α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD)

Koichiro Kamio, Takayuki Yoshida, Congxiao Gao, Takeo Ishii, Fumi Ota, Takashi Motegi, Satoshi Kobayashi, Reiko Fujinawa, Kazuaki Ohtsubo, Shinobu Kitazume, Takashi Angata, Arata Azuma, Akihiko Gemma, Masaharu Nishimura, Tomoko Betsuyaku, Kozui Kida, Naoyuki Taniguchi

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14 Citations (Scopus)

Abstract

Fut8 (α1,6-Fucosyltransferase) heterozygous knock-out (Fut8 +/-) mice had an increased influx of inflammatory cells into the lungs, and this was associated with an up-regulation of matrix metalloproteinases, MMP-2 and MMP-9, after treatment with porcine pancreatic elastase (PPE), exhibiting an emphysema-prone phenotype as compared with wild type mice (Fut8 +/+). The present data as well as our previous data on cigarette-smoke-induced emphysema [8] led us to hypothesize that reduced Fut8 levels leads to COPD with increased inflammatory response in humans and is associated with disease progression. To test this hypothesis, symptomatic current or ex-smokers with stable COPD or at risk outpatients were recruited. We investigated the association between serum Fut8 activity and disease severity, including the extent of emphysema (percentage of low-attenuation area; LAA%), airflow limitation, and the annual rate of decline in forced expiratory volume in 1s (FEV 1). Association with the exacerbation of COPD was also evaluated over a 3-year period. Serum Fut8 and MMP-9 activity were measured. Fut8 activity significantly increased with age among the at risk patients. In the case of COPD patients, however, the association was not clearly observed. A faster annual decline of FEV 1 was significantly associated with lower Fut8 activity. Patients with lower Fut8 activity experienced exacerbations more frequently. These data suggest that reduced Fut8 activity is associated with the progression of COPD and serum Fut8 activity is a non-invasive predictive biomarker candidate for progression and exacerbation of COPD.

Original languageEnglish
Pages (from-to)112-117
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume424
Issue number1
DOIs
Publication statusPublished - 2012 Jul 20

Keywords

  • Biomarker
  • COPD
  • Emphysema
  • α1,6-Fucosyltransferase (Fut8)

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Kamio, K., Yoshida, T., Gao, C., Ishii, T., Ota, F., Motegi, T., Kobayashi, S., Fujinawa, R., Ohtsubo, K., Kitazume, S., Angata, T., Azuma, A., Gemma, A., Nishimura, M., Betsuyaku, T., Kida, K., & Taniguchi, N. (2012). α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD). Biochemical and Biophysical Research Communications, 424(1), 112-117. https://doi.org/10.1016/j.bbrc.2012.06.081