• 7862 Citations
  • 49 h-Index
1979 …2020

Research output per year

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Research Output

  • 7862 Citations
  • 49 h-Index
  • 194 Article
  • 12 Review article
  • 2 Comment/debate
  • 1 Short survey
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Article
2003

Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells

Mukai, M., Che, X. F., Furukawa, T., Sumizawa, T., Aoki, S., Ren, X. Q., Haraguchi, M., Sugimoto, Y., Kobayashi, M., Takamatsu, H. & Akiyama, S. I., 2003 Jun 1, In : Cancer science. 94, 6, p. 557-563 7 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants

Miwa, M., Tsukahara, S., Ishikawa, E., Asada, S., Imai, Y. & Sugimoto, Y., 2003 Dec 10, In : International Journal of Cancer. 107, 5, p. 757-763 7 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Transport of methotrexate, methotrexate polyglutamates, and 17β-estradiol 17-(β-D-glucuronide) by ABCG2: Effects of acquired mutations at R482 on methotrexate transport

Chen, Z. S., Robey, R. W., Belinsky, M. G., Shchaveleva, I., Ren, X. Q., Sugimoto, Y., Ross, D. D., Bates, S. E. & Kruh, G. D., 2003 Jul 15, In : Cancer Research. 63, 14, p. 4048-4054 7 p.

Research output: Contribution to journalArticle

271 Citations (Scopus)
2002

C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance

Imai, Y., Nakane, M., Kage, K., Tsukahara, S., Ishikawa, E., Tsuruo, T., Miki, Y. & Sugimoto, Y., 2002 Jun 1, In : Molecular cancer therapeutics. 1, 8, p. 611-616 6 p.

Research output: Contribution to journalArticle

370 Citations (Scopus)

Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization

Kage, K., Tsukahara, S., Sugiyama, T., Asada, S., Ishikawa, E., Tsuruo, T. & Sugimoto, Y., 2002 Feb 10, In : International Journal of Cancer. 97, 5, p. 626-630 5 p.

Research output: Contribution to journalArticle

248 Citations (Scopus)

Estrone and 17β-estradiol reverse breast cancer resistance protein-mediated multidrug resistance

Imai, Y., Tsukahara, S., Ishikawa, E., Tsuruo, T. & Sugimoto, Y., 2002, In : Japanese Journal of Cancer Research. 93, 3, p. 231-235 5 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Reversal of P-glycoprotein mediated multidrug resistance by a newly synthesized 1,4-benzothiazipine derivative, JTV-519

Che, X. F., Nakajima, Y., Sumizawa, T., Ikeda, R., Ren, X. Q., Zheng, C. L., Mukai, M., Furukawa, T., Haraguchi, M., Gao, H., Sugimoto, Y. & Akiyama, S. I., 2002 Dec 10, In : Cancer Letters. 187, 1-2, p. 111-119 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin

Horie, K., Tomida, A., Sugimoto, Y., Yasugi, T., Yoshikawa, H., Taketani, Y. & Tsuruo, T., 2002 Nov 14, In : Oncogene. 21, 52, p. 7913-7922 10 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Transport of sulfated conjugates by human breast cancer resistance protein (BCRP/ABCG2)

Suzuki, M., Suzuki, H., Sugiyama, Y. & Sugimoto, Y., 2002 Jan 1, In : Japanese Pharmacology and Therapeutics. 30, SUPPL. 2, p. S433-S436+S449-S451

Research output: Contribution to journalArticle

1 Citation (Scopus)
2001

Substrate phage as a tool to identify novel substrate sequences of proteases

Ohkubo, S., Miyadera, K., Sugimoto, Y., Matsuo, K. I., Wierzba, K. & Yamada, Y., 2001 Jan 1, In : Combinatorial Chemistry and High Throughput Screening. 4, 7, p. 573-583 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2000

Identification and characterization of a deletion mutant of DNA topoisomerase I mRNA in a camptothecin-resistant subline of human colon carcinoma

Yanase, K., Sugimoto, Y., Tsukahara, S., Oh-hara, T., Andoh, T. & Tsuruo, T., 2000 May, In : Japanese Journal of Cancer Research. 91, 5, p. 551-559 9 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

New Cdc25B tyrosine phosphatase inhibitors, nocardiones A and B, produced by Nocardia sp. TP-A0248: Taxonomy, fermentation, isolation, structural elucidation and biological properties

Otani, T., Sugimoto, Y., Aoyagi, Y., Igarashi, Y., Furumai, T., Saito, N., Yamada, Y., Asao, T. & Oki, T., 2000 Apr, In : Journal of Antibiotics. 53, 4, p. 337-344 8 p.

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)

Role of P-glycoprotein in all-trans retinoic acid (ATRA) resistance in acute promyelocytic leukaemia cells: Analysis of intracellular concentration of ATRA

Takeshita, A., Shinjo, K., Naito, K., Ohnishi, K., Sugimoto, Y., Yamakawa, Y., Tanimoto, M., Kitamura, K., Naoe, T. & Ohno, R., 2000, In : British Journal of Haematology. 108, 1, p. 90-92 3 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Synthesis of a novel class of cdc25A inhibitors from Vitamin D3

Dodo, K., Takahashi, M., Yamada, Y., Sugimoto, Y., Hashimoto, Y. & Shirai, R., 2000 Apr 3, In : Bioorganic and Medicinal Chemistry Letters. 10, 7, p. 615-617 3 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Synthesis of the novel analogues of dysidiolide and their structure-activity relationship

Takahashi, M., Dodo, K., Sugimoto, Y., Aoyagi, Y., Yamada, Y., Hashimoto, Y. & Shirai, R., 2000 Nov 20, In : Bioorganic and Medicinal Chemistry Letters. 10, 22, p. 2571-2574 4 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
1999

Expression of p120 nucleolar proliferating antigen in human gliomas and growth suppression of glioma cells by p120 ribozyme vector

Sato, K., Nishi, T., Takeshima, H., Kochi, M., Kuratsu, J. I., Masuko, N., Sugimoto, Y., Yamada, Y. & Ushio, Y., 1999 Mar, In : International journal of oncology. 14, 3, p. 417-424 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Identification of substrate sequences for membrane type-1 matrix metalloproteinase using bacteriophage peptide display library

Ohkubo, S., Miyadera, K., Sugimoto, Y., Matsuo, K. I., Wierzba, K. & Yamada, Y., 1999 Dec 20, In : Biochemical and Biophysical Research Communications. 266, 2, p. 308-313 6 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Retroviral expression of a mutant (Gly-533) human DNA topoisomerase I cDNA confers a dominant form of camptothecin resistance

Yanase, K., Sugimoto, Y., Andoh, T. & Tsuruo, T., 1999, In : International Journal of Cancer. 81, 1, p. 134-140 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
1998

Construction of MDR1 vectors for gene therapy

Sugimoto, Y., Gottesman, M. M., Pastan, I. & Tsuruo, T., 1998 Jan 1, In : Methods in Enzymology. 292, p. 523-537 15 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
12 Citations (Scopus)
23 Citations (Scopus)

pHaMDR-DHFR bicistronic expression system for mutational analysis of P- glycoprotein

Zhang, S., Sugimoto, Y., Shoshani, T., Pastan, I. & Gottesman, M. M., 1998 Jan 1, In : Methods in Enzymology. 292, p. 474-480 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
1997

Coexpression of a multidrug resistance gene (MDR1) and herpes simplex virus thymidine kinase gene in a bicistronic retroviral vector Ha-MDR-IRES-TK allows selective killing of MDR1-transduced human tumors transplanted in nude mice

Sugimoto, Y., Sato, S., Tsukahara, S., Suzuki, M., Okochi, E., Gottesman, M. M., Pastan, I. & Tsuruo, T., 1997 Dec 1, In : Cancer Gene Therapy. 4, 1, p. 51-58 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Combination therapy with antibody and interleukin-2 gene transfer against multidrug-resistant cancer cells

Shinohara, T., Sugimoto, Y., Sato, S., Sone, S. & Tsuruo, T., 1997 Nov, In : Japanese Journal of Cancer Research. 88, 11, p. 1100-1107 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

In vivo drug-selectable markers in gene therapy

Sugimoto, Y. & Tsuruo, T., 1997 Jan 1, In : Leukemia. 11, SUPPL. 3, p. 552-556 5 p.

Research output: Contribution to journalArticle

Retroviral coexpression of two different types of drug resistance genes to protect normal cells from combination chemotherapy

Suzuki, M., Sugimoto, Y., Tsukahara, S., Okochi, E., Gottesman, M. M. & Tsuruo, T., 1997 Jun 1, In : Clinical Cancer Research. 3, 6, p. 947-954 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

α-Galactosidase A deficient mice: A model of fabry disease

Ohshima, T., Murray, G. J., Swaim, W. D., Longenecker, G., Quirk, J. M., Cardarelli, C. O., Sugimoto, Y., Pastan, I., Gottesman, M. M., Brady, R. O. & Kulkarni, A. B., 1997 Mar 18, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 6, p. 2540-2544 5 p.

Research output: Contribution to journalArticle

251 Citations (Scopus)
1996

A bicistronic retrovirus vector containing a picornavirus internal ribosome entry site allows for correction of X-linked CGD by selection for MDR1 expression

Sokolic, R. A., Sekhsaria, S., Sugimoto, Y., Whiting-Theobald, N., Linton, G. F., Li, F., Gottesman, M. M. & Malech, H. L., 1996 Jan 1, In : Blood. 87, 1, p. 42-50 9 p.

Research output: Contribution to journalArticle

Open Access
48 Citations (Scopus)

Antitumor activity of a novel podophyllotoxin derivative (TOP-53) against lung cancer and lung metastatic cancer

Utsugi, T., Shibata, J., Sugimoto, Y., Aoyagi, K., Wierzba, K., Kobunai, T., Terada, T., Oh-hara, T., Tsuruo, T. & Yamada, Y., 1996 Jun 15, In : Cancer Research. 56, 12, p. 2809-2814 6 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)
1995
32 Citations (Scopus)

Comparative pharmacodynamic analysis of TAT-59 and tamoxifen in rats bearing DMBA-induced mammary carcinoma

Toko, T., Shibata, J., Sugimoto, Y., Yamaya, H., Yoshida, M., Ogawa, K. & Matsushima, E., 1995 Jan 1, In : Cancer Chemotherapy and Pharmacology. 37, 1-2, p. 7-13 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Retroviral Coexpression of a Multidrug Resistance Gene (MDR1) and Human α-Galactosidase A for Gene Therapy of Fabry Disease

Sugimoto, Y., Aksentijevich, I., Murray, G. J., Brady, R. O., Pastan, I. & Gottesman, M. M., 1995 Jul 1, In : Human Gene Therapy. 6, 7, p. 905-915 11 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)
1994

Antitumor effect on SN-38, active form of CPT-11, on human colorectal cancer cell line

Aiba, K., Funakoshi, S., Mizunuma, N., Dobashi, N., Hirano, A., Sano, M., Kuraishi, Y., Kamada, M., Ohno, N., Sugimoto, Y., Tsuruo, T., Shibata, H. & Horikoshi, N., 1994 Jan 1, In : Japanese Journal of Cancer and Chemotherapy. 21, 10, p. 1601-1606 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site

Sugimoto, Y., Aksentijevich, I., Gottesman, M. M. & Pastan, I., 1994 Jul, In : Bio/Technology. 12, 7, p. 694-698 5 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Exploiting multidrug resistance to treat cancer

Gottesman, M. M., Ambudkar, S. V., Ni, B., Aran, J. M., Sugimoto, Y., Cardarelli, C. O. & Pastan, I., 1994 Jan 1, In : Cold Spring Harbor Symposia on Quantitative Biology. 59, p. 677-683 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Gene Transfer of Drug Resistance Genes Implications for Cancer Therapy

GOTTESMAN, MICHAEL. M., GERMANN, URSULA. A., AKSENTIJEVICH, IVAN., SUGIMOTO, YOSHIKAZU., CARDARELLI, CAROL. O. & PASTAN, IRA., 1994 May, In : Annals of the New York Academy of Sciences. 716, 1, p. 126-143 18 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells

Siegsmund, M. J., Cardarelli, C., Aksentijevich, I., Sugimoto, Y., Pastan, I. & Gottesman, M. M., 1994 Jan 1, In : Journal of Urology. 151, 2, p. 485-491 7 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)
1993

Antitumor Agents. 3. Synthesis and Biological Activity of 4β-Alkyl Derivatives Containing Hydroxy, Amino, and Amido Groups of 4′-O-Demethyl-4-desoxypodophyllotoxin as Antitumor Agents

Terada, T., Fujimoto, K., Nomura, M., Yamashita, J. I., Wierzba, K., Yamazaki, R., Shibata, J., Sugimoto, Y., Yamada, Y., Kobunai, T., Takeda, S., Minami, Y., Yoshida, K. I. & Yamaguchi, H., 1993 Jan 1, In : Journal of Medicinal Chemistry. 36, 12, p. 1689-1699 11 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

cDNA expression cloning of the 85-kDa protein overexpressed in adriamycin-resistant cells

Noguchi, K., Naito, M., Tezuka, K. I., Ishii, S., Seimiya, H., Sugimoto, Y., Amann, E. & Tsuruo, T., 1993 Apr 15, In : Biochemical and Biophysical Research Communications. 192, 1, p. 88-95 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Molecular Cloning and Characterization of the Complementary DNA for the Mr 85,000 Protein Overexpressed in Adriamycin-resistant Human Tumor Cells

Sugimoto, Y., Hamada, H., Tsukahara, S. & Tsuruo, T., 1993 Jun, In : Cancer Research. 53, 11, p. 2538-2543 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Nucleosides and Nucleotides. 123. Synthesis of 1-(2-Deoxy-2-isocyano-β-d-arabinofuranosyl)cytosine and Related Nucleosides as Potential Antitumor Agents

Matsuda, A., Dan, A., Minakawa, N., Tregear, S. J., Okazaki, S., Sugimoto, Y. & Sasaki, T., 1993 Jan 1, In : Journal of Medicinal Chemistry. 36, 26, p. 4190-4194 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The Mechanism of the Difference in Cellular Uptake of Platinum Derivatives in Non‐small Cell Lung Cancer Cell Line (PC‐14) and Its Cisplatin‐resistant Subline (PC‐14/CDDP)

Ohmori, T., Morikage, T., Sugimoto, Y., Fujiwara, Y., Kasahara, K., Nishio, K., Ohta, S., Sasaki, Y., Takahashi, T. & Saijo, N., 1993 Jan, In : Japanese Journal of Cancer Research. 84, 1, p. 83-92 10 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
1992

Determinants of response to the DNA topoisomerase II inhibitors doxorubicin and etoposide in human lung cancer cell lines

Kasahara, K., Fujiwara, Y., Sugimoto, Y., Nishio, K., Tamura, T., Matsuda, T. & Saijo, N., 1992 Jan 15, In : Journal of the National Cancer Institute. 84, 2, p. 113-118 6 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)
32 Citations (Scopus)

Expression of a human multidrug resistance gene in human ovarian carcinoma cell lines

Sekiya, S., Nunoyama, T., Shirasawa, H., Kimura, H., Kawata, M., Iijima, N., Sugimoto, Y., Tsuruo, T. & Takamizawa, H., 1992 Jun, In : Archives of gynecology and obstetrics. 251, 2, p. 79-86 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Increased phosphorylation of nuclear phosphoproteins in human lung‐cancer cells resistant to cis‐diamminedichloroplatinum(II)

Nishio, K., Sugimoto, Y., Kasahara, K., Fujiwara, Y., Nishiwaki, S., Fujiki, H., Ohata, M. & Saijo, N., 1992 Feb 1, In : International Journal of Cancer. 50, 3, p. 438-442 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines

Sugimoto, Y., Ohe, Y., Nishio, K., Ohmori, T., Fujiwara, Y. & SAijo, N., 1992 Nov, In : Cancer Chemotherapy and Pharmacology. 30, 6, p. 417-422 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Mechanisms of collateral sensitivity to fluorouracil of a cis-diamminedichloroplatinum(Ii)-resistant human non-small lung cancer cell line

Sugimoto, Y., Ohe, Y., Nishio, K., Ohmori, T., Morikage, T., Fujiwara, Y. & Saijo, N., 1992 Jun, In : British Journal of Cancer. 65, 6, p. 857-864 8 p.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by cis-diamminedichloroplatinum(II)

Nishio, K., Sugimoto, Y., Fujiwara, Y., Ohmori, T., Morikage, T., Takeda, Y., Ohata, M. & Saijo, N., 1992, In : Journal of Clinical Investigation. 89, 5, p. 1622-1628 7 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)
1991

Characterization of an Etoposide‐resistant Human K562 Cell Line, K/eto

Sugawara, I., Iwahashi, T., Okamoto, K., Sugimoto, Y., Ekimoto, H., Tsuruo, T., Ikeuchi, T. & Mori, S., 1991 Sep, In : Japanese Journal of Cancer Research. 82, 9, p. 1035-1043 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)