• 3452 Citations
  • 25 h-Index
19892013
If you made any changes in Pure these will be visible here soon.

Research Output 1989 2013

  • 3452 Citations
  • 25 h-Index
  • 40 Article
  • 1 Chapter
Filter
Article
2013
5 Citations (Scopus)

Epitope Mapping for Monoclonal Antibody Reveals the Activation Mechanism for αVβ3 Integrin

Kamata, T., Handa, M., Takakuwa, S., Sato, Y., Kawai, Y., Ikeda, Y. & Aiso, S., 2013 Jun 20, In : PLoS One. 8, 6, e66096.

Research output: Contribution to journalArticle

Epitope Mapping
integrins
Integrins
Epitopes
monoclonal antibodies
2010
18 Citations (Scopus)

Structural requirements for activation in αIIbβ3 integrin

Kamata, T., Handa, M., Ito, S., Sato, Y., Ohtani, T., Kawai, Y., Ikeda, Y. & Aiso, S., 2010 Dec 3, In : Journal of Biological Chemistry. 285, 49, p. 38428-38437 10 p.

Research output: Contribution to journalArticle

Integrins
Chemical activation
Glycosylation
Disulfides
Fibrinogen
2008
14 Citations (Scopus)

Key interactions in integrin ectodomain responsible for global conformational change detected by elastic network normal-mode analysis

Matsumoto, A., Kamata, T., Takagi, J., Iwasaki, K. & Yura, K., 2008 Sep 15, In : Biophysical Journal. 95, 6, p. 2895-2908 14 p.

Research output: Contribution to journalArticle

Integrins
Extracellular Matrix
Membrane Proteins
Amino Acids
Mutation
2005
38 Citations (Scopus)

Membrane-proximal α/β stalk interactions differentially regulate integrin activation

Kamata, T., Handa, M., Sato, Y., Ikeda, Y. & Aiso, S., 2005 Jul 1, In : Journal of Biological Chemistry. 280, 26, p. 24775-24783 9 p.

Research output: Contribution to journalArticle

Integrins
Chemical activation
Ligands
Membranes
Divalent Cations
2004
53 Citations (Scopus)

Critical cysteine residues for regulation of integrin αIIbβ3 are clustered in the epidermal growth factor domains of the β3 subunit

Kamata, T., Ambo, H., Puzon-McLaughlin, W., Tieu, K. K., Handa, M., Ikeda, Y. & Takada, Y., 2004 Mar 15, In : Biochemical Journal. 378, 3, p. 1079-1082 4 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Integrins
Cysteine
Disulfides
Protein Disulfide-Isomerases
2002
42 Citations (Scopus)

The role of the CPNKEKEC sequence in the β2 subunit I domain in regulation of integrin αLβ2 (LFA-1)

Kamata, T., Tieu, K. K., Tarui, T., Puzon-McLaughlin, W., Hogg, N. & Takada, Y., 2002 Mar 1, In : Journal of Immunology. 168, 5, p. 2296-2301 6 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
Integrins
Epitopes
Intercellular Adhesion Molecule-1
Disulfides
2001
69 Citations (Scopus)

Amino Acid Residues in the αIIb Subunit that Are Critical for Ligand Binding to Integrin αIIbβ3 Are Clustered in the β-Propeller Model

Kamata, T., Tieu, K. K., Irie, A., Springer, T. A. & Takada, Y., 2001 Nov 23, In : Journal of Biological Chemistry. 276, 47, p. 44275-44283 9 p.

Research output: Contribution to journalArticle

Propellers
Integrins
Ligands
Amino Acids
Binding Sites
11 Citations (Scopus)

Platelet integrin αIIbβ3-ligand interactions: What can we learn from the structure?

Kamata, T. & Takada, Y., 2001, In : International Journal of Hematology. 74, 4, p. 382-389 8 p.

Research output: Contribution to journalArticle

Integrins
Blood Platelets
Ligands
Thrombosis
Platelet Glycoprotein GPIb-IX Complex
907 Citations (Scopus)

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

Weitz-Schmidt, G., Welzenbach, K., Brinkmann, V., Kamata, T., Kallen, J., Bruns, C., Cottens, S., Takada, Y. & Hommel, U., 2001, In : Nature Medicine. 7, 6, p. 687-692 6 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
HLA Antigens
Integrins
Antigens
Allosteric Site
2000
86 Citations (Scopus)

Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin α(IIb)β3

Puzon-McLaughlin, W., Kamata, T. & Takada, Y., 2000 Mar 17, In : Journal of Biological Chemistry. 275, 11, p. 7795-7802 8 p.

Research output: Contribution to journalArticle

Antibody Binding Sites
Integrins
Ligands
Binding Sites
Antibodies
1999
41 Citations (Scopus)
Integrins
Metal ions
Collagen
Adhesion
Metals
1998
18 Citations (Scopus)

Novel point mutations in the αIIb subunit (Phe289 → Ser, Glu324 → Lys and Gln747 → Pro) causing thrombasthenic phenotypes in four Japanese patients

Ambo, H., Kamata, T., Handa, M., Kawai, Y., Oda, A., Murata, M., Takada, Y. & Ikeda, Y., 1998, In : British Journal of Haematology. 102, 3, p. 829-840 12 p.

Research output: Contribution to journalArticle

Thrombasthenia
Point Mutation
Phenotype
Exons
Mutation
192 Citations (Scopus)

Specific interaction of the recombinant disintegrin-like domain of MDC- 15 (Metargidin, ADAM-15) with integrin αvβ3

Zhang, X. P., Kamata, T., Yokoyama, K., Puzon-McLaughlin, W. & Takada, Y., 1998 Mar 27, In : Journal of Biological Chemistry. 273, 13, p. 7345-7350 6 p.

Research output: Contribution to journalArticle

Disintegrins
Integrins
Cell Communication
Snake Venoms
Metalloproteases
36 Citations (Scopus)

Three novel integrin β3 subunit missense mutations (H280P, C560F, and G579S) in thrombasthenia, including one (H280P) prevalent in Japanese patients

Ambo, H., Kamata, T., Handa, M., Taki, M., Kuwajima, M., Kawai, Y., Oda, A., Murata, M., Takada, Y., Watanabe, K. & Ikeda, Y., 1998 Oct 29, In : Biochemical and Biophysical Research Communications. 251, 3, p. 763-768 6 p.

Research output: Contribution to journalArticle

Thrombasthenia
Polymerase chain reaction
Missense Mutation
Platelets
Integrins
1997
103 Citations (Scopus)

Changing ligand specificities of αvβ1 and αvβ3 integrins by swapping a short diverse sequence of the β subunit

Takagi, J., Kamata, T., Meredith, J., Puzon-McLaughlin, W. & Takada, Y., 1997 Aug 8, In : Journal of Biological Chemistry. 272, 32, p. 19794-19800 7 p.

Research output: Contribution to journalArticle

Integrins
Ligands
Vitronectin
Fibrinogen
von Willebrand Factor
38 Citations (Scopus)

Echovirus 1 interaction with the human very late antigen-2 (integrin α2β1) I domain: Identification of two independent virus contact sites distinct from the metal ion-dependent adhesion site

King, S. L., Kamata, T., Cunningham, J. A., Emsley, J., Liddington, R. C., Takada, Y. & Bergelson, J. M., 1997 Nov 7, In : Journal of Biological Chemistry. 272, 45, p. 28518-28522 5 p.

Research output: Contribution to journalArticle

Integrin alpha2beta1
Human Enterovirus B
Viruses
Integrins
Metal ions

Molecular mechanisms of integrin-ligand interaction

Irie, A., Kamata, T. & Takada, Y., 1997, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 42, 10 Suppl, p. 1679-1686 8 p.

Research output: Contribution to journalArticle

Protein Conformation
Cell Adhesion
Integrins
Extracellular Matrix
Signal Transduction
59 Citations (Scopus)
Integrins
Ligands
Vascular Cell Adhesion Molecule-1
Binding Sites
Immobilized Cells
33 Citations (Scopus)

Structural basis of integrin-mediated signal transduction

Takada, Y., Kamata, T., Irie, A., Puzon-McLaughlin, W. & Zhang, X. P., 1997 Oct, In : Matrix Biology. 16, 4, p. 143-151 9 p.

Research output: Contribution to journalArticle

Integrins
Signal Transduction
Ligands
Binding Sites
Conserved Sequence
1996
207 Citations (Scopus)

Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells

Huang, S., Kamata, T., Takada, Y., Ruggeri, Z. M. & Nemerow, G. R., 1996, In : Journal of Virology. 70, 7, p. 4502-4508 7 p.

Research output: Contribution to journalArticle

integrins
Adenoviridae
gene transfer
Integrins
Genes
51 Citations (Scopus)

A novel regulatory epitope defined by a murine monoclonal antibody to the platelet GPIIb-IIIa complex (αIIbβ3 integrin)

Tokuhira, M., Handa, M., Kamata, T., Oda, A., Katayama, M., Tomiyama, Y., Murata, M., Kawai, Y., Watanabe, K. & Ikeda, Y., 1996 Dec, In : Thrombosis and Haemostasis. 76, 6, p. 1038-1046 9 p.

Research output: Contribution to journalArticle

Integrins
Epitopes
Blood Platelets
Monoclonal Antibodies
Antibodies
1 Citation (Scopus)
Integrin alpha4beta1
Integrins
Binding Sites
Ligands
75 Citations (Scopus)
Platelet Glycoprotein GPIIb-IIIa Complex
Integrins
Fibrinogen
Ligands
Mutation
3 Citations (Scopus)
Integrin alpha2beta1
Integrins
Binding Sites
Ligands

Integrin family

Irie, A., Kamata, T. & Takada, Y., 1996 Sep, In : Rinsho byori. The Japanese journal of clinical pathology. Suppl 102, p. 16-23 8 p.

Research output: Contribution to journalArticle

Integrins
1995
87 Citations (Scopus)

Critical amino acid residues for ligand binding are clustered in a predicted β-turn of the third N-terminal repeat in the integrin α4 and α5 subunits

Irie, A., Kamata, T., Puzon-McLaughlin, W. & Takada, Y., 1995, In : EMBO Journal. 14, 22, p. 5550-5556 7 p.

Research output: Contribution to journalArticle

Terminal Repeat Sequences
Integrins
Ligands
Amino Acids
Vascular Cell Adhesion Molecule-1
82 Citations (Scopus)
Complement C3b
Intercellular Adhesion Molecule-1
Threonine
Aspartic Acid
Integrins
116 Citations (Scopus)

Identification of putative ligand-binding sites of the integrin α4β1 (VLA-4, CD49d/CD29)

Kamata, T., Puzon, W. & Takada, Y., 1995, In : Biochemical Journal. 305, 3, p. 945-951 7 p.

Research output: Contribution to journalArticle

Integrin alpha4beta1
Integrins
Epitopes
Binding Sites
Ligands
78 Citations (Scopus)

Platelet unresponsiveness to collagen: Involvement of glycoprotein Ia-IIa (α2β1 integrin) deficiency associated with a myeloproliferative disorder

Handa, M., Watanabe, K., Kawai, Y., Kamata, T., Koyama, T., Nagai, H. & Ikeda, Y., 1995, In : Thrombosis and Haemostasis. 73, 3, p. 521-528 8 p.

Research output: Contribution to journalArticle

Integrin alpha2beta1
Myeloproliferative Disorders
Integrin alpha2
Integrins
Collagen
1994
137 Citations (Scopus)

Direct binding of collagen to the I domain of integrin α2β1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner

Kamata, T. & Takada, Y., 1994 Oct 21, In : Journal of Biological Chemistry. 269, 42, p. 26006-26010 5 p.

Research output: Contribution to journalArticle

Integrin alpha2beta1
Divalent Cations
Integrins
Collagen
Collagen Receptors
140 Citations (Scopus)

Identification of putative ligand binding sites within I domain of integrin α2β1 (VLA-2, CD49b/CD29)

Kamata, T., Puzon, W. & Takada, Y., 1994 Apr 1, In : Journal of Biological Chemistry. 269, 13, p. 9659-9663 5 p.

Research output: Contribution to journalArticle

Integrin alpha2beta1
Human Enterovirus B
Integrins
Collagen
Binding Sites
32 Citations (Scopus)

Rapid improvement of coagulopathy by all-trans retinoic acid in acute promyelocytic leukemia

Kawai, Y., Watanabe, K., Kizaki, M., Murata, M., Kamata, T., Uchida, H., Moriki, T., Yokoyama, K., Tokuhira, M., Nakajima, H., Handa, M. & Ikeda, Y., 1994, In : American Journal of Hematology. 46, 3, p. 184-188 5 p.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
Tretinoin
Hemostatics
Fibrin Fibrinogen Degradation Products
Disseminated Intravascular Coagulation
1993
155 Citations (Scopus)

Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation

Ikeda, Y., Handa, M., Kamata, T., Kawano, K., Kawai, Y., Watanabe, K., Kawakami, K., Sakai, K., Fukuyama, M., Itagaki, I., Yoshioka, A. & Ruggeri, Z. M., 1993, In : Thrombosis and Haemostasis. 69, 5, p. 496-502 7 p.

Research output: Contribution to journalArticle

Platelet Membrane Glycoprotein IIb
von Willebrand Factor
Platelet Aggregation
Ions
Calcium
1992
3 Citations (Scopus)

Extramedullary diseases as presenting features of aleukemic acute monocytic leukemia

Hayashida, T., Araki, Y., Kawano, K., Kamata, T., Kawai, Y., Takeuchi, K., Watanabe, K., Okamoto, S. & Ogawa, T., 1992 Nov, In : [Rinsho ketsueki] The Japanese journal of clinical hematology. 33, 11, p. 1679-1684 6 p.

Research output: Contribution to journalArticle

Leukemia, Monocytic, Acute
Lymphoma
Monocyte-Macrophage Precursor Cells
Drug Therapy
Histocytochemistry

Function of GMP-140, a granule membrane protein of platelets

Michikawa, N., Anbo, H., Araki, Y., Kamata, T., Ikeda, Y., Handa, M., Kawai, Y., Watanabe, K. & Katayama, M., 1992 Mar, In : Rinsho byori. The Japanese journal of clinical pathology. Suppl 92, p. 15-25 11 p.

Research output: Contribution to journalArticle

1991
497 Citations (Scopus)

The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress

Ikeda, Y., Handa, M., Kawano, K., Kamata, T., Murata, M., Araki, Y., Anbo, H., Kawai, Y., Watanabe, K., Itagaki, I., Sakai, K. & Ruggeri, Z. M., 1991 Apr, In : Journal of Clinical Investigation. 87, 4, p. 1234-1240 7 p.

Research output: Contribution to journalArticle

von Willebrand Factor
Platelet Aggregation
Fibrinogen
Platelet Glycoprotein GPIIb-IIIa Complex
Blood Platelets
1990

Effects of anti-platelet agents on shear-induced platelet aggregation

Ikeda, Y., Handa, M., Kawano, K., Kamata, T., Anyasu, H., Araki, Y., kawaiY & Watanabe, K., 1990 Jun, In : [Rinsho ketsueki] The Japanese journal of clinical hematology. 31, 6, p. 787-792 6 p.

Research output: Contribution to journalArticle

Mechanical Stress
Platelet Aggregation Inhibitors
Platelet Aggregation
Blood Platelets
Hemorrhage
10 Citations (Scopus)

Enhancing effect by heparin on shear-induced platelet aggregation

Kawano, K., Ikeda, Y., Handa, M., Kamata, T., Anbo, H., Araki, Y., Kawai, Y., Watanabe, K., Itagaki, I., Kawakami, K., Fukuyama, M. & Sakai, K., 1990, In : Seminars in Thrombosis and Hemostasis. 16, SUPPL., p. 60-65 6 p.

Research output: Contribution to journalArticle

Platelet Aggregation
Heparin
Bernard-Soulier Syndrome
Afibrinogenemia
von Willebrand Diseases
8 Citations (Scopus)

Primary hepatic lymphoma in a patient with autoimmune hemolytic anemia and SLE

Yoshimoto, T., Araki, Y., Kawano, K., Kamata, T., Okamoto, S. & Ogawa, T., 1990 Nov, In : [Rinsho ketsueki] The Japanese journal of clinical hematology. 31, 11, p. 1878-1883 6 p.

Research output: Contribution to journalArticle

Autoimmune Hemolytic Anemia
Systemic Lupus Erythematosus
Lymphoma
Liver
Gallium
1989
5 Citations (Scopus)

Role of membrane glycoproteins in the interaction of blood platelets with the vessel wall--the study on platelet adhesion to in vitro cultured subendothelial matrix.

Kawai, Y., Handa, M., Nagai, H., Kamata, T., Anbo, H., Kawano, K., Araki, Y., Yamamoto, M., Ikeda, Y. & Watanabe, K., 1989 Dec, In : Acta Haematologica Japonica. 52, 8, p. 1312-1321 10 p.

Research output: Contribution to journalArticle

Membrane Glycoproteins
Blood Platelets
Integrin alpha2
Blocking Antibodies
Laminin