β-Carboline-Carbohydrate hybrids: Molecular design, chemical synthesis and evaluation of novel DNA photocleavers

Kazunobu Toshima, Yukiko Okuno, Yoko Nakajima, Shuichi Matsumura

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

β-Carboline present in β-carboline alkaloids from marine organisms was found, for the first time, to cleave DNA at the guanine site upon irradiation with UV light with a long wavelength without any additive, and β-carboline-carbohydrate hybrid system was effective for DNA cleavage.

Original languageEnglish
Pages (from-to)671-673
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number4
DOIs
Publication statusPublished - 2002 Feb 25

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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