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Research Output 2000 2017

  • 919 Citations
  • 15 h-Index
  • 19 Article
  • 1 Chapter
  • 1 Review article
2017
3 Citations (Scopus)

Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis

Watanabe-Matsumoto, S., Moriwaki, Y., Okuda, T., Ohara, S., Yamanaka, K., Abe, Y., Yasui, M. & Misawa, H., 2017 Jan 1, (Accepted/In press) In : Neuroscience Research.

Research output: Contribution to journalArticle

Aquaporin 4
Amyotrophic Lateral Sclerosis
Blood-Brain Barrier
Motor Neuron Disease
Gliosis
2016
1 Citation (Scopus)

Reappraisal of VAChT-Cre: Preference in slow motor neurons innervating type I or IIa muscle fibers

Misawa, H., Inomata, D., Kikuchi, M., Maruyama, S., Moriwaki, Y., Okuda, T., Nukina, N. & Yamanaka, T., 2016, (Accepted/In press) In : Genesis.

Research output: Contribution to journalArticle

Motor Neurons
Muscles
Fatigue
Fluorescence
Presynaptic Terminals
18 Citations (Scopus)

Selective expression of osteopontin in ALS-resistant motor neurons is a critical determinant of late phase neurodegeneration mediated by matrix metalloproteinase-9

Morisaki, Y., Niikura, M., Watanabe, M., Onishi, K., Tanabe, S., Moriwaki, Y., Okuda, T., Ohara, S., Murayama, S., Takao, M., Uchida, S., Yamanaka, K. & Misawa, H., 2016 Jun 6, In : Scientific Reports. 6, 27354.

Research output: Contribution to journalArticle

Osteopontin
Matrix Metalloproteinase 9
Amyotrophic Lateral Sclerosis
Motor Neurons
Fatigue
2012
16 Citations (Scopus)

Osteopontin is an alpha motor neuron marker in the mouse spinal cord

Misawa, H., Hara, M., Tanabe, S., Niikura, M., Moriwaki, Y. & Okuda, T., 2012 Apr, In : Journal of Neuroscience Research. 90, 4, p. 732-742 11 p.

Research output: Contribution to journalArticle

Osteopontin
Motor Neurons
Spinal Cord
Choline O-Acetyltransferase
Carisoprodol
17 Citations (Scopus)

Transmembrane topology and oligomeric structure of the high-affinity choline transporter

Okuda, T., Osawa, C., Yamada, H., Hayashi, K., Nishikawa, S., Ushio, T., Kubo, Y., Satou, M., Ogawa, H. & Haga, T., 2012 Dec 14, In : Journal of Biological Chemistry. 287, 51, p. 42826-42834 9 p.

Research output: Contribution to journalArticle

Topology
Choline
Oligomers
Cysteine
Cells
2011

CHT1, choline transporter 1

Okuda, T., 2011, xPharm: The Comprehensive Pharmacology Reference. Elsevier Inc., p. 1-5 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

choline transporter
14 Citations (Scopus)

Substrate-induced internalization of the high-affinity choline transporter

Okuda, T., Konishi, A., Misawa, H. & Haga, T., 2011 Oct 19, In : Journal of Neuroscience. 31, 42, p. 14989-14997 9 p.

Research output: Contribution to journalArticle

Acetylcholine
Choline
Presynaptic Terminals
Hemicholinium 3
Dynamins
2009
15 Citations (Scopus)

Acetylcholine synthesis and release in NIH3T3 cells coexpressing the high-affinity choline transporter and choline acetyltransferase

Fujii, T., Masai, M., Misawa, H., Okuda, T., Takada-Takatori, Y., Moriwaki, Y., Haga, T. & Kawashima, K., 2009 Oct, In : Journal of Neuroscience Research. 87, 13, p. 3024-3032 9 p.

Research output: Contribution to journalArticle

Choline O-Acetyltransferase
Acetylcholine
Choline
Hemicholinium 3
Cholinergic Neurons
32 Citations (Scopus)

Expression of SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, in murine bronchial epithelial cells

Horiguchi, K., Horiguchi, S., Yamashita, N., Irie, K., Masuda, J., Takano-Ohmuro, H., Himi, T., Miyazawa, M., Moriwaki, Y., Okuda, T., Misawa, H., Ozaki, H. & Kawashima, K., 2009 Sep, In : Journal of Neuroscience Research. 87, 12, p. 2740-2747 8 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Epithelial Cells
Ligands
Macrophages
Palmoplantar Keratoderma
42 Citations (Scopus)

Primary sensory neuronal expression of SLURP-1, an endogenous nicotinic acetylcholine receptor ligand

Moriwaki, Y., Watanabe, Y., Shinagawa, T., Kai, M., Miyazawa, M., Okuda, T., Kawashima, K., Yabashi, A., Waguri, S. & Misawa, H., 2009 Aug, In : Neuroscience Research. 64, 4, p. 403-412 10 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Nicotinic Receptors
Ligands
Proteins
Calcitonin Gene-Related Peptide
2008
9 Citations (Scopus)

Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice

Misawa, H., Fujigaya, H., Nishimura, T., Moriwaki, Y., Okuda, T., Kawashima, K., Nakata, K., Ruggiero, A. M., Blakely, R. D., Nakatsu, F. & Ohno, H., 2008 Jun, In : European Journal of Neuroscience. 27, 12, p. 3109-3117 9 p.

Research output: Contribution to journalArticle

Proteins
Synaptic Vesicles
Presynaptic Terminals
choline transporter
Synaptophysin
2007
94 Citations (Scopus)

β-Catenin regulates excitatory postsynaptic strength at hippocampal synapses

Okuda, T., Yu, L. M. Y., Cingolani, L. A., Kemler, R. & Goda, Y., 2007 Aug 14, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 33, p. 13479-13484 6 p.

Research output: Contribution to journalArticle

Catenins
Synapses
Spine
Cadherins
Neurons
2004
43 Citations (Scopus)
Synaptic Vesicles
Neuromuscular Junction
Choline
Cell Membrane
Acetylcholine
2003
29 Citations (Scopus)

Detection of the high-affinity choline transporter in the MOLT-3 human leukemic T-cell line

Fujii, T., Okuda, T., Haga, T. & Kawashima, K., 2003 Mar 28, In : Life Sciences. 72, 18-19, p. 2131-2134 4 p.

Research output: Contribution to journalArticle

T-cells
T-Lymphocytes
Cell Line
Choline
Hemicholinium 3
68 Citations (Scopus)

High-affinity choline transporter

Okuda, T. & Haga, T., 2003 Apr 1, In : Neurochemical Research. 28, 3-4, p. 483-488 6 p.

Research output: Contribution to journalArticle

Choline
Cholinergic Agents
Cholinergic Neurons
Neurons
Synaptic Transmission
2002
40 Citations (Scopus)

Distribution of the high-affinity choline transporter in the human and macaque monkey spinal cord

Kobayashi, Y., Okuda, T., Fujioka, Y., Matsumura, G., Nishimura, Y. & Haga, T., 2002 Jan 4, In : Neuroscience Letters. 317, 1, p. 25-28 4 p.

Research output: Contribution to journalArticle

Macaca
Haplorhini
Motor Neurons
Spinal Cord
Neurons
55 Citations (Scopus)

Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate

Okuda, T., Okamura, M., Kaitsuka, C., Haga, T. & Gurwitz, D., 2002 Nov 22, In : Journal of Biological Chemistry. 277, 47, p. 45315-45322 8 p.

Research output: Contribution to journalArticle

Choline
Polymorphism
Single Nucleotide Polymorphism
Nucleotides
Valine
2001
80 Citations (Scopus)

Distribution of the high-affinity choline transporter in the central nervous system of the rat

Misawa, H., Nakata, K., Matsuura, J., Nagao, M., Okuda, T. & Haga, T., 2001 Jul 16, In : Neuroscience. 105, 1, p. 87-98 12 p.

Research output: Contribution to journalArticle

Central Nervous System
Cholinergic Neurons
Antibodies
Presynaptic Terminals
Cholinergic Agents
2000
101 Citations (Scopus)

Functional characterization of the human high-affinity choline transporter

Okuda, T. & Haga, T., 2000 Nov 3, In : FEBS Letters. 484, 2, p. 92-97 6 p.

Research output: Contribution to journalArticle

Choline
Cholinergic Neurons
Cholinergic Agents
Neurons
Neurotransmitter Transport Proteins
242 Citations (Scopus)

Identification and characterization of the high-affinity choline transporter

Okuda, T., Haga, T., Kanai, Y., Endou, H., Ishihara, T. & Katsura, I., 2000 Feb, In : Nature Neuroscience. 3, 2, p. 120-125 6 p.

Research output: Contribution to journalArticle

Choline
Cholinergic Neurons
Caenorhabditis elegans
Complementary DNA
Neurotransmitter Transport Proteins

The high-affinity choline transporter

Okuda, T. & Haga, T., 2000, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 45, 10, p. 1722-1727 6 p.

Research output: Contribution to journalReview article

Human Genome Project
Membrane Transport Proteins
Molecular Cloning
Acetylcholine
Neurotransmitter Agents