• 442 Citations
  • 13 h-Index
20042020

Research output per year

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Research Output

  • 442 Citations
  • 13 h-Index
  • 37 Article
  • 1 Editorial
  • 1 Letter
  • 1 Review article
2020

Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction

Inagaki, M., Nishimura, T., Nakanishi, T., Shimada, H., Noguchi, S., Akanuma, S. I., Tachikawa, M., Hosoya, K. I., Tamai, I., Nakashima, E. & Tomi, M., 2020 May 22, In : iScience. 23, 5, 101098.

Research output: Contribution to journalArticle

Open Access

Preface

Takada, T. & Nishimura, T., 2020 Feb, In : Drug Metabolism And Pharmacokinetics. 35, 1, 1 p.

Research output: Contribution to journalEditorial

Open Access
2019

LAT1-Targeting Thermoresponsive Liposomes for Effective Cellular Uptake by Cancer Cells

Maekawa-Matsuura, M., Fujieda, K., Maekawa, Y., Nishimura, T., Nagase, K. & Kanazawa, H., 2019 Apr 8, In : ACS Omega. 4, 4, p. 6443-6451 9 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Quantification of ENT1 and ENT2 Proteins at the Placental Barrier and Contribution of These Transporters to Ribavirin Uptake

Nishimura, T., Sano, Y., Takahashi, Y., Noguchi, S., Uchida, Y., Takagi, A., Tanaka, T., Katakura, S., Nakashima, E., Tachikawa, M., Maruyama, T., Terasaki, T. & Tomi, M., 2019 Jan 1, (Accepted/In press) In : Journal of Pharmaceutical Sciences.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2018

Effect of serotonin transporter genotype on self-reported efficacy and activity changes of brain prefrontal area in response to placebo

Isawa, M., Tashiro, R., Naruse, C., Yamaguchi, Y., Itoh, H., Nishimura, T., Tomi, M., Shimada, H., Saito, H., Mochizuki, M. & Nakashima, E., 2018 Jan 1, In : Pharmazie. 73, 1, p. 35-41 7 p.

Research output: Contribution to journalArticle

Hypotaurine is a substrate of GABA transporter family members GAT2/Slc6a13 and TAUT/Slc6a6

Nishimura, T., Higuchi, K., Yoshida, Y., Sugita-Fujisawa, Y., Kojima, K., Sugimoto, M., Santo, M., Tomi, M. & Nakashima, E., 2018 Jan 1, In : Biological and Pharmaceutical Bulletin. 41, 10, p. 1523-1529 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

LAT1-targeting thermoresponsive fluorescent polymer probes for cancer cell imaging

Matsuura, M., Ohshima, M., Hiruta, Y., Nishimura, T., Nagase, K. & Kanazawa, H., 2018 Jun 1, In : International Journal of Molecular Sciences. 19, 6, 1646.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Mycobacterium triplex pulmonary disease with acquired macrolide resistance in immunocompetent patients

Matsuda, S., Suzuki, S., Morimoto, K., Aono, A., Nishio, K., Asakura, T., Sasaki, Y., Namkoong, H., Nishimura, T., Ogata, H., Hasegawa, N., Kurashima, A., Ishii, M., Tatsumi, K., Mitarai, S. & Goto, H., 2018 Jun 1, In : Clinical Microbiology and Infection. 24, 6, p. 671-672 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line

Takahashi, Y., Nishimura, T., Higuchi, K., Noguchi, S., Tega, Y., Kurosawa, T., Deguchi, Y. & Tomi, M., 2018 Dec 1, In : Pharmaceutical research. 35, 12, 246.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

Cellular Uptake of Levocetirizine by Organic Anion Transporter 4

Noguchi, S., Nishimura, T., Mukaida, S., Benet, L. Z., Nakashima, E. & Tomi, M., 2017 Feb 15, (Accepted/In press) In : Journal of Pharmaceutical Sciences.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts

Inagaki, M., Nishimura, T., Akanuma, S. I., Nakanishi, T., Tachikawa, M., Tamai, I., Hosoya, K. I., Nakashima, E. & Tomi, M., 2017 May 1, In : Placenta. 53, p. 174-182 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Contributions of system A subtypes to α-methylaminoisobutyric acid uptake by placental microvillous membranes of human and rat

Takahashi, Y., Nishimura, T., Maruyama, T., Tomi, M. & Nakashima, E., 2017 Feb 4, (Accepted/In press) In : Amino Acids. p. 1-9 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2016

Contribution of equilibrative nucleoside transporter (ENT) 2 to fluorouracil transport in rat placental trophoblast cells

Takagi, A., Nishimura, T., Akashi, T., Tomi, M. & Nakashima, E., 2016 Jun 20, (Accepted/In press) In : Drug Metabolism and Pharmacokinetics.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Layer II of placental syncytiotrophoblasts expresses MDR1 and BCRP at the apical membrane in rodents

Akashi, T., Nishimura, T., Takaki, Y., Takahashi, M., Shin, B. C., Tomi, M. & Nakashima, E., 2016 Oct 1, In : Reproductive Toxicology. 65, p. 375-381 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2015

Organic Anion Transporter 4-Mediated Transport of Olmesartan at Basal Plasma Membrane of Human Placental Barrier

Noguchi, S., Nishimura, T., Fujibayashi, A., Maruyama, T., Tomi, M. & Nakashima, E., 2015 Sep 1, In : Journal of Pharmaceutical Sciences. 104, 9, p. 3128-3135 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Protective effect of hypotaurine against oxidative stress-induced cytotoxicity in rat placental trophoblasts

Nishimura, T., Duereh, M., Sugita, Y., Yoshida, Y., Higuchi, K., Tomi, M. & Nakashima, E., 2015 Jun 1, In : Placenta. 36, 6, p. 693-698 6 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Role of OAT4 in uptake of estriol precursor 16α-hydroxydehydroepiandrosterone sulfate into human placental syncytiotrophoblasts from fetus

Tomi, M., Eguchi, H., Ozaki, M., Tawara, T., Nishimura, S., Higuchi, K., Maruyama, T., Nishimura, T. & Nakashima, E., 2015 Jul 1, In : Endocrinology. 156, 7, p. 2704-2712 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2014

Basic fibroblast growth factor is essential to maintain endothelial progenitor cell phenotype in TR-BME2 cells

Sai, Y., Nishimura, T., Muta, M., Iizasa, H., Miyata, T. & Nakashima, E., 2014 Apr, In : Biological and Pharmaceutical Bulletin. 37, 4, p. 688-693 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Fetal growth retardation and lack of hypotaurine in ezrin knockout mice

Nishimura, T., Higuchi, K., Sai, Y., Sugita, Y., Yoshida, Y., Tomi, M., Wada, M., Wakayama, T., Tamura, A., Tsukita, S., Soga, T. & Nakashima, E., 2014 Aug 21, In : PloS one. 9, 8, e105423.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Role of protein kinase A in regulating steroid sulfate uptake for estrogen production in human placental choriocarcinoma cells

Tomi, M., Miyata, Y., Noguchi, S., Nishimura, S., Nishimura, T. & Nakashima, E., 2014 Aug, In : Placenta. 35, 8, p. 658-660 3 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts

Nishimura, T., Yagi, R., Usuda, M., Oda, K., Yamazaki, M., Suda, S., Takahashi, Y., Okazaki, F., Sai, Y., Higuchi, K., Maruyama, T., Tomi, M. & Nakashima, E., 2014 May, In : Biochimica et Biophysica Acta - Biomembranes. 1838, 5, p. 1306-1312 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2013

Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells

Oda, K., Nishimura, T., Higuchi, K., Ishido, N., Ochi, K., Iizasa, H., Sai, Y., Tomi, M. & Nakashima, E., 2013 Sep, In : Journal of Pharmaceutical Sciences. 102, 9, p. 3364-3372 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Evaluation of rat in vivo fetal-to-maternal transfer clearances of various xenobiotics by umbilical perfusion

Nishimura, T., Takanohashi, T., Tomi, M., Horikoshi, M., Higuchi, K., Sai, Y. & Nakashima, E., 2013 Sep, In : Journal of Pharmaceutical Sciences. 102, 9, p. 3356-3363 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Systems pharmacology of adverse event mitigation by drug combinations

Zhao, S., Nishimura, T., Chen, Y., Azeloglu, E. U., Gottesman, O., Giannarelli, C., Zafar, M. U., Benard, L., Badimon, J. J., Hajjar, R. J., Goldfarb, J. & Iyengar, R., 2013 Oct 9, In : Science translational medicine. 5, 206, 206ra140.

Research output: Contribution to journalArticle

66 Citations (Scopus)
2012

Mechanism of nucleoside uptake in rat placenta and induction of placental CNT2 in experimental diabetes

Nishimura, T., Chishu, T., Tomi, M., Nakamura, R., Sato, K., Kose, N., Sai, Y. & Nakashima, E., 2012, In : Drug Metabolism And Pharmacokinetics. 27, 4, p. 439-446 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2011

Enhancement of zidovudine transfer to molt-4 cells, a human t-cell model, by dehydroepiandrosterone sulfate

Nishimura, T., Tanaka, J., Tomi, M., Seki, Y., Kose, N., Sai, Y. & Nakashima, E., 2011 Sep, In : Journal of Pharmaceutical Sciences. 100, 9, p. 3959-3967 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Mother-to-fetus transfer of antiviral drugs and the involvement of transporters at the placental barrier

Tomi, M., Nishimura, T. & Nakashima, E., 2011 Sep, In : Journal of Pharmaceutical Sciences. 100, 9, p. 3708-3718 11 p.

Research output: Contribution to journalReview article

28 Citations (Scopus)
2010

Differential expression of ezrin and CLP36 in the two layers of syncytiotrophoblast in rats

Higuchi, K., Iizasa, H., Sai, Y., Horieya, S., Lee, K. E., Wada, M., Deguchi, M., Nishimura, T., Wakayama, T., Tamura, A., Tsukita, S., Kose, N., Kang, Y. S. & Nakashima, E., 2010, In : Biological and Pharmaceutical Bulletin. 33, 8, p. 1400-1406 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

PDZK1 regulates organic anion transporting polypeptide oatp1a in mouse small intestine

Sugiura, T., Otake, T., Shimizu, T., Wakayama, T., Silver, D. L., Utsumi, R., Nishimura, T., Iseki, S., Nakamichi, N., Kubo, Y., Tsuji, A. & Kato, Y., 2010, In : Drug Metabolism And Pharmacokinetics. 25, 6, p. 588-598 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Proton-coupled erythromycin antiport at rat blood-placenta barrier

Sai, Y., Nishimura, T., Ochi, K., Tanaka, N., Takagi, A., Tomi, M., Kose, N., Kobayashi, Y., Miyakoshi, N., Kitagaki, S., Mukai, C. & Nakashima, E., 2010 Sep, In : Drug Metabolism and Disposition. 38, 9, p. 1576-1581 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress

Nishimura, T., Sai, Y., Fujii, J., Muta, M., Iizasa, H., Tomi, M., Deureh, M., Kose, N. & Nakashima, E., 2010 Nov 1, In : Placenta. 31, 11, p. 1003-1009 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2009

Influx Mechanism of 2′,3′-Dideoxyinosine and Uridine at the Blood-Placenta Barrier

Sato, K., Sai, Y., Nishimura, T., Chishu, T., Shimpo, S., Kose, N. & Nakashima, E., 2009 Mar 1, In : Placenta. 30, 3, p. 263-269 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2008

Characterization of the mechanism of zidovudine uptake by rat conditionally immortalized syncytiotrophoblast cell line TR-TBT

Sai, Y., Nishimura, T., Shimpo, S., Chishu, T., Sato, K., Kose, N., Terasaki, T., Mukai, C., Kitagaki, S., Miyakoshi, N., Kang, Y. S. & Nakashima, E., 2008 Jul 1, In : Pharmaceutical research. 25, 7, p. 1647-1653 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

enhancement of zidovudine uptake by dehydroepiandrosterone sulfate in rat syncytiotrophoblast cell line TR-TBT 18d-1

Nishimura, T., Seki, Y., Sato, K., Chishu, T., Kose, N., Terasaki, T., Kang, Y. S., Sai, Y. & Nakashima, E., 2008 Oct, In : Drug Metabolism and Disposition. 36, 10, p. 2080-2085 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Potential of Various Drugs to Inhibit Nucleoside Uptake in Rat Syncytiotrophoblast Cell Line, TR-TBT 18d-1

Chishu, T., Sai, Y., Nishimura, T., Sato, K., Kose, N. & Nakashima, E., 2008 May 1, In : Placenta. 29, 5, p. 461-467 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Species difference in intestinal absorption mechanism of etoposide and digoxin between cynomolgus monkey and rat

Nishimura, T., Kato, Y., Amano, N., Ono, M., Kubo, Y., Kimura, Y., Fujita, H. & Tsuji, A., 2008 Nov, In : Pharmaceutical research. 25, 11, p. 2467-2476 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2007

Asymmetric intestinal first-pass metabolism causes minimal oral bioavailability of midazolam in cynomolgus monkey

Nishimura, T., Amano, N., Kubo, Y., Ono, M., Kato, Y., Fujita, H., Kimura, Y. & Tsuji, A., 2007 Aug 1, In : Drug Metabolism and Disposition. 35, 8, p. 1275-1284 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells: Involvement of organic anion transporting polypeptide (OATP)-B

Nishimura, T., Kubo, Y., Kato, Y., Sai, Y., Ogihara, T. & Tsuji, A., 2007 Jan 1, In : Pharmaceutical research. 24, 1, p. 90-98 9 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2006

Carrier-mediated hepatic uptake of a novel nonrenal excretion type uric acid generation inhibitor, Y-700

Sai, Y., Kato, Y., Nakamura, K., Kato, S., Nishimura, T., Kubo, Y., Tamai, I., Yang, S., Hu, Z., Yamada, I. & Tsuji, A., 2006 Feb, In : Journal of Pharmaceutical Sciences. 95, 2, p. 336-347 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2004

Characterization of renal excretion mechanism for a novel diuretic, M17055, in rats

Nishimura, T., Kato, Y., Sai, Y., Ogihara, T. & Tsuji, A., 2004 Oct, In : Journal of Pharmaceutical Sciences. 93, 10, p. 2558-2566 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)