• 7889 Citations
  • 49 h-Index
1979 …2020

Research output per year

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Research Output

  • 7889 Citations
  • 49 h-Index
  • 194 Article
  • 12 Review article
  • 2 Comment/debate
  • 1 Short survey
2020

Effect of TNIK upregulation on JQ1-resistant human colorectal cancer HCT116 cells

Takahashi, C., Kondo, S., Sadaoka, K., Ishizuka, S., Noguchi, K., Kato, Y. & Sugimoto, Y., 2020 Sep 10, In : Biochemical and Biophysical Research Communications. 530, 1, p. 230-234 5 p.

Research output: Contribution to journalArticle

pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A2

Morita, T., Akiyoshi, T., Sato, R., Katayama, K., Yajima, K., Kataoka, H., Imaoka, A., Sugimoto, Y. & Ohtani, H., 2020 Apr, In : Drug Metabolism And Pharmacokinetics. 35, 2, p. 220-227 8 p.

Research output: Contribution to journalArticle

Putative molecular determinants mediating sensitivity or resistance towards carnosic acid tumor cell responses

Mahmoud, N., Saeed, M. E. M., Sugimoto, Y., Klinger, A., Fleischer, E. & Efferth, T., 2020 Oct, In : Phytomedicine. 77, 153271.

Research output: Contribution to journalArticle

1 Citation (Scopus)

SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death and collateral sensitivity in multidrug-resistant tumor cells

Xu, S. W., Law, B. Y. K., Qu, S. L. Q., Hamdoun, S., Chen, J., Zhang, W., Guo, J. R., Wu, A. G., Mok, S. W. F., Zhang, D. W., Xia, C., Sugimoto, Y., Efferth, T., Liu, L. & Wong, V. K. W., 2020 Mar, In : Pharmacological Research. 153, 104660.

Research output: Contribution to journalArticle

3 Citations (Scopus)

SNAIL- and SLUG-induced side population phenotype of HCT116 human colorectal cancer cells and its regulation by BET inhibitors

Kato, Y., Kondo, S., Itakura, T., Tokunaga, M., Hatayama, S., Katayama, K. & Sugimoto, Y., 2020 Jan 1, In : Biochemical and Biophysical Research Communications. 521, 1, p. 152-157 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

STAT1 upregulates glutaminase and modulates amino acids and glutathione metabolism

Kondo, S., Kato, Y., Minagawa, S. & Sugimoto, Y., 2020 Mar 12, In : Biochemical and Biophysical Research Communications. 523, 3, p. 672-677 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

Collateral sensitivity of drug-resistant ABCB5- and mutation-activated EGFR overexpressing cells towards resveratrol due to modulation of SIRT1 expression

Saeed, M. E. M., Rahama, M., Kuete, V., Dawood, M., Elbadawi, M., Sugimoto, Y. & Efferth, T., 2019 Jun, In : Phytomedicine. 59, 152890.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cytotoxicity of 40 Egyptian plant extracts targeting mechanisms of drug-resistant cancer cells

Hegazy, M. E. F., Abdelfatah, S., Hamed, A. R., Mohamed, T. A., Elshamy, A. A., Saleh, I. A., Reda, E. H., Abdel-Azim, N. S., Shams, K. A., Sakr, M., Sugimoto, Y., Paré, P. W. & Efferth, T., 2019 Jun 1, In : Phytomedicine. 59, 152771.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells

Saeed, M. E. M., Boulos, J. C., Elhaboub, G., Rigano, D., Saab, A., Loizzo, M. R., Hassan, L. E. A., Sugimoto, Y., Piacente, S., Tundis, R., Yagi, S., Khalid, H. & Efferth, T., 2019 Sep 1, In : Phytomedicine. 62, 152945.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Novel pharmacological effects of poly (ADP-ribose) polymerase inhibitor rucaparib on the lactate dehydrogenase pathway

Nonomiya, Y., Noguchi, K., Katayama, K. & Sugimoto, Y., 2019 Mar 19, In : Biochemical and Biophysical Research Communications. 510, 4, p. 501-507 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Regorafenib-Induced Hand-Foot Skin Reaction Is More Severe on the Feet Than on the Hands

Nonomiya, Y., Yokokawa, T., Kawakami, K., Kobayashi, K., Aoyama, T., Takiguchi, T., Sugisaki, T., Suzuki, K., Suenaga, M., Wakatsuki, T., Yamaguchi, K., Sugimoto, Y. & Hama, T., 2019 May 7, In : Oncology research. 27, 5, p. 551-556 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
1 Citation (Scopus)
2018

Betulinic acid exerts cytotoxic activity against multidrug-resistant tumor cells via targeting autocrine motility factor receptor (AMFR)

Saeed, M. E. M., Mahmoud, N., Sugimoto, Y., Efferth, T. & Abdel-Aziz, H., 2018 May 15, In : Frontiers in Pharmacology. 9, MAY, 481.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells

Fujiwara, C., Muramatsu, Y., Nishii, M., Tokunaka, K., Tahara, H., Ueno, M., Yamori, T., Sugimoto, Y. & Seimiya, H., 2018 Dec 1, In : Scientific reports. 8, 1, 14827.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Cytotoxicity of nimbolide towards multidrug-resistant tumor cells and hypersensitivity via cellular metabolic modulation

Mahmoud, N., Saeed, M. E. M., Sugimoto, Y., Klauck, S. M., Greten, H. J. & Efferth, T., 2018 Nov 1, In : Oncotarget. 9, 87, p. 35762-35779 18 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Cytotoxicity of sesquiterpene alkaloids from: Nuphar plants toward sensitive and drug-resistant cell lines

Fukaya, M., Nakamura, S., Hegazy, M. E. F., Sugimoto, Y., Hayashi, N., Nakashima, S., Yoshikawa, M., Efferth, T. & Matsuda, H., 2018, In : Food and Function. 9, 12, p. 6279-6286 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Heat shock protein 90 inhibitors overcome the resistance to Fms-like tyrosine kinase 3 inhibitors in acute myeloid leukemia

Katayama, K., Noguchi, K. & Sugimoto, Y., 2018 Sep 1, In : Oncotarget. 9, 76, p. 34240-34258 19 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

IL-10 promoter transactivation by the viral K-RTA protein involves the host-cell transcription factors, specificity proteins 1 and 3

Miyazawa, M., Noguchi, K., Kujirai, M., Katayama, K., Yamagoe, S. & Sugimoto, Y., 2018 Jan 12, In : Journal of Biological Chemistry. 293, 2, p. 662-676 15 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Molecular determinants of sensitivity or resistance of cancer cells toward sanguinarine

Saeed, M. E. M., Mahmoud, N., Sugimoto, Y., Efferth, T. & Abdel-Aziz, H., 2018 Feb 26, In : Frontiers in Pharmacology. 9, FEB, 136.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells

Takami, M., Katayama, K., Noguchi, K. & Sugimoto, Y., 2018 Jan 1, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Repurposing of bromocriptine for cancer therapy

Seo, E. J., Sugimoto, Y., Greten, H. J. & Efferth, T., 2018 Oct 8, In : Frontiers in Pharmacology. 9, OCT, 1030.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2017

APC mutations as a potential biomarker for sensitivity to tankyrase inhibitors in colorectal cancer

Tanaka, N., Mashima, T., Mizutani, A., Sato, A., Aoyama, A., Gong, B., Yoshida, H., Muramatsu, Y., Nakata, K., Matsuura, M., Katayama, R., Nagayama, S., Fujita, N., Sugimoto, Y. & Seimiya, H., 2017 Apr, In : Molecular cancer therapeutics. 16, 4, p. 752-762 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Functional effects of AKT3 on aurora kinase inhibitorinduced aneuploidy

Noguchi, K., Hongama, K., Hariki, S., Nonomiya, Y., Katayama, K. & Sugimoto, Y., 2017 Feb 3, In : Journal of Biological Chemistry. 292, 5, p. 1910-1924 15 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

mTOR signaling mediates resistance to tankyrase inhibitors in Wnt-driven colorectal cancer

Mashima, T., Taneda, Y., Jang, M. K., Mizutani, A., Muramatsu, Y., Yoshida, H., Sato, A., Tanaka, N., Sugimoto, Y. & Seimiya, H., 2017, In : Oncotarget. 8, 29, p. 47902-47915 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2016

Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells

Nonomiya, Y., Noguchi, K., Tanaka, N., Kasagaki, T., Katayama, K. & Sugimoto, Y., 2016 Dec 1, In : Cancer science. 107, 12, p. 1877-1887 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

RSK1 protects P-glycoprotein/ABCB1 against ubiquitin-proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2 R1

Katayama, K., Fujiwara, C., Noguchi, K. & Sugimoto, Y., 2016 Oct 27, In : Scientific Reports. 6, 36134.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2015

Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking

Saeed, M., Kadioglu, O., Khalid, H., Sugimoto, Y. & Efferth, T., 2015, In : Journal of Nutritional Biochemistry. 26, 1, p. 44-56 13 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Cytotoxicity of 35 medicinal plants from Sudan towards sensitive and multidrug-resistant cancer cells

Saeed, M. E. M., Abdelgadir, H., Sugimoto, Y., Khalid, H. E. & Efferth, T., 2015 Apr 1, In : Journal of Ethnopharmacology. 174, p. 644-658 15 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Cytotoxicity of the sesquiterpene lactones neoambrosin and damsin from Ambrosia maritima against multidrug-resistant cancer cells

Saeed, M., Jacob, S., Sandjo, L. P., Sugimoto, Y., Khalid, H. E., Opatz, T., Thines, E. & Efferth, T., 2015, In : Frontiers in Pharmacology. 6, NOV, 267.

Research output: Contribution to journalArticle

Open Access
19 Citations (Scopus)

Upregulation of cellular glutathione levels in human ABCB5- and murine Abcb5-transfected cells

Kondo, S., Hongama, K., Hanaya, K., Yoshida, R., Kawanobe, T., Katayama, K., Noguchi, K. & Sugimoto, Y., 2015 Dec 15, In : BMC Pharmacology and Toxicology. 16, 1, 37.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2014

Human ABC transporter ABCG2/BCRP expression in chemoresistance: Basic and clinical perspectives for molecular cancer therapeutics

Noguchi, K., Katayama, K. & Sugimoto, Y., 2014 Feb 5, In : Pharmacogenomics and Personalized Medicine. 7, 1, p. 53-64 12 p.

Research output: Contribution to journalReview article

118 Citations (Scopus)

Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function

Katayama, K., Yamaguchi, M., Noguchi, K. & Sugimoto, Y., 2014 Apr 1, In : Cancer Letters. 345, 1, p. 124-131 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Resistance mechanisms of cancer cells to the novel vacuolar H+-ATPase inhibitor archazolid B

Hamm, R., Sugimoto, Y., Steinmetz, H. & Efferth, T., 2014 Oct, In : Investigational new drugs. 32, 5, p. 893-903 11 p., 32.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The lignan, (-)-sesamin reveals cytotoxicity toward cancer cells: Pharmacogenomic determination of genes associated with sensitivity or resistance

Saeed, M., Khalid, H., Sugimoto, Y. & Efferth, T., 2014 Apr 15, In : Phytomedicine. 21, 5, p. 689-696 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2013

Biochemical interaction of anti-HCV telaprevir with the ABC transporters P-glycoprotein and breast cancer resistance protein

Fujita, Y., Noguchi, K., Suzuki, T., Katayama, K. & Sugimoto, Y., 2013, In : BMC Research Notes. 6, 1, 445.

Research output: Contribution to journalArticle

17 Citations (Scopus)

FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin-proteasome pathway in cancer cells

Katayama, K., Noguchi, K. & Sugimoto, Y., 2013 Jun, In : Cancer science. 104, 6, p. 694-702 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2012

Expression of human ABCB5 confers resistance to taxanes and anthracyclines

Kawanobe, T., Kogure, S., Nakamura, S., Sato, M., Katayama, K., Mitsuhashi, J., Noguchi, K. & Sugimoto, Y., 2012 Feb 24, In : Biochemical and Biophysical Research Communications. 418, 4, p. 736-741 6 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)
2011

DNA ligand designed to antagonize EBNA1 represses Epstein-Barr virus-induced immortalization

Yasuda, A., Noguchi, K., Minoshima, M., Kashiwazaki, G., Kanda, T., Katayama, K., Mitsuhashi, J., Bando, T., Sugiyama, H. & Sugimoto, Y., 2011 Dec, In : Cancer science. 102, 12, p. 2221-2230 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo

Yamazaki, R., Nishiyama, Y., Furuta, T., Hatano, H., Igarashi, Y., Asakawa, N., Kodaira, H., Takahashi, H., Aiyama, R., Matsuzaki, T., Yagi, N. & Sugimoto, Y., 2011 Jul, In : Molecular cancer therapeutics. 10, 7, p. 1252-1263 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Novel regulatory role for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin

Masuda, Y., Noguchi, K., Segawa, H., Tanaka, N., Katayama, K., Mitsuhashi, J. & Sugimoto, Y., 2011 Nov 18, In : Biochemical and Biophysical Research Communications. 415, 2, p. 305-312 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2010

A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor

Yashiroda, Y., Okamoto, R., Hatsugai, K., Takemoto, Y., Goshima, N., Saito, T., Hamamoto, M., Sugimoto, Y., Osada, H., Seimiya, H. & Yoshida, M., 2010 Apr 9, In : Biochemical and Biophysical Research Communications. 394, 3, p. 569-573 5 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

BCRP/ABCG2 confers anticancer drug resistance without covalent dimerization

Shigeta, J., Katayama, K., Mitsuhashi, J., Noguchi, K. & Sugimoto, Y., 2010 Aug, In : Cancer science. 101, 8, p. 1813-1821 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Breast cancer resistant protein (BCRP) is a molecular determinant of the outcome of photodynamic therapy (PDT) for centrally located early lung cancer

Usuda, J., Tsunoda, Y., Ichinose, S., Ishizumi, T., Ohtani, K., Maehara, S., Ono, S., Tsutsui, H., Ohira, T., Okunaka, T., Furukawa, K., Sugimoto, Y., Kato, H. & Ikeda, N., 2010 Feb 1, In : Lung Cancer. 67, 2, p. 198-204 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Functional availability of γ-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a

Yoshioka, H., Noguchi, K., Katayama, K., Mitsuhashi, J., Yamagoe, S., Fujimuro, M. & Sugimoto, Y., 2010 Apr 16, In : Biochemical and Biophysical Research Communications. 394, 4, p. 1000-1005 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

In vivo expansion of MDR1-transduced cells accompanied by a post-transplantation chemotherapy regimen with mitomycin C and methotrexate

Mitsuhashi, J., Hosoyama, H., Tsukahara, S., Katayama, K., Noguchi, K., Ito, Y., Hatake, K., Aiba, K., Takahashi, S. & Sugimoto, Y., 2010 Jul 1, In : Journal of Gene Medicine. 12, 7, p. 596-603 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Pharmacological interaction with sunitinib is abolished by a germ-line mutation (1291T>C) of BCRP/ABCG2 gene

Kawahara, H., Noguchi, K., Katayama, K., Mitsuhashi, J. & Sugimoto, Y., 2010 Jun 1, In : Cancer science. 101, 6, p. 1493-1500 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Tankyrase-1 assembly to large protein complexes blocks its telomeric function

Hatsugai, K., Ohishi, T., Sugimoto, Y. & Seimiya, H., 2010 Sep, In : FEBS Letters. 584, 18, p. 3885-3890 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2009

Acyl-CoA synthetase as a cancer survival factor: Its inhibition enhances the efficacy of etoposide

Mashima, T., Sato, S., Okabe, S., Miyata, S., Matsuura, M., Sugimoto, Y., Tsuruo, T. & Seimiya, H., 2009, In : Cancer science. 100, 8, p. 1556-1562 7 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells

Takeshita, A., Yamakage, N., Shinjo, K., Ono, T., Hirano, I., Nakamura, S., Shigeno, K., Tobita, T., Maekawa, M., Kiyoi, H., Naoe, T., Ohnishi, K., Sugimoto, Y. & Ohno, R., 2009, In : Leukemia. 23, 7, p. 1329-1336 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)