• 8614 Citations
  • 41 h-Index
1981 …2020

Research output per year

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Research Output

  • 8614 Citations
  • 41 h-Index
  • 173 Article
  • 7 Review article
  • 1 Letter
  • 1 Short survey
2020

CYP2D6 genotype-guided tamoxifen dosing in hormone receptor-positive metastatic breast cancer (TARGET-1): A randomized, open-label, Phase II study

Tamura, K., Imamura, C. K., Takano, T., Saji, S., Yamanaka, T., Yonemori, K., Takahashi, M., Tsurutani, J., Nishimura, R., Sato, K., Kitani, A., Ueno, N. T., Mushiroda, T., Kubo, M., Fujiwara, Y. & Tanigawara, Y., 2020 Feb 20, In : Journal of Clinical Oncology. 38, 6, p. 558-566 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Evaluation of gefitinib systemic exposure in EGFR-mutated non-small cell lung cancer patients with gefitinib-induced severe hepatotoxicity

Kawamura, T., Imamura, C. K., Kenmotsu, H., Taira, T., Omori, S., Nakashima, K., Wakuda, K., Ono, A., Naito, T., Murakami, H., Mushiroda, T., Takahashi, T. & Tanigawara, Y., 2020 Mar 1, In : Cancer Chemotherapy and Pharmacology. 85, 3, p. 605-614 10 p.

Research output: Contribution to journalArticle

2019

Cerebrospinal pharmacokinetic and pharmacodynamic analysis of efficacy of meropenem in paediatric patients with bacterial meningitis

Ohata, Y., Tomita, Y., Sunakawa, K., Drusano, G. L. & Tanigawara, Y., 2019 Sep, In : International journal of antimicrobial agents. 54, 3, p. 292-300 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Gefitinib exposure and occurrence of interstitial lung disease in Japanese patients with non-small-cell lung cancer

Kawata, T., Higashimori, M., Itoh, Y., Tomkinson, H., Johnson, M. G., Tang, W., Nyberg, F., Jiang, H. & Tanigawara, Y., 2019 Jan 1, In : Cancer Chemotherapy and Pharmacology.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Individualized Dosing of Axitinib Based on First-Dose Area Under the Concentration–Time Curve for Metastatic Renal-Cell Carcinoma

Miura, Y., Imamura, C. K., Uchino, K., Kishida, T., Matsubara, N., Shinojima, T., Kondo, K., Hongo, F., Yoshimura, K., Tanigawara, Y. & Takano, T., 2019 Feb, In : Clinical Genitourinary Cancer. 17, 1, p. e1-e11

Research output: Contribution to journalArticle

1 Citation (Scopus)

Therapeutic Drug Monitoring in Oncology: International Association of Therapeutic Drug Monitoring and Clinical Toxicology Recommendations for 5-Fluorouracil Therapy

Beumer, J. H., Chu, E., Allegra, C., Tanigawara, Y., Milano, G., Diasio, R., Kim, T. W., Mathijssen, R. H., Zhang, L., Arnold, D., Muneoka, K., Boku, N. & Joerger, M., 2019 Mar, In : Clinical Pharmacology and Therapeutics. 105, 3, p. 598-613 16 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)
2018

Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype-Guided Dosing of Tamoxifen

Nakamura, T., Toshimoto, K., Lee, W., Imamura, C., Tanigawara, Y. & Sugiyama, Y., 2018 Jul 1, In : CPT: Pharmacometrics and Systems Pharmacology. 7, 7, p. 474-482 9 p.

Research output: Contribution to journalArticle

Modeling and simulation of bone mineral density in Japanese osteoporosis patients treated with zoledronic acid using tartrate-resistant acid phosphatase 5b, a bone resorption marker

Mori, Y., Kasai, H., Ose, A., Serada, M., Ishiguro, M., Shiraki, M. & Tanigawara, Y., 2018 Feb 8, (Accepted/In press) In : Osteoporosis International. p. 1-9 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Pharmacodynamic analysis of eribulin safety in breast cancer patients using real-world postmarketing surveillance data

Kawamura, T., Kasai, H., Fermanelli, V., Takahashi, T., Sakata, Y., Matsuoka, T., Ishii, M. & Tanigawara, Y., 2018 Jan 1, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

2017

Clinical Factors Predicting Detection of T790M Mutation in Rebiopsy for EGFR-Mutant Non-small-cell Lung Cancer

Kawamura, T., Kenmotsu, H., Omori, S., Nakashima, K., Wakuda, K., Ono, A., Naito, T., Murakami, H., Omae, K., Mori, K., Tanigawara, Y., Nakajima, T., Ohde, Y., Endo, M. & Takahashi, T., 2017, (Accepted/In press) In : Clinical Lung Cancer.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Effect of everolimus on the glucose metabolic pathway in mouse skeletal muscle cells (C2C12)

Yoshida, K., Imamura, C., Hara, K., Mochizuki, M. & Tanigawara, Y., 2017 Aug 1, In : Metabolomics. 13, 8, 98.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Population Pharmacokinetic and Exposure-Response Analysis of Weekly Teriparatide in Osteoporosis Patients

Ose, A., Serada, M., Yamashita, K., Tsurui, K. & Tanigawara, Y., 2017, (Accepted/In press) In : Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Population Pharmacokinetics of Diazoxide in Children with Hyperinsulinemic Hypoglycemia

Kizu, R., Nishimura, K., Sato, R., Kosaki, K., Tanaka, T., Tanigawara, Y. & Hasegawa, T., 2017 Jul 14, (Accepted/In press) In : Hormone Research in Paediatrics.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The effects of advanced age and serum α1-acid glycoprotein on docetaxel unbound exposure and dose-limiting toxicity in cancer patients

Kenmotsu, H., Imamura, C., Ono, A., Omori, S., Nakashima, K., Wakuda, K., Taira, T., Naito, T., Murakami, H., Takahashi, T. & Tanigawara, Y., 2017 Nov 1, In : British Journal of Clinical Pharmacology. 83, 11, p. 2416-2425 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2016

Development of an S-1 dosage formula based on renal function by a prospective pharmacokinetic study

Booka, E., Imamura, C. K., Takeuchi, H., Hamamoto, Y., Gomi, D., Mizukami, T., Ichiyama, T., Tateishi, K., Takahashi, T., Kawakubo, H., Soejima, K., Boku, N., Tanigawara, Y. & Kitagawa, Y., 2016 Jul 1, In : Gastric Cancer. 19, 3, p. 876-886 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole

Imamura, C., Furihata, K., Okamoto, S. & Tanigawara, Y., 2016 Apr 1, In : Journal of Clinical Pharmacology. 56, 4, p. 408-413 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2015

Pharmacokinetic issues on cancer pharmacotherapy

Tanigawara, Y., 2015 Aug 1, In : Nihon rinsho. Japanese journal of clinical medicine. 73, 8, p. 1357-1363 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics, dynamics and toxicity of docetaxel: Why the Japanese dose differs from the Western dose

Kenmotsu, H. & Tanigawara, Y., 2015 May 1, In : Cancer science. 106, 5, p. 497-504 8 p.

Research output: Contribution to journalReview article

51 Citations (Scopus)

The survey for anti-emetic guideline by using questioner

Saeki, T., Tamura, K., Aiba, K., Aogi, K., Lino, K., Imamura, C., Eguchi, K., Okita, K., Kagami, Y., Tanaka, R., Nakagawa, K., Fujii, H., Boku, N., Matsuura, K., Wada, M., Akechi, T., Kakudo, Y., Kim, Y. I., Sasaki, H. N., Shima, Y. & 9 others, Takeda, M., Nagasaki, E., Nishidate, T., Saito, M., Ashikaga, Y., Tanigawara, Y., Hirata, K., Ishioka, C. & Nishiyama, M., 2015 Mar 1, In : Japanese Journal of Cancer and Chemotherapy. 42, 3, p. 305-311 7 p.

Research output: Contribution to journalReview article

2014

Clinical practice guidelines for therapeutic drug monitoring of arbekacin: A consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring

Okada, K., Kimura, T., Mikamo, H., Kasahara, K., Seki, M., Takakura, S., Tokimatsu, I., Ohmagari, N., Takahashi, Y., Matsumoto, K., Igarashi, M., Kobayashi, M., Hamada, Y., Mochizuki, T., Kimura, M., Nishi, Y., Tanigawara, Y. & Takesue, Y., 2014 Jan, In : Journal of Infection and Chemotherapy. 20, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
10 Citations (Scopus)

Population PK modelling and simulation based on fluoxetine and norfluoxetine concentrations in milk: a milk concentration-based prediction model

Tanoshima, R., Bournissen, F. G. A., Tanigawara, Y., Kristensen, J. H., Taddio, A., Ilett, K. F., Begg, E. J., Wallach, I. & Ito, S., 2014 Oct 1, In : British Journal of Clinical Pharmacology. 78, 4, p. 918-928 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Sunitinib-induced severe toxicities in a japanese patient with the ABCG2 421 AA genotype

Miura, Y., Imamura, C. K., Fukunaga, K., Katsuyama, Y., Suyama, K., Okaneya, T., Mushiroda, T., Ando, Y., Takano, T. & Tanigawara, Y., 2014 Dec 16, In : BMC Cancer. 14, 1, 964.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2013

Clinical and bacteriological efficacies of sitafloxacin against community-acquired pneumonia caused by Streptococcus pneumoniae: Nested cohort within a multicenter clinical trial

Fujita, J., Niki, Y., Kadota, J. I., Yanagihara, K., Kaku, M., Watanabe, A., Aoki, N., Hori, S., Tanigawara, Y., Cash, H. L. & Kohno, S., 2013 Jun, In : Journal of Infection and Chemotherapy. 19, 3, p. 472-479 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Clinical dose findings of sitafloxacin treatment: Pharmacokinetic- pharmacodynamic analysis of two clinical trial results for community-acquired respiratory tract infections

Kohno, S., Niki, Y., Kadota, J. I., Yanagihara, K., Kaku, M., Watanabe, A., Aoki, N., Hori, S., Fujita, J. & Tanigawara, Y., 2013 Jun, In : Journal of Infection and Chemotherapy. 19, 3, p. 486-494 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Pharmacogenetic determinants associated with sunitinib-induced toxicity and ethnic difference in Korean metastatic renal cell carcinoma patients

Kim, H. R., Park, H. S., Kwon, W. S., Lee, J. H., Tanigawara, Y., Lim, S. M., Kim, H. S., Shin, S. J., Ahn, J. B. & Rha, S. Y., 2013 Oct 1, In : Cancer Chemotherapy and Pharmacology. 72, 4, p. 825-835 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Polymorphisms in the UGT1A1 gene predict adverse effects of irinotecan in the treatment of gynecologic cancer in Japanese patients

Hirasawa, A., Zama, T., Akahane, T., Nomura, H., Kataoka, F., Saito, K., Okubo, K., Tominaga, E., Makita, K., Susumu, N., Kosaki, K., Tanigawara, Y. & Aoki, D., 2013 Dec 1, In : Journal of Human Genetics. 58, 12, p. 794-798 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Population pharmacokinetics and pharmacodynamics of sitafloxacin in patients with community-acquired respiratory tract infections

Tanigawara, Y., Kaku, M., Totsuka, K., Tsuge, H. & Saito, A., 2013 Oct, In : Journal of Infection and Chemotherapy. 19, 5, p. 858-866 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Practice guidelines for therapeutic drug monitoring of vancomycin: A consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring

Matsumoto, K., Takesue, Y., Ohmagari, N., Mochizuki, T., Mikamo, H., Seki, M., Takakura, S., Tokimatsu, I., Takahashi, Y., Kasahara, K., Okada, K., Igarashi, M., Kobayashi, M., Hamada, Y., Kimura, M., Nishi, Y., Tanigawara, Y. & Kimura, T., 2013 Jun, In : Journal of Infection and Chemotherapy. 19, 3, p. 365-380 16 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Practice guidelines for therapeutic drug monitoring of voriconazole: A consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring

Hamada, Y., Tokimatsu, I., Mikamo, H., Kimura, M., Seki, M., Takakura, S., Ohmagari, N., Takahashi, Y., Kasahara, K., Matsumoto, K., Okada, K., Igarashi, M., Kobayashi, M., Mochizuki, T., Nishi, Y., Tanigawara, Y., Kimura, T. & Takesue, Y., 2013 Jun, In : Journal of Infection and Chemotherapy. 19, 3, p. 381-392 12 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
2012

A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese

Kiyotani, K., Mushiroda, T., Tsunoda, T., Morizono, T., Hosono, N., Kubo, M., Tanigawara, Y., Imamura, C. K., Flockhart, D. A., Aki, F., Hirata, K., Takatsuka, Y., Okazaki, M., Ohsumi, S., Yamakawa, T., Sasa, M., Nakamura, Y. & Zembutsu, H., 2012 Apr 1, In : Human molecular genetics. 21, 7, p. 1665-1672 8 p., ddr597.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Blood-direct InvaderPlus® as a new method for genetic testing

Hirasawa, A., Akahane, T., Tanigawara, Y. & Aoki, D., 2012 Aug 1, In : Personalized Medicine. 9, 6, p. 657-663 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients

Kiyotani, K., Mushiroda, T., Imamura, C. K., Tanigawara, Y., Hosono, N., Kubo, M., Sasa, M., Nakamura, Y. & Zembutsu, H., 2012 Jan 1, In : Breast Cancer Research and Treatment. 131, 1, p. 137-145 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Expression changes in arrestin β 1 and genetic variation in catechol-O-methyltransferase are biomarkers for the response to morphine treatment in cancer patients

Matsuoka, H., Arao, T., Makimura, C., Takeda, M., Kiyota, H., Tsurutani, J., Fujita, Y., Matsumoto, K., Kimura, H., Otsuka, M., Koyama, A., Imamura, C. K., Tanigawara, Y., Yamanaka, T., Tanaka, K., Nishio, K. & Nakagawa, K., 2012 May 1, In : Oncology reports. 27, 5, p. 1393-1399 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation

Tanigawara, Y., Nozawa, K. & Tsuda, H., 2012 Jan 1, In : European Journal of Clinical Pharmacology. 68, 1, p. 39-53 15 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Pharmacokinetics of mizoribine in adult living donor liver transplantation

Shinoda, M., Tanabe, M., Kawachi, S., Ono, Y., Hayakawa, T., Iketani, O., Kojima, M., Itano, O., Obara, H., Kitago, M., Hibi, T., Matsubara, K., Shimojima, N., Fuchimoto, Y., Hoshino, K., Wakabayashi, G., Shimazu, M., Tanigawara, Y., Kuroda, T., Morikawa, Y. & 2 others, Kitajima, M. & Kitagawa, Y., 2012 Jun 1, In : Transplantation Proceedings. 44, 5, p. 1329-1335 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2011

A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures - A randomized, active comparator, double-blind study

Matsumoto, T., Ito, M., Hayashi, Y., Hirota, T., Tanigawara, Y., Sone, T., Fukunaga, M., Shiraki, M. & Nakamura, T., 2011 Oct 1, In : Bone. 49, 4, p. 605-612 8 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

Watanabe, M., Horai, Y., Houten, S. M., Morimoto, K., Sugizaki, T., Arita, E., Mataki, C., Sato, H., Tanigawara, Y., Schoonjans, K., Itoh, H. & Auwerx, J., 2011 Jul 29, In : Journal of Biological Chemistry. 286, 30, p. 26913-26920 8 p.

Research output: Contribution to journalArticle

148 Citations (Scopus)
24 Citations (Scopus)

Optimal dosage regimen of meropenem for pediatric patients based on pharmacokinetic/pharmacodynamic considerations

Ohata, Y., Tomita, Y., Nakayama, M., Kozuki, T., Sunakawa, K. & Tanigawara, Y., 2011 Jan 1, In : Drug Metabolism And Pharmacokinetics. 26, 5, p. 523-531 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Optimal treatment schedule of meropenem for adult patients with febrile neutropenia based on pharmacokinetic-pharmacodynamic analysis

Ohata, Y., Tomita, Y., Nakayama, M., Tamura, K. & Tanigawara, Y., 2011 Dec, In : Journal of Infection and Chemotherapy. 17, 6, p. 831-841 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Overview of the clinical pharmacokinetics of eldecalcitol, a new active vitamin D3 derivative

Abe, M., Tsuji, N., Takahashi, F. & Tanigawara, Y., 2011 Mar 1, In : Japanese Pharmacology and Therapeutics. 39, 3, p. 261-274 14 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)

Pharmacokinetics of eldecalcitol in primary osteoporosis patients - Randomized, double-blind, multicentre, long-term phase III clinical study

Miyata, K., Abe, M., Terao, K., Kawanishi, T., Tsuji, N., Shiraki, M., Nakamura, T., Matsumoto, T. & Tanigawara, Y., 2011 Mar 1, In : Japanese Pharmacology and Therapeutics. 39, 3, p. 299-307 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Population pharmacokinetics and pharmacodynamics of levofloxacin following intravenous infusion for respiratory tract infection

Tanigawara, Y., Shimizu, T. & Totsuka, K., 2011 May 1, In : Japanese Journal of Chemotherapy. 59, SUPPL. 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

S100A10 protein expression is associated with oxaliplatin sensitivity in human colorectal cancer cells

Suzuki, S., Yamayoshi, Y., Nishimuta, A. & Tanigawara, Y., 2011 Dec 30, In : Proteome Science. 9, 76.

Research output: Contribution to journalArticle

9 Citations (Scopus)
2010

Pharmacokinetics of S-1 and CYP2A6 genotype in Japanese patients with advanced cancer

Hirose, T., Fujita, K. I., Nishimura, K., Ishida, H., Yamashita, K., Sunakawa, Y., Mizuno, K., Miwa, K., Nagashima, F., Tanigawara, Y., Adachi, M. & Sasaki, Y., 2010 Aug, In : Oncology reports. 24, 2, p. 529-536 8 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients

Kiyotani, K., Mushiroda, T., Imamura, C. K., Hosono, N., Tsunoda, T., Kubo, M., Tanigawara, Y., Flockhart, D. A., Desta, Z., Skaar, T. C., Aki, F., Hirata, K., Takatsuka, Y., Okazaki, M., Ohsumi, S., Yamakawa, T., Sasa, M., Nakamura, Y. & Zembutsu, H., 2010 Mar 10, In : Journal of Clinical Oncology. 28, 8, p. 1287-1293 7 p.

Research output: Contribution to journalArticle

176 Citations (Scopus)

Therapeutic drug monitoring survey of anti-MRSA agents in Japan

Kobayashi, M., Takesue, Y., Tanigawara, Y., Mikamo, H., Kimura, T., Hirata, S., Shiraishi, T., Sakaeda, T. & Takakura, S., 2010 Mar 1, In : Japanese Journal of Chemotherapy. 58, 2, p. 119-124 6 p.

Research output: Contribution to journalShort survey

3 Citations (Scopus)
2009

A pharmacokinetic and dose escalation study of pegfilgrastim (KRN125) in lung cancer patients with chemotherapy-induced neutropenia

Yamamoto, N., Sekine, I., Nakagawa, K., Takada, M., Fukuoka, M., Tanigawara, Y. & Saijo, N., 2009 Jul 16, In : Japanese journal of clinical oncology. 39, 7, p. 425-430 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

A phase i escalating single-dose and weekly fixed-dose study of cetuximab pharmacokinetics in Japanese patients with solid tumors

Shirao, K., Yoshino, T., Boku, N., Kato, K., Hamaguchi, T., Yasui, H., Yamamoto, N., Tanigawara, Y., Nolting, A. & Yoshino, S., 2009 Jul 1, In : Cancer Chemotherapy and Pharmacology. 64, 3, p. 557-564 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)