kamata, S., Kumagai, Y., Akaike, T., Fukuda, K., Sano, M. & Suematsu, M., 2015 Mar 6, (Accepted/In press) In : Journal of Molecular Medicine.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Hyperhomocysteinemia
Homocysteine
Biological Availability
Reperfusion
13 Citations (Scopus)

Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry

Ohmura, M., Hishiki, T., Yamamoto, T., Nakanishi, T., Kubo, A., Tsuchihashi, K., Tamada, M., Toue, S., Kabe, Y., Saya, H. & Suematsu, M., 2015 Apr 30, In : Nitric Oxide - Biology and Chemistry. 46, p. 102-113 12 p.

Research output: Contribution to journalArticle

Mass spectrometry
Tumors
Mass Spectrometry
Cells
Imaging techniques
18 Citations (Scopus)

Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle

Suhara, T., Hishiki, T., Kasahara, M., Hayakawa, N., Toramaru, T., Nakanishi, T., Kubo, A., Morisaki, H., Kaelin, W. G., Suematsu, M. & Minamishima, Y. A., 2015 Sep 15, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, p. 11642-11647 6 p.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Lactic Acidosis
Lactic Acid
Oxygen
Liver
12 Citations (Scopus)

Involvement of the yciW gene in l-cysteine and l-methionine metabolism in Escherichia coli

Kawano, Y., Ohtsu, I., Tamakoshi, A., Shiroyama, M., Tsuruoka, A., Saiki, K., Takumi, K., Nonaka, G., Nakanishi, T., Hishiki, T., Suematsu, M. & Takagi, H., 2015 Mar 1, In : Journal of Bioscience and Bioengineering. 119, 3, p. 310-313 4 p.

Research output: Contribution to journalArticle

Sulfur
Metabolism
Methionine
Escherichia coli
Cysteine
15 Citations (Scopus)

Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia

Takenouchi, T., Sugiura, Y., Morikawa, T., Nakanishi, T., Nagahata, Y., Sugioka, T., Honda, K., Kubo, A., Hishiki, T., Matsuura, T., Hoshino, T., Takahashi, T., Suematsu, M. & Kajimura, M., 2015 May 5, In : Journal of Cerebral Blood Flow and Metabolism. 35, 5, p. 794-805 12 p.

Research output: Contribution to journalArticle

Induced Hypothermia
Carnitine
Hypothermia
Acetylcholine
Ischemia
2014
40 Citations (Scopus)

Large-area surface-enhanced raman spectroscopy imaging of brain ischemia by gold nanoparticles grown on random nanoarrays of transparent boehmite

Yamazoe, S., Naya, M., Shiota, M., Morikawa, T., Kubo, A., Tani, T., Hishiki, T., Horiuchi, T., Suematsu, M. & Kajimura, M., 2014 Jun 24, In : ACS Nano. 8, 6, p. 5622-5632 11 p.

Research output: Contribution to journalArticle

ischemia
Gold
brain
Raman spectroscopy
Brain
9 Citations (Scopus)

Neutral aminoaciduria in cystathionine β-synthase-deficient mice, an animal model of homocystinuria

Akahoshi, N., Kamata, S., Kubota, M., Hishiki, T., Nagahata, Y., Matsuura, T., Yamazaki, C., Yoshida, Y., Yamada, H., Ishizaki, Y., Suematsu, M., Kasahara, T. & Ishii, I., 2014 Jun 15, In : American Journal of Physiology - Renal Physiology. 306, 12

Research output: Contribution to journalArticle

Cystathionine
Homocystinuria
Neutral Amino Acids
Animal Models
Kidney
89 Citations (Scopus)

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

Yamamoto, T., Takano, N., Ishiwata, K., Ohmura, M., Nagahata, Y., Matsuura, T., Kamata, A., Sakamoto, K., Nakanishi, T., Kubo, A., Hishiki, T. & Suematsu, M., 2014 Mar 17, In : Nature Communications. 5, 3480.

Research output: Contribution to journalArticle

pentose
Pentoses
Pentose Phosphate Pathway
methylation
Methylation
2013
29 Citations (Scopus)

A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting

Syamsunarno, M. R. A. A., Iso, T., Hanaoka, H., Yamaguchi, A., Obokata, M., Koitabashi, N., Goto, K., Hishiki, T., Nagahata, Y., Matsui, H., Sano, M., Kobayashi, M., Kikuchi, O., Sasaki, T., Maeda, K., Murakami, M., Kitamura, T., Suematsu, M., Tsushima, Y., Endo, K. & 2 others, Hotamisligil, G. S. & Kurabayashi, M., 2013 Nov 14, In : PLoS One. 8, 11, e79386.

Research output: Contribution to journalArticle

fatty acid-binding proteins
Fatty Acid-Binding Proteins
fasting
Fasting
Fatty Acids
54 Citations (Scopus)

Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle

Iso, T., Maeda, K., Hanaoka, H., Suga, T., Goto, K., Syamsunarno, M. R. A. A., Hishiki, T., Nagahata, Y., Matsui, H., Arai, M., Yamaguchi, A., Abumrad, N. A., Sano, M., Suematsu, M., Endo, K., Hotamisligil, G. S. & Kurabayashi, M., 2013 Nov, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 11, p. 2549-2557 9 p.

Research output: Contribution to journalArticle

Fatty Acid-Binding Proteins
Myocardium
Skeletal Muscle
Fatty Acids
Fasting
315 Citations (Scopus)

Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes

Tohyama, S., Hattori, F., Sano, M., Hishiki, T., Nagahata, Y., Matsuura, T., Hashimoto, H., Suzuki, T., Yamashita, H., Satoh, Y., Egashira, T., Seki, T., Muraoka, N., Yamakawa, H., Ohgino, Y., Tanaka, T., Yoichi, M., Yuasa, S., Murata, M., Suematsu, M. & 1 others, Fukuda, K., 2013 Jan 3, In : Cell Stem Cell. 12, 1, p. 127-137 11 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Cardiac Myocytes
Heart Diseases
Lactic Acid
Glucose
36 Citations (Scopus)

Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo

Bao, Y., Mukai, K., Hishiki, T., Kubo, A., Ohmura, M., Sugiura, Y., Matsuura, T., Nagahata, Y., Hayakawa, N., Yamamoto, T., Fukuda, R., Saya, H., Suematsu, M. & Minamishima, Y. A., 2013 Sep, In : Molecular Cancer Research. 11, 9, p. 973-985 13 p.

Research output: Contribution to journalArticle

G1 Phase
Glycolysis
Colonic Neoplasms
Cell Division
Cell Cycle
2012
19 Citations (Scopus)

Carbon monoxide: Impact on remethylation/transsulfuration metabolism and its pathophysiologic implications

Hishiki, T., Yamamoto, T., Morikawa, T., Kubo, A., Kajimura, M. & Suematsu, M., 2012 Mar, In : Journal of Molecular Medicine. 90, 3, p. 245-254 10 p.

Research output: Contribution to journalArticle

Carbon Monoxide
Gasotransmitters
Gases
Cystathionine
Heme Oxygenase (Decyclizing)
23 Citations (Scopus)

Gas biology: Tiny molecules controlling metabolic systems

Kajimura, M., Nakanishi, T., Takenouchi, T., Morikawa, T., Hishiki, T., Yukutake, Y. & Suematsu, M., 2012 Nov 15, In : Respiratory Physiology and Neurobiology. 184, 2, p. 139-148 10 p.

Research output: Contribution to journalArticle

Gases
Mass Spectrometry
Metalloproteins
Metabolomics
Capillary Electrophoresis
142 Citations (Scopus)

Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway

Morikawa, T., Kajimura, M., Nakamura, T., Hishiki, T., Nakanishi, T., Yukutake, Y., Nagahata, Y., Ishikawa, M., Hattori, K., Takenouchi, T., Takahashi, T., Ishii, I., Matsubara, K., Kabe, Y., Uchiyama, S., Nagata, E., Gadalla, M. M., Snyder, S. H. & Suematsu, M., 2012 Jan 24, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 4, p. 1293-1298 6 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Carbon Monoxide
Microcirculation
Vasodilation
Brain Hypoxia
42 Citations (Scopus)

Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria

Yamada, H., Akahoshi, N., Kamata, S., Hagiya, Y., Hishiki, T., Nagahata, Y., Matsuura, T., Takano, N., Mori, M., Ishizaki, Y., Izumi, T., Kumagai, Y., Kasahara, T., Suematsu, M. & Ishii, I., 2012 May 1, In : Free Radical Biology and Medicine. 52, 9, p. 1716-1726 11 p.

Research output: Contribution to journalArticle

Cystathionine
Lyases
Nutrition
Methionine
Hepatitis
197 Citations (Scopus)

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

Imaizumi, Y., Okada, Y., Akamatsu, W., Koike, M., Kuzumaki, N., Hayakawa, H., Nihira, T., Kobayashi, T., Ohyama, M., Sato, S., Takanashi, M., Funayama, M., Hirayama, A., Soga, T., Hishiki, T., Suematsu, M., Yagi, T., Ito, D., Kosakai, A., Hayashi, K. & 10 others, Shouji, M., Nakanishi, A., Suzuki, N., Mizuno, Y., Mizushima, N., Amagai, M., Uchiyama, Y., Mochizuki, H., Hattori, N. & Okano, H., 2012, In : Molecular Brain. 5, 1, 35.

Research output: Contribution to journalArticle

Synucleins
Induced Pluripotent Stem Cells
Oxidative Stress
Neurons
Brain
2011
31 Citations (Scopus)

Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice

Ochiai, D., Goda, N., Hishiki, T., Kanai, M., Senoo-Matsuda, N., Soga, T., Johnson, R. S., Yoshimura, Y. & Suematsu, M., 2011 Nov 25, In : Biochemical and Biophysical Research Communications. 415, 3, p. 445-449 5 p.

Research output: Contribution to journalArticle

Nutrition
Metabolism
Hepatocytes
Obesity
Diet
17 Citations (Scopus)

Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria

Ikeda, K., Kubo, A., Akahoshi, N., Yamada, H., Miura, N., Hishiki, T., Nagahata, Y., Matsuura, T., Suematsu, M., Taguchi, R. & Ishii, I., 2011 Jun, In : Analytical and Bioanalytical Chemistry. 400, 7, p. 1853-1863 11 p.

Research output: Contribution to journalArticle

Cystathionine beta-Synthase
Homocystinuria
Fatty Liver
Liver
Phospholipids
20 Citations (Scopus)

Use of serum and urine metabolome analysis for the detection of metabolic changes in patients with stage 1-2 chronic kidney disease

Hayashi, K., Sasamura, H., Hishiki, T., Suematsu, M., Ikeda, S., Soga, T. & Itoh, H., 2011, In : Nephro-Urology Monthly. 3, 3, p. 164-171 8 p.

Research output: Contribution to journalArticle

Metabolome
Chronic Renal Insufficiency
Urine
Metabolomics
Serum
2010
84 Citations (Scopus)

4-Hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway

Zhang, Y., Sano, M., Shinmura, K., Tamaki, K., Katsumata, Y., Matsuhashi, T., Morizane, S., Ito, H., Hishiki, T., Endo, J., Zhou, H., Yuasa, S., Kaneda, R., Suematsu, M. & Fukuda, K., 2010 Oct, In : Journal of Molecular and Cellular Cardiology. 49, 4, p. 576-586 11 p.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Reperfusion Injury
Cardiac Myocytes
Aldehydes
Ligases
22 Citations (Scopus)

Hypotaurine is an energy-saving hepatoprotective compound against ischemia-reperfusion injury of the rat liver

Sakuragawa, T., Hishiki, T., Ueno, Y., Ikeda, S., Soga, T., Yachie-Kinoshita, A., Kajimura, M. & Suematsu, M., 2010 Mar, In : Journal of Clinical Biochemistry and Nutrition. 46, 2, p. 126-134 9 p.

Research output: Contribution to journalArticle

Reperfusion Injury
Liver
Rats
Energy conservation
Taurine
69 Citations (Scopus)

Paradoxical ATP elevation in ischemic penumbra revealed by quantitative imaging mass spectrometry

Hattori, K., Kajimura, M., Hishiki, T., Nakanishi, T., Kubo, A., Nagahata, Y., Ohmura, M., Yachie-Kinoshita, A., Matsuura, T., Morikawa, T., Nakamura, T., Setou, M. & Suematsu, M., 2010 Oct 15, In : Antioxidants and Redox Signaling. 13, 8, p. 1157-1167 11 p.

Research output: Contribution to journalArticle

Mass spectrometry
Mass Spectrometry
Adenosine Triphosphate
Imaging techniques
NAD
8 Citations (Scopus)

Phosphorescence-assisted microvascular O2 measurements reveal alterations of oxygen demand in human metastatic colon cancer in the liver of superimmunodeficient NOG mice

Handa, K., Ohmura, M., Nishime, C., Hishiki, T., Nagahata, Y., Kawai, K., Suemizu, H., Nakamura, M., Wakui, M., Kitagawa, Y., Suematsu, M. & Tsukada, K., 2010, Advances in Experimental Medicine and Biology. Vol. 662. p. 423-429 7 p. (Advances in Experimental Medicine and Biology; vol. 662).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Phosphorescence
Liver Neoplasms
Liver
Colonic Neoplasms
Tumors
3 Citations (Scopus)

Reduced CD73 expression and its association with altered purine nucleotide metabolism in colorectal cancer cells robustly causing liver metastases

Matsuyama, M., Wakui, M., Monnai, M., Mizushima, T., Nishime, C., Kawai, K., Ohmura, M., Suemizu, H., Hishiki, T., Suematsu, M., Murata, M., Chijiwa, T., Furukawa, D., Ogoshi, K., Makuuchi, H. & Nakamura, M., 2010 May, In : Oncology Letters. 1, 3, p. 431-436 6 p.

Research output: Contribution to journalArticle

Purine Nucleotides
Colorectal Neoplasms
Neoplasm Metastasis
Liver
Neoplasms
5 Citations (Scopus)

T-state stabilization of hemoglobin by nitric oxide to form α-nitrosyl heme causes constitutive release of ATP from human erythrocytes

Akatsu, T., Tsukada, K., Hishiki, T., Suga-Numa, K., Tanabe, M., Shimazu, M., Kitagawa, Y., Yachie-Kinoshita, A. & Suematsu, M., 2010, Advances in Experimental Medicine and Biology. Vol. 662. p. 109-114 6 p. (Advances in Experimental Medicine and Biology; vol. 662).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Heme
Nitric Oxide
Stabilization
Adenosine Triphosphate
Erythrocytes
2009
79 Citations (Scopus)

Cystathionine β-synthase as a carbon monoxide-sensitive regulator of bile excretion

Shintani, T., Iwabuchi, T., Soga, T., Kato, Y., Yamamoto, T., Takano, N., Hishiki, T., Ueno, Y., Ikeda, S., Sakuragawa, T., Ishikawa, K., Goda, N., Kitagawa, Y., Kajimura, M., Matsumoto, K. & Suematsu, M., 2009, In : Hepatology. 49, 1, p. 141-150 10 p.

Research output: Contribution to journalArticle

Cystathionine
Carbon Monoxide
Bile
Heme Oxygenase (Decyclizing)
Metabolome
40 Citations (Scopus)

HIF-1α is necessary to support gluconeogenesis during liver regeneration

Tajima, T., Goda, N., Fujiki, N., Hishiki, T., Nishiyama, Y., Senoo-Matsuda, N., Shimazu, M., Soga, T., Yoshimura, Y., Johnson, R. S. & Suematsu, M., 2009 Oct 2, In : Biochemical and Biophysical Research Communications. 387, 4, p. 789-794 6 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Liver Regeneration
Gluconeogenesis
Liver
Hepatectomy
92 Citations (Scopus)

Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart

Endo, J., Sano, M., Katayama, T., Hishiki, T., Shinmura, K., Morizane, S., Matsuhashi, T., Katsumata, Y., Zhang, Y., Ito, H., Nagahata, Y., Marchitti, S., Nishimaki, K., Wolf, A. M., Nakanishi, H., Hattori, F., Vasiliou, V., Adachi, T., Ohsawa, I., Taguchi, R. & 5 others, Hirabayashi, Y., Ohta, S., Suematsu, M., Ogawa, S. & Fukuda, K., 2009 Nov, In : Circulation Research. 105, 11, p. 1118-1127 10 p.

Research output: Contribution to journalArticle

Aldehydes
Oxidative Stress
Glutathione
NADP
Transgenic Mice
10 Citations (Scopus)

Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis

Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanabe, H., Kataoka, K., Suematsu, M. & Handa, H., 2009, In : Toxicological Sciences. 109, 1, p. 143-151 9 p.

Research output: Contribution to journalArticle

Glycogen Debranching Enzyme System
Glycogen
Metabolism
Testis
Rats
2007
68 Citations (Scopus)

Roles of hemoglobin allostery in hypoxia-induced metabolic alterations in erythrocytes: Simulation and its verification by metabolome analysis

Kinoshita, A., Tsukada, K., Soga, T., Hishiki, T., Ueno, Y., Nakayama, Y., Tomita, M. & Suematsu, M., 2007 Apr 6, In : Journal of Biological Chemistry. 282, 14, p. 10731-10741 11 p.

Research output: Contribution to journalArticle

Metabolome
Hemoglobins
Erythrocytes
2,3-Diphosphoglycerate
Glycolysis
2004
7 Citations (Scopus)

Refolding processes of cytochrome P450cam from ferric and ferrous acid forms to the native conformation. Formations of folding intermediates with non-native heme coordination state

Egawa, T., Hishiki, T., Ichikawa, Y., Kanamori, Y., Shimada, H., Takahashi, S., Kitagawa, T. & Ishimura, Y., 2004 Jul 30, In : Journal of Biological Chemistry. 279, 31, p. 32008-32017 10 p.

Research output: Contribution to journalArticle

Camphor 5-Monooxygenase
Cytochromes
Heme
Conformations
Acids
2003
48 Citations (Scopus)

Infrared Spectroscopic and Mutational Studies on Putidaredoxin-Induced Conformational Changes in Ferrous CO-P450cam

Nagano, S., Shimada, H., Tarumi, A., Hishiki, T., Kimata-Ariga, Y., Egawa, T., Suematsu, M., Park, S. Y., Adachi, S. I., Shiro, Y. & Ishimura, Y., 2003 Dec 16, In : Biochemistry. 42, 49, p. 14507-14514 8 p.

Research output: Contribution to journalArticle

Camphor 5-Monooxygenase
Cytochromes
Infrared radiation
Carbon Monoxide
Electrons
2000
48 Citations (Scopus)

X-ray crystal structure and catalytic properties of Thr252Ile mutant of cytochrome P450cam: Roles of Thr252 and water in the active center

Hishiki, T., Shimada, H., Nagano, S., Egawa, T., Kanamori, Y., Makino, R., Park, S. Y., Adachi, S. I., Shiro, Y. & Ishimura, Y., 2000, In : Journal of Biochemistry. 128, 6, p. 965-974 10 p.

Research output: Contribution to journalArticle

Camphor 5-Monooxygenase
Cytochromes
Camphor
Crystal structure
X-Rays
1999
38 Citations (Scopus)

Putidaredoxin-cytochrome P450(cam) interaction: Spin state of the heme iron modulates putidaredoxin structure

Shimada, H., Nagano, S., Ariga, Y., Unno, M., Egawa, T., Hishiki, T., Ishimura, Y., Masuya, F., Obata, T. & Hori, H., 1999 Apr 2, In : Journal of Biological Chemistry. 274, 14, p. 9363-9369 7 p.

Research output: Contribution to journalArticle

Camphor 5-Monooxygenase
Heme
Cams
Iron
Ligands