• 1810 Citations
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19982020

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2020

Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites

Kabe, Y., Takemoto, D., Kanai, A., Hirai, M., Ono, Y., Akazawa, S., Horikawa, M., Kitagawa, Y., Handa, H., Rogi, T., Shibata, H. & Suematsu, M., 2020 Dec 1, In : npj Science of Food. 4, 1, 4.

Research output: Contribution to journalArticle

Open Access

Comparative Glycomic Analysis of Exosome Subpopulations Derived from Pancreatic Cancer Cell Lines

Matsuda, A., Kuno, A., Yoshida, M., Wagatsuma, T., Sato, T., Miyagishi, M., Zhao, J., Suematsu, M., Kabe, Y. & Narimatsu, H., 2020 Jun 5, In : Journal of Proteome Research. 19, 6, p. 2516-2524 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate-Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., Suematsu, M., Shimizu, T. & Takubo, K., 2019 Jul 2, In : Cell Reports. 28, 1, p. 145-158.e9

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Identification of a binding protein for sesamin and characterization of its roles in plant growth

Tera, M., Koyama, T., Murata, J., Furukawa, A., Mori, S., Azuma, T., Watanabe, T., Hori, K., Okazawa, A., Kabe, Y., Suematsu, M., Satake, H., Ono, E. & Horikawa, M., 2019 Dec 1, In : Scientific reports. 9, 1, 8631.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Xanthine oxidase inhibitor ameliorates postischemic renal injury in mice by promoting resynthesis of adenine nucleotides

Fujii, K., Kubo, A., Miyashita, K., Sato, M., Hagiwara, A., Inoue, H., Ryuzaki, M., Tamaki, M., Hishiki, T., Hayakawa, N., Kabe, Y., Itoh, H. & Suematsu, M., 2019 Nov 14, In : JCI Insight. 4, 22, e124816.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor–Initiating Stem Cell–Like Cells Resistant to mTORC1 Inhibition

Wu, R., Murali, R., Kabe, Y., French, S. W., Chiang, Y. M., Liu, S., Sher, L., Wang, C. C., Louie, S. & Tsukamoto, H., 2018 Nov, In : Hepatology. 68, 5, p. 1726-1740 15 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera

Kabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., Minegishi, N., Hozawa, A., Murakami, Y., Kubo, M., Itonaga, M. & Handa, H., 2018 Oct, In : Clinical Chemistry. 64, 10, p. 1463-1473 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2017

Disorganized Steroidogenesis in Adrenocortical Carcinoma, a Case Study

Uchida, T., Nishimoto, K., Fukumura, Y., Asahina, M., Goto, H., Kawano, Y., Shimizu, F., Tsujimura, A., Seki, T., Mukai, K., Kabe, Y., Suematsu, M., Gomez-Sanchez, C. E., Yao, T., Horie, S. & Watada, H., 2017 Mar 1, In : Endocrine pathology. 28, 1, p. 27-35 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
1 Citation (Scopus)

Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1

Pati, M. L., Groza, D., Riganti, C., Kopecka, J., Niso, M., Berardi, F., Hager, S., Heffeter, P., Hirai, M., Tsugawa, H., Kabe, Y., Suematsu, M. & Abate, C., 2017 Mar 1, In : Pharmacological Research. 117, p. 67-74 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Somatic KCNJ5 mutation occurring early in adrenal development may cause a novel form of juvenile primary aldosteronism

Tamura, A., Nishimoto, K., Seki, T., Matsuzawa, Y., Saito, J., Omura, M., Gomez-Sanchez, C. E., Makita, K., Matsui, S., Moriya, N., Inoue, A., Nagata, M., Sasano, H., Nakamura, Y., Yamazaki, Y., Kabe, Y., Mukai, K., Kosaka, T., Oya, M., Suematsu, S. & 1 others, Nishikawa, T., 2017 Feb 5, In : Molecular and Cellular Endocrinology. 441, p. 134-139 6 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6

Lai, K. K. Y., Kweon, S. M., Chi, F., Hwang, E., Kabe, Y., Higashiyama, R., Qin, L., Yan, R., Wu, R. P., Lai, K., Fujii, N., French, S., Xu, J., Wang, J. Y., Murali, R., Mishra, L., Lee, J. S., Ntambi, J. M. & Tsukamoto, H., 2017 May, In : Gastroenterology. 152, 6, p. 1477-1491 15 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2016

Alteration of matrix metalloproteinase-3 O-glycan structure as a biomarker for disease activity of rheumatoid arthritis

Takeshita, M., Kuno, A., Suzuki, K., Matsuda, A., Shimazaki, H., Nakagawa, T., Otomo, Y., Kabe, Y., Suematsu, M., Narimatsu, H. & Takeuchi, T., 2016 May 21, In : Arthritis Research and Therapy. 18, 1, 112.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

Kabe, Y., Nakane, T., Koike, I., Yamamoto, T., Sugiura, Y., Harada, E., Sugase, K., Shimamura, T., Ohmura, M., Muraoka, K., Yamamoto, A., Uchida, T., Iwata, S., Yamaguchi, Y., Krayukhina, E., Noda, M., Handa, H., Ishimori, K., Uchiyama, S., Kobayashi, T. & 1 others, Suematsu, M., 2016 Mar 18, In : Nature communications. 7, 11030.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Human Adrenocortical Remodeling Leading to Aldosterone-Producing Cell Cluster Generation

Nishimoto, K., Seki, T., Hayashi, Y., Mikami, S., Al-Eyd, G., Nakagawa, K., Morita, S., Kosaka, T., Oya, M., Mitani, F., Suematsu, M., Kabe, Y. & Mukai, K., 2016, In : International Journal of Endocrinology. 2016, 7834356.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2015

Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry

Ohmura, M., Hishiki, T., Yamamoto, T., Nakanishi, T., Kubo, A., Tsuchihashi, K., Tamada, M., Toue, S., Kabe, Y., Saya, H. & Suematsu, M., 2015 Apr 30, In : Nitric Oxide - Biology and Chemistry. 46, p. 102-113 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C

Masuda, K., Chiyoda, T., Sugiyama, N., Segura-Cabrera, A., Kabe, Y., Ueki, A., Banno, K., Suematsu, M., Aoki, D., Ishihama, Y., Saya, H. & Kuninaka, S., 2015 Feb 27, In : PloS one. 10, 2, e0118662.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2014

Microscopic imaging mass spectrometry assisted by on-tissue chemical derivatization for visualizing multiple amino acids in human colon cancer xenografts

Toue, S., Sugiura, Y., Kubo, A., Ohmura, M., Karakawa, S., Mizukoshi, T., Yoneda, J., Miyano, H., Noguchi, Y., Kobayashi, T., Kabe, Y. & Suematsu, M., 2014, In : Proteomics. 14, 7-8, p. 810-819 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
2013

Vesnarinone suppresses TNFa mRNA expression by inhibiting valosin-containing protein

Hotta, K., Nashimoto, A., Yasumura, E., Suzuki, M., Azuma, M., Iizumi, Y., Shima, D., Nabeshima, R., Hiramoto, M., Okada, A., Sakata-Sogawa, K., Tokunaga, M., Ito, T., Ando, H., Sakamoto, S., Kabe, Y., Aizawa, S., Imai, T., Yamaguchi, Y., Watanabe, H. & 1 others, Handa, H., 2013 May, In : Molecular Pharmacology. 83, 5, p. 930-938 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Vitamin K2 covalently binds to bak and induces bak-mediated apoptosiss

Karasawa, S., Azuma, M., Kasama, T., Sakamoto, S., Kabe, Y., Imai, T., Yamaguchi, Y., Miyazawa, K. & Handa, H., 2013 Mar 1, In : Molecular Pharmacology. 83, 3, p. 613-620 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2012

HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice

Nishiyama, Y., Goda, N., Kanai, M., Niwa, D., Osanai, K., Yamamoto, Y., Senoo-Matsuda, N., Johnson, R. S., Miura, S., Kabe, Y. & Suematsu, M., 2012 Feb, In : Journal of Hepatology. 56, 2, p. 441-447 7 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway

Morikawa, T., Kajimura, M., Nakamura, T., Hishiki, T., Nakanishi, T., Yukutake, Y., Nagahata, Y., Ishikawa, M., Hattori, K., Takenouchi, T., Takahashi, T., Ishii, I., Matsubara, K., Kabe, Y., Uchiyama, S., Nagata, E., Gadalla, M. M., Snyder, S. H. & Suematsu, M., 2012 Jan 24, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 4, p. 1293-1298 6 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)

Involvement of NF-κB-mediated expression of galectin-3- binding protein in TNF-α-induced breast cancer cell adhesion

Noma, N., Simizu, S., Kambayashi, Y., Kabe, Y., Suematsu, M. & Umezawa, K., 2012 Jun 1, In : Oncology reports. 27, 6, p. 2080-2084 5 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2010

Identification of dynamin-2-mediated endocytosis as a new target of osteoporosis drugs, bisphosphonates

Masaike, Y., Takagi, T., Hirota, M., Yamada, J., Ishihara, S., Yung, T. M. C., Inoue, T., Sawa, C., Sagara, H., Sakamoto, S., Kabe, Y., Takahashi, Y., Yamaguchi, Y. & Handa, H., 2010 Feb 1, In : Molecular Pharmacology. 77, 2, p. 262-269 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2009

Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus

Kuramori, C., Azuma, M., Kume, K., Kaneko, Y., Inoue, A., Yamaguchi, Y., Kabe, Y., Hosoya, T., Kizaki, M., Suematsu, M. & Handa, H., 2009 Feb 6, In : Biochemical and Biophysical Research Communications. 379, 2, p. 519-525 7 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Development and application of high-performance affinity beads: Toward chemical biology and drug discovery

Sakamoto, S., Kabe, Y., Hatakeyama, M., Yamaguchi, Y. & Handa, H., 2009 Mar 5, In : Chemical Record. 9, 1, p. 66-85 20 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Inhibitory effect of N,N-didesmethylgrossularine-1 on inflammatory cytokine production in lipopolysaccharide-stimulated RAW 264.7 cells

Oda, T., Lee, J. S., Sato, Y., Kabe, Y., Sakamoto, S., Handa, H., Mangindaan, R. E. P. & Namikoshi, M., 2009 Dec 1, In : Marine Drugs. 7, 4, p. 589-599 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis

Kuramori, C., Hase, Y., Hoshikawa, K., Watanabe, K., Nishi, T., Hishiki, T., Soga, T., Nashimoto, A., Kabe, Y., Yamaguchi, Y., Watanabe, H., Kataoka, K., Suematsu, M. & Handa, H., 2009 May 13, In : Toxicological Sciences. 109, 1, p. 143-151 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Preparation of conophylline affinity nano-beads and identification of a target protein

Suzuki, E., Ogura, H., Kato, K., Takei, I., Kabe, Y., Handa, H. & Umezawa, K., 2009 Sep 1, In : Bioorganic and Medicinal Chemistry. 17, 17, p. 6188-6195 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: therapeutic implications in tumor angiogenesis

Zou, G. M., Karikari, C., Kabe, Y., Handa, H., Anders, R. A. & Maitraz, A., 2009 Apr, In : Journal of Cellular Physiology. 219, 1, p. 209-218 10 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
2008

Adenine nucleotide translocator transports haem precursors into mitochondria

Azuma, M., Kabe, Y., Kuramori, C., Kondo, M., Yamaguchi, Y. & Handa, H., 2008 Aug 27, In : PloS one. 3, 8, e3070.

Research output: Contribution to journalArticle

42 Citations (Scopus)

A new APE1/Ref-1-dependent pathway leading to reduction of NF-κB and AP-1, and activation of their DNA-binding activity

Ando, K., Hirao, S., Kabe, Y., Ogura, Y., Sato, I., Yamaguchi, Y., Wada, T. & Handa, H., 2008 Aug, In : Nucleic acids research. 36, 13, p. 4327-4336 10 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)
15 Citations (Scopus)

Atrazine binds to F1F0-ATP synthase and inhibits mitochondrial function in sperm

Hase, Y., Tatsuno, M., Nishi, T., Kataoka, K., Kabe, Y., Yamaguchi, Y., Ozawa, N., Natori, M., Handa, H. & Watanabe, H., 2008 Feb 1, In : Biochemical and Biophysical Research Communications. 366, 1, p. 66-72 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Development of a chemical screening system using aqueorin-fused protein

Suzuki, M., Furukawa, S., Kuramori, C., Sawa, C., Kabe, Y., Nakamura, M., Sawada, J. I., Yamaguchi, Y., Sakamoto, S., Inouye, S. & Handa, H., 2008 Apr 11, In : Biochemical and Biophysical Research Communications. 368, 3, p. 600-605 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2007

hnRNP-U enhances the expression of specific genes by stabilizing mRNA

Yugami, M., Kabe, Y., Yamaguchi, Y., Wada, T. & Handa, H., 2007 Jan 9, In : FEBS Letters. 581, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Polymer particles as the carrier for affinity purification

Hatakeyama, M., Nishio, K., Nakamura, M., Sakamoto, S., Kabe, Y., Wada, T. & Handa, H., 2007 Jan 1, In : Kobunshi Ronbunshu. 64, 1, p. 9-20 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The Enteropathogenic E. coli Effector EspB Facilitates Microvillus Effacing and Antiphagocytosis by Inhibiting Myosin Function

Iizumi, Y., Sagara, H., Kabe, Y., Azuma, M., Kume, K., Ogawa, M., Nagai, T., Gillespie, P. G., Sasakawa, C. & Handa, H., 2007 Dec 13, In : Cell Host and Microbe. 2, 6, p. 383-392 10 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)
2006

Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier

Kabe, Y., Ohmori, M., Shinouchi, K., Tsuboi, Y., Hirao, S., Azuma, M., Watanabe, H., Okura, I. & Handa, H., 2006 Oct 20, In : Journal of Biological Chemistry. 281, 42, p. 31729-31735 7 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

TFII-I down-regulates a subset of estrogen-responsive genes through its interaction with an initiator element and estrogen receptor α

Ogura, Y., Azuma, M., Tsuboi, Y., Kabe, Y., Yamaguchi, Y., Wada, T., Watanabe, H. & Handa, H., 2006 Apr 1, In : Genes to Cells. 11, 4, p. 373-381 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2005

GABP, HCF-1 and YY1 are involved in Rb gene expression during myogenesis

Deléhouzée, S., Yoshikawa, T., Sawa, C., Sawada, J. I., Ito, T., Omori, M., Wada, T., Yamaguchi, Y., Kabe, Y. & Handa, H., 2005 Jul 1, In : Genes to Cells. 10, 7, p. 717-731 15 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes

Kabe, Y., Yamada, J., Uga, H., Yamaguchi, Y., Wada, T. & Handa, H., 2005 Jan, In : Molecular and cellular biology. 25, 1, p. 512-522 11 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
2004

Design and synthesis of a solid-supported FR225659 derivative for its receptor screening

Zenkoh, T., Hatori, H., Tanaka, H., Hasegawa, M., Hatakeyama, M., Kabe, Y., Setoi, H., Kawaguchi, H., Handa, H. & Takahashi, T., 2004 Jul 8, In : Organic Letters. 6, 14, p. 2477-2480 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Screening of drug target receptor by using nanotechnology

Hatakeyama, M., Kabe, Y. & Handa, H., 2004, In : Drug Delivery System. 19, 2, p. 127-132 6 p.

Research output: Contribution to journalArticle

1999

Identification of the core domain and the secondary structure of the transcriptional coactivator MBF-1

Ozaki, J., Takemaru, K. I., Ikegami, T., Mishima, M., Ueda, H., Hirose, S., Kabe, Y., Handa, H. & Shirakawa, M., 1999 Sep 6, In : Genes to Cells. 4, 7, p. 415-424 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Resonance assignments, secondary structure and 15N relaxation data of the human transcriptional coactivator hMBF1 (57-148)

Mishima, M., Ozaki, J., Ikegami, T., Kabe, Y., Goto, M., Ueda, H., Hirose, S., Handa, H. & Shirakawa, M., 1999 Oct 18, In : Journal of Biomolecular NMR. 14, 4, p. 373-376 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The role of human MBF1 as a transcriptional coactivator

Kabe, Y., Goto, M., Shima, D., Imai, T., Wada, T., Morohashi, K. I., Shirakawa, M., Hirose, S. & Handa, H., 1999 Nov 26, In : Journal of Biological Chemistry. 274, 48, p. 34196-34202 7 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)
1998

(+)-Rhododendrol and epi-rhododendrin suppress the no production by activated macrophages in vivo

Fushiya, S., Kabe, Y., Ikegaya, Y. & Takano, F., 1998 Nov 2, In : Planta Medica. 64, 7, p. 598-602 5 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)