γ-Herpesviruses and cellular signaling in AIDS-associated malignancies

Kohji Noguchi; Hidesuke Fukazawa; Yuko Murakami; Naoko Takahashi; Satoshi Yamagoe; Yoshimasa Uehara

doi:10.1111/j.1349-7006.2007.00555.x

γ-Herpesviruses and cellular signaling in AIDS-associated malignancies

Kohji Noguchi, Hidesuke Fukazawa, Yuko Murakami, Naoko Takahashi, Satoshi Yamagoe, Yoshimasa Uehara

Research output: Contribution to journal › Review article › peer-review

9 Citations (Scopus)

Abstract

γ-Herpesviruses, Epstein-Barr virus (EBV/HHV-4) and Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), are involved in human carcinogenesis, particularly in immunocompromised patients. Virus-associated malignancies are becoming of significant concern for the mortality of long-lived immunocompromised patients, and therefore, research of advanced strategies for AIDS-related malignancies is an important field in cancer chemotherapy. Detailed understanding of the EBV and KSHV lifecycle and related cancers at the molecular level is required for novel strategies of molecular-targeted cancer chemotherapy. The present review gives a simple outline of the functional interactions between KSHV- and EBV-viral gene products and host cell deregulated signaling pathways as possible targets of chemotherapy against AIDS-related malignancies.

Original language	English
Pages (from-to)	1288-1296
Number of pages	9
Journal	Cancer science
Volume	98
Issue number	9
DOIs	https://doi.org/10.1111/j.1349-7006.2007.00555.x
Publication status	Published - 2007 Sept
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1349-7006.2007.00555.x

Cite this

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title = "γ-Herpesviruses and cellular signaling in AIDS-associated malignancies",

abstract = "γ-Herpesviruses, Epstein-Barr virus (EBV/HHV-4) and Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), are involved in human carcinogenesis, particularly in immunocompromised patients. Virus-associated malignancies are becoming of significant concern for the mortality of long-lived immunocompromised patients, and therefore, research of advanced strategies for AIDS-related malignancies is an important field in cancer chemotherapy. Detailed understanding of the EBV and KSHV lifecycle and related cancers at the molecular level is required for novel strategies of molecular-targeted cancer chemotherapy. The present review gives a simple outline of the functional interactions between KSHV- and EBV-viral gene products and host cell deregulated signaling pathways as possible targets of chemotherapy against AIDS-related malignancies.",

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AU - Noguchi, Kohji

AU - Fukazawa, Hidesuke

AU - Murakami, Yuko

AU - Takahashi, Naoko

AU - Yamagoe, Satoshi

AU - Uehara, Yoshimasa

PY - 2007/9

Y1 - 2007/9

N2 - γ-Herpesviruses, Epstein-Barr virus (EBV/HHV-4) and Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), are involved in human carcinogenesis, particularly in immunocompromised patients. Virus-associated malignancies are becoming of significant concern for the mortality of long-lived immunocompromised patients, and therefore, research of advanced strategies for AIDS-related malignancies is an important field in cancer chemotherapy. Detailed understanding of the EBV and KSHV lifecycle and related cancers at the molecular level is required for novel strategies of molecular-targeted cancer chemotherapy. The present review gives a simple outline of the functional interactions between KSHV- and EBV-viral gene products and host cell deregulated signaling pathways as possible targets of chemotherapy against AIDS-related malignancies.

AB - γ-Herpesviruses, Epstein-Barr virus (EBV/HHV-4) and Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), are involved in human carcinogenesis, particularly in immunocompromised patients. Virus-associated malignancies are becoming of significant concern for the mortality of long-lived immunocompromised patients, and therefore, research of advanced strategies for AIDS-related malignancies is an important field in cancer chemotherapy. Detailed understanding of the EBV and KSHV lifecycle and related cancers at the molecular level is required for novel strategies of molecular-targeted cancer chemotherapy. The present review gives a simple outline of the functional interactions between KSHV- and EBV-viral gene products and host cell deregulated signaling pathways as possible targets of chemotherapy against AIDS-related malignancies.

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γ-Herpesviruses and cellular signaling in AIDS-associated malignancies

Abstract

ASJC Scopus subject areas

UN SDGs

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