δ scores are exportable across cultural and linguistic boundaries

Donald R. Royall, Raymond F. Palmer, Teruyuki Matsuoka, Yuka Kato, Shogo Taniguchi, Mayu Ogawa, Hiroshi Fujimoto, Aiko Okamura, Keisuke Shibata, Kaeko Nakamura, Shutaro Nakaaki, Hiroyuki Koumi, Masaru Mimura, Kenji Fukui, Jin Narumoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The latent variable "δ", can accurately diagnose dementia. Its generalizability across populations is unknown. We constructed a δ homolog ("dT2J") in data collected by the Texas Alzheimer's Research and Care Consortium (TARCC). From this, we calculated a composite d-score "d". We then tested d's generalizability across random subsets of TARCC participants and to a convenience sample of elderly Japanese persons with normal cognition (NC), mild cognitive impairment (MCI), and dementia (AD) (n=176). dT2J was indicated by Instrumental Activities of Daily Living and psychometric measures. Embedded in this battery were the Mini-Mental Status Examination (MMSE) and an executive clock-drawing task (CLOX). Only MMSE and CLOX were available in both TARCC and the Japanese cohort. Therefore, a second composite variable, "T2J", was constructed solely from the factor loadings of CLOX and MMSE on d. The diagnostic accuracy of T2J was estimated in the validation sample, the remainder of the TARCC cohort, and in the Japanese sample. The areas under the receiver operating curve (AUC; ROC) for T2J were compared in each sample, and against d in TARCC. The AUCs for T2J were statistically indiscriminable within TARCC, and in Japanese persons. In Japanese persons, AUCs for T2J were 0.97 for the discrimination between AD versus NC, 0.86 for AD versus MCI, and 0.79 for NC versus MCI. The AUCs for T2J in Japanese persons were higher than any individual psychometric measure in that sample. Valid d-score composites can be abstracted from a subset of δ's indicators. Moreover, those composites are exportable across cultural and linguistic boundaries.

Original languageEnglish
Pages (from-to)561-570
Number of pages10
JournalJournal of Alzheimer's Disease
Volume49
Issue number2
DOIs
Publication statusPublished - 2015 Oct 9

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Linguistics
Dementia
Research
Cognition
Area Under Curve
Psychometrics
Activities of Daily Living
Population
Cognitive Dysfunction

Keywords

  • CLOX
  • dementia
  • Instrumental Activities of Daily Living
  • Spearman's g
  • Δ

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Royall, D. R., Palmer, R. F., Matsuoka, T., Kato, Y., Taniguchi, S., Ogawa, M., ... Narumoto, J. (2015). δ scores are exportable across cultural and linguistic boundaries. Journal of Alzheimer's Disease, 49(2), 561-570. https://doi.org/10.3233/JAD-150261

δ scores are exportable across cultural and linguistic boundaries. / Royall, Donald R.; Palmer, Raymond F.; Matsuoka, Teruyuki; Kato, Yuka; Taniguchi, Shogo; Ogawa, Mayu; Fujimoto, Hiroshi; Okamura, Aiko; Shibata, Keisuke; Nakamura, Kaeko; Nakaaki, Shutaro; Koumi, Hiroyuki; Mimura, Masaru; Fukui, Kenji; Narumoto, Jin.

In: Journal of Alzheimer's Disease, Vol. 49, No. 2, 09.10.2015, p. 561-570.

Research output: Contribution to journalArticle

Royall, DR, Palmer, RF, Matsuoka, T, Kato, Y, Taniguchi, S, Ogawa, M, Fujimoto, H, Okamura, A, Shibata, K, Nakamura, K, Nakaaki, S, Koumi, H, Mimura, M, Fukui, K & Narumoto, J 2015, 'δ scores are exportable across cultural and linguistic boundaries', Journal of Alzheimer's Disease, vol. 49, no. 2, pp. 561-570. https://doi.org/10.3233/JAD-150261
Royall DR, Palmer RF, Matsuoka T, Kato Y, Taniguchi S, Ogawa M et al. δ scores are exportable across cultural and linguistic boundaries. Journal of Alzheimer's Disease. 2015 Oct 9;49(2):561-570. https://doi.org/10.3233/JAD-150261
Royall, Donald R. ; Palmer, Raymond F. ; Matsuoka, Teruyuki ; Kato, Yuka ; Taniguchi, Shogo ; Ogawa, Mayu ; Fujimoto, Hiroshi ; Okamura, Aiko ; Shibata, Keisuke ; Nakamura, Kaeko ; Nakaaki, Shutaro ; Koumi, Hiroyuki ; Mimura, Masaru ; Fukui, Kenji ; Narumoto, Jin. / δ scores are exportable across cultural and linguistic boundaries. In: Journal of Alzheimer's Disease. 2015 ; Vol. 49, No. 2. pp. 561-570.
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