• 1909 Citations
  • 24 h-Index
20012019

Research output per year

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Research Output

  • 1909 Citations
  • 24 h-Index
  • 47 Article
  • 2 Chapter
  • 1 Comment/debate

Accumulation of AMPA Receptors in Autophagosomes in Neuronal Axons Lacking Adaptor Protein AP-4

Matsuda, S., Miura, E., Matsuda, K., Kakegawa, W., Kohda, K., Watanabe, M. & Yuzaki, M., 2008 Mar 13, In : Neuron. 57, 5, p. 730-745 16 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Activity-Dependent Secretion of Synaptic Organizer Cbln1 from Lysosomes in Granule Cell Axons

Ibata, K., Kono, M., Narumi, S., Motohashi, J., Kakegawa, W., Kouda, K. & Yuzaki, M., 2019 Jun 19, In : Neuron. 102, 6, p. 1184-1198.e10

Research output: Contribution to journalArticle

3 Citations (Scopus)
71 Citations (Scopus)

A new rapid protocol for eyeblink conditioning to assess cerebellar motor learning

Emi, K., Kohda, K., Kakegawa, W., Narumi, S. & Yuzaki, M., 2011 Jul 1, In : Neurochemical Research. 36, 7, p. 1314-1322 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum

Kakegawa, W., Mitakidis, N., Miura, E., Abe, M., Matsuda, K., Takeo, Y. H., Kohda, K., Motohashi, J., Takahashi, A., Nagao, S., Muramatsu, S. I., Watanabe, M., Sakimura, K., Aricescu, A. R. & Yuzaki, M., 2015 Jan 21, In : Neuron. 85, 2, p. 316-329 14 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum

Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba, R., Sekine, Y., Sato, Y., Saruta, C., Ishizaki, Y., Yuzaki, M., Kojima, M. & Furuichi, T., 2014 Jun 12, In : PloS one. 9, 6, e99524.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Ca2+ permeability of the channel pore is not essential for the δ2 glutamate receptor to regulate synaptic plasticity and motor coordination

Kakegawa, W., Miyazaki, T., Hirai, H., Motohashi, J., Mishina, M., Watanabe, M. & Yuzaki, M., 2007 Mar 15, In : Journal of Physiology. 579, 3, p. 729-735 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

CAPS1 deficiency perturbs dense-core vesicle trafficking and golgi structure and reduces presynaptic release probability in the mouse brain

Sadakata, T., Kakegawa, W., Shinoda, Y., Hosono, M., Katoh-Semba, R., Sekine, Y., Sato, Y., Tanaka, M., Iwasato, T., Itohara, S., Furuyama, K., Kawaguchi, Y., Ishizaki, Y., Yuzaki, M. & Furuichi, T., 2013, In : Journal of Neuroscience. 33, 44, p. 17326-17334 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Cbln1 downregulates the formation and function of inhibitory synapses in mouse cerebellar Purkinje cells

Ito-Ishida, A., Kakegawa, W., Kohda, K., Miura, E., Okabe, S. & Yuzaki, M., 2014 Apr, In : European Journal of Neuroscience. 39, 8, p. 1268-1280 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Cbln1 is a ligand for an orphan glutamate receptor δ2, a bidirectional synapse organizer

Matsuda, K., Miura, E., Miyazaki, T., Kakegawa, W., Emi, K., Narumi, S., Fukazawa, Y., Ito-lshida, A., Kondo, T., Shigemoto, R., Watanabe, M. & Yuzaki, M., 2010 Apr 16, In : Science. 328, 5976, p. 363-368 6 p.

Research output: Contribution to journalArticle

197 Citations (Scopus)

Cerebellar long-term depression requires dephosphorylation of TARP in Purkinje cells

Nomura, T., Kakegawa, W., Matsuda, S., Kohda, K., Nishiyama, J., Takahashi, T. & Yuzaki, M., 2012 Feb 1, In : European Journal of Neuroscience. 35, 3, p. 402-410 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Chemical labelling for visualizing native AMPA receptors in live neurons

Wakayama, S., Kiyonaka, S., Arai, I., Kakegawa, W., Matsuda, S., Ibata, K., Nemoto, Y. L., Kusumi, A., Yuzaki, M. & Hamachi, I., 2017 Apr 7, In : Nature communications. 8, 14850.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans

Hills, L. B., Masri, A., Konno, K., Kakegawa, W., Lam, A. T. N., Lim-Melia, E., Chandy, N., Hill, R. S., Partlow, J. N., Al-Saffar, M., Nasir, R., Stoler, J. M., Barkovich, A. J., Watanabe, M., Yuzaki, M. & Mochida, G. H., 2013 Oct 15, In : Neurology. 81, 16, p. 1378-1386 9 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRδ2

Kakegawa, W., Miyazaki, T., Emi, K., Matsuda, K., Kohda, K., Motohashi, J., Mishina, M., Kawahara, S., Watanabe, M. & Yuzaki, M., 2008 Feb 6, In : Journal of Neuroscience. 28, 6, p. 1460-1468 9 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses

Takayasu, Y., Iino, M., Kakegawa, W., Maeno, H., Watase, K., Wada, K., Yanagihara, D., Miyazaki, T., Komine, O., Watanabe, M., Tanaka, K. & Ozawa, S., 2005 Sep 21, In : Journal of Neuroscience. 25, 38, p. 8788-8793 6 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

D-Serine regulates cerebellar LTD and motor coordination through the δ glutamate receptor

Kakegawa, W., Miyoshi, Y., Hamase, K., Matsuda, S., Matsuda, K., Kohda, K., Emi, K., Motohashi, J., Konno, R., Zaitsu, K. & Yuzaki, M., 2011 May 1, In : Nature Neuroscience. 14, 5, p. 603-613 11 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)
24 Citations (Scopus)

Functional NMDA receptor channels generated by NMDAR2B gene transfer in rat cerebellar Purkinje cells

Kakegawa, W., Tsuzuki, K., Iino, M. & Ozawa, S., 2003 Feb 1, In : European Journal of Neuroscience. 17, 4, p. 887-891 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia

Iino, M., Goto, K., Kakegawa, W., Okado, H., Sudo, M., Ishiuchi, S., Miwa, A., Takayasu, Y., Saito, I., Tsuzuki, K. & Ozawa, S., 2001 May 4, In : Science. 292, 5518, p. 926-929 4 p.

Research output: Contribution to journalArticle

299 Citations (Scopus)

Ho15J-A new hotfoot allele in a hot spot in the gene encoding the δ2 glutamate receptor

Motohashi, J., Kakegawa, W. & Yuzaki, M., 2007 Apr 6, In : Brain Research. 1140, 1, p. 153-160 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Hyaluronan synthesis supports glutamate transporter activity

Hayashi, M. K., Nishioka, T., Shimizu, H., Takahashi, K., Kakegawa, W., Mikami, T., Hirayama, Y., Koizumi, S., Yoshida, S., Yuzaki, M., Tammi, M., Sekino, Y., Kaibuchi, K., Shigemoto-Mogami, Y., Yasui, M. & Sato, K., 2019 Aug, In : Journal of Neurochemistry. 150, 3, p. 249-263 15 p.

Research output: Contribution to journalArticle

Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release

Sadakata, T., Kakegawa, W., Mizoguchi, A., Washida, M., Katoh-Semba, R., Shutoh, F., Okamoto, T., Nakashima, H., Kimura, K., Tanaka, M., Sekine, Y., Itohara, S., Yuzaki, M., Nagao, S. & Furuichi, T., 2007 Mar 7, In : Journal of Neuroscience. 27, 10, p. 2472-2482 11 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)
21 Citations (Scopus)

Input- and subunit-specific AMPA receptor trafficking underlying long-term potentiation at hippocampal CA3 synapses

Kakegawa, W., Tsuzuki, K., Yoshida, Y., Kameyama, K. & Ozawa, S., 2004 Jul 1, In : European Journal of Neuroscience. 20, 1, p. 101-110 10 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Interneuronal NMDA receptors regulate long-term depression and motor learning in the cerebellum

Kono, M., Kakegawa, W., Yoshida, K. & Yuzaki, M., 2019 Feb 1, In : Journal of Physiology. 597, 3, p. 903-920 18 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Long-term depression at parallel fiber-Purkinje cell synapses

Kohda, K., Kakegawa, W. & Yuzaki, M., 2016 Jan 1, Essentials of Cerebellum and Cerebellar Disorders: A Primer for Graduate Students. Springer International Publishing, p. 329-334 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions

Saegusa, S., Fukaya, M., Kakegawa, W., Tanaka, M., Katsumata, O., Sugawara, T., Hara, Y., Itakura, M., Okubo, T., Sato, T., Yuzaki, M. & Sakagami, H., 2019 May, In : PloS one. 14, 5, e0216960.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Molecular Mechanisms for Learning and Memory: What Happens at the Synapses?

Kakegawa, W. & Yuzaki, M., 2018 Jul 1, In : Brain and nerve = Shinkei kenkyu no shinpo. 70, 7, p. 677-687 11 p.

Research output: Contribution to journalArticle

NMDA Receptor-Mediated PIP5K Activation to Produce PI(4,5)P 2 Is Essential for AMPA Receptor Endocytosis during LTD

Unoki, T., Matsuda, S., Kakegawa, W., Van, N. T. B., Kohda, K., Suzuki, A., Funakoshi, Y., Hasegawa, H., Yuzaki, M. & Kanaho, Y., 2012 Jan 12, In : Neuron. 73, 1, p. 135-148 14 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning

Kakegawa, W., Katoh, A., Narumi, S., Miura, E., Motohashi, J., Takahashi, A., Kohda, K., Fukazawa, Y., Yuzaki, M. & Matsuda, S., 2018 Sep 5, In : Neuron. 99, 5, p. 985-998.e6

Research output: Contribution to journalArticle

20 Citations (Scopus)

Phosphorylation of delta2 glutamate receptors at serine 945 is not required for cerebellar long-term depression

Nakagami, R., Kohda, K., Kakegawa, W., Kondo, T., Kato, N. & Yuzaki, M., 2008 Jun 1, In : Keio Journal of Medicine. 57, 2, p. 105-110 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

PhotonSABER: new tool shedding light on endocytosis and learning mechanisms in vivo

Matsuda, S., Kakegawa, W. & Yuzaki, M., 2019 Jan 1, In : Communicative and Integrative Biology. 12, 1, p. 34-37 4 p.

Research output: Contribution to journalArticle

Open Access

Physiological functions of D-serine mediated through δ2 glutamate receptors in the cerebellum

Kakegawa, W. & Yuzaki, M., 2016 Jan 1, D-Amino Acids: Physiology, Metabolism, and Application. Springer Japan, p. 65-80 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Postsynaptic Expression of a New Calcium Pathway in Hippocampal CA3 Neurons and its Influence on Mossy Fiber Long-Term Potentiation

Kakegawa, W., Yamada, N., Iino, M., Kameyama, K., Umeda, T., Tsuzuki, K. & Ozawa, S., 2002 Jun 1, In : Journal of Neuroscience. 22, 11, p. 4312-4320 9 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Reevaluation of neurodegeneration in lurcher mice: Constitutive ion fluxes cause cell death with, not by, autophagy

Nishiyama, J., Matsuda, K., Kakegawa, W., Yamada, N., Motohashi, J., Mizushima, N. & Yuzaki, M., 2010 Feb 10, In : Journal of Neuroscience. 30, 6, p. 2177-2187 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Reevaluation of the role of parallel fiber synapses in delay eyeblink conditioning in mice using Cbln1 as a tool

Emi, K., Kakegawa, W., Miura, E., Ito-Ishida, A., Kohda, K. & Yuzaki, M., 2013 Nov 15, In : Frontiers in Neural Circuits. 7, NOV, 180.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Rescue of abnormal phenotypes of the δ2 glutamate receptor-null mice by mutant δ2 transgenes

Hirai, H., Miyazaki, T., Kakegawa, W., Matsuda, S., Mishina, M., Watanabe, M. & Yuzaki, M., 2005 Dec 8, In : EMBO Reports. 6, 1, p. 90-95 6 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Rorα regulates multiple aspects of dendrite development in cerebellar purkinje cells in vivo

Takeo, Y. H., Kakegawa, W., Miura, E. & Yuzaki, M., 2015 Sep 9, In : Journal of Neuroscience. 35, 36, p. 12518-12534 17 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Selective and regulated gene expression in murine Purkinje cells by in utero electroporation

Nishiyama, J., Hayashi, Y., Nomura, T., Miura, E., Kakegawa, W. & Yuzaki, M., 2012 Oct, In : European Journal of Neuroscience. 36, 7, p. 2867-2876 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Sindbis viral-mediated expression of Ca2+-permeable AMPA receptors at hippocampal CA1 synapses and induction of NMDA receptor-independent long-term potentiation

Okada, T., Yamada, N., Kakegawa, W., Tsuzuki, K., Kawamura, M., Nawa, H., Iino, M. & Ozawa, S., 2001 May 21, In : European Journal of Neuroscience. 13, 8, p. 1635-1643 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion

Hamoud, N., Tran, V., Aimi, T., Kakegawa, W., Lahaie, S., Thibault, M. P., Pelletier, A., Wong, G. W., Kim, I. S., Kania, A., Yuzaki, M., Bouvier, M. & Côté, J. F., 2018 Dec 1, In : Nature Communications. 9, 1, 4470.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Stargazin regulates AMPA receptor trafficking through adaptor protein complexes during long-term depression

Matsuda, S., Kakegawa, W., Budisantoso, T., Nomura, T., Kohda, K. & Yuzaki, M., 2013 Jan 1, In : Nature communications. 4, 2759.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Structural basis for integration of GluD receptors within synaptic organizer complexes

Elegheert, J., Kakegawa, W., Clay, J. E., Shanks, N. F., Behiels, E., Matsuda, K., Kohda, K., Miura, E., Rossmann, M., Mitakidis, N., Motohashi, J., Chang, V. T., Siebold, C., Greger, I. H., Nakagawa, T., Yuzaki, M. & Aricescu, A. R., 2016 Jul 15, In : Science. 353, 6296, p. 295-300 6 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

The extreme C-terminus of GluRδ2 is essential for induction of long-term depression in cerebellar slices

Kohda, K., Kakegawa, W., Matsuda, S., Nakagami, R., Kakiya, N. & Yuzaki, M., 2007 Mar 1, In : European Journal of Neuroscience. 25, 5, p. 1357-1362 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The N-terminal domain of GluD2 (GluRδ2) recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo

Kakegawa, W., Miyazaki, T., Kohda, K., Matsuda, K., Emi, K., Motohashi, J., Watanabe, M. & Yuzaki, M., 2009 May 6, In : Journal of Neuroscience. 29, 18, p. 5738-5748 11 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
39 Citations (Scopus)
43 Citations (Scopus)

Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins

Matsuda, K., Budisantoso, T., Mitakidis, N., Sugaya, Y., Miura, E., Kakegawa, W., Yamasaki, M., Konno, K., Uchigashima, M., Abe, M., Watanabe, I., Kano, M., Watanabe, M., Sakimura, K., Aricescu, A. R. & Yuzaki, M., 2016 May 18, In : Neuron. 90, 4, p. 752-767 16 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Unlocking the secrets of the δ2 glutamate receptor

Kohda, K., Kakegawa, W. & Yuzaki, M., 2013 Dec 1, In : Communicative and Integrative Biology. 6, 6, e26466.

Research output: Contribution to journalArticle

9 Citations (Scopus)