• 1841 Citations
  • 24 h-Index
20012019
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Research Output 2001 2019

  • 1841 Citations
  • 24 h-Index
  • 48 Article
  • 2 Chapter
2019
1 Citation (Scopus)

Activity-Dependent Secretion of Synaptic Organizer Cbln1 from Lysosomes in Granule Cell Axons

Ibata, K., Kono, M., Narumi, S., Motohashi, J., Kakegawa, W., Kohda, K. & Yuzaki, M., 2019 Jun 19, In : Neuron. 102, 6, p. 1184-1198.e10

Research output: Contribution to journalArticle

Lysosomes
Cathepsin B
Axons
Synapses
Exocytosis

Hyaluronan synthesis supports glutamate transporter activity

Hayashi, M. K., Nishioka, T., Shimizu, H., Takahashi, K., Kakegawa, W., Mikami, T., Hirayama, Y., Koizumi, S., Yoshida, S., Yuzaki, M., Tammi, M., Sekino, Y., Kaibuchi, K., Shigemoto-Mogami, Y., Yasui, M. & Sato, K., 2019 Jan 1, In : Journal of Neurochemistry.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Hyaluronic Acid
Hyaluronoglucosaminidase
Glutamic Acid
Neurology
1 Citation (Scopus)

Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions

Saegusa, S., Fukaya, M., Kakegawa, W., Tanaka, M., Katsumata, O., Sugawara, T., Hara, Y., Itakura, M., Okubo, T., Sato, T., Yuzaki, M. & Sakagami, H., 2019 May 1, In : PloS one. 14, 5, e0216960.

Research output: Contribution to journalArticle

Open Access
Guanine Nucleotide Exchange Factors
Purkinje Cells
Knockout Mice
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Count

PhotonSABER: new tool shedding light on endocytosis and learning mechanisms in vivo

Matsuda, S., Kakegawa, W. & Yuzaki, M., 2019 Jan 1, In : Communicative and Integrative Biology. 12, 1, p. 34-37 4 p.

Research output: Contribution to journalArticle

Open Access
endocytosis
Endocytosis
AMPA Receptors
learning
Learning
2018
3 Citations (Scopus)

Interneuronal NMDA receptors regulate long-term depression and motor learning in the cerebellum

Kono, M., Kakegawa, W., Yoshida, K. & Yuzaki, M., 2018 Jan 1, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

Purkinje Cells
N-Methyl-D-Aspartate Receptors
Cerebellum
Interneurons
Learning

Molecular Mechanisms for Learning and Memory: What Happens at the Synapses?

Kakegawa, W. & Yuzaki, M., 2018 Jul 1, In : Brain and nerve = Shinkei kenkyu no shinpo. 70, 7, p. 677-687 11 p.

Research output: Contribution to journalArticle

Synapses
Learning
Glutamate Receptors
Cerebellum
Neurons
13 Citations (Scopus)

Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning

Kakegawa, W., Katoh, A., Narumi, S., Miura, E., Motohashi, J., Takahashi, A., Kohda, K., Fukazawa, Y., Yuzaki, M. & Matsuda, S., 2018 Sep 5, In : Neuron. 99, 5, p. 985-998.e6

Research output: Contribution to journalArticle

Optogenetics
Neurotransmitter Receptor
AMPA Receptors
Endocytosis
Learning
10 Citations (Scopus)

Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion

Hamoud, N., Tran, V., Aimi, T., Kakegawa, W., Lahaie, S., Thibault, M. P., Pelletier, A., Wong, G. W., Kim, I. S., Kania, A., Yuzaki, M., Bouvier, M. & Côté, J. F., 2018 Dec 1, In : Nature Communications. 9, 1, 4470.

Research output: Contribution to journalArticle

Myoblasts
Fusion reactions
fusion
Muscle
proteins
2017
26 Citations (Scopus)

Chemical labelling for visualizing native AMPA receptors in live neurons

Wakayama, S., Kiyonaka, S., Arai, I., Kakegawa, W., Matsuda, S., Ibata, K., Nemoto, Y. L., Kusumi, A., Yuzaki, M. & Hamachi, I., 2017 Apr 7, In : Nature Communications. 8, 14850.

Research output: Contribution to journalArticle

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
AMPA Receptors
Glutamate Receptors
neurons
Labeling
2016

Long-term depression at parallel fiber-Purkinje cell synapses

Kohda, K., Kakegawa, W. & Yuzaki, M., 2016 Jan 1, Essentials of Cerebellum and Cerebellar Disorders: A Primer for Graduate Students. Springer International Publishing, p. 329-334 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

fiber cells
Purkinje Cells
endocytosis
dendritic cells
synapse

Physiological functions of D-serine mediated through δ2 glutamate receptors in the cerebellum

Kakegawa, W. & Yuzaki, M., 2016 Jan 1, D-Amino Acids: Physiology, Metabolism, and Application. Springer Japan, p. 65-80 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ionotropic Glutamate Receptors
Glutamate Receptors
Cerebellum
Serine
Neuronal Plasticity
46 Citations (Scopus)

Structural basis for integration of GluD receptors within synaptic organizer complexes

Elegheert, J., Kakegawa, W., Clay, J. E., Shanks, N. F., Behiels, E., Matsuda, K., Kohda, K., Miura, E., Rossmann, M., Mitakidis, N., Motohashi, J., Chang, V. T., Siebold, C., Greger, I. H., Nakagawa, T., Yuzaki, M. & Aricescu, A. R., 2016 Jul 15, In : Science. 353, 6296, p. 295-300 6 p.

Research output: Contribution to journalArticle

Ionotropic Glutamate Receptors
Neurotransmitter Receptor
Synapses
Purkinje Cells
Serine
2015
64 Citations (Scopus)

Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum

Kakegawa, W., Mitakidis, N., Miura, E., Abe, M., Matsuda, K., Takeo, Y. H., Kohda, K., Motohashi, J., Takahashi, A., Nagao, S., Muramatsu, S. I., Watanabe, M., Sakimura, K., Aricescu, A. R. & Yuzaki, M., 2015 Jan 21, In : Neuron. 85, 2, p. 316-330 15 p.

Research output: Contribution to journalArticle

Cerebellum
Angiogenesis Inhibitors
Brain
Synapses
Purkinje Cells
17 Citations (Scopus)

Rorα regulates multiple aspects of dendrite development in cerebellar purkinje cells in vivo

Takeo, Y. H., Kakegawa, W., Miura, E. & Yuzaki, M., 2015 Sep 9, In : Journal of Neuroscience. 35, 36, p. 12518-12534 17 p.

Research output: Contribution to journalArticle

Purkinje Cells
Dendrites
Neurologic Mutant Mice
Spinocerebellar Ataxias
Cerebellar Diseases
61 Citations (Scopus)

Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins

Matsuda, K., Budisantoso, T., Mitakidis, N., Sugaya, Y., Miura, E., Kakegawa, W., Yamasaki, M., Konno, K., Uchigashima, M., Abe, M., Watanabe, I., Kano, M., Watanabe, M., Sakimura, K., Aricescu, A. R. & Yuzaki, M., 2015 Nov 2, (Accepted/In press) In : Neuron.

Research output: Contribution to journalArticle

Kainic Acid Receptors
Glutamate Receptors
Proteins
Synapses
Temporal Lobe Epilepsy
2014
8 Citations (Scopus)

Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum

Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba, R., Sekine, Y., Sato, Y., Saruta, C., Ishizaki, Y., Yuzaki, M., Kojima, M. & Furuichi, T., 2014 Jun 12, In : PLoS One. 9, 6, e99524.

Research output: Contribution to journalArticle

Neurotrophin 3
protein secretion
neurotrophins
postnatal development
Brain-Derived Neurotrophic Factor
4 Citations (Scopus)

Cbln1 downregulates the formation and function of inhibitory synapses in mouse cerebellar Purkinje cells

Ishida, A., Kakegawa, W., Kohda, K., Miura, E., Okabe, S. & Yuzaki, M., 2014, In : European Journal of Neuroscience. 39, 8, p. 1268-1280 13 p.

Research output: Contribution to journalArticle

Purkinje Cells
Synapses
Down-Regulation
Interneurons
Cerebellum
2013
14 Citations (Scopus)

CAPS1 deficiency perturbs dense-core vesicle trafficking and golgi structure and reduces presynaptic release probability in the mouse brain

Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba, R., Sekine, Y., Sato, Y., Tanaka, M., Iwasato, T., Itohara, S., Furuyama, K., Kawaguchi, Y., Ishizaki, Y., Yuzaki, M. & Furuichi, T., 2013, In : Journal of Neuroscience. 33, 44, p. 17326-17334 9 p.

Research output: Contribution to journalArticle

Transcription Factor AP-1
Secretory Vesicles
Knockout Mice
Secretogranin II
Brain
41 Citations (Scopus)

Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans

Hills, L. B., Masri, A., Konno, K., Kakegawa, W., Lam, A. T. N., Lim-Melia, E., Chandy, N., Hill, R. S., Partlow, J. N., Al-Saffar, M., Nasir, R., Stoler, J. M., Barkovich, A. J., Watanabe, M., Yuzaki, M. & Mochida, G. H., 2013 Oct 15, In : Neurology. 81, 16, p. 1378-1386 9 p.

Research output: Contribution to journalArticle

Cerebellar Ataxia
Eye Movements
Eye Abnormalities
Purkinje Cells
Cerebellum
19 Citations (Scopus)

Reevaluation of the role of parallel fiber synapses in delay eyeblink conditioning in mice using Cbln1 as a tool

Emi, K., Kakegawa, W., Miura, E., Ishida, A., Kohda, K. & Yuzaki, M., 2013 Nov 15, In : Frontiers in Neural Circuits. 7, NOV, 180.

Research output: Contribution to journalArticle

Synapses
Purkinje Cells
Long-Term Potentiation
Depression
Injections
33 Citations (Scopus)

Stargazin regulates AMPA receptor trafficking through adaptor protein complexes during long-term depression

Matsuda, S., Kakegawa, W., Budisantoso, T., Nomura, T., Kohda, K. & Yuzaki, M., 2013, In : Nature Communications. 4, 2759.

Research output: Contribution to journalArticle

AMPA Receptors
Depression
Endosomes
proteins
N-Methylaspartate
37 Citations (Scopus)
AMPA Receptors
Glutamate Receptors
Phosphorylation
Depression
Serine
9 Citations (Scopus)

Unlocking the secrets of the δ2 glutamate receptor

Kohda, K., Kakegawa, W. & Yuzaki, M., 2013, In : Communicative and Integrative Biology. 6, 6, e26466.

Research output: Contribution to journalArticle

Glutamate Receptors
phosphorylation
Depression
Phosphorylation
endocytosis
2012
21 Citations (Scopus)

Cerebellar long-term depression requires dephosphorylation of TARP in Purkinje cells

Nomura, T., Kakegawa, W., Matsuda, S., Kohda, K., Nishiyama, J., Takahashi, T. & Yuzaki, M., 2012 Feb, In : European Journal of Neuroscience. 35, 3, p. 402-410 9 p.

Research output: Contribution to journalArticle

Purkinje Cells
Depression
Calcineurin
AMPA Receptors
Endocytosis
48 Citations (Scopus)

NMDA Receptor-Mediated PIP5K Activation to Produce PI(4,5)P 2 Is Essential for AMPA Receptor Endocytosis during LTD

Unoki, T., Matsuda, S., Kakegawa, W., Van, N. T. B., Kohda, K., Suzuki, A., Funakoshi, Y., Hasegawa, H., Yuzaki, M. & Kanaho, Y., 2012 Jan 12, In : Neuron. 73, 1, p. 135-148 14 p.

Research output: Contribution to journalArticle

AMPA Receptors
Endocytosis
N-Methyl-D-Aspartate Receptors
N-Methylaspartate
Adaptor Protein Complex 2
18 Citations (Scopus)

Selective and regulated gene expression in murine Purkinje cells by in utero electroporation

Nishiyama, J., Hayashi, Y., Nomura, T., Miura, E., Kakegawa, W. & Yuzaki, M., 2012 Oct, In : European Journal of Neuroscience. 36, 7, p. 2867-2876 10 p.

Research output: Contribution to journalArticle

Electroporation
Purkinje Cells
Gene Expression
Neuronal Plasticity
Neurologic Mutant Mice
2011
1 Citation (Scopus)

A new rapid protocol for eyeblink conditioning to assess cerebellar motor learning

Emi, K., Kohda, K., Kakegawa, W., Narumi, S. & Yuzaki, M., 2011 Jul, In : Neurochemical Research. 36, 7, p. 1314-1322 9 p.

Research output: Contribution to journalArticle

Learning
Data storage equipment
Glutamate Receptors
Viruses
Networks (circuits)
93 Citations (Scopus)

D-Serine regulates cerebellar LTD and motor coordination through the δ glutamate receptor

Kakegawa, W., Miyoshi, Y., Hamase, K., Matsuda, S., Matsuda, K., Kohda, K., Emi, K., Motohashi, J., Konno, R., Zaitsu, K. & Yuzaki, M., 2011 May, In : Nature Neuroscience. 14, 5, p. 603-613 11 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Cerebellum
Serine
Neuronal Plasticity
Purkinje Cells
2010
193 Citations (Scopus)

Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer

Matsuda, K., Miura, E., Miyazaki, T., Kakegawa, W., Emi, K., Narumi, S., Fukazawa, Y., Ito-lshida, A., Kondo, T., Shigemoto, R., Watanabe, M. & Yuzaki, M., 2010 Apr 16, In : Science. 328, 5976, p. 363-368 6 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Synapses
Ligands
Purkinje Cells
Cerebellum
26 Citations (Scopus)

Reevaluation of neurodegeneration in lurcher mice: Constitutive ion fluxes cause cell death with, not by, autophagy

Nishiyama, J., Matsuda, K., Kakegawa, W., Yamada, N., Motohashi, J., Mizushima, N. & Yuzaki, M., 2010 Feb 10, In : Journal of Neuroscience. 30, 6, p. 2177-2187 11 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Autophagy
Cause of Death
Cell Death
Ions
2009
43 Citations (Scopus)

The N-terminal domain of GluD2 (GluRδ2) recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo

Kakegawa, W., Miyazaki, T., Kohda, K., Matsuda, K., Emi, K., Motohashi, J., Watanabe, M. & Yuzaki, M., 2009 May 6, In : Journal of Neuroscience. 29, 18, p. 5738-5748 11 p.

Research output: Contribution to journalArticle

Presynaptic Terminals
Cerebellum
Purkinje Cells
Synapses
Depression
2008
91 Citations (Scopus)

Accumulation of AMPA Receptors in Autophagosomes in Neuronal Axons Lacking Adaptor Protein AP-4

Matsuda, S., Miura, E., Matsuda, K., Kakegawa, W., Kohda, K., Watanabe, M. & Yuzaki, M., 2008 Mar 13, In : Neuron. 57, 5, p. 730-745 16 p.

Research output: Contribution to journalArticle

AMPA Receptors
Axons
Proteins
Neurons
Autophagosomes
53 Citations (Scopus)

Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRδ2

Kakegawa, W., Miyazaki, T., Emi, K., Matsuda, K., Kohda, K., Motohashi, J., Mishina, M., Kawahara, S., Watanabe, M. & Yuzaki, M., 2008 Feb 6, In : Journal of Neuroscience. 28, 6, p. 1460-1468 9 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Purkinje Cells
Synapses
Learning
Depression
6 Citations (Scopus)

Phosphorylation of delta2 glutamate receptors at serine 945 is not required for cerebellar long-term depression

Nakagami, R., Kohda, K., Kakegawa, W., Kondo, T., Kato, N. & Yuzaki, M., 2008 Jun, In : Keio Journal of Medicine. 57, 2, p. 105-110 6 p.

Research output: Contribution to journalArticle

Serine
Protein Kinase C
Purkinje Cells
Phosphorylation
Depression
2007
29 Citations (Scopus)

Ca2+ permeability of the channel pore is not essential for the δ2 glutamate receptor to regulate synaptic plasticity and motor coordination

Kakegawa, W., Miyazaki, T., Hirai, H., Motohashi, J., Mishina, M., Watanabe, M. & Yuzaki, M., 2007 Mar 15, In : Journal of Physiology. 579, 3, p. 729-735 7 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Purkinje Cells
Glutamate Receptors
Transgenes
Synapses
17 Citations (Scopus)

Ho15J-A new hotfoot allele in a hot spot in the gene encoding the δ2 glutamate receptor

Motohashi, J., Kakegawa, W. & Yuzaki, M., 2007 Apr 6, In : Brain Research. 1140, 1, p. 153-160 8 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Alleles
Polymerase Chain Reaction
Genes
Exons
103 Citations (Scopus)

Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release

Sadakata, T., Kakegawa, W., Mizoguchi, A., Washida, M., Katoh-Semba, R., Shutoh, F., Okamoto, T., Nakashima, H., Kimura, K., Tanaka, M., Sekine, Y., Itohara, S., Yuzaki, M., Nagao, S. & Furuichi, T., 2007 Mar 7, In : Journal of Neuroscience. 27, 10, p. 2472-2482 11 p.

Research output: Contribution to journalArticle

Neurotrophin 3
Purkinje Cells
Brain-Derived Neurotrophic Factor
Nerve Growth Factors
Synapses
36 Citations (Scopus)

The extreme C-terminus of GluRδ2 is essential for induction of long-term depression in cerebellar slices

Kohda, K., Kakegawa, W., Matsuda, S., Nakagami, R., Kakiya, N. & Yuzaki, M., 2007 Mar, In : European Journal of Neuroscience. 25, 5, p. 1357-1362 6 p.

Research output: Contribution to journalArticle

Purkinje Cells
Depression
Null Lymphocytes
Synapses
PDZ Domains
42 Citations (Scopus)
Ionotropic Glutamate Receptors
Neuronal Plasticity
Depression
Transgenes
Neurologic Mutant Mice
2006
23 Citations (Scopus)
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
p38 Mitogen-Activated Protein Kinases
Depression
Mitogen-Activated Protein Kinases
2005
71 Citations (Scopus)
AMPA Receptors
Long-Term Potentiation
N-Ethylmaleimide-Sensitive Proteins
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Purkinje Cells
68 Citations (Scopus)

Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses

Takayasu, Y., Iino, M., Kakegawa, W., Maeno, H., Watase, K., Wada, K., Yanagihara, D., Miyazaki, T., Komine, O., Watanabe, M., Tanaka, K. & Ozawa, S., 2005 Sep 21, In : Journal of Neuroscience. 25, 38, p. 8788-8793 6 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Purkinje Cells
Excitatory Amino Acid Transporter 4
Neuroglia
Synapses
20 Citations (Scopus)
Glutamate Receptors
Protein Kinase C
Phosphorylation
Purkinje Cells
Glutathione Transferase
46 Citations (Scopus)

Rescue of abnormal phenotypes of the δ2 glutamate receptor-null mice by mutant δ2 transgenes

Hirai, H., Miyazaki, T., Kakegawa, W., Matsuda, S., Mishina, M., Watanabe, M. & Yuzaki, M., 2005, In : EMBO Reports. 6, 1, p. 90-95 6 p.

Research output: Contribution to journalArticle

Ionotropic Glutamate Receptors
Glutamate Receptors
Transgenes
Glutamic Acid
Phenotype
2004
42 Citations (Scopus)

Input- and subunit-specific AMPA receptor trafficking underlying long-term potentiation at hippocampal CA3 synapses

Kakegawa, W., Tsuzuki, K., Yoshida, Y., Kameyama, K. & Ozawa, S., 2004 Jul, In : European Journal of Neuroscience. 20, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

AMPA Receptors
Long-Term Potentiation
Synapses
Acids
Pyramidal Cells
2003
15 Citations (Scopus)

Functional NMDA receptor channels generated by NMDAR2B gene transfer in rat cerebellar Purkinje cells

Kakegawa, W., Tsuzuki, K., Iino, M. & Ozawa, S., 2003 Feb, In : European Journal of Neuroscience. 17, 4, p. 887-891 5 p.

Research output: Contribution to journalArticle

Purkinje Cells
N-Methyl-D-Aspartate Receptors
Genes
Green Fluorescent Proteins
Synapses
2002
9 Citations (Scopus)

Postsynaptic Expression of a New Calcium Pathway in Hippocampal CA3 Neurons and its Influence on Mossy Fiber Long-Term Potentiation

Kakegawa, W., Yamada, N., Iino, M., Kameyama, K., Umeda, T., Tsuzuki, K. & Ozawa, S., 2002 Jun 1, In : Journal of Neuroscience. 22, 11, p. 4312-4320 9 p.

Research output: Contribution to journalArticle

Long-Term Potentiation
AMPA Receptors
Calcium
Neurons
N-Methyl-D-Aspartate Receptors
2001
296 Citations (Scopus)

Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia

Iino, M., Goto, K., Kakegawa, W., Okado, H., Sudo, M., Ishiuchi, S., Miwa, A., Takayasu, Y., Saito, I., Tsuzuki, K. & Ozawa, S., 2001 May 4, In : Science. 292, 5518, p. 926-929 4 p.

Research output: Contribution to journalArticle

AMPA Receptors
Neuroglia
Synapses
Glutamate Receptors
Purkinje Cells
24 Citations (Scopus)

Sindbis viral-mediated expression of Ca2+-permeable AMPA receptors at hippocampal CA1 synapses and induction of NMDA receptor-independent long-term potentiation

Okada, T., Yamada, N., Kakegawa, W., Tsuzuki, K., Kawamura, M., Nawa, H., Iino, M. & Ozawa, S., 2001, In : European Journal of Neuroscience. 13, 8, p. 1635-1643 9 p.

Research output: Contribution to journalArticle

AMPA Receptors
Long-Term Potentiation
N-Methyl-D-Aspartate Receptors
Synapses
Green Fluorescent Proteins