β blockers in migraine prophylaxis

Toshihiko Shimizu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

β blockers (β-adrenoceptor blockers) are known to be used for the prophylactic treatment of migraine. The improvement of migraine in the patients who recieved propranolol for angina pectoris revealed the effectiveness of propranolol in migraine prophylaxis. Many clinical trials have confirmed that propranolol is effective in the prophylactic treatment of migraine. Other β-blocking drugs, namely nadolol, metoprolol, atenolol, timolol and bisoprolol, have also been demonstrated to be effective in the prophylaxis of migraine. In contrast, several β blockers with intrinsic sympathetic activity (ISA), such as alprenolol, oxprenolol, pindolol and acebutolol, have not been demonstrated to be effective in migraine prophylaxis. In this review, we have descrived the pharmacologic background and pharmacokinetics of the β blockers that demonstrated a prophylactic effect for migraine will be described. We have also reviewed the results of clinical trials of β-blocking drugs for migraine.

Original languageEnglish
Pages (from-to)1125-1130
Number of pages6
JournalBrain and Nerve
Volume61
Issue number10
Publication statusPublished - 2009 Oct

Fingerprint

Migraine Disorders
Propranolol
Alprenolol
Nadolol
Acebutolol
Bisoprolol
Clinical Trials
Oxprenolol
Pindolol
Timolol
Metoprolol
Atenolol
Angina Pectoris
Pharmaceutical Preparations
Adrenergic Receptors
Pharmacokinetics
Therapeutics

Keywords

  • β-adrenoceptor blocking drugs
  • Migraine
  • Prophylaxis
  • Propranolol

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Shimizu, T. (2009). β blockers in migraine prophylaxis. Brain and Nerve, 61(10), 1125-1130.

β blockers in migraine prophylaxis. / Shimizu, Toshihiko.

In: Brain and Nerve, Vol. 61, No. 10, 10.2009, p. 1125-1130.

Research output: Contribution to journalArticle

Shimizu, T 2009, 'β blockers in migraine prophylaxis', Brain and Nerve, vol. 61, no. 10, pp. 1125-1130.
Shimizu T. β blockers in migraine prophylaxis. Brain and Nerve. 2009 Oct;61(10):1125-1130.
Shimizu, Toshihiko. / β blockers in migraine prophylaxis. In: Brain and Nerve. 2009 ; Vol. 61, No. 10. pp. 1125-1130.
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