β-cell replication is the primary mechanism subserving the postnatal expansion of β-cell mass in humans

Juris J. Meier, Alexandra E. Butler, Yoshifumi Saisho, Travis Monchamp, Ryan Galasso, Anil Bhushan, Robert A. Rizza, Peter C. Butler

Research output: Contribution to journalArticle

431 Citations (Scopus)

Abstract

OBJECTIVE-Little is known about the capacity, mechanisms, or timing of growth in β-Cell mass in humans. We sought to establish if the predominant expansion of β-Cell mass in humans occurs in early childhood and if, as in rodents, this coincides with relatively abundant β-Cell replication. We also sought to establish if there is a secondary growth in β-Cell mass coincident with the accelerated somatic growth in adolescence. RESEARCH DESIGN AND METHODS-To address these questions, pancreas volume was determined from abdominal computer tomographies in 135 children aged 4 weeks to 20 years, and morphometric analyses were performed in human pancreatic tissue obtained at autopsy from 46 children aged 2 weeks to 21 years. RESULTS-We report that 1) β-Cell mass expands by several- fold from birth to adulthood, 2) islets grow in size rather than in number during this transition, 3) the relative rate of β-Cell growth is highest in infancy and gradually declines thereafter to adulthood with no secondary accelerated growth phase during adolescence, 4) β-Cell mass (and presumably growth) is highly variable between individuals, and 5) a high rate of β-Cell replication is coincident with the major postnatal expansion of β-Cell mass. CONCLUSIONS-These data imply that regulation of β-Cell replication during infancy plays a major role in β-Cell mass in adult humans.

Original languageEnglish
Pages (from-to)1584-1594
Number of pages11
JournalDiabetes
Volume57
Issue number6
DOIs
Publication statusPublished - 2008 Jun
Externally publishedYes

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Growth
Pancreas
Autopsy
Rodentia
Research Design
Tomography
Parturition

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Meier, J. J., Butler, A. E., Saisho, Y., Monchamp, T., Galasso, R., Bhushan, A., ... Butler, P. C. (2008). β-cell replication is the primary mechanism subserving the postnatal expansion of β-cell mass in humans. Diabetes, 57(6), 1584-1594. https://doi.org/10.2337/db07-1369

β-cell replication is the primary mechanism subserving the postnatal expansion of β-cell mass in humans. / Meier, Juris J.; Butler, Alexandra E.; Saisho, Yoshifumi; Monchamp, Travis; Galasso, Ryan; Bhushan, Anil; Rizza, Robert A.; Butler, Peter C.

In: Diabetes, Vol. 57, No. 6, 06.2008, p. 1584-1594.

Research output: Contribution to journalArticle

Meier, JJ, Butler, AE, Saisho, Y, Monchamp, T, Galasso, R, Bhushan, A, Rizza, RA & Butler, PC 2008, 'β-cell replication is the primary mechanism subserving the postnatal expansion of β-cell mass in humans', Diabetes, vol. 57, no. 6, pp. 1584-1594. https://doi.org/10.2337/db07-1369
Meier, Juris J. ; Butler, Alexandra E. ; Saisho, Yoshifumi ; Monchamp, Travis ; Galasso, Ryan ; Bhushan, Anil ; Rizza, Robert A. ; Butler, Peter C. / β-cell replication is the primary mechanism subserving the postnatal expansion of β-cell mass in humans. In: Diabetes. 2008 ; Vol. 57, No. 6. pp. 1584-1594.
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