• 4103 Citations
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20022020

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Article
2020

FOXO1 regulates developmental lymphangiogenesis by upregulating CXCR4 in the mouse-tail dermis

Niimi, K., Kohara, M., Sedoh, E., Fukumoto, M., Shibata, S., Sawano, T., Tashiro, F., Miyazaki, S., Kubota, Y., Miyazaki, J. I., Inagaki, S. & Furuyama, T., 2020, In : Development (Cambridge). 147, 2, dev181545.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Macrophages fine-tune pupil shape during development

Takahashi, M., Misaki, M., Shibata, S., Iga, T., Shindo, T., Tai-Nagara, I., Hirata, A., Ogawa, M., Miyamoto, T., Nakagawa, T., Ema, M., Ichiyama, Y., Shima, D. T., Hozumi, K., Nishimura, S. & Kubota, Y., 2020 Aug 15, In : Developmental Biology. 464, 2, p. 137-144 8 p.

Research output: Contribution to journalArticle

Open Access

Neuron-derived VEGF contributes to cortical and hippocampal development independently of VEGFR1/2-mediated neurotrophism

Okabe, K., Fukada, H., Tai-Nagara, I., Ando, T., Honda, T., Nakajima, K., Takeda, N., Fong, G. H., Ema, M. & Kubota, Y., 2020 Mar 15, In : Developmental Biology. 459, 2, p. 65-71 7 p.

Research output: Contribution to journalArticle

Open Access
2019

Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model

Ono, S., Egawa, G., Nomura, T., Kitoh, A., Dainichi, T., Otsuka, A., Nakajima, S., Amagai, M., Matsumoto, F., Yamamoto, M., Kubota, Y., Takai, T., Honda, T. & Kabashima, K., 2019 Dec 1, In : Nature communications. 10, 1, 4432.

Research output: Contribution to journalArticle

Open Access

A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis

Kim, Y. H., Choi, J., Yang, M. J., Hong, S. P., Lee, C. K., Kubota, Y., Lim, D. S. & Koh, G. Y., 2019 Dec 1, In : Nature communications. 10, 1, 838.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver

Ueda, T., Yokota, T., Okuzaki, D., Uno, Y., Mashimo, T., Kubota, Y., Sudo, T., Ishibashi, T., Shingai, Y., Doi, Y., Ozawa, T., Nakai, R., Tanimura, A., Ichii, M., Ezoe, S., Shibayama, H., Oritani, K. & Kanakura, Y., 2019 Dec 10, In : Stem cell reports. 13, 6, p. 992-1005 14 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis

Zahra, F. T., Sajib, M. S., Ichiyama, Y., Akwii, R. G., Tullar, P. E., Cobos, C., Minchew, S. A., Doçi, C. L., Zheng, Y., Kubota, Y., Gutkind, J. S. & Mikelis, C. M., 2019 Dec 1, In : Scientific reports. 9, 1, 11666.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Endothelial specific deletion of FOXO1 alters pericyte coverage in the developing retina

Niimi, K., Adachi, Y., Ishikawa, H., Yamaguchi, W., Kubota, Y., Inagaki, S. & Furuyama, T., 2019 Dec 3, In : Biochemical and Biophysical Research Communications. 520, 2, p. 304-310 7 p.

Research output: Contribution to journalArticle

p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia

Yokoyama, M., Shimizu, I., Nagasawa, A., Yoshida, Y., Katsuumi, G., Wakasugi, T., Hayashi, Y., Ikegami, R., Suda, M., Ota, Y., Okada, S., Fruttiger, M., Kobayashi, Y., Tsuchida, M., Kubota, Y. & Minamino, T., 2019 Apr 1, In : Journal of Molecular and Cellular Cardiology. 129, p. 105-117 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity

Naito, H., Iba, T., Wakabayashi, T., Tai-Nagara, I., Suehiro, J. I., Jia, W., Eino, D., Sakimoto, S., Muramatsu, F., Kidoya, H., Sakurai, H., Satoh, T., Akira, S., Kubota, Y. & Takakura, N., 2019 Jan 28, In : Developmental Cell. 48, 2, p. 151-166.e7

Research output: Contribution to journalArticle

5 Citations (Scopus)

Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

Kim, J., Park, J. R., Choi, J., Park, I., Hwang, Y., Bae, H., Kim, Y., Choi, W. J., Yang, J. M., Han, S., Chung, T. Y., Kim, P., Kubota, Y., Augustin, H. G., Oh, W. Y. & Koh, G. Y., 2019 Feb 13, In : Science Advances. 5, 2, eaau6732.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2018

Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction

Lee, S. J., Lee, C. K., Kang, S., Park, I., Kim, Y. H., Kim, S. K., Hong, S. P., Bae, H., He, Y., Kubota, Y. & Koh, G. Y., 2018 Nov 1, In : Journal of Clinical Investigation. 128, 11, p. 5018-5033 16 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Distinct expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after myocardial infarction

Kurotsu, S., Osakabe, R., Isomi, M., Tamura, F., Sadahiro, T., Muraoka, N., Kojima, H., Haginiwa, S., Tani, H., Nara, K., Kubota, Y., Ema, M., Fukuda, K., Suzuki, T. & Ieda, M., 2018 Jan 1, In : Biochemical and Biophysical Research Communications. 495, 1, p. 884-891 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells

Si, S., Nakajima-Takagi, Y., Iga, T., Tsuji, M., Hou, L., Oshima, M., Koide, S., Saraya, A., Yamazaki, S., Takubo, K., Kubota, Y., Minamino, T. & Iwama, A., 2018 Jul 1, In : Experimental Hematology. 63, p. 41-51.e1

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma

Kim, J., Park, D. Y., Bae, H., Park, D. Y., Kim, D., Lee, C. K., Song, S., Chung, T. Y., Lim, D. H., Kubota, Y., Hong, Y. K., He, Y., Augustin, H. G., Oliver, G. & Koh, G. Y., 2017 Oct 2, In : Journal of Clinical Investigation. 127, 10, p. 3877-3896 20 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling

Tai-Nagara, I., Yoshikawa, Y., Numata, N., Ando, T., Okabe, K., Sugiura, Y., Ieda, M., Takakura, N., Nakagawa, O., Zhou, B., Okabayashi, K., Suematsu, M., Kitagawa, Y., Bastmeyer, M., Sato, K., Klein, R., Navankasattusas, S., Li, D. Y., Yamagishi, S. & Kubota, Y., 2017, In : Development (Cambridge). 144, 13, p. 2392-2401 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Plastic roles of pericytes in the blood-retinal barrier

Park, D. Y., Lee, J., Kim, J., Kim, K., Hong, S., Han, S., Kubota, Y., Augustin, H. G., Ding, L., Kim, J. W., Kim, H., He, Y., Adams, R. H. & Koh, G. Y., 2017 May 16, In : Nature communications. 8, 15296.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature

Yamazaki, T., Nalbandian, A., Uchida, Y., Li, W., Arnold, T. D., Kubota, Y., Yamamoto, S., Ema, M. & Mukouyama, Y. S., 2017 Mar 21, In : Cell Reports. 18, 12, p. 2991-3004 14 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Transplanted mesenchymal stem cells are effective for skin regeneration in acute cutaneous wounds of pigs

Ochiai, H., Kishi, K., Kubota, Y., Oka, A., Hirata, E., Yabuki, H., Iso, Y., Suzuki, H. & Umezawa, A., 2017 Dec 1, In : Regenerative Therapy. 7, p. 8-16 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis

Jang, J. Y., Choi, S. Y., Park, I., Park, D. Y., Choe, K., Kim, P., Kim, Y. K., Lee, B. J., Hirashima, M., Kubota, Y., Park, J. W., Cheng, S. Y., Nagy, A., Park, Y. J., Alitalo, K., Shong, M. & Koh, G. Y., 2017 Jun, In : EMBO Molecular Medicine. 9, 6, p. 750-769 20 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

Kim, J., Kim, Y. H., Kim, J., Park, D. Y., Bae, H., Lee, D. H., Kim, K. H., Hong, S. P., Jang, S. P., Kubota, Y., Kwon, Y. G., Lim, D. S. & Koh, G. Y., 2017 Sep 1, In : Journal of Clinical Investigation. 127, 9, p. 3441-3461 21 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)
2016

Developmental regression of hyaloid vasculature is triggered by neurons

Yoshikawa, Y., Yamada, T., Tai-Nagara, I., Okabe, K., Kitagawa, Y., Ema, M. & Kubota, Y., 2016 Jun 27, In : Journal of Experimental Medicine. 213, 7, p. 1175-1183 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress

Karigane, D., Kobayashi, H., Morikawa, T., Ootomo, Y., Sakai, M., Nagamatsu, G., Kubota, Y., Goda, N., Matsumoto, M., Nishimura, E. K., Soga, T., Otsu, K., Suematsu, M., Okamoto, S., Suda, T. & Takubo, K., 2016 Aug 4, In : Cell stem cell. 19, 2, p. 192-204 13 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

SoxF Transcription Factors Are Positive Feedback Regulators of VEGF Signaling

Kim, K., Kim, I. K., Yang, J. M., Lee, E., Koh, B. I., Song, S., Park, J., Lee, S., Choi, C., Kim, J. W., Kubota, Y., Koh, G. Y. & Kim, I., 2016 Sep 16, In : Circulation research. 119, 7, p. 839-852 14 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

The P2X4 receptor is required for neuroprotection via ischemic preconditioning

Ozaki, T., Muramatsu, R., Sasai, M., Yamamoto, M., Kubota, Y., Fujinaka, T., Yoshimine, T. & Yamashita, T., 2016 May 13, In : Scientific reports. 6, 25893.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2015

Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus

Matsuo, K., Kuroda, Y., Nango, N., Shimoda, K., Kubota, Y., Ema, M., Bakiri, L., Wagner, E. F., Takeda, Y., Yashiro, W. & Momose, A., 2015 Nov 15, In : Development (Cambridge). 142, 22, p. 3912-3920 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion

Hong, K. Y., Bae, H., Park, I., Park, D. Y., Kim, K. H., Kubota, Y., Cho, E. S., Kim, H., Adams, R. H., Yoo, O. J. & Koh, G. Y., 2015 Aug 1, In : Development (Cambridge). 142, 15, p. 2623-2632 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

VEGFR3 does not sustain retinal angiogenesis without VEGFR2

Zarkada, G., Heinolainen, K., Makinen, T., Kubota, Y. & Alitalo, K., 2015 Jan 20, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 3, p. 761-766 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
2014

Neurons limit angiogenesis by titrating VEGF in retina

Okabe, K., Kobayashi, S., Yamada, T., Kurihara, T., Tai-Nagara, I., Miyamoto, T., Mukouyama, Y. S., Sato, T. N., Suda, T., Ema, M. & Kubota, Y., 2014 Oct 23, In : Cell. 159, 3, p. 584-596 13 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)
2013

Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells

Ikushima, Y. M., Arai, F., Nakamura, Y., Hosokawa, K., Kubota, Y., Hirashima, M., Toyama, H. & Suda, T., 2013 Jan 4, In : Biochemical and Biophysical Research Communications. 430, 1, p. 20-25 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2012

Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration

Nakamura-Ishizu, A., Okuno, Y., Omatsu, Y., Okabe, K., Morimoto, J., Uede, T., Nagasawa, T., Suda, T. & Kubota, Y., 2012 Jun 7, In : Blood. 119, 23, p. 5429-5437 9 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice

Sano, K., Katsuta, O., Shirae, S., Kubota, Y., Ema, M., Suda, T., Nakamura, M. & Hirashima, M., 2012 Apr 6, In : Biochemical and Biophysical Research Communications. 420, 2, p. 422-427 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Genome-wide identification of endothelial cell-enriched genes in the mouse embryo

Takase, H., Matsumoto, K., Yamadera, R., Kubota, Y., Otsu, A., Suzuki, R., Ishitobi, H., Mochizuki, H., Kojima, T., Takano, S., Uchida, K., Takahashi, S. & Ema, M., 2012 Jul 26, In : Blood. 120, 4, p. 914-923 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Pathological neoangiogenesis depends on oxidative stress regulation by ATM

Okuno, Y., Nakamura-Ishizu, A., Otsu, K., Suda, T. & Kubota, Y., 2012 Aug 1, In : Nature medicine. 18, 8, p. 1208-1216 9 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner

Nakamura-Ishizu, A., Kurihara, T., Okuno, Y., Ozawa, Y., Kishi, K., Goda, N., Tsubota, K., Okano, H., Suda, T. & Kubota, Y., 2012 Mar 1, In : Developmental Biology. 363, 1, p. 106-114 9 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2011

Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing

Okuno, Y., Nakamura-Ishizu, A., Kishi, K., Suda, T. & Kubota, Y., 2011 May 12, In : Blood. 117, 19, p. 5264-5272 9 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero

Kubota, Y., Takubo, K., Hirashima, M., Nagoshi, N., Kishi, K., Okuno, Y., Nakamura-Ishizu, A., Sano, K., Murakami, M., Ema, M., Omatsu, Y., Takahashi, S., Nagasawa, T., Shibuya, M., Okano, H. & Suda, T., 2011 May 1, In : Journal of Experimental Medicine. 208, 5, p. 949-960 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2010

Distribution of adipose-derived stem cells in adipose tissues from human cadavers

Kishi, K., Imanishi, N., Ohara, H., Ninomiya, R., Okabe, K., Hattori, N., Kubota, Y., Nakajima, H. & Nakajima, T., 2010 Oct 1, In : Journal of Plastic, Reconstructive and Aesthetic Surgery. 63, 10, p. 1717-1722 6 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver

Iwasaki, H., Arai, F., Kubota, Y., Dahl, M. & Suda, T., 2010 Jul 29, In : Blood. 116, 4, p. 544-553 10 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Regulation of the HIF-1α level is essential for hematopoietic stem cells

Takubo, K., Goda, N., Yamada, W., Iriuchishima, H., Ikeda, E., Kubota, Y., Shima, H., Johnson, R. S., Hirao, A., Suematsu, M. & Suda, T., 2010 Sep 3, In : Cell stem cell. 7, 3, p. 391-402 12 p.

Research output: Contribution to journalArticle

527 Citations (Scopus)

Von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina

Kurihara, T., Kubota, Y., Ozawa, Y., Takubo, K., Noda, K., Simon, M. C., Johnson, R. S., Suematsu, M., Tsubota, K., Ishida, S., Goda, N., Suda, T. & Okano, H., 2010 May 1, In : Development. 137, 9, p. 1563-1571 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2009

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

Kubota, Y., Takubo, K., Shimizu, T., Ohno, H., Kishi, K., Shibuya, M., Saya, H. & Suda, T., 2009 May 11, In : Journal of Experimental Medicine. 206, 5, p. 1089-1102 14 p.

Research output: Contribution to journalArticle

246 Citations (Scopus)

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

Morikawa, S., Mabuchi, Y., Kubota, Y., Nagai, Y., Niibe, K., Hiratsu, E., Suzuki, S., Miyauchi-Hara, C., Nagoshi, N., Sunabori, T., Shimmura, S., Miyawaki, A., Nakagawa, T., Suda, T., Okano, H. & Matsuzaki, Y., 2009 Oct 26, In : Journal of Experimental Medicine. 206, 11, p. 2483-2496 14 p.

Research output: Contribution to journalArticle

475 Citations (Scopus)
2008

Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche

Kubota, Y., Takubo, K. & Suda, T., 2008 Feb 8, In : Biochemical and Biophysical Research Communications. 366, 2, p. 335-339 5 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Leukemia inhibitory factor regulates microvessel density by modulating oxygen-3 dependent VEGF expression in mice

Kubota, Y., Hirashima, M., Kishi, K., Stewart, C. L. & Suda, T., 2008 Jul 1, In : Journal of Clinical Investigation. 118, 7, p. 2393-2403 11 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Ontogeny and Multipotency of Neural Crest-Derived Stem Cells in Mouse Bone Marrow, Dorsal Root Ganglia, and Whisker Pad

Nagoshi, N., Shibata, S., Kubota, Y., Nakamura, M., Nagai, Y., Satoh, E., Morikawa, S., Okada, Y., Mabuchi, Y., Katoh, H., Okada, S., Fukuda, K., Suda, T., Matsuzaki, Y., Toyama, Y. & Okano, H., 2008 Apr 10, In : Cell stem cell. 2, 4, p. 392-403 12 p.

Research output: Contribution to journalArticle

262 Citations (Scopus)
2007

Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz trigonocephaly) syndrome

Kaname, T., Yanagi, K., Chinen, Y., Makita, Y., Okamoto, N., Maehara, H., Owan, I., Kanaya, F., Kubota, Y., Oike, Y., Yamamoto, T., Kurosawa, K., Fukushima, Y., Bohring, A., Opitz, J. M., Yoshiura, K. I., Niikawa, N. & Naritomi, K., 2007, In : American Journal of Human Genetics. 81, 4, p. 835-841 7 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Rapid, severe repigmentation of congenital melanocytic naevi after curettage and dermabrasion: Histological features

Kishi, K., Matsuda, N., Kubota, Y., Katsube, K. I., Imanishi, N. & Nakajima, T., 2007 Jun 1, In : British Journal of Dermatology. 156, 6, p. 1251-1257 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification

Morita, K., Miyamoto, T., Fujita, N., Kubota, Y., Ito, K., Takubo, K., Miyamoto, K., Ninomiya, K., Suzuki, T., Iwasaki, R., Yagi, M., Takaishi, H., Toyama, Y. & Suda, T., 2007 Jul 9, In : Journal of Experimental Medicine. 204, 7, p. 1613-1623 11 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)
2006

Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization

Nagai, N., Oike, Y., Izumi-Nagai, K., Urano, T., Kubota, Y., Noda, K., Ozawa, Y., Inoue, M., Tsubota, K., Suda, T. & Ishida, S., 2006 Oct 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 26, 10, p. 2252-2259 8 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)