β-Ketothioester as a reactive Knoevenagel donor

Yujiro Hayashi, Yuji Miyamoto, Mitsuru Shoji

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The Knoevenagel condensation of β-ketothioesters with various aldehydes proceeds efficiently, affording the condensation products in moderate to good yield even in cases where the reactions of the corresponding β-ketoesters give the adducts in only low to moderate yield.

Original languageEnglish
Pages (from-to)4079-4082
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number22
DOIs
Publication statusPublished - 2002 May 27
Externally publishedYes

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Keywords

  • β-ketoester
  • β-ketothioester
  • Knoevenagel reaction

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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