β blockers in migraine prophylaxis

Toshihiko Shimizu

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

β blockers (β-adrenoceptor blockers) are known to be used for the prophylactic treatment of migraine. The improvement of migraine in the patients who recieved propranolol for angina pectoris revealed the effectiveness of propranolol in migraine prophylaxis. Many clinical trials have confirmed that propranolol is effective in the prophylactic treatment of migraine. Other β-blocking drugs, namely nadolol, metoprolol, atenolol, timolol and bisoprolol, have also been demonstrated to be effective in the prophylaxis of migraine. In contrast, several β blockers with intrinsic sympathetic activity (ISA), such as alprenolol, oxprenolol, pindolol and acebutolol, have not been demonstrated to be effective in migraine prophylaxis. In this review, we have descrived the pharmacologic background and pharmacokinetics of the β blockers that demonstrated a prophylactic effect for migraine will be described. We have also reviewed the results of clinical trials of β-blocking drugs for migraine.

Original languageEnglish
Pages (from-to)1125-1130
Number of pages6
JournalBrain and Nerve
Volume61
Issue number10
Publication statusPublished - 2009 Oct 1

Keywords

  • Migraine
  • Prophylaxis
  • Propranolol
  • β-adrenoceptor blocking drugs

ASJC Scopus subject areas

  • Clinical Neurology

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