• 9804 Citations
  • 49 h-Index
1989 …2020

Research output per year

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Research Output

2020

5-Aminosalicylic acid intolerance is associated with a risk of adverse clinical outcomes and dysbiosis in patients with ulcerative colitis

Mizuno, S., Ono, K., Mikami, Y., Naganuma, M., Fukuda, T., Minami, K., Masaoka, T., Terada, S., Yoshida, T., Saigusa, K., Hirahara, N., Miyata, H., Suda, W., Hattori, M. & Kanai, T., 2020 Jan 1, In : Intestinal Research. 18, 1, p. 69-78 10 p.

Research output: Contribution to journalArticle

Open Access

A case of intrahepatic cholangiocellular carcinoma due to thorotrast deposition, well-controlled by radiofrequency ablation therapy

Taniki, N., Nakamoto, N., Yoshida, A., Chu, P. S., Ikura, A., Yamataka, K., Morikawa, R., Shiba, S., Yamaguchi, A., Usui, S., Ojiro, K., Ebinuma, H., Saito, H., Kubota, N., Masugi, Y., Sakamto, M. & Kanai, T., 2020 Jan 1, In : Acta Hepatologica Japonica. 61, 5, p. 262-269 8 p.

Research output: Contribution to journalArticle

Open Access

Anti-MAdCAM-1 antibody (PF-00547659) for active refractory Crohn's disease in Japanese and Korean patients: The OPERA study

Saruta, M., Park, D. I., Kim, Y. H., Yang, S. K., Jang, B. I., Cheon, J. H., Im, J. P., Kanai, T., Katsuno, T., Ishiguro, Y., Nagaoka, M., Isogawa, N., Li, Y., Banerjee, A., Ahmad, A., Hassan-Zahraee, M., Clare, R., Gorelick, K. J., Cataldi, F., Watanabe, M. & 1 others, Hibi, T., 2020 Jan 1, In : Intestinal Research. 18, 1, p. 45-55 11 p.

Research output: Contribution to journalArticle

Open Access

A Phase II Study of Regorafenib With a Lower Starting Dose in Patients With Metastatic Colorectal Cancer: Exposure–Toxicity Analysis of Unbound Regorafenib and Its Active Metabolites (RESET Trial)

Suzuki, T., Sukawa, Y., Imamura, C., Masuishi, T., Satake, H., Kumekawa, Y., Funakoshi, S., Kotaka, M., Horie, Y., Kawai, S., Okuda, H., Terazawa, T., Kondoh, C., Kato, K., Yoshimura, K., Ishikawa, H., Hamamoto, Y., Boku, N., Takaishi, H. & Kanai, T., 2020 Mar, In : Clinical Colorectal Cancer. 19, 1, p. 13-21.e3

Research output: Contribution to journalArticle

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., Kanai, T. & Sato, T., 2020 Feb, In : Gastroenterology. 158, 3, p. 638-651.e8

Research output: Contribution to journalArticle

4 Citations (Scopus)

Clinical and endoscopic characteristics of pyogenic granuloma in the small intestine: A case series with literature review

Hayashi, Y., Dr, N. H., Takabayashi, K., Limpias Kamiya, K. J. L., Mutaguchi, M., Miyanaga, R., Hirata, K., Fukuhara, S., Mikami, Y., Sujino, T., Masugi, Y., Naganuma, M., Ogata, H. & Kanai, T., 2020 Feb 15, In : Internal Medicine. 59, 4, p. 501-505 5 p.

Research output: Contribution to journalReview article

Open Access

Clinical implications with tolvaptan on monitored bioimpedance-defined fluid status in patients with cirrhotic ascites: An observational study

Shiba, S., Chu, P. S., Nakamoto, N., Yamataka, K., Taniki, N., Ojiro, K., Yamaguchi, A., Morikawa, R., Yoshida, A., Ikura, A., Ebinuma, H., Saito, H. & Kanai, T., 2020 Mar 5, In : BMC Gastroenterology. 20, 1, 53.

Research output: Contribution to journalArticle

Open Access

Effects of vedolizumab in Japanese patients with Crohn’s disease: a prospective, multicenter, randomized, placebo-controlled Phase 3 trial with exploratory analyses

Watanabe, K., Motoya, S., Ogata, H., Kanai, T., Matsui, T., Suzuki, Y., Shikamura, M., Sugiura, K., Oda, K., Hori, T., Araki, T., Watanabe, M. & Hibi, T., 2020 Mar 1, In : Journal of gastroenterology. 55, 3, p. 291-306 16 p.

Research output: Contribution to journalArticle

Open Access

Efficacy and safety of immediate oral intake in patients with mild acute pancreatitis: A randomized controlled trial

Horibe, M., Iwasaki, E., Nakagawa, A., Matsuzaki, J., Minami, K., Machida, Y., Tamagawa, H., Takimoto, Y., Ueda, M., Katayama, T., Kawasaki, S., Matsushita, M., Seino, T., Fukuhara, S. & Kanai, T., 2020 Jun, In : Nutrition. 74, 110724.

Research output: Contribution to journalArticle

Efficacy of apheresis as maintenance therapy for patients with ulcerative colitis in an open-label prospective multicenter randomised controlled trial

for the CAPTAIN study Group, 2020 Apr 1, In : Journal of gastroenterology. 55, 4, p. 390-400 11 p.

Research output: Contribution to journalArticle

Giant mesocaval shunt formed by recurrent ileal intussusception

Takabayashi, K., Hosoe, N., Ogata, H. & Kanai, T., 2020 Mar 1, In : Internal Medicine. 59, 5, p. 747-748 2 p.

Research output: Contribution to journalComment/debate

Open Access

Horibe GI bleeding prediction score: a simple score for triage decision-making in patients with suspected upper GI bleeding

Horibe, M., Iwasaki, E., Bazerbachi, F., Kaneko, T., Matsuzaki, J., Minami, K., Masaoka, T., Hosoe, N., Ogura, Y., Namiki, S., Hosoda, Y., Ogata, H., Chan, A. T. & Kanai, T., 2020 Jan 1, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

How I do it: Endoscopic diagnosis for superficial non-ampullary duodenal epithelial tumors

Nakayama, A., Kato, M., Takatori, Y., Shimoda, M., Mizutani, M., Tsutsumi, K., Kiguchi, Y., Akimoto, T., Sasaki, M., Mutaguchi, M., Takabayashi, K., Maehata, T., Ochiai, Y., Kanai, T. & Yahagi, N., 2020 Mar 1, In : Digestive Endoscopy. 32, 3, p. 417-424 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Impact of electrical pulse cut mode during endoscopic papillectomy: Pilot randomized clinical trial

Iwasaki, E., Minami, K., Itoi, T., Yamamoto, K., Tsuji, S., Sofuni, A., Tsuchiya, T., Tanaka, R., Tonozuka, R., Machida, Y., Takimoto, Y., Tamagawa, H., Katayama, T., Kawasaki, S., Seino, T., Horibe, M., Fukuhara, S., Kitago, M., Ogata, H. & Kanai, T., 2020 Jan 1, In : Digestive Endoscopy. 32, 1, p. 127-135 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Indigo naturalis is effective even in treatment-refractory patients with ulcerative colitis: a post hoc analysis from the INDIGO study

For the INDIGO Study Group, 2020 Feb 1, In : Journal of gastroenterology. 55, 2, p. 169-180 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Management of perforation related to endoscopic submucosal dissection for superficial duodenal epithelial tumors

Fukuhara, S., Kato, M., Iwasaki, E., Sasaki, M., Tsutsumi, K., Kiguchi, Y., Akimoto, T., Takatori, Y., Nakayama, A., Maehata, T., Minami, K., Ogata, H., Kanai, T. & Yahagi, N., 2020 May, In : Gastrointestinal Endoscopy. 91, 5, p. 1129-1137 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Mucosal concentrations of N-acetyl-5-aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine

Fukuda, T., Naganuma, M., Takabayashi, K., Hagihara, Y., Tanemoto, S., Nomura, E., Yoshimatsu, Y., Sugimoto, S., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Mutaguchi, M., Inoue, N., Ogata, H., Iwao, Y., Abe, T. & Kanai, T., 2020 Jan 1, (Accepted/In press) In : Journal of Gastroenterology and Hepatology (Australia).

Research output: Contribution to journalArticle

Open Access

Multiple immune-related adverse events and anti-tumor efficacy: Real-world data on various solid tumors

Shimozaki, K., Sukawa, Y., Beppu, N., Kurihara, I., Suzuki, S., Mizuno, R., Funakoshi, T., Ikemura, S., Tsugaru, K., Togasaki, K., Kawasaki, K., Hirata, K., Hayashi, H., Hamamoto, Y., Takaishi, H. & Kanai, T., 2020 Jan 1, In : Cancer Management and Research. 12, p. 4585-4593 9 p.

Research output: Contribution to journalArticle

Open Access

Previous Helicobacter pylori infection–induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication

Kishikawa, H., Ojiro, K., Nakamura, K., Katayama, T., Arahata, K., Takarabe, S., Miura, S., Kanai, T. & Nishida, J., 2020 Feb 1, In : Helicobacter. 25, 1, e12669.

Research output: Contribution to journalReview article

Open Access
4 Citations (Scopus)

Somatic inflammatory gene mutations in human ulcerative colitis epithelium

Nanki, K., Fujii, M., Shimokawa, M., Matano, M., Nishikori, S., Date, S., Takano, A., Toshimitsu, K., Ohta, Y., Takahashi, S., Sugimoto, S., Ishimaru, K., Kawasaki, K., Nagai, Y., Ishii, R., Yoshida, K., Sasaki, N., Hibi, T., Ishihara, S., Kanai, T. & 1 others, Sato, T., 2020 Jan 9, In : Nature. 577, 7789, p. 254-259 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Transient hypotension during endoscopic resection of gangliocytic paraganglioma with ampullary involvement

Katayama, T., Iwasaki, E., Minami, K., Fukuhara, S. & Kanai, T., 2020 Jan, In : VideoGIE. 5, 1, p. 26-28 3 p.

Research output: Contribution to journalArticle

Open Access
2019

10-Year Trends in Helicobacter pylori Eradication Rates by Sitafloxacin-Based Third-Line Rescue Therapy

Mori, H., Suzuki, H., Matsuzaki, J., Masaoka, T. & Kanai, T., 2019 Jan 1, (Accepted/In press) In : Digestion.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Adverse events in patients with ulcerative colitis treated with indigo naturalis: a Japanese nationwide survey

INDIGO survey Group, 2019 Oct 1, In : Journal of gastroenterology. 54, 10, p. 891-896 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Capsule endoscopy for small-intestinal disorders: Current status

Hosoe, N., Takabayashi, K., Ogata, H. & Kanai, T., 2019 Jan 1, In : Digestive Endoscopy.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Clinical and endoscopic findings to assist the early detection of duodenal adenoma and adenocarcinoma

Matsuzaki, J., Suzuki, H., Shimoda, M., Mori, H., Fukuhara, S., Miyoshi, S., Masaoka, T., Iwao, Y., Kanai, Y. & Kanai, T., 2019 Mar 1, In : United European Gastroenterology Journal. 7, 2, p. 250-260 11 p.

Research output: Contribution to journalArticle

Clinical utility of novel ultrathin single-balloon enteroscopy: A feasibility study

Takabayashi, K., Hosoe, N., Miyanaga, R., Fukuhara, S., Hukuhara, K., Mizuno, S., Naganuma, M., Yahagi, N., Ogata, H. & Kanai, T., 2019 Jan 1, In : Endoscopy. 51, 5, p. 468-471 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Colonic diverticular bleeding and predictors of the length of hospitalization: An observational study

Wada, M., Nishizawa, T., Kato, M., Hirai, Y., Kinoshita, S., Mori, H., Nakazato, Y., Fujimoto, A., Kikuchi, M., Uraoka, T. & Kanai, T., 2019 Jan 1, In : Journal of Gastroenterology and Hepatology (Australia). 34, 8, p. 1351-1356 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Concerns and Side Effects of Azathioprine during Adalimumab Induction and Maintenance Therapy for Japanese Patients with Crohn's Disease: A Subanalysis of a Prospective Randomised Clinical Trial [DIAMOND Study]

Hisamatsu, T., Matsumoto, T., Watanabe, K., Nakase, H., Motoya, S., Yoshimura, N., Ishida, T., Kato, S., Nakagawa, T., Esaki, M., Nagahori, M., Matsui, T., Naito, Y., Kanai, T., Suzuki, Y., Nojima, M., Watanabe, M., Hibi, T., Andoh, A., Ashida, T. & 71 others, Endo, K., Endo, Y., Esaki, M., Fujita, H., Fujiya, M., Haruma, K., Hibi, T., Hiraoka, S., Hirata, I., Hisamatsu, T., Honda, Y., Iijima, H., Iizuka, B., Ikeya, K., Inoue, T., Inoue, S., Ishida, T., Ishiguro, Y., Ishihara, S., Ito, H., Iwakiri, R., Kagaya, T., Kanai, T., Kashida, H., Kato, S., Kato, J., Katsurada, T., Kinjyo, F., Kobayashi, K., Kodama, M., Kunisaki, R., Kurahara, K., Kurokami, T., Kyouwon, L., Matsuda, K., Matsueda, K., Matsui, T., Matsumoto, T., Mitsuyama, K., Mizokami, Y., Motoya, S., Naito, Y., Nakagawa, T., Nakamura, S., Nakase, H., Nojima, M., Nomura, M., Ogawa, A., Okazaki, K., Otsuka, K., Sakuraba, H., Saruta, M., Sasaki, M., Shirai, T., Suga, T., Sugimura, K., Sugiyama, T., Suzuki, Y., Takeshima, F., Tamaki, H., Tanaka, S., Tanida, S., Tominaga, K., Tomizawa, T., Watanabe, K., Watanabe, M., Watanabe, K., Yamamoto, S., Yamashita, M., Yoshida, A. & Yoshimura, N., 2019 Sep 1, In : Journal of Crohn's and Colitis. 13, 9, p. 1097-1104 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Correction: Vedolizumab in Japanese patients with ulcerative colitis: A Phase 3, randomized, double-blind, placebo-controlled study (PLoS ONE (2019) 14:2 (e0212989) DOI: 10.1371/journal.pone.0212989)

Motoya, S., Watanabe, K., Ogata, H., Kanai, T., Matsui, T., Suzuki, Y., Shikamura, M., Sugiura, K., Oda, K., Hori, T., Araki, T., Watanabe, M. & Hibi, T., 2019 Apr, In : PloS one. 14, 4, e0215491.

Research output: Contribution to journalComment/debate

Open Access
1 Citation (Scopus)

Current knowledge of irritable bowel syndrome-treatment

Masaoka, T. & Kanai, T., 2019 Jan 1, In : Journal of Japanese Society of Gastroenterology. 116, 7, p. 570-575 6 p.

Research output: Contribution to journalArticle

Current new challenges in the management of ulcerative colitis

Fukuda, T., Naganuma, M. & Kanai, T., 2019 Jan 1, In : Intestinal Research. 17, 1, p. 36-44 9 p.

Research output: Contribution to journalReview article

6 Citations (Scopus)

Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis

Yoshimatsu, Y., Naganuma, M., Sugimoto, S., Tanemoto, S., Umeda, S., Fukuda, T., Nomura, E., Yoshida, K., Ono, K., Mutaguchi, M., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Takabayashi, K., Ogata, H., Iwao, Y. & Kanai, T., 2019 Jan 1, In : Digestion.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Efficacy of therapeutic intervention for patients with an ulcerative colitis mayo endoscopic score of 1

Fukuda, T., Naganuma, M., Sugimoto, S., Ono, K., Nanki, K., Mizuno, S., Kimura, K., Mutaguchi, M., Nakazato, Y., Takabayashi, K., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2019 Mar 14, In : Inflammatory bowel diseases. 25, 4, p. 782-788 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Electric endocut and autocut resection for endoscopic papillectomy: A systematic review

Minami, K., Iwasaki, E., Fukuhara, S., Horibe, M., Seino, T., Kawasaki, S., Katayama, T., Takimoto, Y., Tamagawa, H., MacHida, Y., Kanai, T. & Itoi, T., 2019 Jan 1, In : Internal Medicine. 58, 19, p. 2767-2772 6 p.

Research output: Contribution to journalReview article

Open Access

Epigenetic regulation of T helper cells and intestinal pathogenicity

Hagihara, Y., Yoshimatsu, Y., Mikami, Y., Takada, Y., Mizuno, S. & Kanai, T., 2019 Jan 1, In : Seminars in Immunopathology.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Erratum: Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis (Journal of Crohn's and Colitis DOI: 10.1093/ecco-jcc/jjw132)

Shinzaki, S., Matsuoka, K., Iijima, H., Mizuno, S., Serada, S., Fujimoto, M., Arai, N., Koyama, N., Morii, E., Watanabe, M., Hibi, T., Kanai, T., Takehara, T. & Naka, T., 2019 Dec 10, In : Journal of Crohn's and Colitis. 13, 12, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Feasibility study comparing underwater endoscopic mucosal resection and conventional endoscopic mucosal resection for superficial non-ampullary duodenal epithelial tumor < 20 mm

Kiguchi, Y., Kato, M., Nakayama, A., Sasaki, M., Mizutani, M., Tsutsumi, K., Akimoto, T., Takatori, Y., Mutaguchi, M., Takabayashi, K., Ochiai, Y., Maehata, T., Kanai, T. & Yahagi, N., 2019 Jan 1, (Accepted/In press) In : Digestive Endoscopy.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

First report of hepatobiliary Mycobacterium avium infection developing obstructive jaundice in a patient with neutralizing anti–interferon-gamma autoantibodies

Namkoong, H., Asakura, T., Ishii, M., Yoda, S., Masaki, K., Sakagami, T., Iwasaki, E., Yamagishi, Y., Kanai, T., Betsuyaku, T. & Hasegawa, N., 2019 Jan 1, In : New Microbes and New Infections. 27, p. 4-6 3 p.

Research output: Contribution to journalArticle

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P. S., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. & 2 others, Sato, T. & Kanai, T., 2019 Mar 1, In : Nature Microbiology. 4, 3, p. 492-503 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

How Can We Assess "complete Healing" beyond Endoscopic Remission?

Fukuda, T., Naganuma, M. & Kanai, T., 2019 Jun 1, In : Inflammatory bowel diseases. 25, 6, p. E68

Research output: Contribution to journalLetter

Idiopathic Thrombocytopenic Purpura Responsive to Surgery for Crohn's Disease

Mizuno, S., Naganuma, M. & Kanai, T., 2019 Mar 1, In : Inflammatory bowel diseases. 25, 3, 1 p.

Research output: Contribution to journalLetter

Impact of Antimicrobial Prophylaxis for Severe Acute Pancreatitis on the Development of Invasive Candidiasis: A Large Retrospective Multicenter Cohort Study

Horibe, M., Sanui, M., Sasaki, M., Honda, H., Ogura, Y., Namiki, S., Sawano, H., Goto, T., Ikeura, T., Takeda, T., Oda, T., Yasuda, H., Miyazaki, D., Hirose, K., Kitamura, K., Chiba, N., Ozaki, T., Yamashita, T., Koinuma, T., Oshima, T. & 10 others, Yamamoto, T., Hirota, M., Yamamoto, S., Oe, K., Ito, T., Masuda, Y., Saito, N., Iwasaki, E., Kanai, T. & Mayumi, T., 2019 Apr 1, In : Pancreas. 48, 4, p. 537-543 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Intramucosal poorly differentiated and signet-ring cell components in patients with ulcerative colitis-associated high-grade dysplasia

Sugimoto, S., Shimoda, M., Iwao, Y., Mutaguchi, M., Nanki, K., Mizuno, S., Kameyama, K., Ogata, H., Naganuma, M. & Kanai, T., 2019 Jan 1, (Accepted/In press) In : Digestive Endoscopy.

Research output: Contribution to journalArticle

Large volume fluid resuscitation for severe acute pancreatitis is associated with reduced mortality: A multicenter retrospective study

Yamashita, T., Horibe, M., Sanui, M., Sasaki, M., Sawano, H., Goto, T., Ikeura, T., Hamada, T., Oda, T., Yasuda, H., Ogura, Y., Miyazaki, D., Hirose, K., Kitamura, K., Chiba, N., Ozaki, T., Koinuma, T., Oshima, T., Yamamoto, T., Hirota, M. & 9 others, Masuda, Y., Tokuhira, N., Kobayashi, M., Saito, S., Izai, J., Lefor, A. K., Iwasaki, E., Kanai, T. & Mayumi, T., 2019 May 1, In : Journal of Clinical Gastroenterology. 53, 5, p. 385-391 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine

Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M. & 5 others, Ohtsuka, K., Mochizuki, M., Watanabe, M., Hashiguchi, M. & Kanai, T., 2019 Jan 1, In : Journal of Gastroenterology and Hepatology (Australia).

Research output: Contribution to journalReview article

3 Citations (Scopus)

Middle-term prognosis in patients with ulcerative colitis who achieved clinical and endoscopic remission by budesonide rectal foam

ESCORT study Group, 2019 Jan 1, In : PloS one. 14, 8, e0220413.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)