β-Catenin mutations in pulmonary blastomas: Association with morule formation

Shigeki Sekine, Tatsuhiro Shibata, Yoshihiro Matsuno, Arafumi Maeshima, Genichiro Ishii, Michiie Sakamoto, Setsuo Hirohashi

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

To elucidate the contribution of β-catenin gene mutation to the development of pulmonary blastomas, we analysed mutations in three well-differentiated fetal adenocarcinomas (WDFAs) and six biphasic pulmonary blastomas (BPBs). For comparison, eight clear-cell adenocarcinomas with fetal lung features were also examined. β-Catenin gene mutations were found in all three WDFAs, two BPBs, and none of the clear-cell adenocarcinomas with fetal lung features. All tumours with mutations had a common histological feature, namely morule formation, and showed a characteristic heterogeneous β-catenin expression pattern that was revealed by immunohistochemistry. Strong nuclear/cytoplasmic expression of β-catenin was seen in clustered cells in the morular areas and in single cells in glands, and was associated with neuroendocrine differentiation. As β-catenin mutations are rare among lung tumours, this distinctive genetic feature, which is also immunohistochemically detectable as overexpression with a heterogeneous pattern, has diagnostic significance. The presence of this common genetic alteration found in both WDFA and BPB implies a histogenetic linkage between these tumours.

Original languageEnglish
Pages (from-to)214-221
Number of pages8
JournalJournal of Pathology
Volume200
Issue number2
DOIs
Publication statusPublished - 2003 Jun 1
Externally publishedYes

Keywords

  • Morule
  • Neuroendocrine cells
  • Pulmonary blastoma
  • Well-differentiated fetal adenocarcinoma
  • β-catenin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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  • Cite this

    Sekine, S., Shibata, T., Matsuno, Y., Maeshima, A., Ishii, G., Sakamoto, M., & Hirohashi, S. (2003). β-Catenin mutations in pulmonary blastomas: Association with morule formation. Journal of Pathology, 200(2), 214-221. https://doi.org/10.1002/path.1352