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Research Output 1989 2019

2019

10-Year Trends in Helicobacter pylori Eradication Rates by Sitafloxacin-Based Third-Line Rescue Therapy

Mori, H., Suzuki, H., Matsuzaki, J., Masaoka, T. & Kanai, T., 2019 Jan 1, (Accepted/In press) In : Digestion.

Research output: Contribution to journalArticle

Amoxicillin
Helicobacter pylori
Mutation
Microbial Drug Resistance
Meta-Analysis
Indigo Carmine
Ulcerative Colitis
Pulmonary Hypertension
Intussusception
Liver Diseases

Capsule endoscopy for small-intestinal disorders: Current status

Hosoe, N., Takabayashi, K., Ogata, H. & Kanai, T., 2019 Jan 1, In : Digestive Endoscopy.

Research output: Contribution to journalReview article

Capsule Endoscopy
Reading
Crohn Disease
Endoscopy
Intestinal Polyps

Clinical utility of novel ultrathin single-balloon enteroscopy: A feasibility study

Takabayashi, K., Hosoe, N., Miyanaga, R., Fukuhara, S., Hukuhara, K., Mizuno, S., Naganuma, M., Yahagi, N., Ogata, H. & Kanai, T., 2019 Jan 1, In : Endoscopy. 51, 5, p. 468-471 4 p.

Research output: Contribution to journalArticle

Feasibility Studies
Conscious Sedation
Ileum
Outpatients
Safety

Colonic diverticular bleeding and predictors of the length of hospitalization: An observational study

Wada, M., Nishizawa, T., Kato, M., Hirai, Y., Kinoshita, S., Mori, H., Nakazato, Y., Fujimoto, A., Kikuchi, M., Uraoka, T. & Kanai, T., 2019 Jan 1, In : Journal of Gastroenterology and Hepatology (Australia).

Research output: Contribution to journalArticle

Colonoscopy
Observational Studies
Hospitalization
Hemorrhage
Odds Ratio
2 Citations (Scopus)
Azathioprine
Crohn Disease
Randomized Controlled Trials
Kaplan-Meier Estimate
Therapeutics
Feasibility Studies
Endoscopy
Names
Single-Balloon Enteroscopy

Correction: Vedolizumab in Japanese patients with ulcerative colitis: A Phase 3, randomized, double-blind, placebo-controlled study (PLoS ONE (2019) 14:2 (e0212989) DOI: 10.1371/journal.pone.0212989)

Motoya, S., Watanabe, K., Ogata, H., Kanai, T., Matsui, T., Suzuki, Y., Shikamura, M., Sugiura, K., Oda, K., Hori, T., Araki, T., Watanabe, M. & Hibi, T., 2019 Apr 1, In : PloS one. 14, 4, e0215491.

Research output: Contribution to journalComment/debate

Open Access
colitis
Ulcerative Colitis
placebos
Placebos
vedolizumab

Current knowledge of irritable bowel syndrome-treatment

Masaoka, T. & Kanai, T., 2019 Jan 1, In : Journal of Japanese Society of Gastroenterology. 116, 7, p. 570-575 6 p.

Research output: Contribution to journalArticle

Irritable Bowel Syndrome
2 Citations (Scopus)

Current new challenges in the management of ulcerative colitis

Fukuda, T., Naganuma, M. & Kanai, T., 2019 Jan 1, In : Intestinal Research. 17, 1, p. 36-44 9 p.

Research output: Contribution to journalReview article

Ulcerative Colitis
Immunosuppressive Agents
Antibodies
Adrenal Cortex Hormones
Therapeutics

Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis

Yoshimatsu, Y., Naganuma, M., Sugimoto, S., Tanemoto, S., Umeda, S., Fukuda, T., Nomura, E., Yoshida, K., Ono, K., Mutaguchi, M., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Takabayashi, K., Ogata, H., Iwao, Y. & Kanai, T., 2019 Jan 1, In : Digestion.

Research output: Contribution to journalArticle

Indigo Carmine
Suppositories
Ulcerative Colitis
Therapeutics
Rectum
Colitis
Ulcerative Colitis
Neoplasms
Mucous Membrane
Colectomy

Efficacy of therapeutic intervention for patients with an ulcerative colitis mayo endoscopic score of 1

Fukuda, T., Naganuma, M., Sugimoto, S., Ono, K., Nanki, K., Mizuno, S., Hukuhara, K., Mutaguchi, M., Nakazato, Y., Takabayashi, K., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2019 Mar 14, In : Inflammatory bowel diseases. 25, 4, p. 782-788 7 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Recurrence
Colonoscopy
Therapeutics
Blood Vessels

Electric endocut and autocut resection for endoscopic papillectomy: A systematic review

Minami, K., Iwasaki, E., Fukuhara, S., Horibe, M., Seino, T., Kawasaki, S., Katayama, T., Takimoto, Y., Tamagawa, H., MacHida, Y., Kanai, T. & Itoi, T., 2019 Jan 1, In : Internal Medicine. 58, 19, p. 2767-2772 6 p.

Research output: Contribution to journalReview article

Open Access
Pancreatitis
Incidence
Hemorrhage
PubMed
Libraries
1 Citation (Scopus)

Epigenetic regulation of T helper cells and intestinal pathogenicity

Hagihara, Y., Yoshimatsu, Y., Mikami, Y., Takada, Y., Mizuno, S. & Kanai, T., 2019 Jan 1, In : Seminars in Immunopathology.

Research output: Contribution to journalReview article

Helper-Inducer T-Lymphocytes
Inflammatory Bowel Diseases
Epigenomics
Virulence
Immune System

First report of hepatobiliary Mycobacterium avium infection developing obstructive jaundice in a patient with neutralizing anti–interferon-gamma autoantibodies

Namkoong, H., Asakura, T., Ishii, M., Yoda, S., Masaki, K., Sakagami, T., Iwasaki, E., Yamagishi, Y., Kanai, T., Betsuyaku, T. & Hasegawa, N., 2019 Jan 1, In : New Microbes and New Infections. 27, p. 4-6 3 p.

Research output: Contribution to journalArticle

Mycobacterium avium
Mycobacterium Infections
Obstructive Jaundice
Autoantibodies
Jaundice
11 Citations (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Cho, H., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. & 2 others, Sato, T. & Kanai, T., 2019 Jan 1, (Accepted/In press) In : Nature Microbiology.

Research output: Contribution to journalArticle

Th17 Cells
Sclerosing Cholangitis
Liver Diseases
Microbiota
Bacterial Translocation

How Can We Assess "Complete Healing" Beyond Endoscopic Remission?

Fukuda, T., Naganuma, M. & Kanai, T., 2019 May 4, In : Inflammatory bowel diseases. 25, 6, p. e68

Research output: Contribution to journalArticle

Idiopathic Thrombocytopenic Purpura Responsive to Surgery for Crohn's Disease

Mizuno, S., Naganuma, M. & Kanai, T., 2019 Feb 21, In : Inflammatory bowel diseases. 25, 3, p. e26

Research output: Contribution to journalArticle

Idiopathic Thrombocytopenic Purpura
Crohn Disease

Impact of Antimicrobial Prophylaxis for Severe Acute Pancreatitis on the Development of Invasive Candidiasis: A Large Retrospective Multicenter Cohort Study

Horibe, M., Sanui, M., Sasaki, M., Honda, H., Ogura, Y., Namiki, S., Sawano, H., Goto, T., Ikeura, T., Takeda, T., Oda, T., Yasuda, H., Miyazaki, D., Hirose, K., Kitamura, K., Chiba, N., Ozaki, T., Yamashita, T., Koinuma, T., Oshima, T. & 10 others, Yamamoto, T., Hirota, M., Yamamoto, S., Oe, K., Ito, T., Masuda, Y., Saito, N., Iwasaki, E., Kanai, T. & Mayumi, T., 2019 Apr 1, In : Pancreas. 48, 4, p. 537-543 7 p.

Research output: Contribution to journalArticle

Invasive Candidiasis
Pancreatitis
Multicenter Studies
Cohort Studies
Logistic Models

Impact of electrical pulse cut mode during endoscopic papillectomy: Pilot randomized clinical trial

Iwasaki, E., Minami, K., Itoi, T., Yamamoto, K., Tsuji, S., Sofuni, A., Tsuchiya, T., Tanaka, R., Tonozuka, R., Machida, Y., Takimoto, Y., Tamagawa, H., Katayama, T., Kawasaki, S., Seino, T., Horibe, M., Fukuhara, S., Kitago, M., Ogata, H. & Kanai, T., 2019 Jan 1, (Accepted/In press) In : Digestive Endoscopy.

Research output: Contribution to journalArticle

Randomized Controlled Trials
Hemorrhage
Pancreatitis
Adenoma
Artifacts
Cellular Structures
Cadherins
Ulcerative Colitis
Colitis
Signet Ring Cell Carcinoma
3 Citations (Scopus)

Large volume fluid resuscitation for severe acute pancreatitis is associated with reduced mortality: A multicenter retrospective study

Yamashita, T., Horibe, M., Sanui, M., Sasaki, M., Sawano, H., Goto, T., Ikeura, T., Hamada, T., Oda, T., Yasuda, H., Ogura, Y., Miyazaki, D., Hirose, K., Kitamura, K., Chiba, N., Ozaki, T., Koinuma, T., Oshima, T., Yamamoto, T., Hirota, M. & 9 others, Masuda, Y., Tokuhira, N., Kobayashi, M., Saito, S., Izai, J., Lefor, A. K., Iwasaki, E., Kanai, T. & Mayumi, T., 2019 May 1, In : Journal of Clinical Gastroenterology. 53, 5, p. 385-391 7 p.

Research output: Contribution to journalArticle

Resuscitation
Pancreatitis
Multicenter Studies
Retrospective Studies
Mortality
Human Herpesvirus 3
Acute Liver Failure
Hematopoietic Stem Cell Transplantation
Virus Diseases
Herpes Zoster

Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine

Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M. & 5 others, Ohtsuka, K., Mochizuki, M., Watanabe, M., Hashiguchi, M. & Kanai, T., 2019 Jan 1, In : Journal of Gastroenterology and Hepatology (Australia).

Research output: Contribution to journalReview article

Inflammatory Bowel Diseases
Erythrocyte Indices
Leukopenia
Leukocyte Count
Genotype
Fatty Liver
Ultrasonography
Pancreas
Odds Ratio
Magnetic Resonance Imaging

Neutrophil-activating Protein Polymorphism of Helicobacter pylori Determines the Host Risk of Dyspepsia

Matsuzaki, J., Tsugawa, H., Kashiwazaki, Y., Mori, H., Yamamoto, Y., Kameyama, H., Masaoka, T., Kanai, T. & Suzuki, H., 2019 Jan 1, In : CMGH. 8, 2, p. 295-297.e6

Research output: Contribution to journalArticle

Open Access
Dyspepsia
Helicobacter pylori neutrophil-activating protein A

Novel mainstream capnometer system is safe and feasible even under CO 2 insufflation during ERCP-related procedure: A pilot study

Takimoto, Y., Iwasaki, E., Masaoka, T., Fukuhara, S., Kawasaki, S., Seino, T., Katayama, T., Minami, K., Tamagawa, H., Machida, Y., Ogata, H. & Kanai, T., 2019 Feb 1, In : BMJ Open Gastroenterology. 6, 1, e000266.

Research output: Contribution to journalArticle

Open Access
Insufflation
Endoscopic Retrograde Cholangiopancreatography
Carbon Monoxide
Apnea
Bites and Stings
Cysts
Fats
Odds Ratio
Confidence Intervals
Pancreas
1 Citation (Scopus)

Pharmacological effects of TAK-828F: an orally available RORγt inverse agonist, in mouse colitis model and human blood cells of inflammatory bowel disease

Igaki, K., Nakamura, Y., Tanaka, M., Mizuno, S., Yoshimatsu, Y., Komoike, Y., Uga, K., Shibata, A., Imaichi, H., Takayuki, S., Ishimura, Y., Yamasaki, M., Kanai, T., Tsukimi, Y. & Tsuchimori, N., 2019 Jun 1, In : Inflammation Research. 68, 6, p. 493-509 17 p.

Research output: Contribution to journalArticle

Colitis
Inflammatory Bowel Diseases
Blood Cells
Monoclonal Antibodies
Pharmacology

Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35

Koda, Y., Nakamoto, N., Cho, H., Yoshida, A., Mikami, Y., Teratani, T., Tsujikawa, H., Shiba, S., Taniki, N., Sujino, T., Miyamoto, K., Suzuki, T., Yamaguchi, A., Morikawa, R., Sato, K., Sakamoto, M., Yoshimoto, T. & Kanai, T., 2019 Jul 2, In : The Journal of clinical investigation. 130

Research output: Contribution to journalArticle

Open Access
Dendritic Cells
Liver
Wounds and Injuries
Acute Liver Failure
Immunosuppressive Agents
3 Citations (Scopus)

Sustained virologic response to direct-acting antiviral therapy in patients with chronic hepatitis C and hepatocellular carcinoma: A systematic review and meta-analysis

Ji, F., Yeo, Y. H., Wei, M. T., Ogawa, E., Enomoto, M., Lee, D. H., Iio, E., Lubel, J., Wang, W., Wei, B., Ide, T., Preda, C. M., Conti, F., Minami, T., Bielen, R., Sezaki, H., Barone, M., Kolly, P., Cho, H., Virlogeux, V. & 15 others, Eurich, D., Henry, L., Bass, M. B., Kanai, T., Dang, S., Li, Z., Dufour, J. F., Zoulim, F., Andreone, P., Cheung, R. C., Tanaka, Y., Furusyo, N., Toyoda, H., Tamori, A. & Nguyen, M. H., 2019 Jan 1, In : Journal of Hepatology.

Research output: Contribution to journalArticle

Chronic Hepatitis C
Antiviral Agents
Meta-Analysis
Hepatocellular Carcinoma
Therapeutics

The association between environmental factors and the development of Crohn's disease with focusing on passive smoking: A multicenter case-control study in Japan

Kondo, K., Ohfuji, S., Watanabe, K., Yamagami, H., Fukushima, W., Ito, K., Suzuki, Y., Hirota, Y., Motoya, S., Sakuraba, H., Ishiguro, Y., Sasaki, I., Suzuki, K., Fukuda, K., Saruta, M., Shinozaki, M., Shimizu, T., You, A., Nagahori, M., Watanabe, M. & 42 others, Kanai, T., Iizuka, B., Watanabe, T., Kobayashi, K., Kunisaki, R., Sugita, A., Ishige, T., Miura, S., Hokari, R., Hanai, H., Goto, H., Ando, T., Tanida, S., Joh, T., Mizoshita, T., Sasaki, M., Kitamura, K., Umegae, S., Fujiyama, Y., Ando, A., Shimizu, S., Yoshioka, K., Kitano, A., Aomatsu, K., Naito, Y., Yoshida, M., Ooi, M., Matsumoto, T., Fukunaga, K., Iimuro, M., Ikeuchi, H., Ishihara, S., Tanaka, S., Ueno, Y., Matsui, T., Yano, Y., Yamasaki, H., Mitsuyama, K., Yamamoto, S., Tsubouchi, H., Sugimura, K. & Tenjin, T., 2019 Jun 1, In : PloS one. 14, 6, e0216429.

Research output: Contribution to journalArticle

Open Access
Tobacco Smoke Pollution
Crohn disease
case-control studies
Crohn Disease
Case-Control Studies
1 Citation (Scopus)

Toll-Like Receptor 7 Agonist–Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells

Kiyohara, H., Sujino, T., Teratani, T., Miyamoto, K., Arai, M. M., Nomura, E., Harada, Y., Aoki, R., Koda, Y., Mikami, Y., Mizuno, S., Naganuma, M., Hisamatsu, T. & Kanai, T., 2019 Jan 1, In : CMGH. 7, 1, p. 135-156 22 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 7
imiquimod
Dextran Sulfate
Dermatitis
Colitis
1 Citation (Scopus)

Vedolizumab in Japanese patients with ulcerative colitis: A Phase 3, randomized, double-blind, placebo-controlled study

Motoya, S., Watanabe, K., Ogata, H., Kanai, T., Matsui, T., Suzuki, Y., Shikamura, M., Sugiura, K., Oda, K., Hori, T., Araki, T., Watanabe, M. & Hibi, T., 2019 Feb 1, In : PloS one. 14, 2, e0212989.

Research output: Contribution to journalArticle

Open Access
colitis
Ulcerative Colitis
placebos
Placebos
remission
1 Citation (Scopus)
Crohn Disease
Randomized Controlled Trials
Maintenance
Adrenal Cortex Hormones
Adalimumab
2018

5-Aminosalicylic acid aggravates colitis mimicking exacerbation of ulcerative colitis

Miyoshi, J., Matsuoka, K., Yoshida, A., Naganuma, M., Hisamatsu, T., Yajima, T., Inoue, N., Okamoto, S., Iwao, Y., Ogata, H., Ueno, F., Hibi, T. & Kanai, T., 2018 Oct 1, In : Intestinal Research. 16, 4, p. 635-640 6 p.

Research output: Contribution to journalArticle

Mesalamine
Colitis
Ulcerative Colitis
Colonoscopy
Inflammatory Bowel Diseases
1 Citation (Scopus)

Absence of high-risk stigmata predicts good prognosis even in severely anemic patients with suspected acute upper gastrointestinal bleeding

Horibe, M., Ogura, Y., Matsuzaki, J., Kaneko, T., Yokota, T., Okawa, O., Nakatani, Y., Iwasaki, E., Nishizawa, T., Hosoe, N., Masaoka, T., Yahagi, N., Namiki, S. & Kanai, T., 2018 Jan 1, (Accepted/In press) In : United European Gastroenterology Journal.

Research output: Contribution to journalArticle

Christianity
Hemorrhage
Blood Transfusion
Hemoglobins
Mortality
9 Citations (Scopus)
Helicobacter pylori
Mutation
Microbial Sensitivity Tests
Fluoroquinolones
sitafloxacin
2 Citations (Scopus)

A male Korean who was diagnosed with chronic enteropathy associated with SLCO2A1 (CEAS): Case report with literature review

Sun, X., Hosoe, N., Miyanaga, R., Hukuhara, K., Mizuno, S., Takabayashi, K., Naganuma, M., Niizeki, H., Seki, A., Ogata, H. & Kanai, T., 2018 Jan 1, In : BMJ Open Gastroenterology. 5, 1, e000223.

Research output: Contribution to journalArticle

Melena
Mutation
Genes
Exons
Capsule Endoscopes
2 Citations (Scopus)

Analysis of sensitivity and cell death pathways mediated by anti-cancer drugs using three-dimensional culture system

Kinoshita, T., Higuchi, H., Ayano-Kabashima-Niibe, Sakai, G., Hamamoto, Y., Takaishi, H. & Kanai, T., 2018 Jan 1, In : International Journal of Cancer Research. 14, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

irinotecan
Cell Death
Apoptosis
Caspases
Pharmaceutical Preparations
6 Citations (Scopus)

Aortic carboxypeptidase-like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis

Teratani, T., Tomita, K., Suzuki, T., Furuhashi, H., Irie, R., Nishikawa, M., Yamamoto, J., Hibi, T., Miura, S., Minamino, T., Oike, Y., Hokari, R. & Kanai, T., 2018 Apr 2, In : Journal of Clinical Investigation. 128, 4, p. 1581-1596 16 p.

Research output: Contribution to journalArticle

Carboxypeptidases
Ligands
Hepatic Stellate Cells
Proteins
Liver
4 Citations (Scopus)

Burden of impaired sleep quality on work productivity in functional dyspepsia

Matsuzaki, J., Suzuki, H., Togawa, K., Yamane, T., Mori, H., Komori, T., Masaoka, T. & Kanai, T., 2018 Apr 1, In : United European Gastroenterology Journal. 6, 3, p. 398-406 9 p.

Research output: Contribution to journalArticle

Dyspepsia
Sleep
Economics
10 Citations (Scopus)

Clarithromycin expands CD11b+Gr-1+cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia

Namkoong, H., Ishii, M., Fujii, H., Yagi, K., Asami, T., Asakura, T., Suzuki, S., Hegab, A. E., Kamata, H., Tasaka, S., Atarashi, K., Nakamoto, N., Iwata, S., Honda, K., Kanai, T., Hasegawa, N., Koyasu, S. & Betsuyaku, T., 2018 Apr 1, In : PLoS Pathogens. 14, 4, e1006955.

Research output: Contribution to journalArticle

Bacterial Pneumonia
Clarithromycin
Septic Shock
Human Influenza
Pneumococcal Pneumonia
Adenoma
Adenocarcinoma
Neoplasms
Barrett Esophagus
Delayed Diagnosis
13 Citations (Scopus)

Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn's Disease

DIAMOND study group, 2018 Apr 1, In : Clinical Gastroenterology and Hepatology. 16, 4, p. 542-549.e1

Research output: Contribution to journalArticle

Crohn Disease
Pharmacokinetics
Odds Ratio
Confidence Intervals
Azathioprine
3 Citations (Scopus)
Stomach Neoplasms
Neoplasms
Therapeutics
Immunotherapy
Japan
4 Citations (Scopus)

Clinical impact of closure of the mucosal defect after duodenal endoscopic submucosal dissection

Kato, M., Ochiai, Y., Fukuhara, S., Maehata, T., Sasaki, M., Kiguchi, Y., Akimoto, T., Fujimoto, A., Nakayama, A., Kanai, T. & Yahagi, N., 2018 Jan 1, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

Length of Stay
C-Reactive Protein
Logistic Models
Odds Ratio
Confidence Intervals
17 Citations (Scopus)

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S. & 3 others, Koo, B. K., Kanai, T. & Sato, T., 2018 Aug 9, In : Cell. 174, 4, p. 856-869.e17

Research output: Contribution to journalArticle

Stomach Neoplasms
Organoids
Stomach
Screening
Carcinogenesis
1 Citation (Scopus)

Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

Murakami, Y., Sugiyama, K., Ebinuma, H., Nakamoto, N., Ojiro, K., Cho, H., Taniki, N., Saito, Y., Teratani, T., Koda, Y., Suzuki, T., Saito, K., Fukasawa, M., Ikeda, M., Kato, N., Kanai, T. & Saito, H., 2018 Jun 25, In : BMC Cancer. 18, 1, 680.

Research output: Contribution to journalArticle

NF-E2-Related Factor 2
Liver Neoplasms
Hepacivirus
Hepatocytes
Virus Diseases