β-Cell mass and turnover in humans

Effects of obesity and aging

Yoshifumi Saisho, Alexandra E. Butler, Erica Manesso, David Elashoff, Robert A. Rizza, Peter C. Butler

Research output: Contribution to journalArticle

184 Citations (Scopus)

Abstract

OBJECTIVE - We sought to establish β-cell mass, β-cell apoptosis, and β-cell replication in humans in response to obesity and advanced age. RESEARCH DESIGN AND METHODS - We examined human autopsy pancreas from 167 nondiabetic individuals 20-102 years of age. The effect of obesity on β-cell mass was examined in 53 lean and 61 obese subjects, and the effect of aging was examined in 106 lean subjects. RESULTS - β-Cell mass is increased by ∼50%with obesity (from 0.8 to 1.2 g). With advanced aging, the exocrine pancreas undergoes atrophy but β-cell mass is remarkably preserved. There is minimal β-cell replication or apoptosis in lean humans throughout life with no detectable changes with obesity or advanced age. CONCLUSIONS - β-Cell mass in human obesity increases by ∼50% by an increase in β-cell number, the source of which is unknown. β-Cell mass is well preserved in humans with advanced aging.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalDiabetes Care
Volume36
Issue number1
DOIs
Publication statusPublished - 2013 Jan
Externally publishedYes

Fingerprint

Obesity
Apoptosis
Exocrine Pancreas
Atrophy
Pancreas
Autopsy
Research Design
Cell Count

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Saisho, Y., Butler, A. E., Manesso, E., Elashoff, D., Rizza, R. A., & Butler, P. C. (2013). β-Cell mass and turnover in humans: Effects of obesity and aging. Diabetes Care, 36(1), 111-117. https://doi.org/10.2337/dc12-0421

β-Cell mass and turnover in humans : Effects of obesity and aging. / Saisho, Yoshifumi; Butler, Alexandra E.; Manesso, Erica; Elashoff, David; Rizza, Robert A.; Butler, Peter C.

In: Diabetes Care, Vol. 36, No. 1, 01.2013, p. 111-117.

Research output: Contribution to journalArticle

Saisho, Y, Butler, AE, Manesso, E, Elashoff, D, Rizza, RA & Butler, PC 2013, 'β-Cell mass and turnover in humans: Effects of obesity and aging', Diabetes Care, vol. 36, no. 1, pp. 111-117. https://doi.org/10.2337/dc12-0421
Saisho Y, Butler AE, Manesso E, Elashoff D, Rizza RA, Butler PC. β-Cell mass and turnover in humans: Effects of obesity and aging. Diabetes Care. 2013 Jan;36(1):111-117. https://doi.org/10.2337/dc12-0421
Saisho, Yoshifumi ; Butler, Alexandra E. ; Manesso, Erica ; Elashoff, David ; Rizza, Robert A. ; Butler, Peter C. / β-Cell mass and turnover in humans : Effects of obesity and aging. In: Diabetes Care. 2013 ; Vol. 36, No. 1. pp. 111-117.
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