• 2113 Citations
  • 23 h-Index
19992020

Research output per year

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Research Output

  • 2113 Citations
  • 23 h-Index
  • 45 Article
  • 3 Review article
  • 2 Conference contribution
2020

The NOTCH–FOXM1 axis plays a key role in mitochondrial biogenesis in the induction of human stem cell memory–like CAR-T cells

Kondo, T., Ando, M., Nagai, N., Tomisato, W., Srirat, T., Liu, B., Mise-Omata, S., Ikeda, M., Chikuma, S., Nishimasu, H., Nureki, O., Ohmura, M., Hayakawa, N., Hishiki, T., Uchibori, R., Ozawa, K. & Yoshimura, A., 2020 Feb 1, In : Cancer Research. 80, 3, p. 471-483 13 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2019

Xanthine oxidase inhibitor ameliorates postischemic renal injury in mice by promoting resynthesis of adenine nucleotides

Fujii, K., Kubo, A., Miyashita, K., Sato, M., Hagiwara, A., Inoue, H., Ryuzaki, M., Tamaki, M., Hishiki, T., Hayakawa, N., Kabe, Y., Itoh, H. & Suematsu, M., 2019 Nov 14, In : JCI Insight. 4, 22, e124816.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Biochemical, metabolomic, and genetic analyses of dephospho coenzyme a kinase involved in coenzyme a biosynthesis in the human enteric parasite entamoeba histolytica

Nurkanto, A., Jeelani, G., Yamamoto, T., Hishiki, T., Naito, Y., Suematsu, M., Hashimoto, T. & Nozaki, T., 2018 Nov 30, In : Frontiers in Microbiology. 9, NOV, 2902.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target

Nurkanto, A., Jeelani, G., Yamamoto, T., Naito, Y., Hishiki, T., Mori, M., Suematsu, M., Shiomi, K., Hashimoto, T. & Nozaki, T., 2018 Apr, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 1, p. 125-136 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera

Kabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., Minegishi, N., Hozawa, A., Murakami, Y., Kubo, M., Itonaga, M. & Handa, H., 2018 Oct, In : Clinical Chemistry. 64, 10, p. 1463-1473 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: Evidence from fatty acid-binding protein-4 and-5 knockout mice

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Yamaguchi, A., Hanaoka, H., Hishiki, T., Nagahata-Naito, Y., Obinata, H., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Jul 1, In : Cardiovascular Research. 114, 8, p. 1132-1144 13 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Obinata, H., Yamaguchi, A., Hanaoka, H., Hishiki, T., Hayakawa, N., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Dec 1, In : Scientific reports. 8, 1, 12035.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway

Mashima, K., Takahashi, S., Minami, K., Izawa, Y., Abe, T., Tsukada, N., Hishiki, T., Suematsu, M., Kajimura, M. & Suzuki, N., 2018 May 1, In : ASN Neuro. 10

Research output: Contribution to journalArticle

8 Citations (Scopus)
2017

Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice

Umbarawan, Y., Syamsunarno, M. R. A. A., Obinata, H., Yamaguchi, A., Sunaga, H., Matsui, H., Hishiki, T., Matsuura, T., Koitabashi, N., Obokata, M., Hanaoka, H., Haque, A., Kunimoto, F., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2017 Dec, In : Metabolism: clinical and experimental. 77, p. 47-57 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Targeting oxygen-sensing prolyl hydroxylase for metformin-associated lactic acidosis treatment

Oyaizu-Toramaru, T., Suhara, T., Hayakawa, N., Nakamura, T., Kubo, A., Minamishima, S., Yamaguchi, K., Hishiki, T., Morisaki, H., Suematsu, M. & Minamishima, Y., 2017 Aug 1, In : Molecular and Cellular Biology. 37, 16, e00248-17.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The histone 3 lysine 9 methyltransferase inhibitor chaetocin improves prognosis in a rat model of high salt diet-induced heart failure

Ono, T., Kamimura, N., Matsuhashi, T., Nagai, T., Nishiyama, T., Endo, J., Hishiki, T., Nakanishi, T., Shimizu, N., Tanaka, H., Ohta, S., Suematsu, M., Ieda, M., Sano, M., Fukuda, K. & Kaneda, R., 2017 Jan 4, In : Scientific Reports. 7, 39752.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2016

A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system

Iizumi, T., Takahashi, S., Mashima, K., Minami, K., Izawa, Y., Abe, T., Hishiki, T., Suematsu, M., Kajimura, M. & Suzuki, N., 2016 May 4, In : Journal of Neuroinflammation. 13, 1, 99.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells

Tohyama, S., Fujita, J., Hishiki, T., Matsuura, T., Hattori, F., Ohno, R., Kanazawa, H., Seki, T., Nakajima, K., Kishino, Y., Okada, M., Hirano, A., Kuroda, T., Yasuda, S., Sato, Y., Yuasa, S., Sano, M., Suematsu, M. & Fukuda, K., 2016 Apr 12, In : Cell Metabolism. 23, 4, p. 663-674 12 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
2015

Activation of pyruvate dehydrogenase by dichloroacetate has the potential to induce epigenetic remodeling in the heart

Matsuhashi, T., Hishiki, T., Zhou, H., Ono, T., Kaneda, R., Iso, T., Yamaguchi, A., Endo, J., Katsumata, Y., Atsushi, A., Yamamoto, T., Shirakawa, K., Yan, X., Shinmura, K., Suematsu, M., Fukuda, K. & Sano, M., 2015 May 1, In : Journal of Molecular and Cellular Cardiology. 82, p. 116-124 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions

Nakano, S., Ishii, I., Shinmura, K., Tamaki, K., Hishiki, T., Akahoshi, N., Ida, T., Nakanishi, T., Kamata, S., Kumagai, Y., Akaike, T., Fukuda, K., Sano, M. & Suematsu, M., 2015 Mar 6, (Accepted/In press) In : Journal of Molecular Medicine.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry

Ohmura, M., Hishiki, T., Yamamoto, T., Nakanishi, T., Kubo, A., Tsuchihashi, K., Tamada, M., Toue, S., Kabe, Y., Saya, H. & Suematsu, M., 2015 Apr 30, In : Nitric Oxide - Biology and Chemistry. 46, p. 102-113 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle

Suhara, T., Hishiki, T., Kasahara, M., Hayakawa, N., Oyaizu, T., Nakanishi, T., Kubo, A., Morisaki, H., Kaelin, W. G., Suematsu, M. & Minamishima, Y., 2015 Sep 15, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 37, p. 11642-11647 6 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Involvement of the yciW gene in l-cysteine and l-methionine metabolism in Escherichia coli

Kawano, Y., Ohtsu, I., Tamakoshi, A., Shiroyama, M., Tsuruoka, A., Saiki, K., Takumi, K., Nonaka, G., Nakanishi, T., Hishiki, T., Suematsu, M. & Takagi, H., 2015 Mar 1, In : Journal of Bioscience and Bioengineering. 119, 3, p. 310-313 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia

Takenouchi, T., Sugiura, Y., Morikawa, T., Nakanishi, T., Nagahata, Y., Sugioka, T., Honda, K., Kubo, A., Hishiki, T., Matsuura, T., Hoshino, T., Takahashi, T., Suematsu, M. & Kajimura, M., 2015 May 5, In : Journal of Cerebral Blood Flow and Metabolism. 35, 5, p. 794-805 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2014

Large-area surface-enhanced raman spectroscopy imaging of brain ischemia by gold nanoparticles grown on random nanoarrays of transparent boehmite

Yamazoe, S., Naya, M., Shiota, M., Morikawa, T., Kubo, A., Tani, T., Hishiki, T., Horiuchi, T., Suematsu, M. & Kajimura, M., 2014 Jun 24, In : ACS Nano. 8, 6, p. 5622-5632 11 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Neutral aminoaciduria in cystathionine β-synthase-deficient mice, an animal model of homocystinuria

Akahoshi, N., Kamata, S., Kubota, M., Hishiki, T., Nagahata, Y., Matsuura, T., Yamazaki, C., Yoshida, Y., Yamada, H., Ishizaki, Y., Suematsu, M., Kasahara, T. & Ishii, I., 2014 Jun 15, In : American Journal of Physiology - Renal Physiology. 306, 12, p. F1462-F1476

Research output: Contribution to journalArticle

10 Citations (Scopus)

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

Yamamoto, T., Takano, N., Ishiwata, K., Ohmura, M., Nagahata, Y., Matsuura, T., Kamata, A., Sakamoto, K., Nakanishi, T., Kubo, A., Hishiki, T. & Suematsu, M., 2014 Mar 17, In : Nature communications. 5, 3480.

Research output: Contribution to journalArticle

108 Citations (Scopus)
2013

A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting

Syamsunarno, M. R. A. A., Iso, T., Hanaoka, H., Yamaguchi, A., Obokata, M., Koitabashi, N., Goto, K., Hishiki, T., Nagahata, Y., Matsui, H., Sano, M., Kobayashi, M., Kikuchi, O., Sasaki, T., Maeda, K., Murakami, M., Kitamura, T., Suematsu, M., Tsushima, Y., Endo, K. & 2 others, Hotamisligil, G. S. & Kurabayashi, M., 2013 Nov 14, In : PloS one. 8, 11, e79386.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle

Iso, T., Maeda, K., Hanaoka, H., Suga, T., Goto, K., Syamsunarno, M. R. A. A., Hishiki, T., Nagahata, Y., Matsui, H., Arai, M., Yamaguchi, A., Abumrad, N. A., Sano, M., Suematsu, M., Endo, K., Hotamisligil, G. S. & Kurabayashi, M., 2013 Nov 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 11, p. 2549-2557 9 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Distinct metabolic flow enables large-scale purification of mouse and human pluripotent stem cell-derived cardiomyocytes

Tohyama, S., Hattori, F., Sano, M., Hishiki, T., Nagahata, Y., Matsuura, T., Hashimoto, H., Suzuki, T., Yamashita, H., Satoh, Y., Egashira, T., Seki, T., Muraoka, N., Yamakawa, H., Ohgino, Y., Tanaka, T., Yoichi, M., Yuasa, S., Murata, M., Suematsu, M. & 1 others, Fukuda, K., 2013 Jan 3, In : Cell stem cell. 12, 1, p. 127-137 11 p.

Research output: Contribution to journalArticle

360 Citations (Scopus)

Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo

Bao, Y., Mukai, K., Hishiki, T., Kubo, A., Ohmura, M., Sugiura, Y., Matsuura, T., Nagahata, Y., Hayakawa, N., Yamamoto, T., Fukuda, R., Saya, H., Suematsu, M. & Minamishima, Y., 2013 Sep 1, In : Molecular Cancer Research. 11, 9, p. 973-985 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2012
20 Citations (Scopus)

Gas biology: Tiny molecules controlling metabolic systems

Kajimura, M., Nakanishi, T., Takenouchi, T., Morikawa, T., Hishiki, T., Yukutake, Y. & Suematsu, M., 2012 Nov 15, In : Respiratory Physiology and Neurobiology. 184, 2, p. 139-148 10 p.

Research output: Contribution to journalReview article

26 Citations (Scopus)

Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway

Morikawa, T., Kajimura, M., Nakamura, T., Hishiki, T., Nakanishi, T., Yukutake, Y., Nagahata, Y., Ishikawa, M., Hattori, K., Takenouchi, T., Takahashi, T., Ishii, I., Matsubara, K., Kabe, Y., Uchiyama, S., Nagata, E., Gadalla, M. M., Snyder, S. H. & Suematsu, M., 2012 Jan 24, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 4, p. 1293-1298 6 p.

Research output: Contribution to journalArticle

150 Citations (Scopus)

Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria

Yamada, H., Akahoshi, N., Kamata, S., Hagiya, Y., Hishiki, T., Nagahata, Y., Matsuura, T., Takano, N., Mori, M., Ishizaki, Y., Izumi, T., Kumagai, Y., Kasahara, T., Suematsu, M. & Ishii, I., 2012 May 1, In : Free Radical Biology and Medicine. 52, 9, p. 1716-1726 11 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

Imaizumi, Y., Okada, Y., Akamatsu, W., Koike, M., Kuzumaki, N., Hayakawa, H., Nihira, T., Kobayashi, T., Ohyama, M., Sato, S., Takanashi, M., Funayama, M., Hirayama, A., Soga, T., Hishiki, T., Suematsu, M., Yagi, T., Ito, D., Kosakai, A., Hayashi, K. & 10 others, Shouji, M., Nakanishi, A., Suzuki, N., Mizuno, Y., Mizushima, N., Amagai, M., Uchiyama, Y., Mochizuki, H., Hattori, N. & Okano, H., 2012, In : Molecular brain. 5, 1, 35.

Research output: Contribution to journalArticle

218 Citations (Scopus)
2011

Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice

Ochiai, D., Goda, N., Hishiki, T., Kanai, M., Senoo-Matsuda, N., Soga, T., Johnson, R. S., Yoshimura, Y. & Suematsu, M., 2011 Nov 25, In : Biochemical and Biophysical Research Communications. 415, 3, p. 445-449 5 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Triacylglycerol/phospholipid molecular species profiling of fatty livers and regenerated non-fatty livers in cystathionine beta-synthase-deficient mice, an animal model for homocysteinemia/homocystinuria

Ikeda, K., Kubo, A., Akahoshi, N., Yamada, H., Miura, N., Hishiki, T., Nagahata, Y., Matsuura, T., Suematsu, M., Taguchi, R. & Ishii, I., 2011 Jun 1, In : Analytical and bioanalytical chemistry. 400, 7, p. 1853-1863 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
20 Citations (Scopus)
2010

4-Hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway

Zhang, Y., Sano, M., Shinmura, K., Tamaki, K., Katsumata, Y., Matsuhashi, T., Morizane, S., Ito, H., Hishiki, T., Endo, J., Zhou, H., Yuasa, S., Kaneda, R., Suematsu, M. & Fukuda, K., 2010 Oct 1, In : Journal of Molecular and Cellular Cardiology. 49, 4, p. 576-586 11 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Hypotaurine is an energy-saving hepatoprotective compound against ischemia-reperfusion injury of the rat liver

Sakuragawa, T., Hishiki, T., Ueno, Y., Ikeda, S., Soga, T., Yachie-Kinoshita, A., Kajimura, M. & Suematsu, M., 2010 Mar, In : Journal of Clinical Biochemistry and Nutrition. 46, 2, p. 126-134 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Paradoxical ATP elevation in ischemic penumbra revealed by quantitative imaging mass spectrometry

Hattori, K., Kajimura, M., Hishiki, T., Nakanishi, T., Kubo, A., Nagahata, Y., Ohmura, M., Yachie-Kinoshita, A., Matsuura, T., Morikawa, T., Nakamura, T., Setou, M. & Suematsu, M., 2010 Oct 15, In : Antioxidants and Redox Signaling. 13, 8, p. 1157-1167 11 p.

Research output: Contribution to journalReview article

71 Citations (Scopus)

Phosphorescence-assisted microvascular O2 measurements reveal alterations of oxygen demand in human metastatic colon cancer in the liver of superimmunodeficient NOG mice

Handa, K., Ohmura, M., Nishime, C., Hishiki, T., Nagahata, Y., Kawai, K., Suemizu, H., Nakamura, M., Wakui, M., Kitagawa, Y., Suematsu, M. & Tsukada, K., 2010 Dec 1, Oxygen Transport to Tissue XXXI. Takahashi, E. & Bruley, D. (eds.). p. 423-429 7 p. (Advances in Experimental Medicine and Biology; vol. 662).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Reduced CD73 expression and its association with altered purine nucleotide metabolism in colorectal cancer cells robustly causing liver metastases

Matsuyama, M., Wakui, M., Monnai, M., Mizushima, T., Nishime, C., Kawai, K., Ohmura, M., Suemizu, H., Hishiki, T., Suematsu, M., Murata, M., Chijiwa, T., Furukawa, D., Ogoshi, K., Makuuchi, H. & Nakamura, M., 2010 May 1, In : Oncology Letters. 1, 3, p. 431-436 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

T-state stabilization of hemoglobin by nitric oxide to form α-nitrosyl heme causes constitutive release of ATP from human erythrocytes

Akatsu, T., Tsukada, K., Hishiki, T., Suga-Numa, K., Tanabe, M., Shimazu, M., Kitagawa, Y., Yachie-Kinoshita, A. & Suematsu, M., 2010 Dec 1, Oxygen Transport to Tissue XXXI. Takahashi, E. & Bruley, D. (eds.). p. 109-114 6 p. (Advances in Experimental Medicine and Biology; vol. 662).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)
2009

Cystathionine β-synthase as a carbon monoxide-sensitive regulator of bile excretion

Shintani, T., Iwabuchi, T., Soga, T., Kato, Y., Yamamoto, T., Takano, N., Hishiki, T., Ueno, Y., Ikeda, S., Sakuragawa, T., Ishikawa, K., Goda, N., Kitagawa, Y., Kajimura, M., Matsumoto, K. & Suematsu, M., 2009 Mar 9, In : Hepatology. 49, 1, p. 141-150 10 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

HIF-1α is necessary to support gluconeogenesis during liver regeneration

Tajima, T., Goda, N., Fujiki, N., Hishiki, T., Nishiyama, Y., Senoo-Matsuda, N., Shimazu, M., Soga, T., Yoshimura, Y., Johnson, R. S. & Suematsu, M., 2009 Oct 2, In : Biochemical and Biophysical Research Communications. 387, 4, p. 789-794 6 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart

Endo, J., Sano, M., Katayama, T., Hishiki, T., Shinmura, K., Morizane, S., Matsuhashi, T., Katsumata, Y., Zhang, Y., Ito, H., Nagahata, Y., Marchitti, S., Nishimaki, K., Wolf, A. M., Nakanishi, H., Hattori, F., Vasiliou, V., Adachi, T., Ohsawa, I., Taguchi, R. & 5 others, Hirabayashi, Y., Ohta, S., Suematsu, M., Ogawa, S. & Fukuda, K., 2009 Nov, In : Circulation research. 105, 11, p. 1118-1127 10 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis

Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanabe, H., Kataoka, K., Suematsu, M. & Handa, H., 2009 May 13, In : Toxicological Sciences. 109, 1, p. 143-151 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2007
72 Citations (Scopus)
2004

Refolding processes of cytochrome P450cam from ferric and ferrous acid forms to the native conformation. Formations of folding intermediates with non-native heme coordination state

Egawa, T., Hishiki, T., Ichikawa, Y., Kanamori, Y., Shimada, H., Takahashi, S., Kitagawa, T. & Ishimura, Y., 2004 Jul 30, In : Journal of Biological Chemistry. 279, 31, p. 32008-32017 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2003

Infrared Spectroscopic and Mutational Studies on Putidaredoxin-Induced Conformational Changes in Ferrous CO-P450cam

Nagano, S., Shimada, H., Tarumi, A., Hishiki, T., Kimata-Ariga, Y., Egawa, T., Suematsu, M., Park, S. Y., Adachi, S. I., Shiro, Y. & Ishimura, Y., 2003 Dec 16, In : Biochemistry. 42, 49, p. 14507-14514 8 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2000

X-ray crystal structure and catalytic properties of Thr252Ile mutant of cytochrome P450cam: Roles of Thr252 and water in the active center

Hishiki, T., Shimada, H., Nagano, S., Egawa, T., Kanamori, Y., Makino, R., Park, S. Y., Adachi, S. I., Shiro, Y. & Ishimura, Y., 2000 Jan 1, In : Journal of biochemistry. 128, 6, p. 965-974 10 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)
1999

Putidaredoxin-cytochrome P450(cam) interaction: Spin state of the heme iron modulates putidaredoxin structure

Shimada, H., Nagano, S., Ariga, Y., Unno, M., Egawa, T., Hishiki, T., Ishimura, Y., Masuya, F., Obata, T. & Hori, H., 1999 Apr 2, In : Journal of Biological Chemistry. 274, 14, p. 9363-9369 7 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)