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Research Output 2001 2019

  • 1333 Citations
  • 23 h-Index
  • 39 Article
  • 2 Review article
2019
1 Citation (Scopus)

Distinct roles of α7 nAChRs in antigen-presenting cells and CD4+ T cells in the regulation of T cell differentiation

Mashimo, M., Komori, M., Matsui, Y. Y., Murase, M. X., Fujii, T., Takeshima, S., Okuyama, H., Ono, S., Moriwaki, Y., Misawa, H. & Kawashima, K., 2019 Jan 1, In : Frontiers in Immunology. 10, MAY, 1102.

Research output: Contribution to journalArticle

Open Access
Nicotinic Receptors
Antigen-Presenting Cells
Cell Differentiation
T-Lymphocytes
Ovalbumin
2018
1 Citation (Scopus)

Identification of mesothelioma-specific sialylated epitope recognized with monoclonal antibody SKM9-2 in a mucin-like membrane protein HEG1

Matsuura, R., Kaji, H., Tomioka, A., Sato, T., Narimatsu, H., Moriwaki, Y., Misawa, H., Imai, K. & Tsuji, S., 2018 Dec 1, In : Scientific Reports. 8, 1, 14251.

Research output: Contribution to journalArticle

Mesothelioma
Mucins
Epitopes
Membrane Proteins
Monoclonal Antibodies
7 Citations (Scopus)

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes

Komine, O., Yamashita, H., Fujimori-Tonou, N., Koike, M., Jin, S., Moriwaki, Y., Endo, F., Watanabe, S., Uematsu, S., Akira, S., Uchiyama, Y., Takahashi, R., Misawa, H. & Yamanaka, K., 2018 Mar 22, (Accepted/In press) In : Cell Death and Differentiation. p. 1-17 17 p.

Research output: Contribution to journalArticle

Deficiency Diseases
Amyotrophic Lateral Sclerosis
Astrocytes
Disease Progression
Myeloid Differentiation Factor 88

SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes

Moriwaki, Y., Ohno, Y., Ishii, T., Takamura, Y., Kita, Y., Watabe, K., Sango, K., Tsuji, S. & Misawa, H., 2018 Jun 1, In : PLoS One. 13, 6, e0199829.

Research output: Contribution to journalArticle

trans-Golgi Network
endosomes
protein transport
Endosomes
lysosomes
2017
3 Citations (Scopus)

Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis

Watanabe-Matsumoto, S., Moriwaki, Y., Okuda, T., Ohara, S., Yamanaka, K., Abe, Y., Yasui, M. & Misawa, H., 2017 Jan 1, (Accepted/In press) In : Neuroscience Research.

Research output: Contribution to journalArticle

Aquaporin 4
Amyotrophic Lateral Sclerosis
Blood-Brain Barrier
Motor Neuron Disease
Gliosis
41 Citations (Scopus)

Expression and function of the cholinergic system in immune cells

Fujii, T., Mashimo, M., Moriwaki, Y., Misawa, H., Ono, S., Horiguchi, K. & Kawashima, K., 2017 Sep 6, In : Frontiers in Immunology. 8, SEP, 1085.

Research output: Contribution to journalReview article

Cholinergic Agents
Immune System
Spleen
Choline O-Acetyltransferase
Acetylcholine
12 Citations (Scopus)

HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma

Tsuji, S., Washimi, K., Kageyama, T., Yamashita, M., Yoshihara, M., Matsuura, R., Yokose, T., Kameda, Y., Hayashi, H., Morohoshi, T., Tsuura, Y., Yusa, T., Sato, T., Togayachi, A., Narimatsu, H., Nagasaki, T., Nakamoto, K., Moriwaki, Y., Misawa, H., Hiroshima, K. & 2 others, Miyagi, Y. & Imai, K., 2017 Mar 31, In : Scientific Reports. 7, 45768.

Research output: Contribution to journalArticle

Mucins
Membrane Proteins
Therapeutics
Mesothelioma
Gene Silencing
41 Citations (Scopus)

Physiological functions of the cholinergic system in immune cells

Fujii, T., Mashimo, M., Moriwaki, Y., Misawa, H., Ono, S., Horiguchi, K. & Kawashima, K., 2017 May 1, In : Journal of Pharmacological Sciences. 134, 1, p. 1-21 21 p.

Research output: Contribution to journalReview article

Cholinergic Agents
Immune System
Choline O-Acetyltransferase
Dendritic Cells
T-Lymphocytes
2016
3 Citations (Scopus)

A bis-malonic acid fullerene derivative significantly suppressed IL-33-induced IL-6 expression by inhibiting NF-κB activation

Tago, M., Miyagawa, Y., Ueda, F., Mashino, T., Moriwaki, Y., Tago, K., Kasahara, T. & Tamura, H., 2016 Nov 1, In : International Immunopharmacology. 40, p. 254-264 11 p.

Research output: Contribution to journalArticle

Fullerenes
Interleukin-6
Mast Cells
malonic acid
Interleukin-33
1 Citation (Scopus)

Reappraisal of VAChT-Cre: Preference in slow motor neurons innervating type I or IIa muscle fibers

Misawa, H., Inomata, D., Kikuchi, M., Maruyama, S., Moriwaki, Y., Okuda, T., Nukina, N. & Yamanaka, T., 2016, (Accepted/In press) In : Genesis.

Research output: Contribution to journalArticle

Motor Neurons
Muscles
Fatigue
Fluorescence
Presynaptic Terminals
19 Citations (Scopus)

Selective expression of osteopontin in ALS-resistant motor neurons is a critical determinant of late phase neurodegeneration mediated by matrix metalloproteinase-9

Morisaki, Y., Niikura, M., Watanabe, M., Onishi, K., Tanabe, S., Moriwaki, Y., Okuda, T., Ohara, S., Murayama, S., Takao, M., Uchida, S., Yamanaka, K. & Misawa, H., 2016 Jun 6, In : Scientific Reports. 6, 27354.

Research output: Contribution to journalArticle

Osteopontin
Matrix Metalloproteinase 9
Amyotrophic Lateral Sclerosis
Motor Neurons
Fatigue
2015
14 Citations (Scopus)

IL-22/STAT3-induced increases in SLURP1 expression within psoriatic lesions exerts antimicrobial effects against Staphylococcus aureus

Moriwaki, Y., Takada, K., Nagasaki, T., Kubo, N., Ishii, T., Kose, K., Kageyama, T., Tsuji, S., Kawashima, K. & Misawa, H., 2015 Oct 16, In : PLoS One. 10, 10, 140750.

Research output: Contribution to journalArticle

psoriasis
keratinocytes
anti-infective properties
Keratinocytes
Psoriasis
36 Citations (Scopus)

Non-neuronal cholinergic system in regulation of immune function with a focus on α7 nAChRs

Kawashima, K., Fujii, T., Moriwaki, Y., Misawa, H. & Horiguchi, K., 2015 Feb 8, In : International Immunopharmacology. 29, 1, p. 127-134 8 p.

Research output: Contribution to journalArticle

Acetylcholine
T-Lymphocytes
Choline O-Acetyltransferase
Dendritic Cells
B-Lymphocytes
9 Citations (Scopus)
Nested Genes
Keratinocytes
Psoriasis
Skin
Genes
2014
24 Citations (Scopus)

SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205+ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity

Fujii, T., Horiguchi, K., Sunaga, H., Moriwaki, Y., Misawa, H., Kasahara, T., Tsuji, S. & Kawashima, K., 2014, In : Journal of Neuroimmunology. 267, 1-2, p. 43-49 7 p.

Research output: Contribution to journalArticle

Palatine Tonsil
Nicotinic Receptors
Cholinergic Receptors
Dendritic Cells
Cholinergic Agents
26 Citations (Scopus)

T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation

Inoue, M., Arikawa, T., Chen, Y. H., Moriwaki, Y., Price, M., Brown, M., Perfect, J. R. & Shinohara, M. L., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 14, p. 5295-5300 6 p.

Research output: Contribution to journalArticle

Interleukin-1 Receptor-Associated Kinases
Interleukin-10
Endotoxemia
Down-Regulation
Macrophages
2013
10 Citations (Scopus)

Effect of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1) on airway epithelial cells

Narumoto, O., Niikura, Y., Ishii, S., Morihara, H., Okashiro, S., Nakahari, T., Nakano, T., Matsumura, H., Shimamoto, C., Moriwaki, Y., Misawa, H., Yamashita, N., Nagase, T., Kawashima, K. & Yamashita, N., 2013 Aug 16, In : Biochemical and Biophysical Research Communications. 438, 1, p. 175-179 5 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Lymphocytes
Nicotinic Receptors
Epithelial Cells
Antigens
2012
89 Citations (Scopus)

Critical roles of acetylcholine and the muscarinic and nicotinic acetylcholine receptors in the regulation of immune function

Kawashima, K., Fujii, T., Moriwaki, Y. & Misawa, H., 2012 Nov 27, In : Life Sciences. 91, 21-22, p. 1027-1032 6 p.

Research output: Contribution to journalArticle

T-cells
Ovalbumin
Nicotinic Receptors
Muscarinic Receptors
Acetylcholine
13 Citations (Scopus)

Localization of acetylcholine-related molecules in the retina: Implication of the communication from photoreceptor to retinal pigment epithelium

Matsumoto, H., Shibasaki, K., Uchigashima, M., Koizumi, A., Kurachi, M., Moriwaki, Y., Misawa, H., Kawashima, K., Watanabe, M., Kishi, S. & Ishizaki, Y., 2012 Aug 3, In : PLoS One. 7, 8, e42841.

Research output: Contribution to journalArticle

Retinal Pigments
Retinal Pigment Epithelium
acetylcholine
photoreceptors
retina
16 Citations (Scopus)

Osteopontin is an alpha motor neuron marker in the mouse spinal cord

Misawa, H., Hara, M., Tanabe, S., Niikura, M., Moriwaki, Y. & Okuda, T., 2012 Apr, In : Journal of Neuroscience Research. 90, 4, p. 732-742 11 p.

Research output: Contribution to journalArticle

Osteopontin
Motor Neurons
Spinal Cord
Choline O-Acetyltransferase
Carisoprodol
51 Citations (Scopus)

Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function

Kawashima, K., Fujii, T., Moriwaki, Y., Misawa, H. & Horiguchi, K., 2012 Jul, In : Annals of the New York Academy of Sciences. 1261, 1, p. 7-17 11 p.

Research output: Contribution to journalArticle

T-cells
Acetylcholine
T-Lymphocytes
Choline O-Acetyltransferase
Lymphocytes
24 Citations (Scopus)

α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion

Yamakado, H., Moriwaki, Y., Yamasaki, N., Miyakawa, T., Kurisu, J., Uemura, K., Inoue, H., Takahashi, M. & Takahashi, R., 2012 Jun, In : Neuroscience Research. 73, 2, p. 173-177 5 p.

Research output: Contribution to journalArticle

Synucleins
Bacterial Artificial Chromosomes
Transgenic Mice
Parkinson Disease
Anxiety
2011
24 Citations (Scopus)

Cutting edge: Critical role of intracellular osteopontin in antifungal innate immune responses

Inoue, M., Moriwaki, Y., Arikawa, T., Chen, Y. H., Oh, Y. J., Oliver, T. & Shinohara, M. L., 2011 Jan 1, In : Journal of Immunology. 186, 1, p. 19-23 5 p.

Research output: Contribution to journalArticle

Osteopontin
Pneumocystis
Innate Immunity
Protein Isoforms
Toll-Like Receptor 2
2010
15 Citations (Scopus)

Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allosteric α7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditions

Narumoto, O., Horiguchi, K., Horiguchi, S., Moriwaki, Y., Takano-Ohmuro, H., Shoji, S., Misawa, H., Yamashita, N., Nagase, T., Kawashima, K. & Yamashita, N., 2010 Aug, In : Biochemical and Biophysical Research Communications. 398, 4, p. 713-718 6 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Lymphocytes
Nicotinic Receptors
Modulators
Down-Regulation
52 Citations (Scopus)

The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila

Imai, Y., Kanao, T., Sawada, T., Kobayashi, Y., Moriwaki, Y., Ishida, Y., Takeda, K., Ichijo, H., Lu, B. & Takahashi, R., 2010 Dec, In : PLoS Genetics. 6, 12, p. 1-14 14 p., e1001229.

Research output: Contribution to journalArticle

Drosophila
inactivation
phosphotransferases (kinases)
Phosphotransferases
protein
2009
15 Citations (Scopus)

Acetylcholine synthesis and release in NIH3T3 cells coexpressing the high-affinity choline transporter and choline acetyltransferase

Fujii, T., Masai, M., Misawa, H., Okuda, T., Takada-Takatori, Y., Moriwaki, Y., Haga, T. & Kawashima, K., 2009 Oct, In : Journal of Neuroscience Research. 87, 13, p. 3024-3032 9 p.

Research output: Contribution to journalArticle

Choline O-Acetyltransferase
Acetylcholine
Choline
Hemicholinium 3
Cholinergic Neurons
32 Citations (Scopus)

Expression of SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, in murine bronchial epithelial cells

Horiguchi, K., Horiguchi, S., Yamashita, N., Irie, K., Masuda, J., Takano-Ohmuro, H., Himi, T., Miyazawa, M., Moriwaki, Y., Okuda, T., Misawa, H., Ozaki, H. & Kawashima, K., 2009 Sep, In : Journal of Neuroscience Research. 87, 12, p. 2740-2747 8 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Epithelial Cells
Ligands
Macrophages
Palmoplantar Keratoderma
42 Citations (Scopus)

Primary sensory neuronal expression of SLURP-1, an endogenous nicotinic acetylcholine receptor ligand

Moriwaki, Y., Watanabe, Y., Shinagawa, T., Kai, M., Miyazawa, M., Okuda, T., Kawashima, K., Yabashi, A., Waguri, S. & Misawa, H., 2009 Aug, In : Neuroscience Research. 64, 4, p. 403-412 10 p.

Research output: Contribution to journalArticle

Urokinase Plasminogen Activator Receptors
Nicotinic Receptors
Ligands
Proteins
Calcitonin Gene-Related Peptide
2008
9 Citations (Scopus)

Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice

Misawa, H., Fujigaya, H., Nishimura, T., Moriwaki, Y., Okuda, T., Kawashima, K., Nakata, K., Ruggiero, A. M., Blakely, R. D., Nakatsu, F. & Ohno, H., 2008 Jun, In : European Journal of Neuroscience. 27, 12, p. 3109-3117 9 p.

Research output: Contribution to journalArticle

Proteins
Synaptic Vesicles
Presynaptic Terminals
choline transporter
Synaptophysin
56 Citations (Scopus)

L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner

Moriwaki, Y., Kim, Y. J., Ido, Y., Misawa, H., Kawashima, K., Endo, S. & Takahashi, R., 2008 May, In : Neuroscience Research. 61, 1, p. 43-48 6 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Phosphotransferases
Novobiocin
Molecular Chaperones
Protein-Serine-Threonine Kinases
2007
32 Citations (Scopus)

Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice

Fujii, Y. X., Tashiro, A., Arimoto, K., Fujigaya, H., Moriwaki, Y., Misawa, H., Fujii, T., Matsui, M., Kasahara, T. & Kawashima, K., 2007 Aug, In : Journal of Neuroimmunology. 188, 1-2, p. 80-85 6 p.

Research output: Contribution to journalArticle

Muscarinic Receptors
Acetylcholinesterase
Knockout Mice
Interleukin-6
Ovalbumin
55 Citations (Scopus)

Enhanced serum antigen-specific IgG1 and proinflammatory cytokine production in nicotinic acetylcholine receptor α7 subunit gene knockout mice

Fujii, Y. X., Fujigaya, H., Moriwaki, Y., Misawa, H., Kasahara, T., Grando, S. A. & Kawashima, K., 2007 Sep, In : Journal of Neuroimmunology. 189, 1-2, p. 69-74 6 p.

Research output: Contribution to journalArticle

Gene Knockout Techniques
Nicotinic Receptors
Knockout Mice
Immunoglobulin G
Cytokines
140 Citations (Scopus)

Expression and function of genes encoding cholinergic components in murine immune cells

Kawashima, K., Yoshikawa, K., Fujii, Y. X., Moriwaki, Y. & Misawa, H., 2007 May 30, In : Life Sciences. 80, 24-25, p. 2314-2319 6 p.

Research output: Contribution to journalArticle

Gene encoding
Mononuclear Leukocytes
Dendritic Cells
Cholinergic Agents
Macrophages
65 Citations (Scopus)

Immune system expression of SLURP-1 and SLURP-2, two endogenous nicotinic acetylcholine receptor ligands

Moriwaki, Y., Yoshikawa, K., Fukuda, H., Fujii, Y. X., Misawa, H. & Kawashima, K., 2007 May 30, In : Life Sciences. 80, 24-25, p. 2365-2368 4 p.

Research output: Contribution to journalArticle

Immune system
Nicotinic Receptors
Acetylcholine
Immune System
Ligands
27 Citations (Scopus)

PINK1, a gene product of PARK6, accumulates in α-synucleinopathy brains [3]

Murakami, T., Moriwaki, Y., Kawarabayashi, T., Nagai, M., Ohta, Y., Deguchi, K., Kurata, T., Morimoto, N., Takehisa, Y., Matsubara, E., Ikeda, M., Harigaya, Y., Shoji, M., Takahashi, R. & Abe, K., 2007 Jun, In : Journal of Neurology, Neurosurgery and Psychiatry. 78, 6, p. 653-655 3 p.

Research output: Contribution to journalArticle

Multiple System Atrophy
Lewy Bodies
Lewy Body Disease
alpha-Synuclein
Inclusion Bodies
5 Citations (Scopus)

Production and regulation of eotaxin-2/CCL24 in a differentiated human leukemic cell line, HT93

Yoshida, N., Yokota, E., Sonoda, Y., Moriwaki, Y., Kishi, K. & Kasahara, T., 2007 Oct, In : Biological and Pharmaceutical Bulletin. 30, 10, p. 1826-1832 7 p.

Research output: Contribution to journalArticle

Chemokine CCL24
Tretinoin
Cell Line
Interleukin-5
Chemokine CCL11
50 Citations (Scopus)

Ubiquitous expression of acetylcholine and its biological functions in life forms without nervous systems

Kawashima, K., Misawa, H., Moriwaki, Y., Fujii, Y. X., Fujii, T., Horiuchi, Y., Yamada, T., Imanaka, T. & Kamekura, M., 2007 May 30, In : Life Sciences. 80, 24-25, p. 2206-2209 4 p.

Research output: Contribution to journalArticle

Neurology
Nervous System
Acetylcholine
Bamboo
Shiitake Mushrooms
2006
40 Citations (Scopus)

Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals

Misawa, H., Nakata, K., Matsuura, J., Moriwaki, Y., Kawashima, K., Shimizu, T., Shirasawa, T. & Takahashi, R., 2006 Jul, In : Neurobiology of Disease. 23, 1, p. 169-177 9 p.

Research output: Contribution to journalArticle

Motor Neurons
Superoxides
Superoxide Dismutase
Axons
Neurons
2004
60 Citations (Scopus)

Mycobacterium bovis BCG Cell Wall-Specific Differentially Expressed Genes Identified by Differential Display and cDNA Subtraction in Human Macrophages

Begum, N. A., Ishii, K., Kurita-Taniguchi, M., Tanabe, M., Kobayashi, M., Moriwaki, Y., Matsumoto, M., Fukumori, Y., Azuma, I., Toyoshima, K. & Seya, T., 2004 Feb, In : Infection and Immunity. 72, 2, p. 937-948 12 p.

Research output: Contribution to journalArticle

Cell Wall Skeleton
Mycobacterium bovis
Cell Wall
Complementary DNA
Macrophages
2002
99 Citations (Scopus)

Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: Identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures

Begum, N. A., Kobayashi, M., Moriwaki, Y., Matsumoto, M., Toyoshima, K. & Seya, T., 2002, In : Genomics. 80, 6, p. 630-645 16 p.

Research output: Contribution to journalArticle

Metalloproteases
Mycobacterium bovis
Cell Wall
Lipopolysaccharides
Genes
2001
74 Citations (Scopus)
Lysosome-Associated Membrane Glycoproteins
Endosomes
p53 Genes
Bacilli
Mycobacterium bovis