• 3465 Citations
  • 25 h-Index
19892013

Research output per year

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Research Output

2013

Epitope Mapping for Monoclonal Antibody Reveals the Activation Mechanism for αVβ3 Integrin

Kamata, T., Handa, M., Takakuwa, S., Sato, Y., Kawai, Y., Ikeda, Y. & Aiso, S., 2013 Jun 20, In : PloS one. 8, 6, e66096.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2010

Structural requirements for activation in αIIbβ3 integrin

Kamata, T., Handa, M., Ito, S., Sato, Y., Ohtani, T., Kawai, Y., Ikeda, Y. & Aiso, S., 2010 Dec 3, In : Journal of Biological Chemistry. 285, 49, p. 38428-38437 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2008

Key interactions in integrin ectodomain responsible for global conformational change detected by elastic network normal-mode analysis

Matsumoto, A., Kamata, T., Takagi, J., Iwasaki, K. & Yura, K., 2008 Sep 15, In : Biophysical Journal. 95, 6, p. 2895-2908 14 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2007

Platelet immunology: Structure, functions, and polymorphisms of membrane glycoproteins

Ikeda, Y., Matsubara, Y. & Kamata, T., 2007 Jan 1, Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook. Cambridge University Press, p. 21-36 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)
2005

Membrane-proximal α/β stalk interactions differentially regulate integrin activation

Kamata, T., Handa, M., Sato, Y., Ikeda, Y. & Aiso, S., 2005 Jul 1, In : Journal of Biological Chemistry. 280, 26, p. 24775-24783 9 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
2004

Critical cysteine residues for regulation of integrin αIIbβ3 are clustered in the epidermal growth factor domains of the β3 subunit

Kamata, T., Ambo, H., Puzon-McLaughlin, W., Tieu, K. K., Handa, M., Ikeda, Y. & Takada, Y., 2004 Mar 15, In : Biochemical Journal. 378, 3, p. 1079-1082 4 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2002

The role of the CPNKEKEC sequence in the β2 subunit I domain in regulation of integrin αLβ2 (LFA-1)

Kamata, T., Tieu, K. K., Tarui, T., Puzon-McLaughlin, W., Hogg, N. & Takada, Y., 2002 Mar 1, In : Journal of Immunology. 168, 5, p. 2296-2301 6 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2001

Amino Acid Residues in the αIIb Subunit that Are Critical for Ligand Binding to Integrin αIIbβ3 Are Clustered in the β-Propeller Model

Kamata, T., Tieu, K. K., Irie, A., Springer, T. A. & Takada, Y., 2001 Nov 23, In : Journal of Biological Chemistry. 276, 47, p. 44275-44283 9 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Platelet integrin αIIbβ3-ligand interactions: What can we learn from the structure?

Kamata, T. & Takada, Y., 2001 Jan 1, In : International journal of hematology. 74, 4, p. 382-389 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

Weitz-Schmidt, G., Welzenbach, K., Brinkmann, V., Kamata, T., Kallen, J., Bruns, C., Cottens, S., Takada, Y. & Hommel, U., 2001 Jul 9, In : Nature medicine. 7, 6, p. 687-692 6 p.

Research output: Contribution to journalArticle

912 Citations (Scopus)
2000

Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin α(IIb)β3

Puzon-McLaughlin, W., Kamata, T. & Takada, Y., 2000 Mar 17, In : Journal of Biological Chemistry. 275, 11, p. 7795-7802 8 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)
1999
41 Citations (Scopus)
1998

Novel point mutations in the αIIb subunit (Phe289 → Ser, Glu324 → Lys and Gln747 → Pro) causing thrombasthenic phenotypes in four Japanese patients

Ambo, H., Kamata, T., Handa, M., Kawai, Y., Oda, A., Murata, M., Takada, Y. & Ikeda, Y., 1998 Sep 1, In : British Journal of Haematology. 102, 3, p. 829-840 12 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Specific interaction of the recombinant disintegrin-like domain of MDC- 15 (Metargidin, ADAM-15) with integrin αvβ3

Zhang, X. P., Kamata, T., Yokoyama, K., Puzon-McLaughlin, W. & Takada, Y., 1998 Mar 27, In : Journal of Biological Chemistry. 273, 13, p. 7345-7350 6 p.

Research output: Contribution to journalArticle

193 Citations (Scopus)

Three novel integrin β3 subunit missense mutations (H280P, C560F, and G579S) in thrombasthenia, including one (H280P) prevalent in Japanese patients

Ambo, H., Kamata, T., Handa, M., Taki, M., Kuwajima, M., Kawai, Y., Oda, A., Murata, M., Takada, Y., Watanabe, K. & Ikeda, Y., 1998 Oct 29, In : Biochemical and Biophysical Research Communications. 251, 3, p. 763-768 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
1997

Changing ligand specificities of αvβ1 and αvβ3 integrins by swapping a short diverse sequence of the β subunit

Takagi, J., Kamata, T., Meredith, J., Puzon-McLaughlin, W. & Takada, Y., 1997 Aug 8, In : Journal of Biological Chemistry. 272, 32, p. 19794-19800 7 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

Echovirus 1 interaction with the human very late antigen-2 (integrin α2β1) I domain: Identification of two independent virus contact sites distinct from the metal ion-dependent adhesion site

King, S. L., Kamata, T., Cunningham, J. A., Emsley, J., Liddington, R. C., Takada, Y. & Bergelson, J. M., 1997 Nov 7, In : Journal of Biological Chemistry. 272, 45, p. 28518-28522 5 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Molecular mechanisms of integrin-ligand interaction

Irie, A., Kamata, T. & Takada, Y., 1997 Jul, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 42, 10 Suppl, p. 1679-1686 8 p.

Research output: Contribution to journalReview article

59 Citations (Scopus)

Structural basis of integrin-mediated signal transduction

Takada, Y., Kamata, T., Irie, A., Puzon-McLaughlin, W. & Zhang, X. P., 1997 Oct, In : Matrix Biology. 16, 4, p. 143-151 9 p.

Research output: Contribution to journalShort survey

33 Citations (Scopus)
1996

Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells

Huang, S., Kamata, T., Takada, Y., Ruggeri, Z. M. & Nemerow, G. R., 1996 Jun 27, In : Journal of Virology. 70, 7, p. 4502-4508 7 p.

Research output: Contribution to journalArticle

207 Citations (Scopus)

A novel regulatory epitope defined by a murine monoclonal antibody to the platelet GPIIb-IIIa complex (αIIbβ3 integrin)

Tokuhira, M., Handa, M., Kamata, T., Oda, A., Katayama, M., Tomiyama, Y., Murata, M., Kawai, Y., Watanabe, K. & Ikeda, Y., 1996 Dec 1, In : Thrombosis and Haemostasis. 76, 6, p. 1038-1046 9 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
1 Citation (Scopus)

Critical residues of integrin αIIb subunit for binding of αIIbβ3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3)

Kamata, T., Irie, A., Tokuhira, M. & Takada, Y., 1996 Oct 7, In : Journal of Biological Chemistry. 271, 31, p. 18610-18615 6 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Integrin family

Irie, A., Kamata, T. & Takada, Y., 1996 Sep, In : Rinsho byori. The Japanese journal of clinical pathology. Suppl 102, p. 16-23 8 p.

Research output: Contribution to journalReview article

1995

Critical amino acid residues for ligand binding are clustered in a predicted β-turn of the third N-terminal repeat in the integrin α4 and α5 subunits

Irie, A., Kamata, T., Puzon-McLaughlin, W. & Takada, Y., 1995 Jan 1, In : EMBO Journal. 14, 22, p. 5550-5556 7 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)
82 Citations (Scopus)

Identification of putative ligand-binding sites of the integrin α4β1 (VLA-4, CD49d/CD29)

Kamata, T., Puzon, W. & Takada, Y., 1995 Jan 1, In : Biochemical Journal. 305, 3, p. 945-951 7 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)

Platelet unresponsiveness to collagen: Involvement of glycoprotein Ia-IIa (α2β1 integrin) deficiency associated with a myeloproliferative disorder

Handa, M., Watanabe, K., Kawai, Y., Kamata, T., Koyama, T., Nagai, H. & Ikeda, Y., 1995 Jan 1, In : Thrombosis and Haemostasis. 73, 3, p. 521-528 8 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)
1994

Direct binding of collagen to the I domain of integrin α2β1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner

Kamata, T. & Takada, Y., 1994 Oct 21, In : Journal of Biological Chemistry. 269, 42, p. 26006-26010 5 p.

Research output: Contribution to journalArticle

137 Citations (Scopus)

Identification of putative ligand binding sites within I domain of integrin α2β1 (VLA-2, CD49b/CD29)

Kamata, T., Puzon, W. & Takada, Y., 1994 Apr 1, In : Journal of Biological Chemistry. 269, 13, p. 9659-9663 5 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)

Rapid improvement of coagulopathy by all‐trans retinoic acid in acute promyelocytic leukemia

Kawai, Y., Watanabe, K., Kizaki, M., Murata, M., Kamata, T., Uchida, H., Moriki, T., Yokoyama, K., Tokuhira, M., Nakajima, H., Handa, M. & Ikeda, Y., 1994 Jul, In : American journal of hematology. 46, 3, p. 184-188 5 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
1993

Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation

Ikeda, Y., Handa, M., Kamata, T., Kawano, K., Kawai, Y., Watanabe, K., Kawakami, K., Sakai, K., Fukuyama, M., Itagaki, I., Yoshioka, A. & Ruggeri, Z. M., 1993 Jun 1, In : Thrombosis and Haemostasis. 69, 5, p. 496-502 7 p.

Research output: Contribution to journalArticle

155 Citations (Scopus)
1992

Extramedullary diseases as presenting features of aleukemic acute monocytic leukemia

Hayashida, T., Araki, Y., Kawano, K., Kamata, T., Kawai, Y., Takeuchi, K., Watanabe, K., Okamoto, S. & Ogawa, T., 1992 Nov, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 33, 11, p. 1679-1684 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Function of GMP-140, a granule membrane protein of platelets

Michikawa, N., Anbo, H., Araki, Y., Kamata, T., Ikeda, Y., Handa, M., Kawai, Y., Watanabe, K. & Katayama, M., 1992 Mar 1, In : Rinsho byori. The Japanese journal of clinical pathology. Suppl 92, p. 15-25 11 p.

Research output: Contribution to journalReview article

1991

The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress

Ikeda, Y., Handa, M., Kawano, K., Kamata, T., Murata, M., Araki, Y., Anbo, H., Kawai, Y., Watanabe, K., Itagaki, I., Sakai, K. & Ruggeri, Z. M., 1991 Apr, In : Journal of Clinical Investigation. 87, 4, p. 1234-1240 7 p.

Research output: Contribution to journalArticle

Open Access
498 Citations (Scopus)
1990

Effects of anti-platelet agents on shear-induced platelet aggregation

Ikeda, Y., Handa, M., Kawano, K., Kamata, T., Anyasu, H., Araki, Y., kawaiY & Watanabe, K., 1990 Jun 1, In : [Rinsho ketsueki] The Japanese journal of clinical hematology. 31, 6, p. 787-792 6 p.

Research output: Contribution to journalArticle

Enhancing effect by heparin on shear-induced platelet aggregation

Kawano, K., Ikeda, Y., Handa, M., Kamata, T., Anbo, H., Araki, Y., Kawai, Y., Watanabe, K., Itagaki, I., Kawakami, K., Fukuyama, M. & Sakai, K., 1990 Jan 1, In : Seminars in Thrombosis and Hemostasis. 16, SUPPL., p. 60-65 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Primary hepatic lymphoma in a patient with autoimmune hemolytic anemia and SLE

Yoshimoto, T., Araki, Y., Kawano, K., Kamata, T., Okamoto, S. & Ogawa, T., 1990 Nov, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 31, 11, p. 1878-1883 6 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)
1989

Role of membrane glycoproteins in the interaction of blood platelets with the vessel wall--the study on platelet adhesion to in vitro cultured subendothelial matrix.

Kawai, Y., Handa, M., Nagai, H., Kamata, T., Anbo, H., Kawano, K., Araki, Y., Yamamoto, M., Ikeda, Y. & Watanabe, K., 1989 Dec 1, In : Acta Haematologica Japonica. 52, 8, p. 1312-1321 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)