γ-Herpesviruses and cellular signaling in AIDS-associated malignancies

Kohji Noguchi, Hidesuke Fukazawa, Yuko Murakami, Naoko Takahashi, Satoshi Yamagoe, Yoshimasa Uehara

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

γ-Herpesviruses, Epstein-Barr virus (EBV/HHV-4) and Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), are involved in human carcinogenesis, particularly in immunocompromised patients. Virus-associated malignancies are becoming of significant concern for the mortality of long-lived immunocompromised patients, and therefore, research of advanced strategies for AIDS-related malignancies is an important field in cancer chemotherapy. Detailed understanding of the EBV and KSHV lifecycle and related cancers at the molecular level is required for novel strategies of molecular-targeted cancer chemotherapy. The present review gives a simple outline of the functional interactions between KSHV- and EBV-viral gene products and host cell deregulated signaling pathways as possible targets of chemotherapy against AIDS-related malignancies.

Original languageEnglish
Pages (from-to)1288-1296
Number of pages9
JournalCancer science
Volume98
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Noguchi, K., Fukazawa, H., Murakami, Y., Takahashi, N., Yamagoe, S., & Uehara, Y. (2007). γ-Herpesviruses and cellular signaling in AIDS-associated malignancies. Cancer science, 98(9), 1288-1296. https://doi.org/10.1111/j.1349-7006.2007.00555.x