Research Output per year
Research Output
2020
Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine
Sato, T., Sase, M., Ishikawa, S., Kajita, M., Asano, J., Sato, T., Mori, Y. & Ohteki, T., 2020 Dec 1, In : Scientific reports. 10, 1, 8308.Research output: Contribution to journal › Article
Open Access
Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma
Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., Kanai, T. & Sato, T., 2020 Feb, In : Gastroenterology. 158, 3, p. 638-651.e8Research output: Contribution to journal › Article
4
Citations
(Scopus)
Development of a Scalable Coculture System for Gut Anaerobes and Human Colon Epithelium
Sasaki, N., Miyamoto, K., Maslowski, K. M., Ohno, H., Kanai, T. & Sato, T., 2020 Jul, In : Gastroenterology. 159, 1, p. 388-390.e5Research output: Contribution to journal › Article
Open Access
Organoid Derivation and Orthotopic Xenotransplantation for Studying Human Intestinal Stem Cell Dynamics
Sugimoto, S., Fujii, M. & Sato, T., 2020, In : Methods in molecular biology (Clifton, N.J.). 2171, p. 303-320 18 p.Research output: Contribution to journal › Article
Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages
Sato, T., Ishikawa, S., Asano, J., Yamamoto, H., Fujii, M., Sato, T., Yamamoto, K., Kitagaki, K., Akashi, T., Okamoto, R. & Ohteki, T., 2020 Aug 1, In : Nature Cell Biology. 22, 8, p. 919-926 8 p.Research output: Contribution to journal › Article
Somatic inflammatory gene mutations in human ulcerative colitis epithelium
Nanki, K., Fujii, M., Shimokawa, M., Matano, M., Nishikori, S., Date, S., Takano, A., Toshimitsu, K., Ohta, Y., Takahashi, S., Sugimoto, S., Ishimaru, K., Kawasaki, K., Nagai, Y., Ishii, R., Yoshida, K., Sasaki, N., Hibi, T., Ishihara, S., Kanai, T. & 1 others, , 2020 Jan 9, In : Nature. 577, 7789, p. 254-259 6 p.Research output: Contribution to journal › Article
5
Citations
(Scopus)
2019
Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia
Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 May 16, In : Oncogene. 38, 20, p. 3962-3969 8 p.Research output: Contribution to journal › Article
2
Citations
(Scopus)
Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis
Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P. S., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. & 2 others, , 2019 Mar 1, In : Nature Microbiology. 4, 3, p. 492-503 12 p.Research output: Contribution to journal › Article
28
Citations
(Scopus)
Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis
Matsui, S., Okabayashi, K., Tsuruta, M., Shigeta, K., Seishima, R., Ishida, T., Kondo, T., Suzuki, Y., Hasegawa, H., Shimoda, M., Sugimoto, S., Sato, T. & Kitagawa, Y., 2019 Jul, In : Cancer science. 110, 7, p. 2156-2165 10 p.Research output: Contribution to journal › Article
Open Access
4
Citations
(Scopus)
2018
Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling
Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R. & Ohno, H., 2018 Feb 1, In : Journal of Experimental Medicine. 215, 2, p. 501-519 19 p.Research output: Contribution to journal › Article
23
Citations
(Scopus)
Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis
Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S. & 3 others, , 2018 Aug 9, In : Cell. 174, 4, p. 856-869.e17Research output: Contribution to journal › Article
36
Citations
(Scopus)
Erratum to: Efficient genetic engineering of human intestinal organoids using electroporation (Nature Protocols, (2015), 10, 10, (1474-1485), 10.1038/nprot.2015.088)
Fujii, M., Matano, M., Nanki, K. & Sato, T., 2018 Jan 1, (Accepted/In press) In : Nature Protocols.Research output: Contribution to journal › Article
Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential
Loomans, C. J. M., Williams Giuliani, N., Balak, J., Ringnalda, F., van Gurp, L., Huch, M., Boj, S. F., Sato, T., Kester, L., de Sousa Lopes, S. M. C., Roost, M. S., Bonner-Weir, S., Engelse, M. A., Rabelink, T. J., Heimberg, H., Vries, R. G. J., van Oudenaarden, A., Carlotti, F., Clevers, H. & de Koning, E. J. P., 2018 Mar 13, In : Stem cell reports. 10, 3, p. 712-724 13 p.Research output: Contribution to journal › Article
33
Citations
(Scopus)
Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition
Fujii, M., Matano, M., Toshimitsu, K., Takano, A., Mikami, Y., Nishikori, S., Sugimoto, S. & Sato, T., 2018 Dec 6, In : Cell Stem Cell. 23, 6, p. 787-793.e6Research output: Contribution to journal › Article
28
Citations
(Scopus)
Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression
Seino, T., Kawasaki, S., Shimokawa, M., Tamagawa, H., Toshimitsu, K., Fujii, M., Ohta, Y., Matano, M., Nanki, K., Kawasaki, K., Takahashi, S., Sugimoto, S., Iwasaki, E., Takagi, J., Itoi, T., Kitago, M., Kitagawa, Y., Kanai, T. & Sato, T., 2018 Jan 1, (Accepted/In press) In : Cell Stem Cell.Research output: Contribution to journal › Article
99
Citations
(Scopus)
Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system
Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 Dec 1, In : Scientific Reports. 8, 1, 2821.Research output: Contribution to journal › Article
11
Citations
(Scopus)
Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites
Mito, A., Nakano, Y., Saitoh, T., Gouraud, S. S. S., Yamaguchi, Y., Sato, T., Sasaki, N. & Kojima-Aikawa, K., 2018 Jan 1, In : Glycobiology. 28, 1, p. 21-31 11 p.Research output: Contribution to journal › Article
4
Citations
(Scopus)
Reconstruction of the Human Colon Epithelium In Vivo
Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., Kanai, T. & Sato, T., 2018 Feb 1, In : Cell Stem Cell. 22, 2, p. 171-176.e5Research output: Contribution to journal › Article
34
Citations
(Scopus)
2017
Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes
Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T. & 19 others, , 2017 May 1, In : Nature Cell Biology. 19, 5, p. 530-541 12 p.Research output: Contribution to journal › Article
48
Citations
(Scopus)
IL-22BP dictates characteristics of Peyer's patch follicleassociated epithelium for antigen uptake
Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H. & Ohno, H., 2017 Jun 1, In : Journal of Experimental Medicine. 214, 6, p. 1607-1618 12 p.Research output: Contribution to journal › Article
23
Citations
(Scopus)
Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice
Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., Suda, W., Hattori, M., Amagai, M., Ohyama, M. & Kanai, T., 2017 Aug 15, In : Cell Reports. 20, 7, p. 1513-1524 12 p.Research output: Contribution to journal › Article
22
Citations
(Scopus)
Visualization and targeting of LGR5 + human colon cancer stem cells
Shimokawa, M., Ohta, Y., Nishikori, S., Matano, M., Takano, A., Fujii, M., Date, S., Sugimoto, S., Kanai, T. & Sato, T., 2017 May 11, In : Nature. 545, 7653, p. 187-192 6 p.Research output: Contribution to journal › Article
194
Citations
(Scopus)
2016
A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis
Fujii, M., Shimokawa, M., Date, S., Takano, A., Matano, M., Nanki, K., Ohta, Y., Toshimitsu, K., Nakazato, Y., Kawasaki, K., Uraoka, T., Watanabe, T., Kanai, T. & Sato, T., 2016 Jun 2, In : Cell Stem Cell. 18, 6, p. 827-838 12 p.Research output: Contribution to journal › Article
195
Citations
(Scopus)
Active and water-soluble form of lipidated wnt protein is maintained by a serum glycoprotein afamin/α-albumin
Mihara, E., Hirai, H., Yamamoto, H., Tamura-Kawakami, K., Matano, M., Kikuchi, A., Sato, T. & Takagi, J., 2016 Feb 23, In : eLife. 5, FEBRUARY2016, e11621.Research output: Contribution to journal › Article
53
Citations
(Scopus)
Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways
Kikuchi, I., Takahashi-Kanemitsu, A., Sakiyama, N., Tang, C., Tang, P. J., Noda, S., Nakao, K., Kassai, H., Sato, T., Aiba, A. & Hatakeyama, M., 2016 Sep 21, In : Nature Communications. 7, 12887.Research output: Contribution to journal › Article
19
Citations
(Scopus)
EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells
Nakajo, A., Yoshimura, S. I., Togawa, H., Kunii, M., Iwano, T., Izumi, A., Noguchi, Y., Watanabe, A., Goto, A., Sato, T. & Harada, A., 2016, In : Journal of Cell Biology. 212, 3, p. 297-306 10 p.Research output: Contribution to journal › Article
16
Citations
(Scopus)
Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response
Saito, Y., Nakaoka, T., Sakai, K., Muramatsu, T., Toshimitsu, K., Kimura, M., Kanai, T., Sato, T. & Saito, H., 2016 May 4, In : Scientific Reports. 6, 25311.Research output: Contribution to journal › Article
15
Citations
(Scopus)
Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation
Dominguez-Brauer, C., Hao, Z., Elia, A. J., Fortin, J. M., Nechanitzky, R., Brauer, P. M., Sheng, Y., Mana, M. D., Chio, I. I. C., Haight, J., Pollett, A., Cairns, R., Tworzyanski, L., Inoue, S., Reardon, C., Marques, A., Silvester, J., Cox, M. A., Wakeham, A., Yilmaz, O. H. & 5 others, , 2016 Aug 4, In : Cell stem cell. 19, 2, p. 205-216 12 p.Research output: Contribution to journal › Article
9
Citations
(Scopus)
SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling
Oudhoff, M. J., Braam, M. J. S., Freeman, S. A., Wong, D., Rattray, D. G., Wang, J., Antignano, F., Snyder, K., Refaeli, I., Hughes, M. R., McNagny, K. M., Gold, M. R., Arrowsmith, C. H., Sato, T., Rossi, F. M. V., Tatlock, J. H., Owen, D. R., Brown, P. J. & Zaph, C., 2016 Apr 4, In : Developmental Cell. 37, 1, p. 47-57 11 p.Research output: Contribution to journal › Article
41
Citations
(Scopus)
Tissue-specific mutation accumulation in human adult stem cells during life
Blokzijl, F., De Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., Nijman, I. J., Martincorena, I., Mokry, M., Wiegerinck, C. L., Middendorp, S., Sato, T., Schwank, G., Nieuwenhuis, E. E. S., Verstegen, M. M. A., Van Der Laan, L. J. W. & 8 others, , 2016 Jan 1, In : Nature. 538, 7624, p. 260-264 5 p.Research output: Contribution to journal › Article
272
Citations
(Scopus)
Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress
Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irié, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K. & Fukada, T., 2016 Oct, In : PLoS Genetics. 12, 10, e1006349.Research output: Contribution to journal › Article
35
Citations
(Scopus)
2015
An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium
Pin, C., Parker, A., Gunning, A. P., Ohta, Y., Johnson, I. T., Carding, S. R. & Sato, T., 2015 Feb 1, In : Integrative Biology (United Kingdom). 7, 2, p. 213-228 16 p.Research output: Contribution to journal › Article
14
Citations
(Scopus)
Combination therapy with infliximab and thiopurine compared to infliximab monotherapy in maintaining remission of postoperative crohn's disease
Sakuraba, A., Okamoto, S., Matsuoka, K., Sato, T., Naganuma, M., Hisamatsu, T., Iwao, Y., Ogata, H., Kanai, T. & Hibi, T., 2015 May 6, In : Digestion. 91, 3, p. 233-238 6 p.Research output: Contribution to journal › Article
7
Citations
(Scopus)
Efficient genetic engineering of human intestinal organoids using electroporation
Fujii, M., Matano, M., Nanki, K. & Sato, T., 2015 Oct 29, In : Nature Protocols. 10, 10, p. 1474-1485 12 p.Research output: Contribution to journal › Article
78
Citations
(Scopus)
Ink4a/arf-dependent loss of parietal cells induced by oxidative stress promotes CD44-dependent gastric tumorigenesis
Seishima, R., Wada, T., Tsuchihashi, K., Okazaki, S., Yoshikawa, M., Oshima, H., Oshima, M., Sato, T., Hasegawa, H., Kitagawa, Y., Goldenring, J. R., Saya, H. & Nagano, O., 2015 Jun 1, In : Cancer Prevention Research. 8, 6, p. 492-501 10 p.Research output: Contribution to journal › Article
10
Citations
(Scopus)
Mini-Gut Organoids: Reconstitution of the Stem Cell Niche
Date, S. & Sato, T., 2015 Nov 13, In : Annual Review of Cell and Developmental Biology. 31, p. 269-289 21 p.Research output: Contribution to journal › Article
70
Citations
(Scopus)
Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids
Matano, M., Date, S., Shimokawa, M., Takano, A., Fujii, M., Ohta, Y., Watanabe, T., Kanai, T. & Sato, T., 2015 Mar, In : Nature medicine. 21, 3, p. 256-262 7 p.Research output: Contribution to journal › Article
399
Citations
(Scopus)
Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer
Oshima, H., Nakayama, M., Han, T. S., Naoi, K., Ju, X., Maeda, Y., Robine, S., Tsuchiya, K., Sato, T., Sato, H., Taketo, M. M. & Oshima, M., 2015 Feb 15, In : Cancer Research. 75, 4, p. 766-776 11 p.Research output: Contribution to journal › Article
42
Citations
(Scopus)
2014
Classical Th1 cells obtain colitogenicity by co-existence of RORγt-expressing T cells in experimental colitis
Saigusa, K., Hisamatsu, T., Handa, T., Sujino, T., Mikami, Y., Hayashi, A., Mizuno, S., Takeshita, K., Sato, T., Matsuoka, K. & Kanai, T., 2014 Oct 1, In : Inflammatory bowel diseases. 20, 10, p. 1820-1827 8 p.Research output: Contribution to journal › Article
3
Citations
(Scopus)
Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin
Takabayashi, K., Kashiwagi, K., Kawata, T., Sato, T., Matsuoka, K., Hisamatsu, T., Takaishi, H., Hibi, T., Ogata, H., Yahagi, N., Kitagawa, Y., Shigematsu, N. & Kanai, T., 2014 Jan 1, In : Cancer Biology and Therapy. 15, 1, p. 81-88 8 p.Research output: Contribution to journal › Article
5
Citations
(Scopus)
Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production In Crohn's disease
Mizuno, S., Mikami, Y., Kamada, N., Handa, T., Hayashi, A., Sato, T., Matsuoka, K., Matano, M., Ohta, Y., Sugita, A., Koganei, K., Sahara, R., Takazoe, M., Hisamatsu, T. & Kanai, T., 2014 Aug, In : Inflammatory bowel diseases. 20, 8, p. 1426-1434 9 p.Research output: Contribution to journal › Article
37
Citations
(Scopus)
KLF5 regulates the integrity and oncogenicity of intestinal stem cells
Nakaya, T., Ogawa, S., Manabe, I., Tanaka, M., Sanada, M., Sato, T., Taketo, M. M., Nakao, K., Clevers, H., Fukayama, M., Kuroda, M. & Nagai, R., 2014 May 15, In : Cancer Research. 74, 10, p. 2882-2891 10 p.Research output: Contribution to journal › Article
36
Citations
(Scopus)
Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation
Mikami, Y., Mizuno, S., Nakamoto, N., Hayashi, A., Sujino, T., Sato, T., Kamada, N., Matsuoka, K., Hisamatsu, T., Ebinuma, H., Hibi, T., Yoshimura, A. & Kanai, T., 2014 Jan 2, In : PloS one. 9, 1, e84619.Research output: Contribution to journal › Article
9
Citations
(Scopus)
Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2
Simmini, S., Bialecka, M., Huch, M., Kester, L., Van De Wetering, M., Sato, T., Beck, F., Van Oudenaarden, A., Clevers, H. & Deschamps, J., 2014, In : Nature communications. 5, 5728.Research output: Contribution to journal › Article
45
Citations
(Scopus)
2013
A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice
Hayashi, A., Sato, T., Kamada, N., Mikami, Y., Matsuoka, K., Hisamatsu, T., Hibi, T., Roers, A., Yagita, H., Ohteki, T., Yoshimura, A. & Kanai, T., 2013 Jun 12, In : Cell Host and Microbe. 13, 6, p. 711-722 12 p.Research output: Contribution to journal › Article
112
Citations
(Scopus)
Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice
Handa, T., Kanai, T., Sato, T., Mikami, Y., Sujino, T., Hayashi, A., Mizuno, S., Matsumoto, A., Hisamatsu, T. & Hibi, T., 2013 Feb 1, In : Immunology Letters. 150, 1-2, p. 123-129 7 p.Research output: Contribution to journal › Article
Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues
Miyake, M., Toguchi, H., Nishibayashi, T., Higaki, K., Sugita, A., Koganei, K., Kamada, N., Kitazume, M. T., Hisamatsu, T., Sato, T., Okamoto, S., Kanai, T. & Hibi, T., 2013 Aug, In : Journal of Pharmaceutical Sciences. 102, 8, p. 2564-2571 8 p.Research output: Contribution to journal › Article
13
Citations
(Scopus)
IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis
Matsumoto, A., Kanai, T., Mikami, Y., Chu, P. S., Nakamoto, N., Ebinuma, H., Saito, H., Sato, T., Yagita, H. & Hibi, T., 2013 Apr 23, In : PloS one. 8, 4, e62853.Research output: Contribution to journal › Article
20
Citations
(Scopus)
In vitro expansion of single Lgr5 + liver stem cells induced by Wnt-driven regeneration
Huch, M., Dorrell, C., Boj, S. F., Van Es, J. H., Li, V. S. W., Van De Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., Haft, A., Vries, R. G., Grompe, M. & Clevers, H., 2013 Feb 14, In : Nature. 494, 7436, p. 247-250 4 p.Research output: Contribution to journal › Article
662
Citations
(Scopus)
Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients
Miyoshi, J., Matsuoka, K., Inoue, N., Hisamatsu, T., Ichikawa, R., Yajima, T., Okamoto, S., Naganuma, M., Sato, T., Kanai, T., Ogata, H., Iwao, Y. & Hibi, T., 2013 Dec 15, In : Journal of Crohn's and Colitis. 7, 12, p. e609-e614Research output: Contribution to journal › Article
36
Citations
(Scopus)