β-Catenin mutations in pulmonary blastomas: Association with morule formation

Shigeki Sekine, Tatsuhiro Shibata, Yoshihiro Matsuno, Arafumi Maeshima, Genichiro Ishii, Michiie Sakamoto, Setsuo Hirohashi

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

To elucidate the contribution of β-catenin gene mutation to the development of pulmonary blastomas, we analysed mutations in three well-differentiated fetal adenocarcinomas (WDFAs) and six biphasic pulmonary blastomas (BPBs). For comparison, eight clear-cell adenocarcinomas with fetal lung features were also examined. β-Catenin gene mutations were found in all three WDFAs, two BPBs, and none of the clear-cell adenocarcinomas with fetal lung features. All tumours with mutations had a common histological feature, namely morule formation, and showed a characteristic heterogeneous β-catenin expression pattern that was revealed by immunohistochemistry. Strong nuclear/cytoplasmic expression of β-catenin was seen in clustered cells in the morular areas and in single cells in glands, and was associated with neuroendocrine differentiation. As β-catenin mutations are rare among lung tumours, this distinctive genetic feature, which is also immunohistochemically detectable as overexpression with a heterogeneous pattern, has diagnostic significance. The presence of this common genetic alteration found in both WDFA and BPB implies a histogenetic linkage between these tumours.

Original languageEnglish
Pages (from-to)214-221
Number of pages8
JournalJournal of Pathology
Volume200
Issue number2
Publication statusPublished - 2003 Jun 1
Externally publishedYes

Fingerprint

Pulmonary Blastoma
Catenins
Mutation
Clear Cell Adenocarcinoma
Adenocarcinoma
Lung
Neoplasms
Genes
Immunohistochemistry

Keywords

  • β-catenin
  • Morule
  • Neuroendocrine cells
  • Pulmonary blastoma
  • Well-differentiated fetal adenocarcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Sekine, S., Shibata, T., Matsuno, Y., Maeshima, A., Ishii, G., Sakamoto, M., & Hirohashi, S. (2003). β-Catenin mutations in pulmonary blastomas: Association with morule formation. Journal of Pathology, 200(2), 214-221.

β-Catenin mutations in pulmonary blastomas : Association with morule formation. / Sekine, Shigeki; Shibata, Tatsuhiro; Matsuno, Yoshihiro; Maeshima, Arafumi; Ishii, Genichiro; Sakamoto, Michiie; Hirohashi, Setsuo.

In: Journal of Pathology, Vol. 200, No. 2, 01.06.2003, p. 214-221.

Research output: Contribution to journalArticle

Sekine, S, Shibata, T, Matsuno, Y, Maeshima, A, Ishii, G, Sakamoto, M & Hirohashi, S 2003, 'β-Catenin mutations in pulmonary blastomas: Association with morule formation', Journal of Pathology, vol. 200, no. 2, pp. 214-221.
Sekine S, Shibata T, Matsuno Y, Maeshima A, Ishii G, Sakamoto M et al. β-Catenin mutations in pulmonary blastomas: Association with morule formation. Journal of Pathology. 2003 Jun 1;200(2):214-221.
Sekine, Shigeki ; Shibata, Tatsuhiro ; Matsuno, Yoshihiro ; Maeshima, Arafumi ; Ishii, Genichiro ; Sakamoto, Michiie ; Hirohashi, Setsuo. / β-Catenin mutations in pulmonary blastomas : Association with morule formation. In: Journal of Pathology. 2003 ; Vol. 200, No. 2. pp. 214-221.
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