Toshiro Sato

Research output

Research output per year 2000 2012 2013 2014 2015 2016 2018 2020 2021 2022 2022

• 102 Article
• 11 Review article
• 6 Short survey
• 5 Comment/debate
• 7 More
  • 4 Chapter
  • 2 Letter
  • 1 Conference contribution

Research output per year

Research output per year

Search results

• 2022

  Cell–matrix interface regulates dormancy in human colon cancer stem cells

  Ohta, Y., Fujii, M., Takahashi, S., Takano, A., Nanki, K., Matano, M., Hanyu, H., Saito, M., Shimokawa, M., Nishikori, S., Hatano, Y., Ishii, R., Sawada, K., Machinaga, A., Ikeda, W., Imamura, T. & Sato, T., 2022 Aug 25, In: Nature. 608, 7924, p. 784-794 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Neoplastic Stem Cells 100%
  • Colonic Neoplasms 85%
  • Drug Therapy 55%
  • Organoids 49%
  • Recurrence 32%
  1 Citation (Scopus)

• Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System

  Yachida, S., Totoki, Y., Noë, M., Nakatani, Y., Horie, M., Kawasaki, K., Nakamura, H., Saito-Adachi, M., Suzuki, M., Takai, E., Hama, N., Higuchi, R., Hirono, S., Shiba, S., Kato, M., Furukawa, E., Arai, Y., Rokutan, H., Hashimoto, T., Mitsunaga, S., & 19 othersKanda, M., Tanaka, H., Takata, S., Shimomura, A., Oshima, M., Hackeng, W. M., Okumura, T., Okano, K., Yamamoto, M., Yamaue, H., Morizane, C., Arihiro, K., Furukawa, T., Sato, T., Kiyono, T., Brosens, L. A. A., Wood, L. D., Hruban, R. H. & Shibata, T., 2022 Mar 1, In: Cancer Discovery. 12, 3, p. 692-711 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroendocrine Carcinoma 100%
  • Chromatin Immunoprecipitation Sequencing 50%
  • Whole Exome Sequencing 46%
  • Whole Genome Sequencing 45%
  • Neuroendocrine Tumors 43%
  5 Citations (Scopus)

• Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer

  Toshimitsu, K., Takano, A., Fujii, M., Togasaki, K., Matano, M., Takahashi, S., Kanai, T. & Sato, T., 2022 Jun, In: Nature Chemical Biology. 18, 6, p. 605-614 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Organoids 100%
  • Preclinical Drug Evaluations 72%
  • Epigenomics 66%
  • Colorectal Neoplasms 60%
  • Neoplasms 19%
  2 Citations (Scopus)

• Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium

  Higa, T., Okita, Y., Matsumoto, A., Nakayama, S., Oka, T., Sugahara, O., Koga, D., Takeishi, S., Nakatsumi, H., Hosen, N., Robine, S., Taketo, M. M., Sato, T. & Nakayama, K. I., 2022 Dec, In: Nature communications. 13, 1, 1500.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cyclin Dependent Kinase Inhibitor 100%
  • Cell Activity 85%
  • Cellular Reprogramming 79%
  • epithelium 77%
  • Plastic Property 71%
  2 Citations (Scopus)
• 2021

  An organoid-based organ-repurposing approach to treat short bowel syndrome

  Sugimoto, S., Kobayashi, E., Fujii, M., Ohta, Y., Arai, K., Matano, M., Ishikawa, K., Miyamoto, K., Toshimitsu, K., Takahashi, S., Nanki, K., Hakamata, Y., Kanai, T. & Sato, T., 2021 Apr 1, In: Nature. 592, 7852, p. 99-104 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Short Bowel Syndrome 100%
  • Organoids 96%
  • Colon 58%
  • Small Intestine 38%
  • Ileum 31%
  36 Citations (Scopus)

• Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: Study protocol

  Nakagawara, K., Namkoong, H., Terai, H., Masaki, K., Tanosaki, T., Shimamoto, K., Lee, H., Tanaka, H., Okamori, S., Kabata, H., Chubachi, S., Ikemura, S., Kamata, H., Yasuda, H., Kawada, I., Ishii, M., Ishibashi, Y., Harada, S., Fujita, T., Ito, D., & 66 othersBun, S., Tabuchi, H., Kanzaki, S., Shimizu, E., Fukuda, K., Yamagami, J., Kobayashi, K., Hirano, T., Inoue, T., Kagyo, J., Shiomi, T., Ohgino, K., Sayama, K., Otsuka, K., Miyao, N., Odani, T., Oyamada, Y., Masuzawa, K., Nakayama, S., Suzuki, Y., Baba, R., Nakachi, I., Kuwahara, N., Ishiguro, T., Mashimo, S., Minematsu, N., Ueda, S., Manabe, T., Funatsu, Y., Koh, H., Yoshiyama, T., Saito, F., Ishioka, K., Takahashi, S., Nakamura, M., Goto, A., Harada, N., Kusaka, Y., Nakano, Y., Nishio, K., Tateno, H., Edahiro, R., Takeda, Y., Kumanogoh, A., Kodama, N., Okamoto, M., Umeda, A., Hagimura, K., Sato, T., Miyazaki, N., Takemura, R., Sato, Y., Takebayashi, T., Nakahara, J., Mimura, M., Ogawa, K., Shimmura, S., Negishi, K., Tsubota, K., Amagai, M., Goto, R., Ibuka, Y., Hasegawa, N., Kitagawa, Y., Kanai, T. & Fukunaga, K., 2021 Nov 26, In: BMJ Open Respiratory Research. 8, 1, e001015.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Multicenter Studies 100%
  • Japan 94%
  • Cohort Studies 78%
  • Infections 27%
  • Social Determinants of Health 25%
  1 Citation (Scopus)

• Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps

  Chen, B., Scurrah, C. R., McKinley, E. T., Simmons, A. J., Ramirez-Solano, M. A., Zhu, X., Markham, N. O., Heiser, C. N., Vega, P. N., Rolong, A., Kim, H., Sheng, Q., Drewes, J. L., Zhou, Y., Southard-Smith, A. N., Xu, Y., Ro, J., Jones, A. L., Revetta, F., Berry, L. D., & 32 othersNiitsu, H., Islam, M., Pelka, K., Hofree, M., Chen, J. H., Sarkizova, S., Ng, K., Giannakis, M., Boland, G. M., Aguirre, A. J., Anderson, A. C., Rozenblatt-Rosen, O., Regev, A., Hacohen, N., Kawasaki, K., Sato, T., Goettel, J. A., Grady, W. M., Zheng, W., Washington, M. K., Cai, Q., Sears, C. L., Goldenring, J. R., Franklin, J. L., Su, T., Huh, W. J., Vandekar, S., Roland, J. T., Liu, Q., Coffey, R. J., Shrubsole, M. J. & Lau, K. S., 2021 Dec 22, In: Cell. 184, 26, p. 6262-6280.e26

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Polyps 100%
  • Heterogeneity 90%
  • Colorectal Neoplasms 62%
  • Metaplasia 42%
  • Atlases 42%
  20 Citations (Scopus)

• Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening

  Ebisudani, T., Sugimoto, S., Haga, K., Mitsuishi, A., Takai-Todaka, R., Fujii, M., Toshimitsu, K., Hamamoto, J., Sugihara, K., Hishida, T., Asamura, H., Fukunaga, K., Yasuda, H., Katayama, K. & Sato, T., 2021 Jun 8, In: Cell Reports. 35, 10, 109218.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirus Infections 100%
  • Severe Acute Respiratory Syndrome 90%
  • Preclinical Drug Evaluations 82%
  • Nelfinavir 58%
  • Coronavirus 58%
  15 Citations (Scopus)

• Mapping the human genetic architecture of COVID-19

  COVID-19 Host Genetics Initiative, 2021 Dec 16, In: Nature. 600, 7889, p. 472-477 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Human Genetics 82%
  • Infections 32%
  • Mendelian Randomization Analysis 27%
  • Research Personnel 23%
  177 Citations (Scopus)

• Nasal delivery of single-domain antibody improves symptoms of SARS-CoV-2 infection in an animal model

  Haga, K., Takai-Todaka, R., Matsumura, Y., Song, C., Takano, T., Tojo, T., Nagami, A., Ishida, Y., Masaki, H., Tsuchiya, M., Ebisudani, T., Sugimoto, S., Sato, T., Yasuda, H., Fukunaga, K., Sawada, A., Nemoto, N., Murata, K., Morimoto, T. & Katayama, K., 2021 Oct, In: PLoS Pathogens. 17, 10, e1009542.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe acute respiratory syndrome coronavirus 100%
  • Single-Domain Antibodies 85%
  • Coronavirus Infections 83%
  • Severe Acute Respiratory Syndrome 74%
  • Coronavirus 72%
  9 Citations (Scopus)

• S100P Expression via DNA Hypomethylation Promotes Cell Growth in the Sessile Serrated Adenoma/Polyp-Cancer Sequence

  Takahashi, S., Okamoto, K., Tanahashi, T., Fujimoto, S., Nakagawa, T., Bando, M., Ma, B., Kawaguchi, T., Fujino, Y., Mitsui, Y., Kitamura, S., Miyamoto, H., Sato, Y., Muguruma, N., Bando, Y., Sato, T., Fujimori, T. & Takayama, T., 2021 Sep 1, In: Digestion. 102, 5, p. 789-802 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Polyps 100%
  • Organoids 92%
  • Adenoma 91%
  • DNA 54%
  • Growth 49%

• Worldwide association of lifestyle-related factors and COVID-19 mortality

  Wang, J., Sato, T. & Sakuraba, A., 2021, In: Annals of Medicine. 53, 1, p. 1528-1533 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirus 100%
  • Life Style 64%
  • Mortality 40%
  • Overweight 28%
  • Hyperlipidemias 15%
  3 Citations (Scopus)
• 2020

  An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping

  Kawasaki, K., Toshimitsu, K., Matano, M., Fujita, M., Fujii, M., Togasaki, K., Ebisudani, T., Shimokawa, M., Takano, A., Takahashi, S., Ohta, Y., Nanki, K., Igarashi, R., Ishimaru, K., Ishida, H., Sukawa, Y., Sugimoto, S., Saito, Y., Maejima, K., Sasagawa, S., & 16 othersLee, H., Kim, H. G., Ha, K., Hamamoto, J., Fukunaga, K., Maekawa, A., Tanabe, M., Ishihara, S., Hamamoto, Y., Yasuda, H., Sekine, S., Kudo, A., Kitagawa, Y., Kanai, T., Nakagawa, H. & Sato, T., 2020 Nov 25, In: Cell. 183, 5, p. 1420-1435.e21

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Organoids 100%
  • Lethal 90%
  • Genotype 54%
  • Phenotype 45%
  • Mutation 32%
  45 Citations (Scopus)

• Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine

  Sato, T., Sase, M., Ishikawa, S., Kajita, M., Asano, J., Sato, T., Mori, Y. & Ohteki, T., 2020 Dec 1, In: Scientific reports. 10, 1, 8308.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intestines 100%
  • Stem Cells 81%
  • Epithelial Cells 78%
  • Regeneration 61%
  • Tetraspanins 26%
  10 Citations (Scopus)

• Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

  Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., Kanai, T. & Sato, T., 2020 Feb, In: Gastroenterology. 158, 3, p. 638-651.e8

  Research output: Contribution to journal › Article › peer-review

  • Organoids 100%
  • Ergonomics 90%
  • Human Chromosomes 86%
  • Adenoma 71%
  • Colon 61%
  34 Citations (Scopus)

• Depressed Colorectal Cancer: A New Paradigm in Early Colorectal Cancer

  Kudo, S. E., Kouyama, Y., Ogawa, Y., Ichimasa, K., Hamada, T., Kato, K., Kudo, K., Masuda, T., Otsu, H., Misawa, M., Mori, Y., Kudo, T., Hayashi, T., Wakamura, K., Miyachi, H., Sawada, N., Sato, T., Shibata, T., Hamatani, S., Nemoto, T., & 6 othersIshida, F., Niida, A., Miyano, S., Oshima, M., Ogino, S. & Mimori, K., 2020 Dec 1, In: Clinical and translational gastroenterology. 11, 12, p. e00269

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Colorectal Neoplasms 100%
  • Adenoma 85%
  • Carcinoma 83%
  • Whole Exome Sequencing 13%
  • RNA Sequence Analysis 12%
  3 Citations (Scopus)

• Development of a Scalable Coculture System for Gut Anaerobes and Human Colon Epithelium

  Sasaki, N., Miyamoto, K., Maslowski, K. M., Ohno, H., Kanai, T. & Sato, T., 2020 Jul, In: Gastroenterology. 159, 1, p. 388-390.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access
  24 Citations (Scopus)

• LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium

  Zwiggelaar, R. T., Lindholm, H. T., Fosslie, M., Pedersen, M. T., Ohta, Y., Díez-Sánchez, A., Martín-Alonso, M., Ostrop, J., Matano, M., Parmar, N., Kvaløy, E., Spanjers, R. R., Nazmi, K., Rye, M., Drabløs, F., Arrowsmith, C., Dahl, J. A., Jensen, K. B., Sato, T. & Oudhoff, M. J., 2020 Sep, In: Science Advances. 6, 37, eabc0367.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Paneth Cells 100%
  • Intestinal Mucosa 72%
  • Organoids 60%
  • Epithelium 52%
  • Genes 27%
  10 Citations (Scopus)

• Population difference in allele frequency of hla-c*05 and its correlation with covid-19 mortality

  Sakuraba, A., Haider, H. & Sato, T., 2020 Nov, In: Viruses. 12, 11, 1333.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • HLA Antigens 100%
  • Gene Frequency 95%
  • Coronavirus 54%
  • Mortality 49%
  • Population 38%
  22 Citations (Scopus)

• Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages

  Sato, T., Ishikawa, S., Asano, J., Yamamoto, H., Fujii, M., Sato, T., Yamamoto, K., Kitagaki, K., Akashi, T., Okamoto, R. & Ohteki, T., 2020 Aug 1, In: Nature Cell Biology. 22, 8, p. 919-926 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell Lineage 100%
  • Cell Differentiation 77%
  • Stem Cells 70%
  • Lymphocytic choriomeningitis virus 44%
  • Interferons 43%
  9 Citations (Scopus)

• Somatic inflammatory gene mutations in human ulcerative colitis epithelium

  Nanki, K., Fujii, M., Shimokawa, M., Matano, M., Nishikori, S., Date, S., Takano, A., Toshimitsu, K., Ohta, Y., Takahashi, S., Sugimoto, S., Ishimaru, K., Kawasaki, K., Nagai, Y., Ishii, R., Yoshida, K., Sasaki, N., Hibi, T., Ishihara, S., Kanai, T., & 1 othersSato, T., 2020 Jan 9, In: Nature. 577, 7789, p. 254-259 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Ulcerative Colitis 100%
  • Interleukin-17 80%
  • Epithelium 77%
  • Organoids 66%
  • Colon 61%
  99 Citations (Scopus)
• 2019

  Cnnm4 deficiency suppresses Ca²⁺ signaling and promotes cell proliferation in the colon epithelia

  Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 May 16, In: Oncogene. 38, 20, p. 3962-3969 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Colon 100%
  • Epithelium 95%
  • Cell Proliferation 82%
  • Capsaicin 47%
  • ErbB Receptors 39%
  8 Citations (Scopus)

• Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

  Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P. S., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K., & 2 othersSato, T. & Kanai, T., 2019 Mar 1, In: Nature Microbiology. 4, 3, p. 492-503 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Sclerosing Cholangitis 100%
  • Th17 Cells 93%
  • Liver Diseases 66%
  • Microbiota 29%
  • Bacterial Translocation 26%
  142 Citations (Scopus)

• Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis

  Matsui, S., Okabayashi, K., Tsuruta, M., Shigeta, K., Seishima, R., Ishida, T., Kondo, T., Suzuki, Y., Hasegawa, H., Shimoda, M., Sugimoto, S., Sato, T. & Kitagawa, Y., 2019 Jul, In: Cancer science. 110, 7, p. 2156-2165 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-13 100%
  • Carcinogenesis 67%
  • Obesity 61%
  • Colorectal Neoplasms 58%
  • Cytokines 36%
  14 Citations (Scopus)
• 2018

  Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling

  Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R. & Ohno, H., 2018 Feb 1, In: Journal of Experimental Medicine. 215, 2, p. 501-519 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins 100%
  • Peyer's Patches 66%
  • Cell Differentiation 55%
  • Epithelium 52%
  • Organoids 22%
  48 Citations (Scopus)

• Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

  Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S., & 3 othersKoo, B. K., Kanai, T. & Sato, T., 2018 Aug 9, In: Cell. 174, 4, p. 856-869.e17

  Research output: Contribution to journal › Article › peer-review

  • Stomach Neoplasms 100%
  • Mutation 97%
  • Organoids 94%
  • Carcinogenesis 88%
  • Stomach 82%
  144 Citations (Scopus)

• Erratum to: Efficient genetic engineering of human intestinal organoids using electroporation (Nature Protocols, (2015), 10, 10, (1474-1485), 10.1038/nprot.2015.088)

  Fujii, M., Matano, M., Nanki, K. & Sato, T., 2018 Jan 1, (Accepted/In press) In: Nature Protocols.

  Research output: Contribution to journal › Article › peer-review

  • Electroporation 100%
  • Organoids 93%
  • Genetic Engineering 89%
  • Plasmids 57%
  2 Citations (Scopus)

• Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

  Loomans, C. J. M., Williams Giuliani, N., Balak, J., Ringnalda, F., van Gurp, L., Huch, M., Boj, S. F., Sato, T., Kester, L., de Sousa Lopes, S. M. C., Roost, M. S., Bonner-Weir, S., Engelse, M. A., Rabelink, T. J., Heimberg, H., Vries, R. G. J., van Oudenaarden, A., Carlotti, F., Clevers, H. & de Koning, E. J. P., 2018 Mar 13, In: Stem cell reports. 10, 3, p. 712-724 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Organoids 100%
  • Marker 66%
  • C-Peptide 58%
  • Stem Cells 56%
  • Proliferative 50%
  83 Citations (Scopus)

• Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

  Fujii, M., Matano, M., Toshimitsu, K., Takano, A., Mikami, Y., Nishikori, S., Sugimoto, S. & Sato, T., 2018 Dec 6, In: Cell stem cell. 23, 6, p. 787-793.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Organoids 100%
  • Efficiency 18%
  • Small Cytoplasmic RNA 15%
  • Stem Cells 12%
  • Intestinal Diseases 10%
  181 Citations (Scopus)

• Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

  Seino, T., Kawasaki, S., Shimokawa, M., Tamagawa, H., Toshimitsu, K., Fujii, M., Ohta, Y., Matano, M., Nanki, K., Kawasaki, K., Takahashi, S., Sugimoto, S., Iwasaki, E., Takagi, J., Itoi, T., Kitago, M., Kitagawa, Y., Kanai, T. & Sato, T., 2018 Mar 1, In: Cell stem cell. 22, 3, p. 454-467.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Organoids 100%
  • Stem Cell Niche 98%
  • Stem Cell Factor 92%
  • Disease Progression 60%
  • Adenocarcinoma 59%
  291 Citations (Scopus)

• Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

  Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 Dec 1, In: Scientific reports. 8, 1, 2821.

  Research output: Contribution to journal › Article › peer-review

  • Organoids 100%
  • Cholangiocarcinoma 88%
  • Hepatocytes 63%
  • Intrahepatic Bile Ducts 11%
  • Cytochrome P-450 CYP3A 9%
  21 Citations (Scopus)

• Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites

  Mito, A., Nakano, Y., Saitoh, T., Gouraud, S. S. S., Yamaguchi, Y., Sato, T., Sasaki, N. & Kojima-Aikawa, K., 2018 Jan 1, In: Glycobiology. 28, 1, p. 21-31 11 p.

  Research output: Contribution to journal › Article › peer-review

  • rat ZG16 protein 100%
  • Lectin 44%
  • Carbohydrates 38%
  • Colorectal Neoplasms 34%
  • Binding Sites 33%
  10 Citations (Scopus)

• Reconstruction of the Human Colon Epithelium In Vivo

  Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., Kanai, T. & Sato, T., 2018 Feb 1, In: Cell stem cell. 22, 2, p. 171-176.e5

  Research output: Contribution to journal › Article › peer-review

  • Colon 100%
  • Epithelium 95%
  • Organoids 81%
  • Stem Cells 60%
  • Heterografts 18%
  101 Citations (Scopus)
• 2017

  Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

  Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T., & 19 othersSasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J. I., Duchen, M. R., Nam, J. M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. & Fujita, Y., 2017 May 1, In: Nature Cell Biology. 19, 5, p. 530-541 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Epithelial Cells 100%
  • pyruvate dehydrogenase kinase 4 26%
  • Filamins 23%
  • Mitochondrial Membrane Potential 16%
  • Intestinal Mucosa 16%
  113 Citations (Scopus)

• IL-22BP dictates characteristics of Peyer's patch follicleassociated epithelium for antigen uptake

  Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H. & Ohno, H., 2017 Jun 1, In: Journal of Experimental Medicine. 214, 6, p. 1607-1618 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • interleukin-22 100%
  • Peyer's Patches 95%
  • Carrier Proteins 62%
  • Epithelium 56%
  • Antigens 46%
  37 Citations (Scopus)

• Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice

  Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., Suda, W., Hattori, M., Amagai, M., Ohyama, M. & Kanai, T., 2017 Aug 15, In: Cell Reports. 20, 7, p. 1513-1524 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dysbiosis 100%
  • Lactobacillus 91%
  • Biotin 87%
  • Alopecia 85%
  • Vancomycin 51%
  55 Citations (Scopus)

• Visualization and targeting of LGR5 + human colon cancer stem cells

  Shimokawa, M., Ohta, Y., Nishikori, S., Matano, M., Takano, A., Fujii, M., Date, S., Sugimoto, S., Kanai, T. & Sato, T., 2017 May 11, In: Nature. 545, 7653, p. 187-192 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Neoplastic Stem Cells 100%
  • Colonic Neoplasms 85%
  • Neoplasms 30%
  • Colorectal Neoplasms 16%
  • Organoids 13%
  378 Citations (Scopus)
• 2016

  A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

  Fujii, M., Shimokawa, M., Date, S., Takano, A., Matano, M., Nanki, K., Ohta, Y., Toshimitsu, K., Nakazato, Y., Kawasaki, K., Uraoka, T., Watanabe, T., Kanai, T. & Sato, T., 2016 Jun 2, In: Cell stem cell. 18, 6, p. 827-838 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Organoids 100%
  • Colorectal Neoplasms 60%
  • Carcinogenesis 58%
  • Mutation Accumulation 21%
  • Genetic Profile 19%
  414 Citations (Scopus)

• Active and water-soluble form of lipidated wnt protein is maintained by a serum glycoprotein afamin/α-albumin

  Mihara, E., Hirai, H., Yamamoto, H., Tamura-Kawakami, K., Matano, M., Kikuchi, A., Sato, T. & Takagi, J., 2016 Feb 23, In: eLife. 5, FEBRUARY2016, e11621.

  Research output: Contribution to journal › Article › peer-review

  • Colony-Forming Units Assay 100%
  • Wnt Proteins 99%
  • Detergents 72%
  • Detergent 64%
  • Buffers 63%
  103 Citations (Scopus)

• Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways

  Kikuchi, I., Takahashi-Kanemitsu, A., Sakiyama, N., Tang, C., Tang, P. J., Noda, S., Nakao, K., Kassai, H., Sato, T., Aiba, A. & Hatakeyama, M., 2016 Sep 21, In: Nature communications. 7, 12887.

  Research output: Contribution to journal › Article › peer-review

  • Hedgehogs 100%
  • notches 82%
  • tyrosine 80%
  • Tyrosine 70%
  • phosphorylation 53%
  29 Citations (Scopus)

• EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells

  Nakajo, A., Yoshimura, S. I., Togawa, H., Kunii, M., Iwano, T., Izumi, A., Noguchi, Y., Watanabe, A., Goto, A., Sato, T. & Harada, A., 2016, In: Journal of Cell Biology. 212, 3, p. 297-306 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Carrier Proteins 100%
  • Epithelial Cells 84%
  • Small Intestine 64%
  • Dynamins 62%
  • mouse EHBP1L1 protein 60%
  32 Citations (Scopus)

• Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response

  Saito, Y., Nakaoka, T., Sakai, K., Muramatsu, T., Toshimitsu, K., Kimura, M., Kanai, T., Sato, T. & Saito, H., 2016 May 4, In: Scientific reports. 6, 25311.

  Research output: Contribution to journal › Article › peer-review

  • Organoids 100%
  • DNA Demethylation 77%
  • DNA Methylation 75%
  • Interferons 30%
  • Neoplasms 24%
  19 Citations (Scopus)

• Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

  Dominguez-Brauer, C., Hao, Z., Elia, A. J., Fortin, J. M., Nechanitzky, R., Brauer, P. M., Sheng, Y., Mana, M. D., Chio, I. I. C., Haight, J., Pollett, A., Cairns, R., Tworzyanski, L., Inoue, S., Reardon, C., Marques, A., Silvester, J., Cox, M. A., Wakeham, A., Yilmaz, O. H., & 5 othersSabatini, D. M., van Es, J. H., Clevers, H., Sato, T. & Mak, T. W., 2016 Aug 4, In: Cell stem cell. 19, 2, p. 205-216 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Stem Cell Niche 100%
  • Equidae 95%
  • Wnt Signaling Pathway 87%
  • Colorectal Neoplasms 30%
  • Stem Cells 28%
  14 Citations (Scopus)

• SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling

  Oudhoff, M. J., Braam, M. J. S., Freeman, S. A., Wong, D., Rattray, D. G., Wang, J., Antignano, F., Snyder, K., Refaeli, I., Hughes, M. R., McNagny, K. M., Gold, M. R., Arrowsmith, C. H., Sato, T., Rossi, F. M. V., Tatlock, J. H., Owen, D. R., Brown, P. J. & Zaph, C., 2016 Apr 4, In: Developmental Cell. 37, 1, p. 47-57 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Catenins 100%
  • Regeneration 66%
  • Carcinogenesis 60%
  • Methylation 35%
  • Protein 32%
  69 Citations (Scopus)

• Tissue-specific mutation accumulation in human adult stem cells during life

  Blokzijl, F., De Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., Nijman, I. J., Martincorena, I., Mokry, M., Wiegerinck, C. L., Middendorp, S., Sato, T., Schwank, G., Nieuwenhuis, E. E. S., Verstegen, M. M. A., Van Der Laan, L. J. W., & 8 othersDe Jonge, J., Ijzermans, J. N. M., Vries, R. G., Van De Wetering, M., Stratton, M. R., Clevers, H., Cuppen, E. & Van Boxtel, R., 2016, In: Nature. 538, 7624, p. 260-264 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Mutation Accumulation 100%
  • Adult Stem Cells 84%
  • Mutation 35%
  • Small Intestine 24%
  • Colon 21%
  505 Citations (Scopus)

• Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress

  Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irié, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K. & Fukada, T., 2016 Oct, In: PLoS Genetics. 12, 10, e1006349.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • zinc-binding protein 100%
  • endoplasmic reticulum stress 88%
  • Endoplasmic Reticulum Stress 76%
  • stem cells 68%
  • transporters 59%
  62 Citations (Scopus)
• 2015

  An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium

  Pin, C., Parker, A., Gunning, A. P., Ohta, Y., Johnson, I. T., Carding, S. R. & Sato, T., 2015 Feb 1, In: Integrative Biology (United Kingdom). 7, 2, p. 213-228 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Fission 100%
  • Intestinal Mucosa 94%
  • Organoids 87%
  • Paneth Cells 65%
  • Growth 45%
  21 Citations (Scopus)

• Combination therapy with infliximab and thiopurine compared to infliximab monotherapy in maintaining remission of postoperative crohn's disease

  Sakuraba, A., Okamoto, S., Matsuoka, K., Sato, T., Naganuma, M., Hisamatsu, T., Iwao, Y., Ogata, H., Kanai, T. & Hibi, T., 2015 May 6, In: Digestion. 91, 3, p. 233-238 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Infliximab 100%
  • Crohn Disease 81%
  • Recurrence 21%
  • Therapeutics 14%
  • Kaplan-Meier Estimate 9%
  8 Citations (Scopus)

• Efficient genetic engineering of human intestinal organoids using electroporation

  Fujii, M., Matano, M., Nanki, K. & Sato, T., 2015 Oct 29, In: Nature Protocols. 10, 10, p. 1474-1485 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Electroporation 100%
  • Organoids 93%
  • Genetic Engineering 89%
  • Growth Factor 83%
  • Modification 39%
  169 Citations (Scopus)

• Ink4a/arf-dependent loss of parietal cells induced by oxidative stress promotes CD44-dependent gastric tumorigenesis

  Seishima, R., Wada, T., Tsuchihashi, K., Okazaki, S., Yoshikawa, M., Oshima, H., Oshima, M., Sato, T., Hasegawa, H., Kitagawa, Y., Goldenring, J. R., Saya, H. & Nagano, O., 2015 Jun 1, In: Cancer Prevention Research. 8, 6, p. 492-501 10 p.

  Research output: Contribution to journal › Article › peer-review

  • spasmolytic polypeptide 100%
  • Carcinogenesis 97%
  • Oxidative Stress 93%
  • Stomach 91%
  • Metaplasia 59%
  12 Citations (Scopus)