• 1629 Citations
  • 23 h-Index
1987 …2019
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Research Output 1987 2019

  • 1629 Citations
  • 23 h-Index
  • 78 Article
2019

Analyzing Upward Deviation of Actual vs Predicted Drug Sales in Japan for a Reasonable Drug-Pricing Policy

Shibata, S., Fukumoto, D., Suzuki, T. & Ozaki, K., 2019 Jan 1, (Accepted/In press) In : Therapeutic Innovation and Regulatory Science.

Research output: Contribution to journalArticle

Japan
Costs and Cost Analysis
Pharmaceutical Preparations
Health Expenditures
Drug Costs
2018
1 Citation (Scopus)

Anticancer Drug Prescription Patterns in Japan: Future Directions in Cancer Therapy

Shibata, S., Matsushita, M., Saito, Y. & Suzuki, T., 2018 Nov 1, In : Therapeutic Innovation and Regulatory Science. 52, 6, p. 718-723 6 p.

Research output: Contribution to journalArticle

Drug Prescriptions
Japan
Pharmaceutical Preparations
Neoplasms
Health Expenditures
2017
3 Citations (Scopus)

An empirical study of the prescription pattern of drugs for hematological malignancies in Japan from 2010-2014

Shibata, S., Wayama, Y., Tsuyuki, A., Matsushita, M., Chiba, K., Matsuki, E., Okamoto, S. & Suzuki, T., 2017, In : Biological and Pharmaceutical Bulletin. 40, 6, p. 894-901 8 p.

Research output: Contribution to journalArticle

Prescription Drugs
Hematologic Neoplasms
Japan
Pharmaceutical Preparations
Pharmaceutical Databases
1 Citation (Scopus)

CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients

Matsushita, M., Ozawa, K., Suzuki, T., Nakamura, M., Nakano, N., Kanchi, S., Ichikawa, D., Matsuki, E., Sakurai, M., Karigane, D., Kasahara, H., Tsukamoto, N., Shimizu, T., Mori, T., Nakajima, H., Okamoto, S., Kawakami, Y. & Hattori, Y., 2017 Sep 1, In : Blood Cancer Journal. 7, 9, e601.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Stem Cells
Therapeutics
T-Lymphocytes
Japan
Pharmaceutical Preparations
Generic Drugs
Linear Models
2 Citations (Scopus)

Impact of generic entry to off-patent branded medicines in Japanese pharmaceutical market

Fukumoto, D. & Suzuki, T., 2017 Sep 1, In : Journal of Generic Medicines. 13, 3, p. 114-122 9 p.

Research output: Contribution to journalArticle

Nonprescription Drugs
Pharmaceutical Preparations
Off-Label Use
Police
Health Expenditures
Generic Drugs
Japan
Cytostatic Agents
Pharmaceutical Preparations
Neoplasms
2016
6 Citations (Scopus)
France
Germany
Japan
Pharmaceutical Preparations
Central Nervous System Agents
6 Citations (Scopus)

Evaluating the Effectiveness of Repricing for Market Expansion in the Japanese Drug Pricing System

Shibata, S., Uemura, R. & Suzuki, T., 2016 Nov 1, In : Therapeutic Innovation and Regulatory Science. 50, 6, p. 751-758 8 p.

Research output: Contribution to journalArticle

Costs and Cost Analysis
Pharmaceutical Preparations
Japan
National Health Programs
Reward
8 Citations (Scopus)
Drug Discovery
Reward
Japan
Pharmaceutical Preparations
Orphan Drug Production
8 Citations (Scopus)
Drug Discovery
Reward
Pharmaceutical Preparations
Japan
Neurosciences
2015
2 Citations (Scopus)

Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation

Fujimori, K., Takaki, J., Shigemoto-Mogami, Y., Sekino, Y., Suzuki, T. & Sato, K., 2015, In : Journal of Pharmacological Sciences. 127, 1, p. 145-149 5 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Paroxetine
Glutamic Acid
Down-Regulation
Astrocytes
2012
16 Citations (Scopus)

Biphasic time course of the changes in aldosterone biosynthesis under high-salt conditions in dahl salt-sensitive rats

Morizane, S., Mitani, F., Ozawa, K., Ito, K., Matsuhashi, T., Katsumata, Y., Ito, H., Yan, X., Shinmura, K., Nishiyama, A., Honma, S., Suzuki, T., Funder, J. W., Fukuda, K. & Sano, M., 2012 May, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 32, 5, p. 1194-1203 10 p.

Research output: Contribution to journalArticle

Inbred Dahl Rats
Aldosterone
Salts
Adrenal Glands
Renin-Angiotensin System
6 Citations (Scopus)

Cell-autonomous enhancement of glutamate-uptake by female astrocytes

Morizawa, Y., Sato, K., Takaki, J., Kawasaki, A., Shibata, K., Suzuki, T., Ohta, S. & Koizumi, S., 2012 Aug, In : Cellular and Molecular Neurobiology. 32, 6, p. 953-956 4 p.

Research output: Contribution to journalArticle

Astrocytes
Glutamic Acid
Gonadal Hormones
Neuroglia
Brain
84 Citations (Scopus)
Amino Acid Transport System X-AG
Microglia
Glutamic Acid
Down-Regulation
Inflammation
9 Citations (Scopus)

RNA editing of the Q/R site of GluA2 in different cultured cell lines that constitutively express different levels of RNA editing enzyme ADAR2

Yamashita, T., Tadami, C., Nishimoto, Y., Hideyama, T., Kimura, D., Suzuki, T. & Kwak, S., 2012 May, In : Neuroscience Research. 73, 1, p. 42-48 7 p.

Research output: Contribution to journalArticle

RNA Editing
Adenosine Deaminase
Cultured Cells
RNA Precursors
RNA
2011
3 Citations (Scopus)

Blocking effect of NIP-142 on the KCNQ1/KCNE1 channel current expressed in HEK293 cells

Namekata, I., Tsuruoka, N., Tsuneoka, Y., Matsuda, T., Takahara, A., Tanaka, Y., Suzuki, T., Takahashi, T., Iida-Tanaka, N. & Tanaka, H., 2011, In : Biological and Pharmaceutical Bulletin. 34, 1, p. 153-155 3 p.

Research output: Contribution to journalArticle

HEK293 Cells
Delayed Rectifier Potassium Channels
Benzopyrans
Cardiac Arrhythmias
NIP142
2010
92 Citations (Scopus)

Induced loss of ADAR2 engenders slow death of motor neurons from Q/R site-unedited GluR2

Hideyama, T., Yamashita, T., Suzuki, T., Tsuji, S., Higuchi, M., Seeburg, P. H., Takahashi, R., Misawa, H. & Kwak, S., 2010 Sep 8, In : Journal of Neuroscience. 30, 36, p. 11917-11925 9 p.

Research output: Contribution to journalArticle

Adenosine Deaminase
Motor Neurons
AMPA Receptors
RNA
Oculomotor Nerve
3 Citations (Scopus)

Inhibition of septation in bacillus subtilis by a peptide antibiotic, edeine B1

Shimotohno, K. W., Kawamura, F., Natori, Y., Nanamiya, H., Magae, J., Ogata, H., Endo, T., Suzuki, T. & Yamaki, H., 2010 Apr 10, In : Biological and Pharmaceutical Bulletin. 33, 4, p. 568-571 4 p.

Research output: Contribution to journalArticle

Bacillus subtilis
Anti-Bacterial Agents
Peptides
Protein Biosynthesis
Polymerization
272 Citations (Scopus)

Nongenetic method for purifying stem cell-derived cardiomyocytes

Hattori, F., Chen, H., Yamashita, H., Tohyama, S., Satoh, Y. S., Yuasa, S., Li, W., Yamakawa, H., Tanaka, T., Onitsuka, T., Shimoji, K., Ohno, Y., Egashira, T., Kaneda, R., Murata, M., Hidaka, K., Morisaki, T., Sasaki, E., Suzuki, T., Sano, M. & 3 others, Makino, S., Oikawa, S. & Fukuda, K., 2010 Jan, In : Nature Methods. 7, 1, p. 61-66 6 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Stem cells
Cardiac Myocytes
Stem Cells
Callithrix
6 Citations (Scopus)

Novel etiological and therapeutic strategies for neurodiseases: RNA editing enzyme abnormality in sporadic amyotrophic lateral sclerosis

Hideyama, T., Yamashita, T., Nishimoto, Y., Suzuki, T. & Kwak, S., 2010 May 17, In : Journal of Pharmacological Sciences. 113, 1, p. 9-13 5 p.

Research output: Contribution to journalArticle

RNA Editing
Adenosine Deaminase
RNA
Enzymes
Motor Neuron Disease

Novel etiological and therapeutic strategies for neurodiseases: Preface

Ikegaya, Y. & Suzuki, T., 2010 May 17, In : Journal of Pharmacological Sciences. 113, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

Genetic Epigenesis
Genetic Predisposition to Disease
Nervous System Diseases
Epigenomics
Therapeutics
6 Citations (Scopus)

The resorcylic acid lactone hypothemycin selectively inhibits the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cells

Fukazawa, H., Ikeda, Y., Fukuyama, M., Suzuki, T., Hori, H., Okuda, T. & Uehara, Y., 2010 Feb, In : Biological and Pharmaceutical Bulletin. 33, 2, p. 168-173 6 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Extracellular Signal-Regulated MAP Kinases
Lactones
Acids
Protein Kinases
2009
14 Citations (Scopus)

A receptor-independent effect of estrone sulfate on the hERG channel

Kakusaka, S., Asayama, M., Kaihara, A., Sasano, T., Suzuki, T., Kurokawa, J. & Furukawa, T., 2009, In : Journal of Pharmacological Sciences. 109, 1, p. 152-156 5 p.

Research output: Contribution to journalArticle

Estrogens
Estradiol Receptors
Estriol
Estrone
HEK293 Cells
26 Citations (Scopus)

Genetic analysis of hepatitis C virus with defective genome and its infectivity in vitro

Sugiyama, K., Suzuki, K., Nakazawa, T., Funami, K., Hishiki, T., Ogawa, K., Saito, S., Shimotohno, K. W., Suzuki, T., Shimizu, Y., Tobita, R., Hijikata, M., Takaku, H. & Shimotohno, K., 2009 Jul, In : Journal of Virology. 83, 13, p. 6922-6928 7 p.

Research output: Contribution to journalArticle

Hepatitis C virus
Hepacivirus
genetic techniques and protocols
pathogenicity
Genome
71 Citations (Scopus)

Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis

Tokudome, S., Sano, M., Shinmura, K., Matsuhashi, T., Morizane, S., Moriyama, H., Tamaki, K., Hayashida, K., Nakanishi, H., Yoshikawa, N., Shimizu, N., Endo, J., Katayama, T., Murata, M., Yuasa, S., Kaneda, R., Tomita, K., Eguchi, N., Urade, Y., Asano, K. & 5 others, Utsunomiya, Y., Suzuki, T., Taguchi, R., Tanaka, H. & Fukuda, K., 2009 Jun 1, In : Journal of Clinical Investigation. 119, 6, p. 1477-1488 12 p.

Research output: Contribution to journalArticle

prostaglandin R2 D-isomerase
Lipocalins
Prostaglandin D2
Reperfusion Injury
Cardiac Myocytes
21 Citations (Scopus)
Ion Channels
Cardiac Arrhythmias
Heart Diseases
Myocardium
Hormones
Myocardial Contraction
Cardiovascular Agents
Cardiac Arrhythmias
Heart Diseases
Myocardium
2006

Continuous depolarization induces choline acetyltransferase activity in septal and hippocampal co-cultured embryonic rat neurons

Suzuki, T. & Shimotohno, K., 2006 Feb 6, In : Neuroscience Letters. 394, 1, p. 79-81 3 p.

Research output: Contribution to journalArticle

Choline O-Acetyltransferase
Acetylcholine
Neurons
Coculture Techniques
Cell Culture Techniques
2005
31 Citations (Scopus)

Atria selective prolongation by NIP-142, an antiarrhythmic agent, of refractory period and action potential duration in guinea pig myocardium

Matsuda, T., Takeda, K., Ito, M., Yamagishi, R., Tamura, M., Nakamura, H., Tsuruoka, N., Saito, T., Masumiya, H., Suzuki, T., Iida-Tanaka, N., Itokawa-Matsuda, M., Yamashita, T., Tsuruzoe, N., Tanaka, H. & Shigenobu, K., 2005 May, In : Journal of Pharmacological Sciences. 98, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

Action Potentials
Myocardium
Guinea Pigs
Xenopus
Heart Ventricles
2004
6 Citations (Scopus)

Long-lived retrograde fluorescent labeling of corticospinal neurons in the living animal

Suzuki, T., Abe, Y., McGehee, D. S., Keath, J. R., Yajima, H., Sharma, K. & Brorson, J. R., 2004 Aug, In : Brain Research Protocols. 13, 3, p. 183-188 6 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Neurons
Fluorescent Dyes
Coloring Agents
Fluorescence
3 Citations (Scopus)

Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons

Suzuki, T., Takagi, R. & Kawashima, K., 2004 Feb 6, In : Neuroscience Letters. 356, 1, p. 57-60 4 p.

Research output: Contribution to journalArticle

Picrotoxin
GABA-A Receptors
gamma-Aminobutyric Acid
Acetylcholine
Neurons
44 Citations (Scopus)

Selective Expression of Heteromeric AMPA Receptors Driven by Flip-Flop Differences

Brorson, J. R., Li, D. & Suzuki, T., 2004 Apr 7, In : Journal of Neuroscience. 24, 14, p. 3461-3470 10 p.

Research output: Contribution to journalArticle

AMPA Receptors
Glutamate Receptors
Protein Isoforms
Arginine
Ions
2003
4 Citations (Scopus)

Endogenous glutamatergic synaptic activity elicits acetylcholine release from rat cultured septal cells

Suzuki, T., Matsugi, T., Takagi, R. & Kawashima, K., 2003 Nov 1, In : Neuroscience Research. 47, 3, p. 341-347 7 p.

Research output: Contribution to journalArticle

AMPA Receptors
Acetylcholine
Cultured Cells
omega-Conotoxin GVIA
6-Cyano-7-nitroquinoxaline-2,3-dione
16 Citations (Scopus)

Recent advances in the study of AMPA receptors

Suzuki, T., Tsuzuki, K., Kameyama, K. & Kwak, S., 2003, In : Folia Pharmacologica Japonica. 122, 6, p. 515-526 12 p.

Research output: Contribution to journalArticle

AMPA Receptors
RNA Editing
Glutamate Receptors
Neuroglia
Permeability
2001
3 Citations (Scopus)

Functional expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors precedes the development of cholinergic phenotype in embryonic rat septal cells in culture

Suzuki, T., Matsugi, T., Takagi, R., Kanagawa, M., Hirata, M., Nakamura, T., Kudo, Y. & Kawashima, K., 2001 Sep 28, In : Neuroscience Letters. 311, 2, p. 89-92 4 p.

Research output: Contribution to journalArticle

Isoxazoles
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Cholinergic Agents
Cell Culture Techniques
Phenotype
1999
6 Citations (Scopus)

Enhancement of the serotonin-mediated acetylcholine release by repeated desmethylimipramine treatment in the hippocampus of freely moving rats

Fujii, T., Ohba, S., Nakai, K., Fujimoto, K., Suzuki, T. & Kawashima, K., 1999, In : Japanese Journal of Pharmacology. 80, 4, p. 303-309 7 p.

Research output: Contribution to journalArticle

Desipramine
Acetylcholine
Hippocampus
Serotonin
Cholinergic Agents
1998
29 Citations (Scopus)
Fenclonine
8-Hydroxy-2-(di-n-propylamino)tetralin
Serotonin Receptor Agonists
Microdialysis
Acetylcholine
1997
8 Citations (Scopus)
Angiotensin Type 1 Receptor
Angiotensin Receptor Antagonists
Inbred SHR Rats
Antihypertensive Agents
Stroke
46 Citations (Scopus)

Demonstration of the facilitatory role of 8-OH-DPAT on cholinergic transmission in the rat hippocampus using in vivo microdialysis

Fujii, T., Yoshizawa, M., Nakai, K., Fujimoto, K., Suzuki, T. & Kawashima, K., 1997 Jul 4, In : Brain Research. 761, 2, p. 244-249 6 p.

Research output: Contribution to journalArticle

8-Hydroxy-2-(di-n-propylamino)tetralin
Microdialysis
Cholinergic Agents
Acetylcholine
Hippocampus
18 Citations (Scopus)

Nitric oxide increases stimulation-evoked acetylcholine release from rat hippocampal slices by a cyclic GMP-independent mechanism

Suzuki, T., Nakajima, K., Fujimoto, K., Fujii, T. & Kawashima, K., 1997 Jun 20, In : Brain Research. 760, 1-2, p. 158-162 5 p.

Research output: Contribution to journalArticle

Cyclic GMP
Acetylcholine
Nitric Oxide
Nitroprusside
Atropine
1996
11 Citations (Scopus)
Inbred SHR Rats
Locomotion
Heart Rate
Stroke
Blood Pressure
85 Citations (Scopus)

Localization and synthesis of acetylcholine in human leukemic T cell lines

Fujii, T., Tsuchiya, T., Yamada, S., Fujimoto, K., Suzuki, T., Kasahara, T. & Kawashima, K., 1996, In : Journal of Neuroscience Research. 44, 1, p. 66-72 7 p.

Research output: Contribution to journalArticle

Acetylcholine
T-Lymphocytes
Cell Line
Carnitine O-Acetyltransferase
Choline O-Acetyltransferase
1 Citation (Scopus)

Phorbol ester enhances choline uptake in cultured porcine brain endothelial cells

Suzuki, T., Ikeda, C., Fujii, T., Fujimoto, K., Morita, I., Murota, S. I. & Kawashima, K., 1996, In : Biogenic Amines. 12, 1, p. 49-54 6 p.

Research output: Contribution to journalArticle

Phorbol Esters
Choline
Swine
Endothelial Cells
Brain
1995
11 Citations (Scopus)

Antihypertensive effect of chronic KT3-671, a structurally new nonpeptide angiotensin AT1-receptor antagonist, in stroke-prone spontaneously hypertensive rats

Amano, H., Fujimoto, K., Suzuki, T., Fujii, T., Mochizuki, S., Tomiyama, A. & Kawashima, K., 1995, In : Japanese Journal of Pharmacology. 69, 3, p. 215-222 8 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Angiotensin Receptor Antagonists
Inbred SHR Rats
Antihypertensive Agents
Stroke
3 Citations (Scopus)
tetrandrine
Trichlormethiazide
Telemetry
Inbred SHR Rats
Antihypertensive Agents
42 Citations (Scopus)

Expression of Choline Acetyltransferase mRNA and Protein in T-Lymphocytes

Fujii, T., Yamada, S., Tajima, S., Fujimoto, K., Suzuki, T., Kawashima, K. & MlSAWA, H., 1995, In : Proceedings of the Japan Academy, Series B. 71, 7, p. 231-235 5 p.

Research output: Contribution to journalArticle

choline acetyltransferase
acetylcholine
choline
Choline O-Acetyltransferase
lymphocytes
28 Citations (Scopus)

Role of nitric oxide in the control of blood pressure in young and adult spontaneously hypertensive rats

Akiba, Y., Yamaguchi, N., Amano, H., Fujii, T., Fujimoto, K., Suzuki, T. & Kawashima, K., 1995, In : Clinical and Experimental Pharmacology and Physiology. 22, SUPPL. 1

Research output: Contribution to journalArticle

Inbred SHR Rats
NG-Nitroarginine Methyl Ester
Nitroprusside
Young Adult
Nitric Oxide
40 Citations (Scopus)

Species differences in the concentration of acetylcholine, a neurotransmitter, in whole blood and plasma

Fujii, T., Yamada, S., Yamaguchi, N., Fujimoto, K., Suzuki, T. & Kawashima, K., 1995 Dec 15, In : Neuroscience Letters. 201, 3, p. 207-210 4 p.

Research output: Contribution to journalArticle

Acetylcholine
Neurotransmitter Agents
Swine
Goats
Horses
1994
47 Citations (Scopus)
Tacrine
Cholinesterase Inhibitors
Acetylcholine
Hippocampus
Cholinesterases