• 3221 Citations
  • 30 h-Index
1993 …2019
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Research Output 1993 2019

  • 3221 Citations
  • 30 h-Index
  • 92 Article
  • 7 Chapter
  • 1 Book
  • 1 Review article
2019
2 Citations (Scopus)

Structure-activity relationship studies of Bz amide-containing α-GalCer derivatives as natural killer T cell modulators

Kishi, J., Inuki, S., Hirata, N., Kashiwabara, E., Yoshidome, D., Ichihara, O. & Fujimoto, Y., 2019 Apr 15, In : Bioorganic and Medicinal Chemistry Letters. 29, 8, p. 970-973 4 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
T-cells
Structure-Activity Relationship
Amides
Modulators
1 Citation (Scopus)

Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity

Matsumaru, T., Ikeno, R., Shuchi, Y., Iwamatsu, T., Tadokoro, T., Yamasaki, S., Fujimoto, Y., Furukawa, A. & Maenaka, K., 2019 Jan 1, In : Chemical Communications. 55, 5, p. 711-714 4 p.

Research output: Contribution to journalArticle

Glycerol
Derivatives
Immune system
Lipids
Assays

Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety

Inuki, S., Sato, K., Zui, N., Yamaguchi, R., Matsumaru, T. & Fujimoto, Y., 2019 Oct 4, In : Journal of Organic Chemistry. 84, 19, p. 12680-12685 6 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Palladium
Derivatives

Total synthesis of naturally occurring chiral cyclopropane fatty acids and related compounds

Inuki, S. & Fujimoto, Y., 2019 Apr 18, In : Tetrahedron Letters. 60, 16, p. 1083-1090 8 p.

Research output: Contribution to journalReview article

Bioactivity
Immunosuppressive Agents
Microorganisms
cyclopropane fatty acids
2018
11 Citations (Scopus)

Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity

Shibata, N., Kunisawa, J., Hosomi, K., Fujimoto, Y., Mizote, K., Kitayama, N., Shimoyama, A., Mimuro, H., Sato, S., Kishishita, N., Ishii, K. J., Fukase, K. & Kiyono, H., 2018 May 1, In : Mucosal Immunology. 11, 3, p. 693-702 10 p.

Research output: Contribution to journalArticle

Alcaligenes
Lymphoid Tissue
Immunoglobulin A
Lipopolysaccharides
Peyer's Patches
5 Citations (Scopus)

Potent Th2 Cytokine Bias of Natural Killer T Cell by CD1d Glycolipid Ligands: Anchoring Effect of Polar Groups in the Lipid Component

Inuki, S., Kashiwabara, E., Hirata, N., Kishi, J., Nabika, E. & Fujimoto, Y., 2018 Jul 26, In : Angewandte Chemie - International Edition. 57, 31, p. 9655-9659 5 p.

Research output: Contribution to journalArticle

T-cells
Glycolipids
Lipids
Ligands
Cytokines
4 Citations (Scopus)
Toll-Like Receptor 2
Functional groups
Ligands
Lipids
Amides
3 Citations (Scopus)

Syntheses and Immunological Evaluation of Self-Adjuvanting Clustered N-Acetyl and N-Propionyl Sialyl-Tn Combined with a T-helper Cell Epitope as Antitumor Vaccine Candidates

Chang, T. C., Manabe, Y., Fujimoto, Y., Ohshima, S., Kametani, Y., Kabayama, K., Nimura, Y., Lin, C. C. & Fukase, K., 2018 Jul 2, In : Angewandte Chemie - International Edition. 57, 27, p. 8219-8224 6 p.

Research output: Contribution to journalArticle

Epitopes
Vaccines
Antigens
Tumor-Associated Carbohydrate Antigens
Carbohydrates
1 Citation (Scopus)

Synthesis of Cyclopropane Fatty Acids by C(sp3)−C(sp3) Cross-Coupling Reaction and Formal Synthesis of α-Mycolic Acid

Iwasaki, T., Terahigashi, S., Wang, Y., Tanaka, A., Zhao, H., Fujimoto, Y., Fukase, K. & Kambe, N., 2018 Oct 4, In : Advanced Synthesis and Catalysis. 360, 19, p. 3810-3817 8 p.

Research output: Contribution to journalArticle

Mycolic Acids
Fatty acids
Acids
Carbon
Functional groups
2 Citations (Scopus)

The second and third amino acids of Pam2 lipopeptides are key for the proliferation of cytotoxic T cells

Takeda, Y., Azuma, M., Hatsugai, R., Fujimoto, Y., Hashimoto, M., Fukase, K., Matsumoto, M. & Seya, T., 2018 Jan 1, (Accepted/In press) In : Innate Immunity.

Research output: Contribution to journalArticle

Lipopeptides
Dendritic Cells
T-Lymphocytes
Amino Acids
Cysteine

Time-lapse monitoring of TLR2 ligand internalization with newly developed fluorescent probes

Arai, Y., Yokoyama, K., Kawahara, Y., Feng, Q., Ohta, I., Shimoyama, A., Inuki, S., Fukase, K., Kabayama, K. & Fujimoto, Y., 2018 Jan 1, In : Organic and Biomolecular Chemistry. 16, 20, p. 3824-3830 7 p.

Research output: Contribution to journalArticle

Fluorescent Dyes
Ligands
ligands
Monitoring
probes
2017
3 Citations (Scopus)

A Comprehensive Study of the Interaction between Peptidoglycan Fragments and the Extracellular Domain of Mycobacterium tuberculosis Ser/Thr Kinase PknB

Wang, Q., Marchetti, R., Prisic, S., Ishii, K., Arai, Y., Ohta, I., Inuki, S., Uchiyama, S., Silipo, A., Molinaro, A., Husson, R. N., Fukase, K. & Fujimoto, Y., 2017 Nov 2, In : ChemBioChem. 18, 21, p. 2094-2098 5 p.

Research output: Contribution to journalArticle

Peptidoglycan
Mycobacterium tuberculosis
Phosphotransferases
Interferometry
Peptides
10 Citations (Scopus)

Chemical Synthesis of d -glycero- d -manno-Heptose 1,7-Bisphosphate and Evaluation of Its Ability to Modulate NF-κB Activation

Inuki, S., Aiba, T., Kawakami, S., Akiyama, T., Inoue, J. I. & Fujimoto, Y., 2017 Jun 16, In : Organic Letters. 19, 12, p. 3079-3082 4 p.

Research output: Contribution to journalArticle

Heptoses
Membrane Glycoproteins
Chemical activation
assaying
activation
1 Citation (Scopus)

Convergent Synthesis of Digalactosyl Diacylglycerols

Inuki, S., Kishi, J., Kashiwabara, E., Aiba, T. & Fujimoto, Y., 2017 Dec 15, In : Organic Letters. 19, 24, p. 6482-6485 4 p.

Research output: Contribution to journalArticle

galactose
Diglycerides
Galactose
linkages
synthesis
5 Citations (Scopus)

Employing BINOL-Phosphoroselenoyl Chloride for Selective Inositol Phosphorylation and Synthesis of Glycosyl Inositol Phospholipid from Entamoeba histolytica

Aiba, T., Suehara, S., Choy, S. L., Maekawa, Y., Lotter, H., Murai, T., Inuki, S., Fukase, K. & Fujimoto, Y., 2017 Jun 16, In : Chemistry - A European Journal. 23, 34, p. 8304-8308 5 p.

Research output: Contribution to journalArticle

Phosphorylation
Phospholipids
Inositol
Phosphatidylinositols
Chlorides
16 Citations (Scopus)

Formal Total Synthesis of l -Ossamine via Decarboxylative Functionalization Using Visible-Light-Mediated Photoredox Catalysis in a Flow System

Inuki, S., Sato, K., Fukuyama, T., Ryu, I. & Fujimoto, Y., 2017 Jan 20, In : Journal of Organic Chemistry. 82, 2, p. 1248-1253 6 p.

Research output: Contribution to journalArticle

Catalysis
Threonine
Derivatives
3 Citations (Scopus)

Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex

Okamoto, N., Mizote, K., Honda, H., Saeki, A., Watanabe, Y., Yamaguchi-Miyamoto, T., Fukui, R., Tanimura, N., Motoi, Y., Akashi-Takamura, S., Kato, T., Fujishita, S., Kimura, T., Ohto, B. U., Shimizu, T., Hirokawa, T., Miyake, K., Fukase, K., Fujimoto, Y., Nagai, Y. & 1 others, Takatsu, K., 2017, In : Journal of Biological Chemistry. 292, 37, p. 15378-15394 17 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Innate Immunity
Derivatives
Chemical activation
Dendritic Cells
3 Citations (Scopus)

Synthesis of Peptidoglycan Fragments from Enterococcus faecalis with Fmoc-Strategy for Glycan Elongation

Wang, N., Hasegawa, H., Huang, C. Y., Fukase, K. & Fujimoto, Y., 2017 Jan 3, In : Chemistry - An Asian Journal. 12, 1, p. 27-30 4 p.

Research output: Contribution to journalArticle

Peptidoglycan
Enterococcus faecalis
Polysaccharides
Elongation
Bacterial Proteins
3 Citations (Scopus)

Synthetic analogs of an Entamoeba histolytica glycolipid designed to combat intracellular Leishmania infection

Choy, S. L., Bernin, H., Aiba, T., Bifeld, E., Lender, S. C., Mühlenpfordt, M., Noll, J., Eick, J., Marggraff, C., Niss, H., Roldán, N. G., Tanaka, S., Kitamura, M., Fukase, K., Clos, J., Tannich, E., Fujimoto, Y. & Lotter, H., 2017 Dec 1, In : Scientific Reports. 7, 1, 9472.

Research output: Contribution to journalArticle

Entamoeba histolytica
Cutaneous Leishmaniasis
Leishmania
Glycolipids
Parasites
3 Citations (Scopus)

Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids

Inuki, S., Ohta, I., Ishibashi, S., Takamatsu, M., Fukase, K. & Fujimoto, Y., 2017 Aug 4, In : Journal of Organic Chemistry. 82, 15, p. 7832-7838 7 p.

Research output: Contribution to journalArticle

Cardiolipins
Cell membranes
Bioactivity
Phospholipids
Membranes
2016
9 Citations (Scopus)

Characterization of a novel D-Glycero-D-talo-oct-2-ulosonic acid-substituted lipid A moiety in the lipopolysaccharide produced by the acetic acid bacterium Acetobacter pasteurianus NBRC 3283

Hashimoto, M., Ozono, M., Furuyashiki, M., Baba, R., Hashiguchi, S., Suda, Y., Fukase, K. & Fujimoto, Y., 2016 Sep 30, In : Journal of Biological Chemistry. 291, 40, p. 21184-21194 11 p.

Research output: Contribution to journalArticle

Acetobacter
Lipid A
Acetic Acid
Lipopolysaccharides
Bacteria
9 Citations (Scopus)

Discovery of a Novel Scaffold as an Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid, Longamide B

Shiokawa, Z., Kashiwabara, E., Yoshidome, D., Fukase, K., Inuki, S. & Fujimoto, Y., 2016 Dec 16, In : ChemMedChem. 11, 24, p. 2682-2689 8 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Alkaloids
Scaffolds
Thioamides
Derivatives
6 Citations (Scopus)

Efficient Synthesis of (-)-Hanishin, (-)-Longamide B, and (-)-Longamide B Methyl Ester through Piperazinone Formation from 1,2-Cyclic Sulfamidates

Shiokawa, Z., Inuki, S., Fukase, K. & Fujimoto, Y., 2016 Mar 1, In : Synlett. 27, 4, p. 616-620 5 p., st-2015-u0727-l.

Research output: Contribution to journalArticle

Scaffolds
hanishin
longamide B
longamide B methyl ester
pyrrolopiperazinone
8 Citations (Scopus)

Isolated polar amino acid residues modulate lipid binding in the large hydrophobic cavity of CD1d

Inuki, S., Aiba, T., Hirata, N., Ichihara, O., Yoshidome, D., Kita, S., Maenaka, K., Fukase, K. & Fujimoto, Y., 2016 Nov 18, In : ACS Chemical Biology. 11, 11, p. 3132-3139 8 p.

Research output: Contribution to journalArticle

Ligands
Lipids
Amino Acids
Glycolipids
Proteins

Peptidoglycan microarray as a novel tool to explore protein–ligand recognition

Wang, N., Hirata, A., Nokihara, K., Fukase, K. & Fujimoto, Y., 2016 Nov 4, In : Biopolymers. p. 422-429 8 p.

Research output: Contribution to journalArticle

Peptidoglycan
Microarrays
Proteins
Amorphous carbon
Cell growth
13 Citations (Scopus)

Regioselective phosphorylation of: Myo -inositol with BINOL-derived phosphoramidites and its application for protozoan lysophosphatidylinositol

Aiba, T., Sato, M., Umegaki, D., Iwasaki, T., Kambe, N., Fukase, K. & Fujimoto, Y., 2016, In : Organic and Biomolecular Chemistry. 14, 28, p. 6672-6675 4 p.

Research output: Contribution to journalArticle

inositols
phosphorylation
Phosphorylation
Inositol
fatty acids
14 Citations (Scopus)
Diaminopimelic Acid
Peptidoglycan
Mycobacterium
Innate Immunity
fragments
2015
1 Citation (Scopus)

Microbial glycoconjugates recognition with tlrs and nlrs in innate immunity

Fujimoto, Y. & Fukase, K., 2015 Jan 1, Glycoscience: Biology and Medicine. Springer Japan, p. 685-690 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glycoconjugates
Innate Immunity
Immune system
Ligands
Immune System

S

Fukase, K., Tanaka, K., Fujimoto, Y., Shimoyama, A. & Manabe, Y., 2015 Jan 1, Glycochemical Synthesis: Strategies and Applications. Wiley Blackwell, p. 205-219 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glycosylation
Microfluidics
Oligosaccharides
Asparagine
Temperature control
3 Citations (Scopus)
Amino Alcohols
Hydroxy Acids
Threonine
Serine
Derivatives
2014
72 Citations (Scopus)

Molecular basis for bacterial peptidoglycan recognition by LysM domains

Mesnage, S., Dellarole, M., Baxter, N. J., Rouget, J. B., Dimitrov, J. D., Wang, N., Fujimoto, Y., Hounslow, A. M., Lacroix-Desmazes, S., Fukase, K., Foster, S. J. & Williamson, M. P., 2014 Jun 30, In : Nature Communications. 5, 4269.

Research output: Contribution to journalArticle

Peptidoglycan
modules
polysaccharides
carbohydrates
Polysaccharides
9 Citations (Scopus)

Practical and efficient method for α-sialylation with an azide sialyl donor using a microreactor

Uchinashi, Y., Tanaka, K., Manabe, Y., Fujimoto, Y. & Fukase, K., 2014 Feb 12, In : Journal of Carbohydrate Chemistry. 33, 2, p. 55-67 13 p.

Research output: Contribution to journalArticle

Microfluidics
Azides
Disaccharides
Temperature control
Temperature
1 Citation (Scopus)

Solid-phase synthesis of bacterial cell wall peptidoglycan fragments

Kadonaga, Y., Wang, N., Fujimoto, Y. & Fukase, K., 2014, In : Chemistry Letters. 43, 9, p. 1461-1463 3 p.

Research output: Contribution to journalArticle

Peptidoglycan
Cells
Immunologic Adjuvants
Functional groups
Bacteria
23 Citations (Scopus)

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane

Tanimura, N., Saitoh, S. I., Ohto, U., Akashi-Takamura, S., Fujimoto, Y., Fukase, K., Shimizu, T. & Miyake, K., 2014, In : International Immunology. 26, 6, p. 307-314 8 p., dxt071.

Research output: Contribution to journalArticle

Lipid A
Dimerization
Cell Membrane
Inflammation
Up-Regulation
2013
11 Citations (Scopus)

Glycan Sequence-Dependent Nod2 Activation Investigated by Using a Chemically Synthesized Bacterial Peptidoglycan Fragment Library

Wang, N., Huang, C. Y., Hasegawa, M., Inohara, N., Fujimoto, Y. & Fukase, K., 2013 Mar, In : ChemBioChem. 14, 4, p. 482-488 7 p.

Research output: Contribution to journalArticle

Nod2 Signaling Adaptor Protein
Oligomerization
Peptidoglycan
Polysaccharides
Nucleotides
13 Citations (Scopus)

Human SAP is a novel peptidoglycan recognition protein that induces complement-independent phagocytosis of Staphylococcus aureus

An, J. H., Kurokawa, K., Jung, D. J., Kim, M. J., Kim, C. H., Fujimoto, Y., Fukase, K., Coggeshall, K. M. & Lee, B. L., 2013 Sep 15, In : Journal of Immunology. 191, 6, p. 3319-3327 9 p.

Research output: Contribution to journalArticle

Serum Amyloid P-Component
Teichoic Acids
Phagocytosis
Staphylococcus aureus
Peptidoglycan
10 Citations (Scopus)

Innate immunomodulation by lipophilic termini of lipopolysaccharide; Synthesis of lipid As from Porphyromonas gingivalis and other bacteria and their immunomodulative responses

Fujimoto, Y., Shimoyama, A., Saeki, A., Kitayama, N., Kasamatsu, C., Tsutsui, H. & Fukase, K., 2013 May, In : Molecular BioSystems. 9, 5, p. 987-996 10 p.

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Immunomodulation
Lipopolysaccharides
Bacteria
Lipids
21 Citations (Scopus)

Nickel-butadiene catalytic system for the cross-coupling of bromoalkanoic acids with alkyl grignard reagents: A practical and versatile method for preparing fatty acids

Iwasaki, T., Higashikawa, K., Reddy, V. P., Ho, W. W. S., Fujimoto, Y., Fukase, K., Terao, J., Kuniyasu, H. & Kambe, N., 2013 Feb 25, In : Chemistry - A European Journal. 19, 9, p. 2956-2960 5 p.

Research output: Contribution to journalArticle

Nickel
Butadiene
Fatty acids
Fatty Acids
Acids
10 Citations (Scopus)

Separation and characterization of the immunostimulatory components in unpolished rice black vinegar (kurozu)

Hashimoto, M., Obara, K., Ozono, M., Furuyashiki, M., Ikeda, T., Suda, Y., Fukase, K., Fujimoto, Y. & Shigehisa, H., 2013 Dec, In : Journal of Bioscience and Bioengineering. 116, 6, p. 688-696 9 p.

Research output: Contribution to journalArticle

Acetic acid
Acetic Acid
Fermentation
Ethanol
Acetobacter
7 Citations (Scopus)

Synthesis and biological activity of phosphoglycolipids from Thermus thermophilus

Fujimoto, Y., Mitsunobe, K., Fujiwara, S., Mori, M., Hashimoto, M., Suda, Y., Kusumoto, S. & Fukase, K., 2013 Aug 14, In : Organic and Biomolecular Chemistry. 11, 30, p. 5034-5041 8 p.

Research output: Contribution to journalArticle

Thermus thermophilus
glycerols
activity (biology)
Bioactivity
Glycerol
2012
18 Citations (Scopus)

Peptidoglycan as Nod1 ligand; Fragment structures in the environment, chemical synthesis, and their innate immunostimulation

Fujimoto, Y., Pradipta, A. R., Inohara, N. & Fukase, K., 2012 May, In : Natural Product Reports. 29, 5, p. 568-579 12 p.

Research output: Contribution to journalArticle

Peptidoglycan
Immunization
Ligands
Cell Wall
Cells
18 Citations (Scopus)

Synthesis and immunomodulatory activities of Helicobacter pylori lipophilic terminus of lipopolysaccharide including lipid A

Fujimoto, Y., Shimoyama, A., Suda, Y. & Fukase, K., 2012 Jul 15, In : Carbohydrate Research. 356, p. 37-43 7 p.

Research output: Contribution to journalArticle

Lipid A
Helicobacter pylori
Lipopolysaccharides
Cytokines
Assays
2 Citations (Scopus)

Synthesis of bacterial glycoconjugates and their bio-functional studies in innate immunity

Fukase, K., Fujimoto, Y., Shimoyama, A. & Tanaka, K., 2012, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 70, 2, p. 113-130 18 p.

Research output: Contribution to journalArticle

Glycoconjugates
Ligands
Lipopolysaccharides
Bacteria
Lipid A
2011
35 Citations (Scopus)

Chemical Synthesis of helicobacter pylori lipopolysaccharide partial structures and their selective proinflammatory responses

Shimoyama, A., Saeki, A., Tanimura, N., Tsutsui, H., Miyake, K., Suda, Y., Fujimoto, Y. & Fukase, K., 2011 Dec 16, In : Chemistry - A European Journal. 17, 51, p. 14464-14474 11 p.

Research output: Contribution to journalArticle

Lipid A
Lipids
Lipopolysaccharides
Interleukin-18
Ethanolamines
15 Citations (Scopus)

Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2

Sawahata, R., Shime, H., Yamazaki, S., Inoue, N., Akazawa, T., Fujimoto, Y., Fukase, K., Matsumoto, M. & Seya, T., 2011 Apr, In : Microbes and Infection. 13, 4, p. 350-358 9 p.

Research output: Contribution to journalArticle

Lipopeptides
Mycoplasma
Natural Killer Cells
Dendritic Cells
Lipoproteins
49 Citations (Scopus)

Nod1 ligands induce site-specific vascular inflammation

Nishio, H., Kanno, S., Onoyama, S., Ikeda, K., Tanaka, T., Kusuhara, K., Fujimoto, Y., Fukase, K., Sueishi, K. & Hara, T., 2011 May, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 5, p. 1093-1099 7 p.

Research output: Contribution to journalArticle

Arteritis
Blood Vessels
Ligands
Inflammation
Endothelial Cells
14 Citations (Scopus)

Stereoselective glycosylation of 3-deoxy-d-manno-2-octulosonic acid with batch and microfluidic methods

Shimoyama, A., Fujimoto, Y. & Fukase, K., 2011, In : Synlett. 16, p. 2359-2362 4 p., U04811ST.

Research output: Contribution to journalArticle

Glycosylation
Glycosides
Microfluidics
Conformations
2-octulosonic acid
13 Citations (Scopus)
Nod1 Signaling Adaptor Protein
Peptidoglycan
Oligomerization
Diaminopimelic Acid
Ligands
2010
13 Citations (Scopus)

Characterization of natural human nucleotide-binding oligomerization domain protein 1 (Nod1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment

Pradipta, A. R., Fujimoto, Y., Hasegawa, M., Inohara, N. & Fukase, K., 2010 Jul 30, In : Journal of Biological Chemistry. 285, 31, p. 23607-23613 7 p.

Research output: Contribution to journalArticle

Nod1 Signaling Adaptor Protein
Oligomerization
Modulators
Nucleotides
Ligands
2 Citations (Scopus)

Chemical Synthesis of Bacterial Lipid A

Kusumoto, S., Fukase, K. & Fujimoto, Y., 2010, Microbial Glycobiology. Elsevier Inc., p. 413-427 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lipid A
Artificial Cells
Glycoconjugates
Innate Immunity
Purification