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Research Output 2000 2019

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Article
2019
1 Citation (Scopus)

Cnnm4 deficiency suppresses Ca 2+ signaling and promotes cell proliferation in the colon epithelia

Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 May 16, In : Oncogene. 38, 20, p. 3962-3969 8 p.

Research output: Contribution to journalArticle

Colon
Epithelium
Cell Proliferation
Capsaicin
Epidermal Growth Factor Receptor
15 Citations (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Cho, H., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. & 2 others, Sato, T. & Kanai, T., 2019 Jan 1, (Accepted/In press) In : Nature Microbiology.

Research output: Contribution to journalArticle

Th17 Cells
Sclerosing Cholangitis
Liver Diseases
Microbiota
Bacterial Translocation

Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis

Matsui, S., Okabayashi, K., Tsuruta, M., Shigeta, K., Seishima, R., Ishida, T., Kondo, T., Suzuki, Y., Hasegawa, H., Shimoda, M., Sugimoto, S., Sato, T. & Kitagawa, Y., 2019 Jul 1, In : Cancer science. 110, 7, p. 2156-2165 10 p.

Research output: Contribution to journalArticle

Open Access
Interleukin-13
Carcinogenesis
Obesity
Colorectal Neoplasms
Cytokines
2018
14 Citations (Scopus)

Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling

Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R. & Ohno, H., 2018 Feb 1, In : Journal of Experimental Medicine. 215, 2, p. 501-519 19 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Peyer's Patches
Cell Differentiation
Epithelium
Organoids
21 Citations (Scopus)

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S. & 3 others, Koo, B. K., Kanai, T. & Sato, T., 2018 Aug 9, In : Cell. 174, 4, p. 856-869.e17

Research output: Contribution to journalArticle

Stomach Neoplasms
Organoids
Stomach
Screening
Carcinogenesis
Organoids
Genetic engineering
Genetic Engineering
Electroporation
Plasmids
17 Citations (Scopus)

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

Loomans, C. J. M., Williams Giuliani, N., Balak, J., Ringnalda, F., van Gurp, L., Huch, M., Boj, S. F., Sato, T., Kester, L., de Sousa Lopes, S. M. C., Roost, M. S., Bonner-Weir, S., Engelse, M. A., Rabelink, T. J., Heimberg, H., Vries, R. G. J., van Oudenaarden, A., Carlotti, F., Clevers, H. & de Koning, E. J. P., 2018 Mar 13, In : Stem Cell Reports. 10, 3, p. 1088-1101 14 p.

Research output: Contribution to journalArticle

Organoids
Stem Cells
Tissue
Medical problems
Insulin
7 Citations (Scopus)

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Fujii, M., Matano, M., Toshimitsu, K., Takano, A., Mikami, Y., Nishikori, S., Sugimoto, S. & Sato, T., 2018 Dec 6, In : Cell Stem Cell. 23, 6, p. 787-793.e6

Research output: Contribution to journalArticle

Organoids
Small Cytoplasmic RNA
Stem Cells
Clustered Regularly Interspaced Short Palindromic Repeats
RNA Sequence Analysis
57 Citations (Scopus)

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Seino, T., Kawasaki, S., Shimokawa, M., Tamagawa, H., Toshimitsu, K., Fujii, M., Ohta, Y., Matano, M., Nanki, K., Kawasaki, K., Takahashi, S., Sugimoto, S., Iwasaki, E., Takagi, J., Itoi, T., Kitago, M., Kitagawa, Y., Kanai, T. & Sato, T., 2018 Jan 1, (Accepted/In press) In : Cell Stem Cell.

Research output: Contribution to journalArticle

Organoids
Stem Cell Niche
Stem Cell Factor
Disease Progression
Adenocarcinoma
8 Citations (Scopus)

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 Dec 1, In : Scientific Reports. 8, 1, 2821.

Research output: Contribution to journalArticle

Organoids
Cholangiocarcinoma
Hepatocytes
Intrahepatic Bile Ducts
Cytochrome P-450 CYP3A
3 Citations (Scopus)

Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites

Mito, A., Nakano, Y., Saitoh, T., Gouraud, S. S. S., Yamaguchi, Y., Sato, T., Sasaki, N. & Kojima-Aikawa, K., 2018 Jan 1, In : Glycobiology. 28, 1, p. 21-31 11 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Cell growth
Binding Sites
Cells
Carbohydrates
21 Citations (Scopus)

Reconstruction of the Human Colon Epithelium In Vivo

Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., Kanai, T. & Sato, T., 2018 Feb 1, In : Cell Stem Cell. 22, 2, p. 171-176.e5

Research output: Contribution to journalArticle

Colon
Epithelium
Organoids
Stem Cells
Heterografts
2017
34 Citations (Scopus)

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T. & 19 others, Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J. I., Duchen, M. R., Nam, J. M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. & Fujita, Y., 2017 May 1, In : Nature Cell Biology. 19, 5, p. 530-541 12 p.

Research output: Contribution to journalArticle

Epithelial Cells
Filamins
Mitochondrial Membrane Potential
Intestinal Mucosa
Lactic Acid
18 Citations (Scopus)

IL-22BP dictates characteristics of Peyer's patch follicleassociated epithelium for antigen uptake

Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H. & Ohno, H., 2017 Jun 1, In : Journal of Experimental Medicine. 214, 6, p. 1607-1618 12 p.

Research output: Contribution to journalArticle

Peyer's Patches
Carrier Proteins
Epithelium
Antigens
interleukin-22
10 Citations (Scopus)

Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice

Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., Suda, W., Hattori, M., Amagai, M., Ohyama, M. & Kanai, T., 2017 Aug 15, In : Cell Reports. 20, 7, p. 1513-1524 12 p.

Research output: Contribution to journalArticle

Dysbiosis
Alopecia
Lactobacillus
Biotin
Physiology
143 Citations (Scopus)

Visualization and targeting of LGR5 + human colon cancer stem cells

Shimokawa, M., Ohta, Y., Nishikori, S., Matano, M., Takano, A., Fujii, M., Date, S., Sugimoto, S., Kanai, T. & Sato, T., 2017 May 11, In : Nature. 545, 7653, p. 187-192 6 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Colonic Neoplasms
Neoplasms
Colorectal Neoplasms
Organoids
2016
143 Citations (Scopus)

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Fujii, M., Shimokawa, M., Date, S., Takano, A., Matano, M., Nanki, K., Ohta, Y., Toshimitsu, K., Nakazato, Y., Kawasaki, K., Uraoka, T., Watanabe, T., Kanai, T. & Sato, T., 2016 Jun 2, In : Cell Stem Cell. 18, 6, p. 827-838 12 p.

Research output: Contribution to journalArticle

Organoids
Colorectal Neoplasms
Carcinogenesis
Transcriptome
Heterografts
42 Citations (Scopus)

Active and water-soluble form of lipidated wnt protein is maintained by a serum glycoprotein afamin/α-albumin

Mihara, E., Hirai, H., Yamamoto, H., Tamura-Kawakami, K., Matano, M., Kikuchi, A., Sato, T. & Takagi, J., 2016 Feb 23, In : eLife. 5, FEBRUARY2016, e11621.

Research output: Contribution to journalArticle

Wnt Proteins
Colony-Forming Units Assay
Detergents
Albumins
Assays
16 Citations (Scopus)

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways

Kikuchi, I., Takahashi-Kanemitsu, A., Sakiyama, N., Tang, C., Tang, P. J., Noda, S., Nakao, K., Kassai, H., Sato, T., Aiba, A. & Hatakeyama, M., 2016 Sep 21, In : Nature Communications. 7, 12887.

Research output: Contribution to journalArticle

Hedgehogs
notches
Tyrosine
tyrosine
Phosphorylation
12 Citations (Scopus)

EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells

Nakajo, A., Yoshimura, S. I., Togawa, H., Kunii, M., Iwano, T., Izumi, A., Noguchi, Y., Watanabe, A., Goto, A., Sato, T. & Harada, A., 2016, In : Journal of Cell Biology. 212, 3, p. 297-306 10 p.

Research output: Contribution to journalArticle

Carrier Proteins
Epithelial Cells
Small Intestine
Dynamins
Lysosomes
13 Citations (Scopus)

Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response

Saito, Y., Nakaoka, T., Sakai, K., Muramatsu, T., Toshimitsu, K., Kimura, M., Kanai, T., Sato, T. & Saito, H., 2016 May 4, In : Scientific Reports. 6, 25311.

Research output: Contribution to journalArticle

Organoids
DNA Methylation
Neoplasms
DNA
Interferons
8 Citations (Scopus)

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

Dominguez-Brauer, C., Hao, Z., Elia, A. J., Fortin, J. M., Nechanitzky, R., Brauer, P. M., Sheng, Y., Mana, M. D., Chio, I. I. C., Haight, J., Pollett, A., Cairns, R., Tworzyanski, L., Inoue, S., Reardon, C., Marques, A., Silvester, J., Cox, M. A., Wakeham, A., Yilmaz, O. H. & 5 others, Sabatini, D. M., van Es, J. H., Clevers, H., Sato, T. & Mak, T. W., 2016 Aug 4, In : Cell Stem Cell. 19, 2, p. 205-216 12 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Wnt Signaling Pathway
Equidae
Colorectal Neoplasms
Stem Cells
34 Citations (Scopus)

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling

Oudhoff, M. J., Braam, M. J. S., Freeman, S. A., Wong, D., Rattray, D. G., Wang, J., Antignano, F., Snyder, K., Refaeli, I., Hughes, M. R., McNagny, K. M., Gold, M. R., Arrowsmith, C. H., Sato, T., Rossi, F. M. V., Tatlock, J. H., Owen, D. R., Brown, P. J. & Zaph, C., 2016 Apr 4, In : Developmental Cell. 37, 1, p. 47-57 11 p.

Research output: Contribution to journalArticle

Catenins
Regeneration
Carcinogenesis
Methylation
Proteins
198 Citations (Scopus)

Tissue-specific mutation accumulation in human adult stem cells during life

Blokzijl, F., De Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., Nijman, I. J., Martincorena, I., Mokry, M., Wiegerinck, C. L., Middendorp, S., Sato, T., Schwank, G., Nieuwenhuis, E. E. S., Verstegen, M. M. A., Van Der Laan, L. J. W. & 8 others, De Jonge, J., Ijzermans, J. N. M., Vries, R. G., Van De Wetering, M., Stratton, M. R., Clevers, H., Cuppen, E. & Van Boxtel, R., 2016 Jan 1, In : Nature. 538, 7624, p. 260-264 5 p.

Research output: Contribution to journalArticle

Adult Stem Cells
Mutation
Small Intestine
Colon
Mutation Rate
28 Citations (Scopus)

Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress

Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irié, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K. & Fukada, T., 2016 Oct 1, In : PLoS Genetics. 12, 10, e1006349.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
homeostasis
endoplasmic reticulum
transporters
stem cells
2015
13 Citations (Scopus)

An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium

Pin, C., Parker, A., Gunning, A. P., Ohta, Y., Johnson, I. T., Carding, S. R. & Sato, T., 2015 Feb 1, In : Integrative Biology (United Kingdom). 7, 2, p. 213-228 16 p.

Research output: Contribution to journalArticle

Organoids
Intestinal Mucosa
Paneth Cells
Growth
Stem cells
7 Citations (Scopus)

Combination therapy with infliximab and thiopurine compared to infliximab monotherapy in maintaining remission of postoperative crohn's disease

Sakuraba, A., Okamoto, S., Matsuoka, K., Sato, T., Naganuma, M., Hisamatsu, T., Iwao, Y., Ogata, H., Kanai, T. & Hibi, T., 2015 May 6, In : Digestion. 91, 3, p. 233-238 6 p.

Research output: Contribution to journalArticle

Crohn Disease
Recurrence
Therapeutics
Infliximab
Remission Induction
57 Citations (Scopus)

Efficient genetic engineering of human intestinal organoids using electroporation

Fujii, M., Matano, M., Nanki, K. & Sato, T., 2015 Oct 29, In : Nature Protocols. 10, 10, p. 1474-1485 12 p.

Research output: Contribution to journalArticle

Organoids
Genetic engineering
Genetic Engineering
Electroporation
Genes
10 Citations (Scopus)

Ink4a/arf-dependent loss of parietal cells induced by oxidative stress promotes CD44-dependent gastric tumorigenesis

Seishima, R., Wada, T., Tsuchihashi, K., Okazaki, S., Yoshikawa, M., Oshima, H., Oshima, M., Sato, T., Hasegawa, H., Kitagawa, Y., Goldenring, J. R., Saya, H. & Nagano, O., 2015 Jun 1, In : Cancer Prevention Research. 8, 6, p. 492-501 10 p.

Research output: Contribution to journalArticle

Stomach
Carcinogenesis
Oxidative Stress
Reactive Oxygen Species
Metaplasia
57 Citations (Scopus)

Mini-Gut Organoids: Reconstitution of the Stem Cell Niche

Date, S. & Sato, T., 2015 Nov 13, In : Annual Review of Cell and Developmental Biology. 31, p. 269-289 21 p.

Research output: Contribution to journalArticle

Organoids
Stem Cell Niche
Stem Cells
Carcinogenesis
Epithelium
344 Citations (Scopus)

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids

Matano, M., Date, S., Shimokawa, M., Takano, A., Fujii, M., Ohta, Y., Watanabe, T., Kanai, T. & Sato, T., 2015, In : Nature Medicine. 21, 3, p. 256-262 7 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Organoids
Human Engineering
Tumors
Colorectal Neoplasms
37 Citations (Scopus)

Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer

Oshima, H., Nakayama, M., Han, T. S., Naoi, K., Ju, X., Maeda, Y., Robine, S., Tsuchiya, K., Sato, T., Sato, H., Taketo, M. M. & Oshima, M., 2015 Feb 15, In : Cancer Research. 75, 4, p. 766-776 11 p.

Research output: Contribution to journalArticle

Intestinal Neoplasms
Epithelium
Epithelial Cells
Dextran Sulfate
Intestinal Mucosa
2014
3 Citations (Scopus)

Classical Th1 cells obtain colitogenicity by co-existence of RORγt-expressing T cells in experimental colitis

Saigusa, K., Hisamatsu, T., Handa, T., Sujino, T., Mikami, Y., Hayashi, A., Mizuno, S., Takeshita, K., Sato, T., Matsuoka, K. & Kanai, T., 2014 Oct 1, In : Inflammatory Bowel Diseases. 20, 10, p. 1820-1827 8 p.

Research output: Contribution to journalArticle

Th1 Cells
Colitis
T-Lymphocytes
Th17 Cells
Cell Count
5 Citations (Scopus)

Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin

Takabayashi, K., Kashiwagi, K., Kawata, T., Sato, T., Matsuoka, K., Hisamatsu, T., Takaishi, H., Hibi, T., Ogata, H., Yahagi, N., Kitagawa, Y., Shigematsu, N. & Kanai, T., 2014 Jan, In : Cancer Biology and Therapy. 15, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Seeds
Apoptosis
In Situ Nick-End Labeling
Heterografts
36 Citations (Scopus)

Cross-talk between RORγt + innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production In Crohn's disease

Mizuno, S., Mikami, Y., Kamada, N., Handa, T., Hayashi, A., Sato, T., Matsuoka, K., Matano, M., Ohta, Y., Sugita, A., Koganei, K., Sahara, R., Takazoe, M., Hisamatsu, T. & Kanai, T., 2014, In : Inflammatory Bowel Diseases. 20, 8, p. 1426-1434 9 p.

Research output: Contribution to journalArticle

Crohn Disease
Macrophages
Lymphocytes
interleukin-22
Mucous Membrane
31 Citations (Scopus)

KLF5 regulates the integrity and oncogenicity of intestinal stem cells

Nakaya, T., Ogawa, S., Manabe, I., Tanaka, M., Sanada, M., Sato, T., Taketo, M. M., Nakao, K., Clevers, H., Fukayama, M., Kuroda, M. & Nagai, R., 2014 May 15, In : Cancer Research. 74, 10, p. 2882-2891 10 p.

Research output: Contribution to journalArticle

Stem Cells
Catenins
Colorectal Neoplasms
Intestinal Neoplasms
Induced Pluripotent Stem Cells
9 Citations (Scopus)

Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation

Mikami, Y., Mizuno, S., Nakamoto, N., Hayashi, A., Sujino, T., Sato, T., Kamada, N., Matsuoka, K., Hisamatsu, T., Ebinuma, H., Hibi, T., Yoshimura, A. & Kanai, T., 2014 Jan 2, In : PLoS One. 9, 1, e84619.

Research output: Contribution to journalArticle

Macrophages
dendritic cells
Liver
Dendritic Cells
macrophages
41 Citations (Scopus)

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2

Simmini, S., Bialecka, M., Huch, M., Kester, L., Van De Wetering, M., Sato, T., Beck, F., Van Oudenaarden, A., Clevers, H. & Deschamps, J., 2014, In : Nature Communications. 5, 6728.

Research output: Contribution to journalArticle

stem cells
Stem cells
Stomach
Transcription Factors
Stem Cells
2013
93 Citations (Scopus)

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice

Hayashi, A., Sato, T., Kamada, N., Mikami, Y., Matsuoka, K., Hisamatsu, T., Hibi, T., Roers, A., Yagita, H., Ohteki, T., Yoshimura, A. & Kanai, T., 2013 Jun 12, In : Cell Host and Microbe. 13, 6, p. 711-722 12 p.

Research output: Contribution to journalArticle

Clostridium butyricum
Colitis
Interleukin-10
Macrophages
Mucous Membrane

Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice

Handa, T., Kanai, T., Sato, T., Mikami, Y., Sujino, T., Hayashi, A., Mizuno, S., Matsumoto, A., Hisamatsu, T. & Hibi, T., 2013 Feb, In : Immunology Letters. 150, 1-2, p. 123-129 7 p.

Research output: Contribution to journalArticle

Colitis
Dendritic Cells
Bone Marrow
Immune Tolerance
Antigen Presentation
12 Citations (Scopus)

Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues

Miyake, M., Toguchi, H., Nishibayashi, T., Higaki, K., Sugita, A., Koganei, K., Kamada, N., Kitazume, M. T., Hisamatsu, T., Sato, T., Okamoto, S., Kanai, T. & Hibi, T., 2013 Aug, In : Journal of Pharmaceutical Sciences. 102, 8, p. 2564-2571 8 p.

Research output: Contribution to journalArticle

Intestinal Absorption
Pharmaceutical Preparations
Metoprolol
Atenolol
Ulcerative Colitis
20 Citations (Scopus)

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

Matsumoto, A., Kanai, T., Mikami, Y., Cho, H., Nakamoto, N., Ebinuma, H., Saito, H., Sato, T., Yagita, H. & Hibi, T., 2013 Apr 23, In : PLoS One. 8, 4, e62853.

Research output: Contribution to journalArticle

hepatitis
Liver
Hepatitis
T-cells
Lymphocytes
579 Citations (Scopus)

In vitro expansion of single Lgr5 + liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., Van Es, J. H., Li, V. S. W., Van De Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., Haft, A., Vries, R. G., Grompe, M. & Clevers, H., 2013 Feb 14, In : Nature. 494, 7436, p. 247-250 4 p.

Research output: Contribution to journalArticle

Organoids
Regeneration
Stem Cells
Liver
Bile Ducts
30 Citations (Scopus)

Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients

Miyoshi, J., Matsuoka, K., Inoue, N., Hisamatsu, T., Ichikawa, R., Yajima, T., Okamoto, S., Naganuma, M., Sato, T., Kanai, T., Ogata, H., Iwao, Y. & Hibi, T., 2013 Dec 15, In : Journal of Crohn's and Colitis. 7, 12

Research output: Contribution to journalArticle

Tacrolimus
Ulcerative Colitis
Steroids
Remission Induction
Colectomy
65 Citations (Scopus)

TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease

Yoneno, K., Hisamatsu, T., Shimamura, K., Kamada, N., Ichikawa, R., Kitazume, M. T., Mori, M., Uo, M., Namikawa, Y., Matsuoka, K., Sato, T., Koganei, K., Sugita, A., Kanai, T. & Hibi, T., 2013 May, In : Immunology. 139, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Crohn Disease
Mucous Membrane
Macrophages
Cytokines
246 Citations (Scopus)

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

Huch, M., Bonfanti, P., Boj, S. F., Sato, T., Loomans, C. J. M., Van De Wetering, M., Sojoodi, M., Li, V. S. W., Schuijers, J., Gracanin, A., Ringnalda, F., Begthel, H., Hamer, K., Mulder, J., Van Es, J. H., De Koning, E., Vries, R. G. J., Heimberg, H. & Clevers, H., 2013 Oct 16, In : EMBO Journal. 32, 20, p. 2708-2721 14 p.

Research output: Contribution to journalArticle

Organoids
Ducts
Pancreas
Stem cells
Stem Cells
2012
5 Citations (Scopus)

CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis

Mizukami, T., Kanai, T., Mikami, Y., Hayashi, A., Doi, T., Handa, T., Matsumoto, A., Jun, L., Matsuoka, K., Sato, T., Hisamatsu, T. & Hibi, T., 2012 Sep, In : Immunology Letters. 147, 1-2, p. 75-79 5 p.

Research output: Contribution to journalArticle

Bacterial Infections
Sepsis
Peritoneal Macrophages
Macrophages
Punctures
58 Citations (Scopus)

Cdx2 determines the fate of postnatal intestinal endoderm

Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, C. A., Winton, D. J., Wright, N. A., Freund, J. N., Deschamps, J. & Beck, F., 2012 Feb 1, In : Development. 139, 3, p. 465-474 10 p.

Research output: Contribution to journalArticle

Endoderm
Stomach
Aptitude
Morphogenesis
Organoids
167 Citations (Scopus)

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B. K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., Van Es, J. H. & Clevers, H., 2012 Jan, In : Nature Methods. 9, 1, p. 81-83 3 p.

Research output: Contribution to journalArticle

Organoids
Retroviridae
Cell culture
Gene expression
Small Intestine
364 Citations (Scopus)

Dll1 + secretory progenitor cells revert to stem cells upon crypt damage

Van Es, J. H., Sato, T., Van De Wetering, M., Lyubimova, A., Yee Nee, A. N., Gregorieff, A., Sasaki, N., Zeinstra, L., Van Den Born, M., Korving, J., Martens, A. C. M., Barker, N., Van Oudenaarden, A. & Clevers, H., 2012 Oct, In : Nature Cell Biology. 14, 10, p. 1099-1104 6 p.

Research output: Contribution to journalArticle

Stem Cells
Organoids
Enterocytes
Clone Cells
Ligands