α-Synuclein aggregation in the olfactory bulb of middle-aged common marmoset

Reona Kobayashi, Junko Takahashi-Fujigasaki, Seiji Shiozawa, Chikako Hara-Miyauchi, Takashi Inoue, Hirotaka James Okano, Erika Sasaki, Hideyuki Okano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The synaptic protein α-synuclein has been identified as a major component of Lewy bodies, a pathological hallmark of Parkinson's disease (PD). Prior to the formation of Lewy bodies, mislocalization and aggregation of the α-synuclein in brain tissue is frequently observed in various neurodegenerative diseases. Aberrant accumulation and localization of α-synuclein are also observed in the aging human brain, for which reason aging is regarded as a risk factor for neurodegenerative disease. To investigate changes in α-synuclein properties in the aging brain, we compared α-synuclein immunoreactivity in brain tissue of young (2-years-old) and middle-aged (6-years-old) common marmoset (Callithrix jacchus). Our analyses revealed marked changes in α-synuclein immunoreactivity in the olfactory bulb of common marmosets of these age cohorts. Perikaryal α-synuclein aggregations were formed in the olfactory bulb in middle-aged animals. We also observed signals of α-synuclein accumulation in hippocampus in this cohort; however, unlike in the olfactory bulb, hippocampal α-synuclein signals were localized in the synaptic terminals. We did not observe either of these features in younger marmosets, which suggest that aging may play a role in these phenomena.Our results using common marmoset brain corresponded with the observation that the α-synuclein aggregations were first occurred from olfactory bulb in human normal aged and PD brain. Therefore, common marmoset is expected as useful model for α-synuclein pathology.

Original languageEnglish
JournalNeuroscience Research
DOIs
Publication statusAccepted/In press - 2015 Nov 11

Fingerprint

Synucleins
Callithrix
Olfactory Bulb
Brain
Lewy Bodies
Neurodegenerative Diseases
Parkinson Disease
Presynaptic Terminals
Hippocampus

Keywords

  • Common marmoset
  • Olfactory bulb
  • Parkinson's disease
  • α-Synuclein

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kobayashi, R., Takahashi-Fujigasaki, J., Shiozawa, S., Hara-Miyauchi, C., Inoue, T., Okano, H. J., ... Okano, H. (Accepted/In press). α-Synuclein aggregation in the olfactory bulb of middle-aged common marmoset. Neuroscience Research. https://doi.org/10.1016/j.neures.2015.11.006

α-Synuclein aggregation in the olfactory bulb of middle-aged common marmoset. / Kobayashi, Reona; Takahashi-Fujigasaki, Junko; Shiozawa, Seiji; Hara-Miyauchi, Chikako; Inoue, Takashi; Okano, Hirotaka James; Sasaki, Erika; Okano, Hideyuki.

In: Neuroscience Research, 11.11.2015.

Research output: Contribution to journalArticle

Kobayashi, R, Takahashi-Fujigasaki, J, Shiozawa, S, Hara-Miyauchi, C, Inoue, T, Okano, HJ, Sasaki, E & Okano, H 2015, 'α-Synuclein aggregation in the olfactory bulb of middle-aged common marmoset', Neuroscience Research. https://doi.org/10.1016/j.neures.2015.11.006
Kobayashi R, Takahashi-Fujigasaki J, Shiozawa S, Hara-Miyauchi C, Inoue T, Okano HJ et al. α-Synuclein aggregation in the olfactory bulb of middle-aged common marmoset. Neuroscience Research. 2015 Nov 11. https://doi.org/10.1016/j.neures.2015.11.006
Kobayashi, Reona ; Takahashi-Fujigasaki, Junko ; Shiozawa, Seiji ; Hara-Miyauchi, Chikako ; Inoue, Takashi ; Okano, Hirotaka James ; Sasaki, Erika ; Okano, Hideyuki. / α-Synuclein aggregation in the olfactory bulb of middle-aged common marmoset. In: Neuroscience Research. 2015.
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