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19992019

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2019

Circulating microRNA-1246 as a possible biomarker for early tumor recurrence of hepatocellular carcinoma

Chuma, M., Toyoda, H., Matsuzaki, J., Saito, Y., Kumada, T., Tada, T., Kaneoka, Y., Maeda, A., Yokoo, H., Ogawa, K., Kamiyama, T., Taketomi, A., Matsuno, Y., Yazawa, K., Takeda, K., Kunisaki, C., Ogushi, K., Moriya, S., Hara, K., Nozaki, A. & 6 others, Kondo, M., Fukuda, H., Numata, K., Tanaka, K., Maeda, S. & Sakamoto, N., 2019 Jul, In : Hepatology Research. 49, 7, p. 810-822 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging

Uchida, R., Saito, Y., Nogami, K., Kajiyama, Y., Suzuki, Y., Kawase, Y., Nakaoka, T., Muramatsu, T., Kimura, M. & Saito, H., 2019 Dec 1, In : npj Aging and Mechanisms of Disease. 5, 1, 1.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1 Citation (Scopus)

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma

Saito, Y., Muramatsu, T., Kanai, Y., Ojima, H., Sukeda, A., Hiraoka, N., Arai, E., Sugiyama, Y., Matsuzaki, J., Uchida, R., Yoshikawa, N., Furukawa, R. & Saito, H., 2019 Apr 23, In : Cell Reports. 27, 4, p. 1265-1276.e4

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

Generation of human hepatic progenitor cells with regenerative and metabolic capacities from primary hepatocytes

Katsuda, T., Matsuzaki, J., Yamaguchi, T., Yamada, Y., Prieto-Vila, M., Hosaka, K., Takeuchi, A., Saito, Y. & Ochiya, T., 2019 Aug 8, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets

Lau, D. K., Mouradov, D., Wasenang, W., Luk, I. Y., Scott, C. M., Williams, D. S., Yeung, Y. H., Limpaiboon, T., Iatropoulos, G. F., Jenkins, L. J., Reehorst, C. M., Chionh, F., Nikfarjam, M., Croagh, D., Dhillon, A. S., Weickhardt, A. J., Muramatsu, T., Saito, Y., Tebbutt, N. C., Sieber, O. M. & 1 others, Mariadason, J. M., 2019 Nov 22, In : iScience. 21, p. 624-637 14 p.

Research output: Contribution to journalArticle

Open Access

Glucose depletion enhances the stem cell phenotype and gemcitabine resistance of cholangiocarcinoma organoids through AKT phosphorylation and reactive oxygen species

Yoshikawa, N., Saito, Y., Manabe, H., Nakaoka, T., Uchida, R., Furukawa, R., Muramatsu, T., Sugiyama, Y., Kimura, M. & Saito, H., 2019 Dec, In : Cancers. 11, 12, 1993.

Research output: Contribution to journalArticle

Open Access

Vonoprazan-based third-line therapy has a higher eradication rate against sitafloxacin-resistant Helicobacter pylori

Saito, Y., Konno, K., Sato, M., Nakano, M., Kato, Y., Saito, H. & Serizawa, H., 2019 Jan 1, In : Cancers. 11, 1, 116.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)
2018

Anticancer Drug Prescription Patterns in Japan: Future Directions in Cancer Therapy

Shibata, S., Matsushita, M., Saito, Y. & Suzuki, T., 2018 Nov 1, In : Therapeutic Innovation and Regulatory Science. 52, 6, p. 718-723 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Bile acid metabolism regulated by the gut microbiota promotes non-alcoholic steatohepatitis-associated hepatocellular carcinoma in mice

Yamada, S., Takashina, Y., Watanabe, M., Nagamine, R., Saito, Y., Kamada, N. & Saito, H., 2018 Jan 1, In : Oncotarget. 9, 11, p. 9925-9939 15 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy

Tsugawa, H., Mori, H., Matsuzaki, J., Sato, A., Saito, Y., Imoto, M., Suematsu, M. & Suzuki, H., 2018 Jan 1, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Dual effects of the Nrf2 inhibitor for inhibition of hepatitis C virus and hepatic cancer cells

Murakami, Y., Sugiyama, K., Ebinuma, H., Nakamoto, N., Ojiro, K., Cho, H., Taniki, N., Saito, Y., Teratani, T., Koda, Y., Suzuki, T., Saito, K., Fukasawa, M., Ikeda, M., Kato, N., Kanai, T. & Saito, H., 2018 Jun 25, In : BMC Cancer. 18, 1, 680.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 Dec 1, In : Scientific Reports. 8, 1, 2821.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2017

Cluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids

Nakaoka, T., Saito, Y., Shimamoto, Y., Muramatsu, T., Kimura, M., Kanai, Y. & Saito, H., 2017 Apr 1, In : Cancer Science. 108, 4, p. 678-684 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis

Yamada, S., Kamada, N., Amiya, T., Nakamoto, N., Nakaoka, T., Kimura, M., Saito, Y., Ejima, C., Kanai, T. & Saito, H., 2017 Nov 29, In : BMC Gastroenterology. 17, 1, 136.

Research output: Contribution to journalArticle

15 Citations (Scopus)
1 Citation (Scopus)
2016
2 Citations (Scopus)

Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response

Saito, Y., Nakaoka, T., Sakai, K., Muramatsu, T., Toshimitsu, K., Kimura, M., Kanai, T., Sato, T. & Saito, H., 2016 May 4, In : Scientific Reports. 6, 25311.

Research output: Contribution to journalArticle

15 Citations (Scopus)

microRNA-mediated resistance to hypoglycemia in the HepG2 human hepatoma cell line

Ueki, S., Murakami, Y., Yamada, S., Kimura, M., Saito, Y. & Saito, H., 2016 Sep 15, In : BMC Cancer. 16, 1, 732.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2015

First-line eradication for Helicobacter pylori -positive gastritis by esomeprazole-based triple therapy is influenced by CYP2C19 genotype

Saito, Y., Serizawa, H., Kato, Y., Nakano, M., Nakamura, M., Saito, H., Suzuki, H. & Kanai, T., 2015 Dec 28, In : World Journal of Gastroenterology. 21, 48, p. 13548-13554 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2014

Alterations of epigenetics and microRNAs in cancer and cancer stem cell

Saito, Y., 2014 Jan 1, In : Frontiers in Genetics. 5, AUG, Article 283.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Astaxanthin supplementation effects on adipocyte size and lipid profile in OLETF rats with hyperphagia and visceral fat accumulation

Kimura, M., Iida, M., Yamauchi, H., Suzuki, M., Shibasaki, T., Saito, Y. & Saito, H., 2014 Jan 1, In : Journal of Functional Foods. 11, C, p. 114-120 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Epigenetic alterations and microRNA misexpression in cancer and autoimmune diseases: a critical review

Saito, Y., Saito, H., Liang, G. & Friedman, J. M., 2014 Oct 1, In : Clinical reviews in allergy & immunology. 47, 2, p. 128-135 8 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Inhibitors of enhancer of zeste homolog 2 (EZH2) activate tumor-suppressor microRNAs in human cancer cells

Hibino, S., Saito, Y., Muramatsu, T., Otani, A., Kasai, Y., Kimura, M. & Saito, H., 2014 Jan 1, In : Oncogenesis. 3, 5, e104.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus

Sugiyama, K., Ebinuma, H., Nakamoto, N., Sakasegawa, N., Murakami, Y., Chu, P. S., Usui, S., Ishibashi, Y., Wakayama, Y., Taniki, N., Murata, H., Saito, Y., Fukasawa, M., Saito, K., Yamagishi, Y., Wakita, T., Takaku, H., Hibi, T., Saito, H. & Kanai, T., 2014 Apr 9, In : PloS one. 9, 4, e94460.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis

Takaki, Y., Saito, Y., Takasugi, A., Toshimitsu, K., Yamada, S., Muramatsu, T., Kimura, M., Sugiyama, K., Suzuki, H., Arai, E., Ojima, H., Kanai, Y. & Saito, H., 2014 Oct 1, In : Cancer science. 105, 10, p. 1254-1260 7 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Surveillance using trimodal imaging endoscopy after endoscopic submucosal dissection for superficial gastric neoplasia

Imaeda, H., Hosoe, N., Kashiwagi, K., Ida, Y., Nakamura, R., Suzuki, H., Saito, Y., Yahagi, N., Iwao, Y., Kitagawa, Y., Hibi, T., Ogata, H. & Kanai, T., 2014 Nov 21, In : World Journal of Gastroenterology. 20, 43, p. 16311-16317 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2013

Bile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis

Matsuzaki, J., Suzuki, H., Tsugawa, H., Watanabe, M., Hossain, S., Arai, E., Saito, Y., Sekine, S., Akaike, T., Kanai, Y., Mukaisho, K. I., Auwerx, J. & Hibi, T., 2013 Dec, In : Gastroenterology. 145, 6, p. 1300-1311 12 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Derangement of ghrelin secretion after long-term high-fat diet feeding in rats

Sugiishi, A., Kimura, M., Kamiya, R., Ueki, S., Yoneya, M., Saito, Y. & Saito, H., 2013 Oct 1, In : Hepatology Research. 43, 10, p. 1105-1114 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Improvement of reflux symptom related quality of life after Helicobacter pylori eradication therapy

Hirata, K., Suzuki, H., Matsuzaki, J., Masaoka, T., Saito, Y., Nishizawa, T., Iwasaki, E., Fukuhara, S., Okada, S. & Hibi, T., 2013 Mar 1, In : Journal of Clinical Biochemistry and Nutrition. 52, 2, p. 172-178 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Suppressive effect of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) on hepatitis C virus replication

Sato, A., Saito, Y., Sugiyama, K., Sakasegawa, N., Muramatsu, T., Fukuda, S., Yoneya, M., Kimura, M., Ebinuma, H., Hibi, T., Ikeda, M., Kato, N. & Saito, H., 2013 Aug 16, In : Journal of Cellular Biochemistry. 114, 9, p. 1987-1996 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells

Saito, Y., Suzuki, H., Imaeda, H., Matsuzaki, J., Hirata, K., Tsugawa, H., Hibino, S., Kanai, Y., Saito, H. & Hibi, T., 2013 Apr 15, In : International Journal of Cancer. 132, 8, p. 1751-1760 10 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
2012

Development of a novel microRNA promoter microarray for ChIP-on-chip assay to identify epigenetically regulated microRNAs

Saito, Y., Suzuki, H., Taya, T., Nishizawa, M., Tsugawa, H., Matsuzaki, J., Hirata, K., Saito, H. & Hibi, T., 2012 Sep 14, In : Biochemical and Biophysical Research Communications. 426, 1, p. 33-37 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Efficacy of sitafloxacin-based rescue therapy for Helicobacter pylori after failures of first- and second-line therapies

Matsuzaki, J., Suzuki, H., Nishizawa, T., Hirata, K., Tsugawa, H., Saito, Y., Okada, S., Fukuhara, S. & Hibi, T., 2012 Mar 1, In : Antimicrobial Agents and Chemotherapy. 56, 3, p. 1643-1645 3 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

MicroRNAs in cancers and neurodegenerative disorders

Saito, Y. & Saito, H., 2012 Dec 1, In : Frontiers in Genetics. 3, SEP, Article 194.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Overexpression of miR-142-5p and miR-155 in Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Resistant to Helicobacter pylori Eradication

Saito, Y., Suzuki, H., Tsugawa, H., Imaeda, H., Matsuzaki, J., Hirata, K., Hosoe, N., Nakamura, M., Mukai, M., Saito, H. & Hibi, T., 2012 Nov 28, In : PloS one. 7, 11, e47396.

Research output: Contribution to journalArticle

82 Citations (Scopus)
2011

Dysfunctional gastric emptying with down-regulation of muscle-specific MicroRNAs in helicobacter pylori-infected mice

Saito, Y., Suzuki, H., Tsugawa, H., Suzuki, S., Matsuzaki, J., Hirata, K. & Hibi, T., 2011 Jan, In : Gastroenterology. 140, 1, p. 189-198 10 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
19 Citations (Scopus)

Enhanced bacterial efflux system is the first step to the development of metronidazole resistance in Helicobacter pylori

Tsugawa, H., Suzuki, H., Muraoka, H., Ikeda, F., Hirata, K., Matsuzaki, J., Saito, Y. & Hibi, T., 2011 Jan 14, In : Biochemical and Biophysical Research Communications. 404, 2, p. 656-660 5 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Etiological difference between ultrashort- and short-segment Barrett's esophagus

Matsuzaki, J., Suzuki, H., Asakura, K., Saito, Y., Hirata, K., Takebayashi, T. & Hibi, T., 2011 Mar 1, In : Journal of gastroenterology. 46, 3, p. 332-338 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

MicroRNAs in hepatobiliary and pancreatic cancers

Saito, Y., Suzuki, H., Matsuura, M., Sato, A., Kasai, Y., Yamada, K., Saito, H. & Hibi, T., 2011 Dec 1, In : Frontiers in Genetics. 2, SEP, Article 66.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Two amino acids mutation of ferric uptake regulator determines helicobacter pylori resistance to metronidazole

Tsugawa, H., Suzuki, H., Satoh, K., Hirata, K., Matsuzaki, J., Saito, Y., Suematsu, M. & Hibi, T., 2011 Jan 1, In : Antioxidants and Redox Signaling. 14, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)
2010

Autofluorescence videoendoscopy system using the SAFE-3000 for assessing superficial gastric neoplasia

Imaeda, H., Hosoe, N., Kashiwagi, K., Ida, Y., Saito, Y., Suzuki, H., Aiura, K., Ogata, H., Kumai, K. & Hibi, T., 2010 Apr, In : Journal of Gastroenterology and Hepatology (Australia). 25, 4, p. 706-711 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Clinical results of observation of the upper gastrointestinal tract by transgastrostomic endoscopy using an ultrathin endoscope

Imaeda, H., Hosoe, N., Nakamizo, H., Kashiwagi, K., Suzuki, H., Saito, Y., Suganuma, K., Ida, Y., Matsuzaki, J., Iwasaki, E., Iwao, Y., Ogata, H. & Hibi, T., 2010 Dec, In : Journal of Gastroenterology and Hepatology (Australia). 25, 12, p. 1850-1854 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Contribution of efflux pumps to clarithromycin resistance in Helicobacter pylori

Hirata, K., Suzuki, H., Nishizawa, T., Tsugawa, H., Muraoka, H., Saito, Y., Matsuzaki, J. & Hibi, T., 2010 May, In : Journal of Gastroenterology and Hepatology (Australia). 25, SUPPL. 1, p. S75-S79

Research output: Contribution to journalArticle

64 Citations (Scopus)

DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8

Kurita, S., Higuchi, H., Saito, Y., Nakamoto, N., Takaishi, H., Tada, S., Saito, H., Gores, G. J. & Hibi, T., 2010 Jun 1, In : Cancer science. 101, 6, p. 1431-1439 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Gallstones increase the prevalence of Barrett's esophagus

Matsuzaki, J., Suzuki, H., Asakura, K., Saito, Y., Hirata, K., Takebayashi, T. & Hibi, T., 2010 Feb 1, In : Journal of gastroenterology. 45, 2, p. 171-178 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2009

Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells

Saito, Y., Suzuki, H., Tsugawa, H., Nakagawa, I., Matsuzaki, J., Kanai, Y. & Hibi, T., 2009 Jul 30, In : Oncogene. 28, 30, p. 2738-2744 7 p.

Research output: Contribution to journalArticle

143 Citations (Scopus)

Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells

Saito, Y., Friedman, J. M., Chihara, Y., Egger, G., Chuang, J. C. & Liang, G., 2009 Feb 13, In : Biochemical and Biophysical Research Communications. 379, 3, p. 726-731 6 p.

Research output: Contribution to journalArticle

200 Citations (Scopus)