• 7862 Citations
  • 49 h-Index
1979 …2020

Research output per year

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Research Output

  • 7862 Citations
  • 49 h-Index
  • 194 Article
  • 12 Review article
  • 2 Comment/debate
  • 1 Short survey
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Article
1979

Distribution and excretion of N-ethyloxycarbonylaminomethy-L-isoleucine in mice

Fukuma, M., Fujita, H. & Sugimoto, Y., 1979 Jan 1, In : Japanese Journal of Cancer and Chemotherapy. 6, 2, p. 409-417 9 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
1980
Open Access
1981

Alteration of membrane-associated enzymes in drug-resistant sublines of mouse lymphoblastoma L5178Y cells

Sugimoto, Y., Nishimura, T., Suzuki, H. & Tanaka, N., 1981 Jan 1, In : Journal of Antibiotics. 34, 9, p. 1200-1205 6 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Evidence of altered influx of adriamycin into anthracycline-resistant cells

Sugimoto, Y., Nishimura, T., Suzuki, H. & Tanaka, N., 1981 Jan 1, In : Journal of Antibiotics. 34, 8, p. 1064-1066 3 p.

Research output: Contribution to journalArticle

Open Access
27 Citations (Scopus)

Mechanism of inactivation of hepatitis B surface antigen by N(α)-cocoyl-L-arginine ethyl ester

Sugimoto, Y. & Toyoshima, S., 1981, In : Antimicrobial Agents and Chemotherapy. 20, 1, p. 120-127 8 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
1982

Mechanism of action of 2-crotonyloxymethyl-4,5,6-trihydroxycyclohex-2-enone, a sh inhibitory antitumor antibiotic, and its effect on drug-resistant neoplastic cells

Sugimoto, Y., Suzuki, H., Yamaki, H., Nishimura, T. & Tanaka, N., 1982 Jan 1, In : The Journal of Antibiotics. 35, 9, p. 1222-1230 9 p.

Research output: Contribution to journalArticle

Open Access
32 Citations (Scopus)
1983

Alteration of plasma membrane of drug-resistant tumor cells: 230-Kilodalton protein identified by monoclonal antibody

Sugimoto, Y., Suzuki, H. & Tanaka, N., 1983 Aug 12, In : Biochemical and Biophysical Research Communications. 114, 3, p. 969-975 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Incorporation of bile acid of low concentration into model and biological membranes studied by H and 31P NMR1

Saitô, H., Sugimoto, Y., Tabeta, R., Suzuki, S., Izumi, G., Kodama, M., Toyoshima, S. & Nagata, C., 1983 Dec, In : Journal of biochemistry. 94, 6, p. 1877-1887 11 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
1984
8 Citations (Scopus)

Isolation, drug sensitivity, and some biochemical and genetical properties of macromomycin-resistant mouse lymphoblastoma l5178y cells

Suzuki, H., Sugimoto, Y., Tanaka, K., Nishimura, T. & Tanaka, N., 1984 Jan, In : Journal of Antibiotics. 37, 5, p. 602-609 8 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
1986

A2 H NMR study on alteration of the membrane organization of mouse b16 melanoma cells treated with 12-O-tetradecanoylphorbol-13-acetate

Sugimoto, Y., Saito, H., Tabeta, R. & Kodama, M., 1986 Oct, In : Journal of biochemistry. 100, 4, p. 867-874 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Transplantability and Sensitivity to Natural Killer Cells of Aclarubicin-resistant Murine Lymphoma

Sugimoto, Y., Hirakawa, Y., Tanaka, N., Tahara, M., Sato, I., Nishimura, T., Suzuki, H. & Tanaka, N., 1986 Nov 1, In : Cancer Research. 46, 11, p. 5646-5648 3 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
1987

Acquisition of Metastatic Ability in Hybridomas between Two Low Metastatic Clones of Murine Colon Adenocarcinoma 26 Defective in Either Platelet-aggregating Activity or in Vivo Growth Potential

Sugimoto, Y., Oh-hara, T., Watanabe, M., Saito, H., Yamori, T. & Tsuruo, T., 1987 Aug, In : Cancer Research. 47, 16, p. 4396-4401 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
Open Access
36 Citations (Scopus)

Detection of Multidrug Resistance Markers, P-Glycoprotein and mdrl mRNA, in Human Leukemia Cells

Tsuruo, T., Sugimoto, Y., Hamada, H., Roninson, I., Okumura, M., Adachi, K., Morishima, Y. & Ohno, R., 1987 Jan 1, In : Japanese Journal of Cancer Research GANN. 78, 12, p. 1415-1419 5 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

DNA-mediated Transfer and Cloning of a Human Multidrug-resistant Gene of Adriamycin-resistant Myelogenous Leukemia K562

Sugimoto, Y. & Tsuruo, T., 1987 May 15, In : Cancer Research. 47, 10, p. 2620-2625 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
1988

Detection of drug resistance in human hematologic malignancy by monoclonal antibodies

Ohtsu, T., Shimoyama, M., Hamada, H., Sugimoto, Y., Ohkochi, E., Tsuruo, T., Ishida, Y., Tobinai, K. & Minato, K., 1988 Jan 1, In : Acta Haematologica Japonica. 51, 8, p. 310-320 11 p.

Research output: Contribution to journalArticle

Identification of a Platelet-aggregating Factor of Murine Colon Adenocarcinoma 26: Mr 44,000 Membrane Protein as Determined by Monoclonal Antibodies

Watanabe, M., Okochi, E., Sugimoto, Y. & Tsuruo, T., 1988 Nov, In : Cancer Research. 48, 22, p. 6411-6416 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Mr 85,000 membrane protein specifically expressed in adriamycin-resistant human tumor cells

Hamada, H., Okochi, E., Watanabe, M., Oh-hara, T., Sugimoto, Y., Kawabata, H. & Tsuruo, T., 1988 Dec 1, In : Cancer Research. 48, p. 7082-7087 6 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
1989

A Fluorine-containing Anthracycline (ME2303) as a New Antitumor Agent against Murine and Human Tumors and Their Multidrug-resistant Sublines

Tsuruo, T., Yusa, K., Sudo, Y., Takamori, R. & Sugimoto, Y., 1989 Oct 15, In : Cancer Research. 49, 20, p. 5537-5542 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Expression of P‐Glycoprotein mRNA in Human Gastric Tumors

Sugimoto, Y., Asami, N. & Tsuruo, T., 1989 Oct, In : Japanese Journal of Cancer Research. 80, 10, p. 993-999 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Multidrug Resistance in Cultured Human Leukemia and Lymphoma Cell Lines Detected by a Monoclonal Antibody, MRK16

Ishida, Y., Ohtsu, T., Hamada, H., Sugimoto, Y., Tobinai, K., Minato, K., Tsuruo, T. & Shimoyama, M., 1989 Oct, In : Japanese Journal of Cancer Research. 80, 10, p. 1006-1013 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
1990

3′-Deamino-3′-morpholino-13-deoxo-10-hydroxycarminomycin Conquers Multidrug Resistance by Rapid Influx following Higher Frequency of Formation of DNA Single- and Double-Strand Breaks

Horichi, N., Tapiero, H., Sugimoto, Y., Bungo, M., Nishiyama, M., Fourcade, A., Lampidis, T. J., Kasahara, K., Sasaki, Y., Takahashi, T. & Saijo, N., 1990 Aug 1, In : Cancer Research. 50, 15, p. 4698-4701 4 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Collateral sensitivity of cisplatin-resistant human lung cancer cell lines to thymidylate synthase inhibitors

Ohe, Y., Sugimoto, Y. & Saijo, N., 1990 Dec 1, In : Cancer Journal. 3, 6, p. 332-336 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Cross-resistance to tumour promoters in human cancer cell lines resistant to adriamycin or cisplatin

Nishio, K., Sugimoto, Y., Nakagawa, K., Niimi, S., Fujiwara, Y., Bungo, M., Kasahara, K., Fujiki, H. & Saijo, N., 1990 Sep, In : British Journal of Cancer. 62, 3, p. 415-419 5 p.

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)

Decreased Expression of DNA Topoisomerase I in Camptothecin-resistant Tumor Cell Lines as Determined by a Monoclonal Antibody

Sugimoto, Y., Tsukahara, S., Oh-hara, T., Isoe, T. & Tsuruo, T., 1990 Nov 1, In : Cancer Research. 50, 21, p. 6925-6930 6 p.

Research output: Contribution to journalArticle

221 Citations (Scopus)

Detection of 300-kilodalton membrane protein in adriamycin-resistant human tumor cells by a monoclonal antibody MRK18

Sugimoto, Y., Okochi, E., Hamada, H., Oh-hara, T. & Tsuruo, T., 1990 Jun 15, In : Biochemical and Biophysical Research Communications. 169, 2, p. 686-691 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Detection of Proteins that Recognize Platinum‐modified DNA Using Gel Mobility Shift Assay

Fujiwara, Y., Kasahara, K., Sugimoto, Y., Nishio, K., Ohmori, T. & Saijo, N., 1990 Dec, In : Japanese Journal of Cancer Research. 81, 12, p. 1210-1213 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Determinants of Drug Response in a Cisplatin‐resistant Human Lung Cancer Cell Line

Fujiwara, Y., Sugimoto, Y., Kasahara, K., Bungo, M., Yamakido, M., Tew, K. D. & Saijo, N., 1990 May, In : Japanese Journal of Cancer Research. 81, 5, p. 527-535 9 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Elevated Expression of DNA Topoisomerase II in Camptothecin-resistant Human Tumor Cell Lines

Sugimoto, Y., Tsukahara, S., Oh-hara, T., Tsuruo, T. & Liu, L. F., 1990 Dec 15, In : Cancer Research. 50, 24, p. 7962-7965 4 p.

Research output: Contribution to journalArticle

125 Citations (Scopus)

Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: Characterization and mechanism of resistance

Kanzawa, F., Sugimoto, Y., Minato, K., Kasahara, K., Bungo, M., Nagakawa, K., Fujiwara, Y., Liu, L. F. & Saijo, N., 1990 Jan 1, In : Cancer Research. 50, 18, p. 5919-5924 6 p.

Research output: Contribution to journalArticle

165 Citations (Scopus)

Establishment of highly metastatic variants of murine colon adenocarcinoma 26 under serum‐free conditions

Sugimoto, Y., Oh‐hara, T., Heike, Y., Watanabe, M., Nakatsuru, Y., Ishikawa, T. & Tsuruo, T., 1990 Jul 15, In : International Journal of Cancer. 46, 1, p. 118-124 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Expression of a Mr 41,000 Glycoprotein Associated with Thrombin-independent Platelet Aggregation in High Metastatic Variants of Murine B16 Melanoma

Watanabe, M., Sugimoto, Y. & Tsuruo, T., 1990 Oct 15, In : Cancer Research. 50, 20, p. 6657-6662 6 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Inhibition of lung colonization of mouse colon 26 adenocarcinoma by recombinant mouse interferon β through a modification of platelet function

Tsuruo, T., Saito, H., Watanabe, M., Sugimoto, Y., Yamori, T. & Oh-Hara, T., 1990 Mar 1, In : Clinical & Experimental Metastasis. 8, 2, p. 203-213 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Low metastatic potential of clone from murine colon adenocarcinoma 26 increased by transfection of activated c-erbb-2 gene

Yusa, K., Sugimoto, Y., Yamori, T., Yamamoto, T., Toyoshima, K. & Tsuruo, T., 1990 Oct 17, In : Journal of the National Cancer Institute. 82, 20, p. 1633-1636 4 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Mechanism of action of a new macromolecular antitumor antibiotic, C-1027

Sugimoto, Y., Otani, T., Ole, S., Wierzba, K. & Yamada, Y., 1990 Jan 1, In : The Journal of Antibiotics. 43, 4, p. 417-421 5 p.

Research output: Contribution to journalArticle

Open Access
79 Citations (Scopus)

Menogaril, an Anthracycline Compound with a Novel Mechanism of Action: Cellular Pharmacology

Wierzba, K., Sugimoto, Y., Matsuo, K. ., Toko, T., Takeda, S., Yamada, Y. & Tsukagoshi, S., 1990 Aug, In : Japanese Journal of Cancer Research. 81, 8, p. 842-849 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

TAT-59, a new triphenylethylene derivative with antitumor activity against hormone-dependent tumors

Toko, T., Sugimoto, Y., Matsuo, K. I., Yamasaki, R., Takeda, S., Wierzba, K., Asao, T. & Yamada, Y., 1990 Mar, In : European Journal of Cancer and Clinical Oncology. 26, 3, p. 397-404 8 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
1991

Characterization of an Etoposide‐resistant Human K562 Cell Line, K/eto

Sugawara, I., Iwahashi, T., Okamoto, K., Sugimoto, Y., Ekimoto, H., Tsuruo, T., Ikeuchi, T. & Mori, S., 1991 Sep, In : Japanese Journal of Cancer Research. 82, 9, p. 1035-1043 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Establishment of a human leukemia subline resistant to the growth‐inhibitory effect of 12‐o‐tetradecanoylphorbol 13‐acetate (TPA) and showing non‐P‐glycoprotein‐mediated multi‐drug resistance

Takeda, Y., Nishio, K., Sugimoto, Y., Kasahara, K., Kubo, S., Fujiwara, Y., Saijo, N. & Niitani, H., 1991 Jul 30, In : International Journal of Cancer. 48, 6, p. 931-937 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Identification and Characterization of Three DNA‐binding Proteins on the Promoter of the Human MDRl Gene in Drug‐sensitive and ‐resistant Cells

Ogura, M., Takatori, T., Sugimoto, Y. & Tsuruo, T., 1991 Oct, In : Japanese Journal of Cancer Research. 82, 10, p. 1151-1159 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Metallothionein Content Correlates with the Sensitivity of Human Small Cell Lung Cancer Cell Lines to Cisplatin

Kasahara, K., Fujiwara, Y., Nishio, K., Ohmori, T., Sugimoto, Y. & Saijo, N., 1991 Jun, In : Cancer Research. 51, 12, p. 3237-3242 6 p.

Research output: Contribution to journalArticle

237 Citations (Scopus)

Suppression of Experimental Lung Colonization of a Metastatic Variant of Murine Colon Adenocarcinoma 26 by a Monoclonal Antibody 8F11 Inhibiting Tumor Cell-induced Platelet Aggregation

Sugimoto, Y., Watanabe, M., Oh-hara, T., Sato, S. & Tsuruo, T., 1991 Feb, In : Cancer Research. 51, 3, p. 921-925 5 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

The development of a treatment model for lymph node metastasis in nude mice transplanted with rat fibrosarcoma clone A

Soejima, Y., Shen, W. M., Minato, K., Nishio, K., Sugimoto, Y., Fujiwara, Y., Tamura, T., Hara, K. & Saijo, N., 1991 Jan 1, In : Invasion and Metastasis. 11, 3, p. 174-180 7 p.

Research output: Contribution to journalArticle

1992

Determinants of response to the DNA topoisomerase II inhibitors doxorubicin and etoposide in human lung cancer cell lines

Kasahara, K., Fujiwara, Y., Sugimoto, Y., Nishio, K., Tamura, T., Matsuda, T. & Saijo, N., 1992 Jan 15, In : Journal of the National Cancer Institute. 84, 2, p. 113-118 6 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)
32 Citations (Scopus)

Expression of a human multidrug resistance gene in human ovarian carcinoma cell lines

Sekiya, S., Nunoyama, T., Shirasawa, H., Kimura, H., Kawata, M., Iijima, N., Sugimoto, Y., Tsuruo, T. & Takamizawa, H., 1992 Jun, In : Archives of gynecology and obstetrics. 251, 2, p. 79-86 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Increased phosphorylation of nuclear phosphoproteins in human lung‐cancer cells resistant to cis‐diamminedichloroplatinum(II)

Nishio, K., Sugimoto, Y., Kasahara, K., Fujiwara, Y., Nishiwaki, S., Fujiki, H., Ohata, M. & Saijo, N., 1992 Feb 1, In : International Journal of Cancer. 50, 3, p. 438-442 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines

Sugimoto, Y., Ohe, Y., Nishio, K., Ohmori, T., Fujiwara, Y. & SAijo, N., 1992 Nov, In : Cancer Chemotherapy and Pharmacology. 30, 6, p. 417-422 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)