• 7862 Citations
  • 49 h-Index
1979 …2020

Research output per year

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Research Output

  • 7862 Citations
  • 49 h-Index
  • 194 Article
  • 12 Review article
  • 2 Comment/debate
  • 1 Short survey
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Article

3′-Deamino-3′-morpholino-13-deoxo-10-hydroxycarminomycin Conquers Multidrug Resistance by Rapid Influx following Higher Frequency of Formation of DNA Single- and Double-Strand Breaks

Horichi, N., Tapiero, H., Sugimoto, Y., Bungo, M., Nishiyama, M., Fourcade, A., Lampidis, T. J., Kasahara, K., Sasaki, Y., Takahashi, T. & Saijo, N., 1990 Aug 1, In : Cancer Research. 50, 15, p. 4698-4701 4 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

A2 H NMR study on alteration of the membrane organization of mouse b16 melanoma cells treated with 12-O-tetradecanoylphorbol-13-acetate

Sugimoto, Y., Saito, H., Tabeta, R. & Kodama, M., 1986 Oct, In : Journal of biochemistry. 100, 4, p. 867-874 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

ABCG2 transports sulfated conjugates of steroids and xenobiotics

Suzuki, M., Suzuki, H., Sugimoto, Y. & Sugiyama, Y., 2003 Jun 20, In : Journal of Biological Chemistry. 278, 25, p. 22644-22649 6 p.

Research output: Contribution to journalArticle

273 Citations (Scopus)

A bicistronic retrovirus vector containing a picornavirus internal ribosome entry site allows for correction of X-linked CGD by selection for MDR1 expression

Sokolic, R. A., Sekhsaria, S., Sugimoto, Y., Whiting-Theobald, N., Linton, G. F., Li, F., Gottesman, M. M. & Malech, H. L., 1996 Jan 1, In : Blood. 87, 1, p. 42-50 9 p.

Research output: Contribution to journalArticle

Open Access
48 Citations (Scopus)

Acquisition of Metastatic Ability in Hybridomas between Two Low Metastatic Clones of Murine Colon Adenocarcinoma 26 Defective in Either Platelet-aggregating Activity or in Vivo Growth Potential

Sugimoto, Y., Oh-hara, T., Watanabe, M., Saito, H., Yamori, T. & Tsuruo, T., 1987 Aug, In : Cancer Research. 47, 16, p. 4396-4401 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking

Saeed, M., Kadioglu, O., Khalid, H., Sugimoto, Y. & Efferth, T., 2015, In : Journal of Nutritional Biochemistry. 26, 1, p. 44-56 13 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Acyl-CoA synthetase as a cancer survival factor: Its inhibition enhances the efficacy of etoposide

Mashima, T., Sato, S., Okabe, S., Miyata, S., Matsuura, M., Sugimoto, Y., Tsuruo, T. & Seimiya, H., 2009 Jul 23, In : Cancer science. 100, 8, p. 1556-1562 7 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Additive antitumor effect of concurrent treatment of 4-hydroxy tamoxifen with 5-fluorouracil but not with doxorubicin in estrogen receptor-positive breast cancer cells

Kurebayashi, J., Nukatsuka, M., Nagase, H., Nomura, T., Hirono, M., Yamamoto, Y., Sugimoto, Y., Oka, T. & Sonoo, H., 2007 Mar 1, In : Cancer Chemotherapy and Pharmacology. 59, 4, p. 515-525 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

A Fluorine-containing Anthracycline (ME2303) as a New Antitumor Agent against Murine and Human Tumors and Their Multidrug-resistant Sublines

Tsuruo, T., Yusa, K., Sudo, Y., Takamori, R. & Sugimoto, Y., 1989 Oct 15, In : Cancer Research. 49, 20, p. 5537-5542 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Alteration of membrane-associated enzymes in drug-resistant sublines of mouse lymphoblastoma L5178Y cells

Sugimoto, Y., Nishimura, T., Suzuki, H. & Tanaka, N., 1981 Jan 1, In : Journal of Antibiotics. 34, 9, p. 1200-1205 6 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

Alteration of plasma membrane of drug-resistant tumor cells: 230-Kilodalton protein identified by monoclonal antibody

Sugimoto, Y., Suzuki, H. & Tanaka, N., 1983 Aug 12, In : Biochemical and Biophysical Research Communications. 114, 3, p. 969-975 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

A novel cinnamic acid derivative that inhibits Cdc25 dual-specificity phosphatase activity

Aoyagi, Y., Masuko, N., Ohkubo, S., Kitade, M., Nagai, K., Okazaki, S., Wierzba, K., Terada, T., Sugimoto, Y. & Yamada, Y., 2005 Sep 1, In : Cancer science. 96, 9, p. 614-619 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor

Yashiroda, Y., Okamoto, R., Hatsugai, K., Takemoto, Y., Goshima, N., Saito, T., Hamamoto, M., Sugimoto, Y., Osada, H., Seimiya, H. & Yoshida, M., 2010 Apr 9, In : Biochemical and Biophysical Research Communications. 394, 3, p. 569-573 5 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Antimetastatic and anticancer activity of S-1, a new oral dihydropyrimidine-dehydrogenase-inhibiting fluoropyrimidine, alone and in combination with paclitaxel in an orthotopically implanted human breast cancer model.

Nukatsuka, M., Fujioka, A., Nakagawa, F., Oshimo, H., Kitazato, K., Uchida, J., Sugimoto, Y., Nagayama, S. & Fukushima, M., 2004 Dec, In : International journal of oncology. 25, 6, p. 1531-1536 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Antimitotic activity and reversal of breast cancer resistance protein-mediated drug resistance by stilbenoids from Bletilla striata

Morita, H., Koyama, K., Sugimoto, Y. & Kobayashi, J., 2005 Feb 15, In : Bioorganic and Medicinal Chemistry Letters. 15, 4, p. 1051-1054 4 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Antitumor activity of a novel podophyllotoxin derivative (TOP-53) against lung cancer and lung metastatic cancer

Utsugi, T., Shibata, J., Sugimoto, Y., Aoyagi, K., Wierzba, K., Kobunai, T., Terada, T., Oh-hara, T., Tsuruo, T. & Yamada, Y., 1996 Jun 15, In : Cancer Research. 56, 12, p. 2809-2814 6 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Antitumor Agents. 3. Synthesis and Biological Activity of 4β-Alkyl Derivatives Containing Hydroxy, Amino, and Amido Groups of 4′-O-Demethyl-4-desoxypodophyllotoxin as Antitumor Agents

Terada, T., Fujimoto, K., Nomura, M., Yamashita, J. I., Wierzba, K., Yamazaki, R., Shibata, J., Sugimoto, Y., Yamada, Y., Kobunai, T., Takeda, S., Minami, Y., Yoshida, K. I. & Yamaguchi, H., 1993 Jan 1, In : Journal of Medicinal Chemistry. 36, 12, p. 1689-1699 11 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Antitumor effect on SN-38, active form of CPT-11, on human colorectal cancer cell line

Aiba, K., Funakoshi, S., Mizunuma, N., Dobashi, N., Hirano, A., Sano, M., Kuraishi, Y., Kamada, M., Ohno, N., Sugimoto, Y., Tsuruo, T., Shibata, H. & Horikoshi, N., 1994 Jan 1, In : Japanese Journal of Cancer and Chemotherapy. 21, 10, p. 1601-1606 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

APC mutations as a potential biomarker for sensitivity to tankyrase inhibitors in colorectal cancer

Tanaka, N., Mashima, T., Mizutani, A., Sato, A., Aoyama, A., Gong, B., Yoshida, H., Muramatsu, Y., Nakata, K., Matsuura, M., Katayama, R., Nagayama, S., Fujita, N., Sugimoto, Y. & Seimiya, H., 2017 Apr, In : Molecular cancer therapeutics. 16, 4, p. 752-762 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

A T3587G germ-line mutation of the MDR1 gene encodes a nonfunctional P-glycoprotein

Mutoh, K., Mitsuhashi, J., Kimura, Y., Tsukahara, S., Ishikawa, E., Sai, K., Ozawa, S., Sawada, J. I., Ueda, K., Katayama, K. & Sugimoto, Y., 2006 Apr 1, In : Molecular cancer therapeutics. 5, 4, p. 877-884 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

BCRP/ABCG2 confers anticancer drug resistance without covalent dimerization

Shigeta, J., Katayama, K., Mitsuhashi, J., Noguchi, K. & Sugimoto, Y., 2010 Aug 1, In : Cancer science. 101, 8, p. 1813-1821 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Benefits of TS-1 plus leucovorin combination therapy for colorectal cancer: evaluation of therapeutic effect of TS-1 and leucovorin combination therapy using rodent model fed a low folate diet

Tsujimoto, H., Tsukioka, S., Koizumi, K., Nakagawa, F., Uchida, J., Sugimoto, Y., Oka, T., Fukushima, M. & Watanabe, T., 2007 Mar, In : Gan to kagaku ryoho. Cancer & chemotherapy. 34, 3, p. 413-418 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Betulinic acid exerts cytotoxic activity against multidrug-resistant tumor cells via targeting autocrine motility factor receptor (AMFR)

Saeed, M. E. M., Mahmoud, N., Sugimoto, Y., Efferth, T. & Abdel-Aziz, H., 2018 May 15, In : Frontiers in Pharmacology. 9, MAY, 481.

Research output: Contribution to journalArticle

12 Citations (Scopus)
8 Citations (Scopus)

Biochemical interaction of anti-HCV telaprevir with the ABC transporters P-glycoprotein and breast cancer resistance protein

Fujita, Y., Noguchi, K., Suzuki, T., Katayama, K. & Sugimoto, Y., 2013, In : BMC Research Notes. 6, 1, 445.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors

Wang, X., Furukawa, T., Nitanda, T., Okamoto, M., Sugimoto, Y., Akiyama, S. I. & Baba, M., 2003 Jan 1, In : Molecular Pharmacology. 63, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

Breast cancer resistance protein (BCRP) affected acquired resistance to gefitinib in a "never-smoked" female patient with advanced non-small cell lung cancer

Usuda, J., Ohira, T., Suga, Y., Oikawa, T., Ichinose, S., Inoue, T., Ohtani, K., Maehara, S., Imai, K., Kubota, M., Tsunoda, Y., Tsutsui, H., Furukawa, K., Okunaka, T., Sugimoto, Y. & Kato, H., 2007 Nov 1, In : Lung Cancer. 58, 2, p. 296-299 4 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Breast cancer resistance protein exports sulfated estrogens but not free estrogens

Imai, Y., Asada, S., Tsukahara, S., Ishikawa, E., Tsuruo, T. & Sugimoto, Y., 2003 Sep 1, In : Molecular Pharmacology. 64, 3, p. 610-618 9 p.

Research output: Contribution to journalArticle

182 Citations (Scopus)

Breast cancer-resistance protein expression using immunohistochemical staining and treatment by gefitinib for non-small cell lung cancer

Oikawa, T., Ohira, T., Usuda, J., Suga, Y., Nakajima, E., Saijo, T., Tsuboi, M., Hirano, T., Sugimoto, Y. & Kato, H., 2008 Apr, In : Journal of Tokyo Medical University. 66, 2, p. 224-230 7 p.

Research output: Contribution to journalArticle

Breast cancer resistant protein (BCRP) is a molecular determinant of the outcome of photodynamic therapy (PDT) for centrally located early lung cancer

Usuda, J., Tsunoda, Y., Ichinose, S., Ishizumi, T., Ohtani, K., Maehara, S., Ono, S., Tsutsui, H., Ohira, T., Okunaka, T., Furukawa, K., Sugimoto, Y., Kato, H. & Ikeda, N., 2010 Feb 1, In : Lung Cancer. 67, 2, p. 198-204 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance

Imai, Y., Nakane, M., Kage, K., Tsukahara, S., Ishikawa, E., Tsuruo, T., Miki, Y. & Sugimoto, Y., 2002 Jun 1, In : Molecular cancer therapeutics. 1, 8, p. 611-616 6 p.

Research output: Contribution to journalArticle

370 Citations (Scopus)

cDNA expression cloning of the 85-kDa protein overexpressed in adriamycin-resistant cells

Noguchi, K., Naito, M., Tezuka, K. I., Ishii, S., Seimiya, H., Sugimoto, Y., Amann, E. & Tsuruo, T., 1993 Apr 15, In : Biochemical and Biophysical Research Communications. 192, 1, p. 88-95 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells

Fujiwara, C., Muramatsu, Y., Nishii, M., Tokunaka, K., Tahara, H., Ueno, M., Yamori, T., Sugimoto, Y. & Seimiya, H., 2018 Dec 1, In : Scientific reports. 8, 1, 14827.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Characterization of an Etoposide‐resistant Human K562 Cell Line, K/eto

Sugawara, I., Iwahashi, T., Okamoto, K., Sugimoto, Y., Ekimoto, H., Tsuruo, T., Ikeuchi, T. & Mori, S., 1991 Sep, In : Japanese Journal of Cancer Research. 82, 9, p. 1035-1043 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

CMC-544 (inotuzumab ozogamicin), an anti-CD22 immuno-conjugate of calicheamicin, alters the levels of target molecules of malignant B-cells

Takeshita, A., Yamakage, N., Shinjo, K., Ono, T., Hirano, I., Nakamura, S., Shigeno, K., Tobita, T., Maekawa, M., Kiyoi, H., Naoe, T., Ohnishi, K., Sugimoto, Y. & Ohno, R., 2009, In : Leukemia. 23, 7, p. 1329-1336 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

CMC-544 (inotuzumab ozogamicin) shows less effect on multidrug resistant cells: Analyses in cell lines and cells from patients with B-cell chronic lymphocytic leukaemia and lymphoma

Takeshita, A., Shinjo, K., Yamakage, N., Ono, T., Hirano, I., Matsui, H., Shigeno, K., Nakamura, S., Tobita, T., Maekawa, M., Ohnishi, K., Sugimoto, Y., Kiyoi, H., Naoe, T. & Ohno, R., 2009 Jul, In : British Journal of Haematology. 146, 1, p. 34-43 10 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)
32 Citations (Scopus)

Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice

Sugimoto, Y., Sato, S., Tsukahara, S., Suzuki, M., Okochi, E., Gottesman, M. M., Pastan, I. & Tsuruo, T., 1997 Dec 1, In : Cancer Gene Therapy. 4, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Collateral sensitivity of cisplatin-resistant human lung cancer cell lines to thymidylate synthase inhibitors

Ohe, Y., Sugimoto, Y. & Saijo, N., 1990 Dec 1, In : Cancer Journal. 3, 6, p. 332-336 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Collateral sensitivity of drug-resistant ABCB5- and mutation-activated EGFR overexpressing cells towards resveratrol due to modulation of SIRT1 expression

Saeed, M. E. M., Rahama, M., Kuete, V., Dawood, M., Elbadawi, M., Sugimoto, Y. & Efferth, T., 2019 Jun, In : Phytomedicine. 59, 152890.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Combination therapy with antibody and interleukin-2 gene transfer against multidrug-resistant cancer cells

Shinohara, T., Sugimoto, Y., Sato, S., Sone, S. & Tsuruo, T., 1997 Nov, In : Japanese Journal of Cancer Research. 88, 11, p. 1100-1107 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Comparative pharmacodynamic analysis of TAT-59 and tamoxifen in rats bearing DMBA-induced mammary carcinoma

Toko, T., Shibata, J., Sugimoto, Y., Yamaya, H., Yoshida, M., Ogawa, K. & Matsushima, E., 1995 Jan 1, In : Cancer Chemotherapy and Pharmacology. 37, 1-2, p. 7-13 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Construction of a high efficiency retroviral vector for gene therapy of Hunter's syndrome

Hong, Y., Yu, S. S., Kim, J. M., Lee, K., Na, Y. S., Whitley, C. B., Sugimoto, Y. & Kim, S., 2003 Jan 1, In : Journal of Gene Medicine. 5, 1, p. 18-29 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Construction of MDR1 vectors for gene therapy

Sugimoto, Y., Gottesman, M. M., Pastan, I. & Tsuruo, T., 1998 Jan 1, In : Methods in Enzymology. 292, p. 523-537 15 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Contrasting effects of extended low dose versus standard dose shorter course UFT chemotherapy on microscopic versus macroscopic established tumors: Implications for optimal postoperative adjuvant chemotherapy

Uchida, J., Okabe, H., Nakano, K., Fujioka, A., Saito, H., Sugimoto, Y., Oka, T. & Fukushima, M., 2007 Aug, In : Oncology reports. 18, 2, p. 313-319 7 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Cross-resistance to tumour promoters in human cancer cell lines resistant to adriamycin or cisplatin

Nishio, K., Sugimoto, Y., Nakagawa, K., Niimi, S., Fujiwara, Y., Bungo, M., Kasahara, K., Fujiki, H. & Saijo, N., 1990 Sep, In : British Journal of Cancer. 62, 3, p. 415-419 5 p.

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)

Cytotoxicity of 35 medicinal plants from Sudan towards sensitive and multidrug-resistant cancer cells

Saeed, M. E. M., Abdelgadir, H., Sugimoto, Y., Khalid, H. E. & Efferth, T., 2015 Apr 1, In : Journal of Ethnopharmacology. 174, p. 644-658 15 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Cytotoxicity of 40 Egyptian plant extracts targeting mechanisms of drug-resistant cancer cells

Hegazy, M. E. F., Abdelfatah, S., Hamed, A. R., Mohamed, T. A., Elshamy, A. A., Saleh, I. A., Reda, E. H., Abdel-Azim, N. S., Shams, K. A., Sakr, M., Sugimoto, Y., Paré, P. W. & Efferth, T., 2019 Jun 1, In : Phytomedicine. 59, 152771.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells

Saeed, M. E. M., Boulos, J. C., Elhaboub, G., Rigano, D., Saab, A., Loizzo, M. R., Hassan, L. E. A., Sugimoto, Y., Piacente, S., Tundis, R., Yagi, S., Khalid, H. & Efferth, T., 2019 Sep 1, In : Phytomedicine. 62, 152945.

Research output: Contribution to journalArticle

7 Citations (Scopus)